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The map label for this gene is betA [H]

Identifier: 89053983

GI number: 89053983

Start: 1462264

End: 1463934

Strand: Reverse

Name: betA [H]

Synonym: Jann_1492

Alternate gene names: 89053983

Gene position: 1463934-1462264 (Counterclockwise)

Preceding gene: 89053984

Following gene: 89053979

Centisome position: 33.9

GC content: 58.71

Gene sequence:

>1671_bases
ATGGAAGCAGATTATGTCGTTATTGGAGCGGGATCAGCAGGTTGCGCGGTGACCTACAGGTTGGCAGAGGCCGGGAAATC
TGTGCTCGTTGTCGAGCATGGCGGGTCCGATTGGGGGCCATTCATCAACATGCCCGCCGCGCTGAGCTATCCGATGGGCA
TGAAGCGCTACGACTGGGGCTACGTGACCGAGCCCGAACCGCACATGAACAATCGCGTCATGGCCTGTCCCCGTGGCAAG
GTGGTCGGAGGGTCCTCCTCAATCAACGGGATGATCTACGTTCGCGGCCATGCGCGCGACTTTGACACCTGGGCAGAAAT
GGGAGCCGATGGTTGGTCCTATGCCGACGTGCTGCCTTATTTCAAACGCGCGGAGACCTGGCACGGCGACGCCGGGGAGC
CCGCCTTCCGAGGCAGTGACGGGCCGGTTCACGTCACCCGGGGCACGCGCAAAAATCCGCTTTATCAGGCGTTTATCGAC
GCTGGTATGCAGGCTGGTTATGGCGCGACGGACGATTACAACGGATATCGGCAGGAGGGGTTCGGCGCGTTTGAGATGAC
CGTTTACAAAGGTAAACGGTGGTCTGCGGCCAGCGCCTATCTTAGGCCCGCACTTGCCAAACCAAACTGCGATATGGTGC
GTGGCCTGGTGCAACGGATCGAGTTTAAGGAGGGCCGGGCAACGGGTGTTCGTCTGGCAGATGGCAGCCTGATCCGAGTG
CGCTGCGAAGTGGTCCTGTGCGCCGGTGCGATCAATTCACCTAAAATTCTAATGCTTAGTGGAATTGGGCCAGCCAAGCA
TTTGGCAGAACATGGTATTTCAGTGGTCGCGGACCGTGCGGGCGTCGGTCAAAACCTGCAAGATCACCTGGAAATGTATA
TCCAGTACGCCGCATCCAAGCCTGTTTCGATCGCACCCTACTGGTCGCTCTGGGGAAAAGCGGCGGTGGGCGCGCAATGG
CTGTTCACCAAGACAGGGCTGGGGGCCACCAACAACTTTGAATCCTGTGGCTTCATTCGCTCCAGCGCAGGGGTGGAATA
TCCTGATATTCAATACCATTTTCTTCCAATCGCGATCCGGTATGACGGCCAGATGCCCCCGGGCGGGCACGGTTTCCAAG
CCCATACCGGCCCCATGCGGTCCCCCTCCCGGGGTGAAATCACGCTCCGCAGTCAAGACCCAGCGCAAGCTCCGAAAATC
CAGTTCAACTACATGTCCCACGAAAAGGACTGGCGGGATTTCCGCCGCGCTATCCGCCTGACGCGCGAGATCTTCGCCAC
CGAACCCATGGCGGAGTACGTCGATCATGAGATCCAACCCGGCGATGCCGCGCAATTCGATGACGCCTTGGATGCGGTCA
TTCGCGAGCATGCTGAATCGGCTTACCACCCCTGTGGAACCGCACGAGTGGGGCAGAGAAATGACCCAATGTCGGTTGTA
GATCCCCAGACCTCGGTGATTGGCGTCAGCAGTTTGCGCGTGGCAGACAGTTCGATTTTTCCTTTGATTCCAAATGGAAA
CCTGAACGCTCCATCAATTATGGTCGGGGAAAAGGCCGCGGATCACATCCTGGGTCGCCGTGTGCCCGCCGAGAATCTGA
CGCCTTGGATCGCACCGGATTGGCAGTCGACACAACGGGAAAGCCATGCCGTAAAGGCTGCGGCTGAATAG

Upstream 100 bases:

>100_bases
GCTCAGGCATCGGGCGCGAGAACTCGCGCACCGCTGTTGAGCATTACAGCCAACTCAAGACTGTTTACGTCGGAATGTCC
CCTGTGGAGGCCGCATTCTG

Downstream 100 bases:

