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The map label for this gene is thlA [H]

Identifier: 89053159

GI number: 89053159

Start: 638776

End: 639957

Strand: Direct

Name: thlA [H]

Synonym: Jann_0668

Alternate gene names: 89053159

Gene position: 638776-639957 (Clockwise)

Preceding gene: 89053158

Following gene: 89053160

Centisome position: 14.79

GC content: 65.31

Gene sequence:

>1182_bases
ATGGCCTACATACCTTACGGGGCCTATTGGTCGACGCCCTTTGCCCGCTGGCAGGGGAGCCTGGCGCATCTGAACTCGGT
GCAGTTCGCCGCTCATGTGGGGCGGGGAGAGCTGACGCGCATGGGACTGCTTGCCGACAGTTTCGATTTTGCCGCCTTCG
GGCAGACGGTGATCCAGAAGGGCAGCTTCTTCGGGGGGCCGTGGTTCACGGCGATGCTGGGGGCAGAGGGTCTGGCTGCG
CCGATGGTCAGCCAGGCCTGTGCCACGGGCGCGCGGTTGGTCGCAACGGCGGTGGGTGAGATCGCGCAGGGGGCGACGCA
GGCGCTGATCGTGTCGGGGGATCGCACGTCCAACGGCCCCCATGTCTACTTTCCGGCGCCCGGCGGCCCTGGGGGAACCG
GGGTTGCCGAGGATGTGGTGATGGACAATTTCGGGCACGATCCCTGGGCGTGCAACGCGATGATCCAGACCGGCGAAAAC
GTGGCTGCGCGCGACGGGATTTCGACCGAGGAGCAACACGATCTGGTCGCCTGCAGGCGGGCGCAATACGATGATGCGCT
GGCGGATGGGCGTGCGTTTCAGCGCCGTTACATGCGGGTGCTGGACGTGCCCGATGCCCGGTTTCGCAAGACAGTGGCCG
TGTTGGAGGGCGATGAGGGTGTTGAGCCGCTGGATGCGGAGAAACTGACACGGTTGAAGCCGGTGGTTCCCGGGGGGACG
ATCACGTTTGCCGGACAAACGCATCCCGCGGACGGGAATGCTGGAATGGTTGTGGTGGCCGACCGTGCGCAGGCCTTGGA
GATTGGGGATGGGCCCGTGGTAGAGGTTCTGGCCGTCGGTCAGGCGCGGGAGGAGAAGGGGTTCATGCCCGCCGCGCCGA
TCAAGGCGACGCGGGTTGCGCTGGGCCGCGCGGACCTCGGGATCGAAGATGTGGATGCCATCAAGTCGCACAACCCGTTT
GCGGTCAACGACATCGCCTTCGCGCGAGCGTTTGATCTGGATTGGCGCGGAATGAACAACTTTGGAAGCTCGTTGATCTG
GGGGCATCCGCAGGGGCCAACGGGTCTGCGGGGGATGATCGAACTTGTAGAAGAATTAGCCCTGCGCGGAGGCGGGGTGG
GCCTGTTCCAGGGCTGTGCTGCCGGGGACTCGGCCATGGCCGTCGTGTTGAAAGTTGGCTAG

Upstream 100 bases:

>100_bases
GCAACCTCAATTTCGCCCGGATCCGGGCCGGGCGCGCGGATCTGATCGCGCGGCTCTATGATCCCTCGGACCCCGCCTCG
ATCACTTTGGGAGAGCTGTG

Downstream 100 bases:

>100_bases
CGCGCAGAGCGCGTGAAGGACGTAAAAGGGAGTATACCGGCATGGCAAATGCAGCGACGTTTTTCGTAGATCGCCACATG
GCTGAAGGCAGGGCGGACAA

Product: thiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MAYIPYGAYWSTPFARWQGSLAHLNSVQFAAHVGRGELTRMGLLADSFDFAAFGQTVIQKGSFFGGPWFTAMLGAEGLAA
PMVSQACATGARLVATAVGEIAQGATQALIVSGDRTSNGPHVYFPAPGGPGGTGVAEDVVMDNFGHDPWACNAMIQTGEN
VAARDGISTEEQHDLVACRRAQYDDALADGRAFQRRYMRVLDVPDARFRKTVAVLEGDEGVEPLDAEKLTRLKPVVPGGT
ITFAGQTHPADGNAGMVVVADRAQALEIGDGPVVEVLAVGQAREEKGFMPAAPIKATRVALGRADLGIEDVDAIKSHNPF
AVNDIAFARAFDLDWRGMNNFGSSLIWGHPQGPTGLRGMIELVEELALRGGGVGLFQGCAAGDSAMAVVLKVG

Sequences:

