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The map label for this gene is hisQ [H]

Identifier: 89053621

GI number: 89053621

Start: 1091904

End: 1092785

Strand: Reverse

Name: hisQ [H]

Synonym: Jann_1130

Alternate gene names: 89053621

Gene position: 1092785-1091904 (Counterclockwise)

Preceding gene: 89053622

Following gene: 89053620

Centisome position: 25.31

GC content: 63.38

Gene sequence:

>882_bases
ATGTTCAGCTTCTGCGAAGACCCCTCCACGCTTGCGACGTTCCAATGGTTCAGCTGCTACCTGACCAATGGCGTCCATAT
GCTGTTCTATCAGAGCTTCCTGACGGTTGCGGTGCTTCTGGCGGTCGCCGCCCCCCTGTCGCTGGCGTTTGGCTTTGCCT
CTGCCACTGCATCCCGGTCCCCGGTTCTTCCGCTGCGCCTTGTCGGCAAGGGCTATACGTCCATGGTGCGCGGCATCCCG
GACATCGTGTTCTTCCTGTTCTTCGTCCTCGTCCTGGATCAGGGGATCGAATACCTGCGCCACACCATCGCCTGCCCCGA
CTGGGACGAGCCGATCCGCCAGGGCGCGAACTTTCTGGTCTGTGACGCCGCCCGCACGCCCCAGGGCGCCGCCCCGCAAT
GGGTGCACGAGACCTATAACTTCGGCCTTGCCGCGCTGACCTACGCCATCGTCTTCGGGGCCTTTTGCGGGAATGTCCTT
TACGGTGCGATGAACGCGGTGCCCCGGCCGCAGTTGGAAACCGCCGCCGCTTACGGCCTGTCGACGCGCCAGATCTTCTG
GCGCATCCTGGTGCCGCAGATGTGGATCTACGCGCTGCCGGGCCTTTCCAACATCTGGATGATCCTGATCAAAGCGACAC
CCTTGCTGTTCCTTCTGGGCATTGAGGATATCGTCTACTGGGCCCGAGAAATTGGCGGCTCGCGCAACGCCCGCTTTACC
TATCCGCACCCCGACTGGCGCTTCTGGTACTTCCTGGGCCTGCTGATCTTCTACCTCTGCTTCACACGACTGTCCGAGAT
TGTGCTGGCCCGCCTCACGCGCCGCCTGTCGCGGGGGCAGGCCACGGCGGGCGGCGACGCGATGCGAAAGGCTGCGGCTT
GA

Upstream 100 bases:

>100_bases
AGGCCGGTGTCCTGGCTGTCTAACAGAGGCCACGGCGCGCGGCGCTCCCCCTTCATCTGGGCACATACACCTCGATCCCG
CCCCCAACCCCAAGCCCCCC

Downstream 100 bases:

>100_bases
CCCGCCGCATGCGCCACGCGCCCAAGGCTTTTGCAAAAGCCTTGCCAGAGCCTTGCAAGGCTCTGGTCACGCCCTTGCAA
GGGCGTGGGAAAACCCTTGC

Product: binding-protein-dependent transport systems inner membrane component

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MFSFCEDPSTLATFQWFSCYLTNGVHMLFYQSFLTVAVLLAVAAPLSLAFGFASATASRSPVLPLRLVGKGYTSMVRGIP
DIVFFLFFVLVLDQGIEYLRHTIACPDWDEPIRQGANFLVCDAARTPQGAAPQWVHETYNFGLAALTYAIVFGAFCGNVL
YGAMNAVPRPQLETAAAYGLSTRQIFWRILVPQMWIYALPGLSNIWMILIKATPLLFLLGIEDIVYWAREIGGSRNARFT
YPHPDWRFWYFLGLLIFYLCFTRLSEIVLARLTRRLSRGQATAGGDAMRKAAA

Sequences:

>Translated_293_residues
MFSFCEDPSTLATFQWFSCYLTNGVHMLFYQSFLTVAVLLAVAAPLSLAFGFASATASRSPVLPLRLVGKGYTSMVRGIP
DIVFFLFFVLVLDQGIEYLRHTIACPDWDEPIRQGANFLVCDAARTPQGAAPQWVHETYNFGLAALTYAIVFGAFCGNVL
YGAMNAVPRPQLETAAAYGLSTRQIFWRILVPQMWIYALPGLSNIWMILIKATPLLFLLGIEDIVYWAREIGGSRNARFT
YPHPDWRFWYFLGLLIFYLCFTRLSEIVLARLTRRLSRGQATAGGDAMRKAAA
>Mature_293_residues
MFSFCEDPSTLATFQWFSCYLTNGVHMLFYQSFLTVAVLLAVAAPLSLAFGFASATASRSPVLPLRLVGKGYTSMVRGIP
DIVFFLFFVLVLDQGIEYLRHTIACPDWDEPIRQGANFLVCDAARTPQGAAPQWVHETYNFGLAALTYAIVFGAFCGNVL
YGAMNAVPRPQLETAAAYGLSTRQIFWRILVPQMWIYALPGLSNIWMILIKATPLLFLLGIEDIVYWAREIGGSRNARFT
YPHPDWRFWYFLGLLIFYLCFTRLSEIVLARLTRRLSRGQATAGGDAMRKAAA

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=240, Percent_Identity=29.1666666666667, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1787087, Length=218, Percent_Identity=29.3577981651376, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 32860; Mature: 32860

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSFCEDPSTLATFQWFSCYLTNGVHMLFYQSFLTVAVLLAVAAPLSLAFGFASATASRS
CCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVLPLRLVGKGYTSMVRGIPDIVFFLFFVLVLDQGIEYLRHTIACPDWDEPIRQGANFLV
CCCHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEE
CDAARTPQGAAPQWVHETYNFGLAALTYAIVFGAFCGNVLYGAMNAVPRPQLETAAAYGL
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
STRQIFWRILVPQMWIYALPGLSNIWMILIKATPLLFLLGIEDIVYWAREIGGSRNARFT
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEC
YPHPDWRFWYFLGLLIFYLCFTRLSEIVLARLTRRLSRGQATAGGDAMRKAAA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MFSFCEDPSTLATFQWFSCYLTNGVHMLFYQSFLTVAVLLAVAAPLSLAFGFASATASRS
CCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVLPLRLVGKGYTSMVRGIPDIVFFLFFVLVLDQGIEYLRHTIACPDWDEPIRQGANFLV
CCCHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEE
CDAARTPQGAAPQWVHETYNFGLAALTYAIVFGAFCGNVLYGAMNAVPRPQLETAAAYGL
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
STRQIFWRILVPQMWIYALPGLSNIWMILIKATPLLFLLGIEDIVYWAREIGGSRNARFT
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEC
YPHPDWRFWYFLGLLIFYLCFTRLSEIVLARLTRRLSRGQATAGGDAMRKAAA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]