>100_bases
GCTTAGCCGTCGATCCGAAGCACCCGACCGAAAGGCGCGTCGACACCGGCACGTCCCGGCACGACCCAAAGGACAGGAAA
CGGCGGCGGCGGCCCGATCG

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MEADYVVIGAGSAGCAVTYRLAEAGKSVLVVEHGGSDWGPFINMPAALSYPMGMKRYDWGYVTEPEPHMNNRVMACPRGK
VVGGSSSINGMIYVRGHARDFDTWAEMGADGWSYADVLPYFKRAETWHGDAGEPAFRGSDGPVHVTRGTRKNPLYQAFID
AGMQAGYGATDDYNGYRQEGFGAFEMTVYKGKRWSAASAYLRPALAKPNCDMVRGLVQRIEFKEGRATGVRLADGSLIRV
RCEVVLCAGAINSPKILMLSGIGPAKHLAEHGISVVADRAGVGQNLQDHLEMYIQYAASKPVSIAPYWSLWGKAAVGAQW
LFTKTGLGATNNFESCGFIRSSAGVEYPDIQYHFLPIAIRYDGQMPPGGHGFQAHTGPMRSPSRGEITLRSQDPAQAPKI
QFNYMSHEKDWRDFRRAIRLTREIFATEPMAEYVDHEIQPGDAAQFDDALDAVIREHAESAYHPCGTARVGQRNDPMSVV
DPQTSVIGVSSLRVADSSIFPLIPNGNLNAPSIMVGEKAADHILGRRVPAENLTPWIAPDWQSTQRESHAVKAAAE

Sequences:

>Translated_556_residues
MEADYVVIGAGSAGCAVTYRLAEAGKSVLVVEHGGSDWGPFINMPAALSYPMGMKRYDWGYVTEPEPHMNNRVMACPRGK
VVGGSSSINGMIYVRGHARDFDTWAEMGADGWSYADVLPYFKRAETWHGDAGEPAFRGSDGPVHVTRGTRKNPLYQAFID
AGMQAGYGATDDYNGYRQEGFGAFEMTVYKGKRWSAASAYLRPALAKPNCDMVRGLVQRIEFKEGRATGVRLADGSLIRV
RCEVVLCAGAINSPKILMLSGIGPAKHLAEHGISVVADRAGVGQNLQDHLEMYIQYAASKPVSIAPYWSLWGKAAVGAQW
LFTKTGLGATNNFESCGFIRSSAGVEYPDIQYHFLPIAIRYDGQMPPGGHGFQAHTGPMRSPSRGEITLRSQDPAQAPKI
QFNYMSHEKDWRDFRRAIRLTREIFATEPMAEYVDHEIQPGDAAQFDDALDAVIREHAESAYHPCGTARVGQRNDPMSVV
DPQTSVIGVSSLRVADSSIFPLIPNGNLNAPSIMVGEKAADHILGRRVPAENLTPWIAPDWQSTQRESHAVKAAAE
>Mature_556_residues
MEADYVVIGAGSAGCAVTYRLAEAGKSVLVVEHGGSDWGPFINMPAALSYPMGMKRYDWGYVTEPEPHMNNRVMACPRGK
VVGGSSSINGMIYVRGHARDFDTWAEMGADGWSYADVLPYFKRAETWHGDAGEPAFRGSDGPVHVTRGTRKNPLYQAFID
AGMQAGYGATDDYNGYRQEGFGAFEMTVYKGKRWSAASAYLRPALAKPNCDMVRGLVQRIEFKEGRATGVRLADGSLIRV
RCEVVLCAGAINSPKILMLSGIGPAKHLAEHGISVVADRAGVGQNLQDHLEMYIQYAASKPVSIAPYWSLWGKAAVGAQW
LFTKTGLGATNNFESCGFIRSSAGVEYPDIQYHFLPIAIRYDGQMPPGGHGFQAHTGPMRSPSRGEITLRSQDPAQAPKI
QFNYMSHEKDWRDFRRAIRLTREIFATEPMAEYVDHEIQPGDAAQFDDALDAVIREHAESAYHPCGTARVGQRNDPMSVV
DPQTSVIGVSSLRVADSSIFPLIPNGNLNAPSIMVGEKAADHILGRRVPAENLTPWIAPDWQSTQRESHAVKAAAE