>Translated_393_residues
MAYIPYGAYWSTPFARWQGSLAHLNSVQFAAHVGRGELTRMGLLADSFDFAAFGQTVIQKGSFFGGPWFTAMLGAEGLAA
PMVSQACATGARLVATAVGEIAQGATQALIVSGDRTSNGPHVYFPAPGGPGGTGVAEDVVMDNFGHDPWACNAMIQTGEN
VAARDGISTEEQHDLVACRRAQYDDALADGRAFQRRYMRVLDVPDARFRKTVAVLEGDEGVEPLDAEKLTRLKPVVPGGT
ITFAGQTHPADGNAGMVVVADRAQALEIGDGPVVEVLAVGQAREEKGFMPAAPIKATRVALGRADLGIEDVDAIKSHNPF
AVNDIAFARAFDLDWRGMNNFGSSLIWGHPQGPTGLRGMIELVEELALRGGGVGLFQGCAAGDSAMAVVLKVG
>Mature_392_residues
AYIPYGAYWSTPFARWQGSLAHLNSVQFAAHVGRGELTRMGLLADSFDFAAFGQTVIQKGSFFGGPWFTAMLGAEGLAAP
MVSQACATGARLVATAVGEIAQGATQALIVSGDRTSNGPHVYFPAPGGPGGTGVAEDVVMDNFGHDPWACNAMIQTGENV
AARDGISTEEQHDLVACRRAQYDDALADGRAFQRRYMRVLDVPDARFRKTVAVLEGDEGVEPLDAEKLTRLKPVVPGGTI
TFAGQTHPADGNAGMVVVADRAQALEIGDGPVVEVLAVGQAREEKGFMPAAPIKATRVALGRADLGIEDVDAIKSHNPFA
VNDIAFARAFDLDWRGMNNFGSSLIWGHPQGPTGLRGMIELVEELALRGGGVGLFQGCAAGDSAMAVVLKVG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=443, Percent_Identity=26.410835214447, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI148539872, Length=310, Percent_Identity=26.1290322580645, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=25.765306122449, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI4501853, Length=297, Percent_Identity=28.956228956229, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=25.7731958762887, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788554, Length=390, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=26.25, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=27.1573604060914, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=24.3589743589744, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25147385, Length=386, Percent_Identity=24.0932642487047, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551802, Length=414, Percent_Identity=26.0869565217391, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=25.7575757575758, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24655093, Length=387, Percent_Identity=24.031007751938, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=23.469387755102, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17137578, Length=200, Percent_Identity=26.5, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41283; Mature: 41152

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYIPYGAYWSTPFARWQGSLAHLNSVQFAAHVGRGELTRMGLLADSFDFAAFGQTVIQK
CCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHC
GSFFGGPWFTAMLGAEGLAAPMVSQACATGARLVATAVGEIAQGATQALIVSGDRTSNGP
CCCCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
HVYFPAPGGPGGTGVAEDVVMDNFGHDPWACNAMIQTGENVAARDGISTEEQHDLVACRR
EEEECCCCCCCCCCHHHHHHHHCCCCCCCEEHHHEECCCCHHHCCCCCCCHHHHHHHHHH
AQYDDALADGRAFQRRYMRVLDVPDARFRKTVAVLEGDEGVEPLDAEKLTRLKPVVPGGT
HCCCHHHHCCHHHHHHHHHHHCCCCHHHHHEEEEEECCCCCCCCCHHHHHHHCCCCCCCE
ITFAGQTHPADGNAGMVVVADRAQALEIGDGPVVEVLAVGQAREEKGFMPAAPIKATRVA
EEECCCCCCCCCCCCEEEEECCCCEEECCCCCEEEEEECCCCHHHCCCCCCCCCHHHHEE
LGRADLGIEDVDAIKSHNPFAVNDIAFARAFDLDWRGMNNFGSSLIWGHPQGPTGLRGMI
ECCCCCCCHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHH
ELVEELALRGGGVGLFQGCAAGDSAMAVVLKVG
HHHHHHHHCCCCCHHHHHCCCCCCEEEEEEEEC
>Mature Secondary Structure 
AYIPYGAYWSTPFARWQGSLAHLNSVQFAAHVGRGELTRMGLLADSFDFAAFGQTVIQK
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHC
GSFFGGPWFTAMLGAEGLAAPMVSQACATGARLVATAVGEIAQGATQALIVSGDRTSNGP
CCCCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
HVYFPAPGGPGGTGVAEDVVMDNFGHDPWACNAMIQTGENVAARDGISTEEQHDLVACRR
EEEECCCCCCCCCCHHHHHHHHCCCCCCCEEHHHEECCCCHHHCCCCCCCHHHHHHHHHH
AQYDDALADGRAFQRRYMRVLDVPDARFRKTVAVLEGDEGVEPLDAEKLTRLKPVVPGGT
HCCCHHHHCCHHHHHHHHHHHCCCCHHHHHEEEEEECCCCCCCCCHHHHHHHCCCCCCCE
ITFAGQTHPADGNAGMVVVADRAQALEIGDGPVVEVLAVGQAREEKGFMPAAPIKATRVA
EEECCCCCCCCCCCCEEEEECCCCEEECCCCCEEEEEECCCCHHHCCCCCCCCCHHHHEE
LGRADLGIEDVDAIKSHNPFAVNDIAFARAFDLDWRGMNNFGSSLIWGHPQGPTGLRGMI
ECCCCCCCHHHHHHHCCCCEEECCCCEEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHH
ELVEELALRGGGVGLFQGCAAGDSAMAVVLKVG
HHHHHHHHCCCCCHHHHHCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA