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The map label for this gene is hisM [H]

Identifier: 89053620

GI number: 89053620

Start: 1090937

End: 1091776

Strand: Reverse

Name: hisM [H]

Synonym: Jann_1129

Alternate gene names: 89053620

Gene position: 1091776-1090937 (Counterclockwise)

Preceding gene: 89053621

Following gene: 89053619

Centisome position: 25.28

GC content: 63.81

Gene sequence:

>840_bases
ATGAGTTGCGCGCAGACGATCCAAGACTACGCCCTCCGCTCCCTCGGCATCGGCGAACGCGCTCTGCCCCAGGGCGACGT
GACGCTGTGCGAACAGGTCGTCCTCATCGGCTCGGGCATGATCTGGAACGTCTATTTCGGCGTCCTGGCCCTGTCGTTCG
GCTTCTTCTTCGCCGTCGCCCTCGCTGTCGCCAAAGCCTCCCCCCGTTTCATGCTCCGCAAACCGGCGGAGTGGTTCATC
TTCCTGTTCCGGGGCTCGCCCCTCTTCATCCAGTTCTTCATGGCCTATGAGGCTTTCGTGATGCTGCCCCGCCTGGGCTA
TGAGTTCGAGCTCTTCGGCATCGCCATCGAGGCCGAGACCCGCTGGTTCGCCCGCGCCTGGCTCGGGGCCCTCATCGTCC
TGTTCTGCAACACCTCCGCCTATGCGGCCGAGATCTTCTACGGCGCACTCCGCTCGGTCCCCAAAGGCGATCTGGAGGCC
GCCGACGCCTATGGCCTGACCGGCTGGACCAAGTTCAGGCGCATCACCTTCCCCACCACGATGCGCCTCGCATGGCCCGC
CTACACCAACGAGGCGATCTTCATGTTCCACGCCACCGCACTGGTGTTCTTCAGCTCCTTTCCCGCCTTCCAGCAGCGCG
GCGATGCGCTCTACTACGCCTCCTACTTCGCCGACCGCACGTTCAACCCGTTCATCCCCTATCCCATCGTGGGGGCTTAT
TTCATTGCCCTCACCCTTCTGGTGATCGCGCTTTTTGGGGCGATCAACCGCCGCCTGAACCGCCACTTGCCGTCGGACCG
GCGGGCAAAGCTGCGCATTCGACCGACGCTGATCCGGTAG

Upstream 100 bases:

>100_bases
CTTTTGCAAAAGCCTTGCCAGAGCCTTGCAAGGCTCTGGTCACGCCCTTGCAAGGGCGTGGGAAAACCCTTGCAAGGGTT
TTGCGCCAAGGCCTTCGCCC

Downstream 100 bases:

>100_bases
AGGACCTCCGGTAAGCGGAGTTTCGCGAGTTTCAACAATCCAGTCAGGTTTTCCGTAGCACCCCTCAGCCGTCGCGCGCG
GTAGGGTCACACCACCCCTG

Product: binding-protein-dependent transport systems inner membrane component

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MSCAQTIQDYALRSLGIGERALPQGDVTLCEQVVLIGSGMIWNVYFGVLALSFGFFFAVALAVAKASPRFMLRKPAEWFI
FLFRGSPLFIQFFMAYEAFVMLPRLGYEFELFGIAIEAETRWFARAWLGALIVLFCNTSAYAAEIFYGALRSVPKGDLEA
ADAYGLTGWTKFRRITFPTTMRLAWPAYTNEAIFMFHATALVFFSSFPAFQQRGDALYYASYFADRTFNPFIPYPIVGAY
FIALTLLVIALFGAINRRLNRHLPSDRRAKLRIRPTLIR

Sequences:

>Translated_279_residues
MSCAQTIQDYALRSLGIGERALPQGDVTLCEQVVLIGSGMIWNVYFGVLALSFGFFFAVALAVAKASPRFMLRKPAEWFI
FLFRGSPLFIQFFMAYEAFVMLPRLGYEFELFGIAIEAETRWFARAWLGALIVLFCNTSAYAAEIFYGALRSVPKGDLEA
ADAYGLTGWTKFRRITFPTTMRLAWPAYTNEAIFMFHATALVFFSSFPAFQQRGDALYYASYFADRTFNPFIPYPIVGAY
FIALTLLVIALFGAINRRLNRHLPSDRRAKLRIRPTLIR
>Mature_278_residues
SCAQTIQDYALRSLGIGERALPQGDVTLCEQVVLIGSGMIWNVYFGVLALSFGFFFAVALAVAKASPRFMLRKPAEWFIF
LFRGSPLFIQFFMAYEAFVMLPRLGYEFELFGIAIEAETRWFARAWLGALIVLFCNTSAYAAEIFYGALRSVPKGDLEAA
DAYGLTGWTKFRRITFPTTMRLAWPAYTNEAIFMFHATALVFFSSFPAFQQRGDALYYASYFADRTFNPFIPYPIVGAYF
IALTLLVIALFGAINRRLNRHLPSDRRAKLRIRPTLIR

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=234, Percent_Identity=32.4786324786325, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788226, Length=229, Percent_Identity=29.6943231441048, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787086, Length=177, Percent_Identity=26.5536723163842, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI87082239, Length=160, Percent_Identity=31.25, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787087, Length=229, Percent_Identity=26.6375545851528, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 31701; Mature: 31569

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCAQTIQDYALRSLGIGERALPQGDVTLCEQVVLIGSGMIWNVYFGVLALSFGFFFAVA
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LAVAKASPRFMLRKPAEWFIFLFRGSPLFIQFFMAYEAFVMLPRLGYEFELFGIAIEAET
HHHHCCCCCCEEECCHHHEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCH
RWFARAWLGALIVLFCNTSAYAAEIFYGALRSVPKGDLEAADAYGLTGWTKFRRITFPTT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCHHHHEEEECCCE
MRLAWPAYTNEAIFMFHATALVFFSSFPAFQQRGDALYYASYFADRTFNPFIPYPIVGAY
EEEECCCCCCCEEEEHHHHHHHHHHCCHHHHHCCCEEEEEHHHHCCCCCCCCCHHHHHHH
FIALTLLVIALFGAINRRLNRHLPSDRRAKLRIRPTLIR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCC
>Mature Secondary Structure 
SCAQTIQDYALRSLGIGERALPQGDVTLCEQVVLIGSGMIWNVYFGVLALSFGFFFAVA
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LAVAKASPRFMLRKPAEWFIFLFRGSPLFIQFFMAYEAFVMLPRLGYEFELFGIAIEAET
HHHHCCCCCCEEECCHHHEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCH
RWFARAWLGALIVLFCNTSAYAAEIFYGALRSVPKGDLEAADAYGLTGWTKFRRITFPTT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCHHHHEEEECCCE
MRLAWPAYTNEAIFMFHATALVFFSSFPAFQQRGDALYYASYFADRTFNPFIPYPIVGAY
EEEECCCCCCCEEEEHHHHHHHHHHCCHHHHHCCCEEEEEHHHHCCCCCCCCCHHHHHHH
FIALTLLVIALFGAINRRLNRHLPSDRRAKLRIRPTLIR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]