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=559, Percent_Identity=48.3005366726297, Blast_Score=501, Evalue=1e-142,
Organism=Escherichia coli, GI1786503, Length=540, Percent_Identity=52.5925925925926, Blast_Score=528, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17532301, Length=558, Percent_Identity=43.1899641577061, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24642042, Length=573, Percent_Identity=34.9040139616056, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24642048, Length=563, Percent_Identity=34.8134991119005, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI45551458, Length=564, Percent_Identity=34.7517730496454, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI45549471, Length=564, Percent_Identity=34.7517730496454, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI17137792, Length=560, Percent_Identity=33.75, Blast_Score=264, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24650267, Length=568, Percent_Identity=33.4507042253521, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24642059, Length=562, Percent_Identity=33.8078291814947, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24642055, Length=572, Percent_Identity=33.7412587412587, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24642039, Length=561, Percent_Identity=34.7593582887701, Blast_Score=258, Evalue=7e-69,
Organism=Drosophila melanogaster, GI18859995, Length=573, Percent_Identity=32.8097731239092, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI24642051, Length=567, Percent_Identity=32.0987654320988, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24642037, Length=565, Percent_Identity=31.5044247787611, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24642035, Length=565, Percent_Identity=31.858407079646, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI18859993, Length=574, Percent_Identity=32.404181184669, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24645930, Length=584, Percent_Identity=26.7123287671233, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24642057, Length=593, Percent_Identity=26.3069139966273, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 60731; Mature: 60731

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEADYVVIGAGSAGCAVTYRLAEAGKSVLVVEHGGSDWGPFINMPAALSYPMGMKRYDWG
CCCCEEEEECCCCCCEEEEEEHHCCCEEEEEECCCCCCCCCCCCCCHHCCCCCCCCCCCC
YVTEPEPHMNNRVMACPRGKVVGGSSSINGMIYVRGHARDFDTWAEMGADGWSYADVLPY
CCCCCCCCCCCEEEECCCCCEECCCCCCCEEEEEEECCCCHHHHHHHCCCCCCHHHHHHH
FKRAETWHGDAGEPAFRGSDGPVHVTRGTRKNPLYQAFIDAGMQAGYGATDDYNGYRQEG
HHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCC
FGAFEMTVYKGKRWSAASAYLRPALAKPNCDMVRGLVQRIEFKEGRATGVRLADGSLIRV
CCEEEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCEEEE
RCEVVLCAGAINSPKILMLSGIGPAKHLAEHGISVVADRAGVGQNLQDHLEMYIQYAASK
EEEEEEEECCCCCCCEEEEECCCHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHCCC
PVSIAPYWSLWGKAAVGAQWLFTKTGLGATNNFESCGFIRSSAGVEYPDIQYHFLPIAIR
CCEECCHHHHHCCHHCCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEEEE
YDGQMPPGGHGFQAHTGPMRSPSRGEITLRSQDPAQAPKIQFNYMSHEKDWRDFRRAIRL
ECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHH
TREIFATEPMAEYVDHEIQPGDAAQFDDALDAVIREHAESAYHPCGTARVGQRNDPMSVV
HHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
DPQTSVIGVSSLRVADSSIFPLIPNGNLNAPSIMVGEKAADHILGRRVPAENLTPWIAPD
CCCCCEEEEEEEEECCCCCEEEECCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCC
WQSTQRESHAVKAAAE
CHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEADYVVIGAGSAGCAVTYRLAEAGKSVLVVEHGGSDWGPFINMPAALSYPMGMKRYDWG
CCCCEEEEECCCCCCEEEEEEHHCCCEEEEEECCCCCCCCCCCCCCHHCCCCCCCCCCCC
YVTEPEPHMNNRVMACPRGKVVGGSSSINGMIYVRGHARDFDTWAEMGADGWSYADVLPY
CCCCCCCCCCCEEEECCCCCEECCCCCCCEEEEEEECCCCHHHHHHHCCCCCCHHHHHHH
FKRAETWHGDAGEPAFRGSDGPVHVTRGTRKNPLYQAFIDAGMQAGYGATDDYNGYRQEG
HHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCC
FGAFEMTVYKGKRWSAASAYLRPALAKPNCDMVRGLVQRIEFKEGRATGVRLADGSLIRV
CCEEEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCEEEE
RCEVVLCAGAINSPKILMLSGIGPAKHLAEHGISVVADRAGVGQNLQDHLEMYIQYAASK
EEEEEEEECCCCCCCEEEEECCCHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHCCC
PVSIAPYWSLWGKAAVGAQWLFTKTGLGATNNFESCGFIRSSAGVEYPDIQYHFLPIAIR
CCEECCHHHHHCCHHCCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEEEE
YDGQMPPGGHGFQAHTGPMRSPSRGEITLRSQDPAQAPKIQFNYMSHEKDWRDFRRAIRL
ECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHH
TREIFATEPMAEYVDHEIQPGDAAQFDDALDAVIREHAESAYHPCGTARVGQRNDPMSVV
HHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
DPQTSVIGVSSLRVADSSIFPLIPNGNLNAPSIMVGEKAADHILGRRVPAENLTPWIAPD
CCCCCEEEEEEEEECCCCCEEEECCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCC
WQSTQRESHAVKAAAE
CHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]