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The map label for this gene is hbaA [H]

Identifier: 89053160

GI number: 89053160

Start: 639999

End: 641510

Strand: Direct

Name: hbaA [H]

Synonym: Jann_0669

Alternate gene names: 89053160

Gene position: 639999-641510 (Clockwise)

Preceding gene: 89053159

Following gene: 89053161

Centisome position: 14.82

GC content: 64.81

Gene sequence:

>1512_bases
ATGGCAAATGCAGCGACGTTTTTCGTAGATCGCCACATGGCTGAAGGCAGGGCGGACAAGCCCGCATTCGTTGAGGCTGA
TGGCAAGGAGCGGGTGCTGACATACGGGCAGCTCCACGTCGAATCCGGGCGTTTTGCCGGCGCTCTGGGGCGGCACGGCG
TGCGGCGGGAAGAGCGGATCGCGATGATTGTGCGCGATCAGATCGAATGGCCAGTGGTGTTCTGGGGCGCGATGAAGGCG
GGCGCGATCCCGGTGCCGCTGAACACGCTGCTCAGCTCCGACGTCTATGAGACGATCCTGACGGACAGCCGGGCGTCGAT
CCTCGTCGTGTCGGAGGAAATGTGGGAGGTGGTGGAACCCGCCACCCGCGACAACGCCTTCCTGCGCGCGATTCTGGTGA
TCGGCGATGCGCCGGAGATGACGGAGAGTTACCGGGATTTCACCGATGGCGCGCCGGAGGTGGAAACGGTCGCGGCGAAT
GACGATGAACTGGCGTTCTGGCTCTATTCGTCGGGGTCTACCGGGCAGCCCAAGGGGGTGCGGCATGTCCATGGGGCGTT
GAAGGCGACGTGCGAGACGTTTGGCGACCAGGTCCTGGGCATCCGGGAGGACGACGTTGTTTATTCCGTTGCGAAGATGT
TCTTTGCATACGGCTTGGGCAACGCGGTGTCGTTCCCGCAATCGGTCGGGGCCACGACGGTGCTGTTTGGCGGGCGACCC
ACGCCGCCTGTGGTCTTTGATATCCTTGCCAAGCACCGCCCCAGCATTCTGTGCGCCGTGCCGACGCTGTTTGCGGCGTT
GGTGCAGGCCGCAGATGGCGCGCCGAAGCACGGGTTGCGGTTGTGCACGTCCGCCGGGGAAGCCCTGCCGAGAGACGTGG
GCGAGGGGTGGGACAGGCTGACCGGAGTGGAGATCGTGGACGGTGTCGGGTCCACCGAGATGCTGCACATCTTCCTGTCC
AACGCGCCGGGCGATTGCGTCTATGGCACCTCGGGGACCGCCGTGCCGGGGTATGAGCTGCGTCTGGTCAATGAGCATGA
CGAGGAGCTCGCGGACGGCGAGGTCGGCGAGCTTCTGGTGCGCGGGCCGTCCAGCGCGGACGGGTATTGGAACCGGCGCG
CGAAGTCCCAGGCGACATTCGAGGGGATGTGGACGCGCACCGGCGACAAGTACGAGCGCAAGGATGGGCGCTACATCTAC
TGTGGGCGCACGGACGACATGTTCAAGGTCTCGGGCATCTGGGTGTCGCCCTTTGAAGTGGAGAGCGCGTTGGTTGACCA
TGCCTCGGTTCTGGAGGCCGCCGTCGTGGCGCGCGCGGATGAGGCGGGTTTGGACAAACCAGCGGCCTTCGTGGTGCTGA
CAGAGGGGGCAGAGGTGCCGGAGGCGGAGGCCTTGAAGGCGTTCGTGAAGGACAAGATCGGCATGTGGAAATACCCGCGC
TGGGTGGAGATTGTCGAGGATCTGCCGAAGACGGCGACGGGCAAGATCCAGCGGTTCAAGCTGCGCGCCTGA

Upstream 100 bases:

>100_bases
TGTTCCAGGGCTGTGCTGCCGGGGACTCGGCCATGGCCGTCGTGTTGAAAGTTGGCTAGCGCGCAGAGCGCGTGAAGGAC
GTAAAAGGGAGTATACCGGC

Downstream 100 bases:

>100_bases
TGTGGGGCGCGGGCCATGTGACGGCGGGCGGCAAGCGGCTGGAATACCGCTGCTGGGGGGATGCGCCCGAGGACGGCCGT
TGTGTGGTTCTGCTGCATGA

Product: benzoate-CoA ligase family

Products: NA

Alternate protein names: 4-hydroxybenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MANAATFFVDRHMAEGRADKPAFVEADGKERVLTYGQLHVESGRFAGALGRHGVRREERIAMIVRDQIEWPVVFWGAMKA
GAIPVPLNTLLSSDVYETILTDSRASILVVSEEMWEVVEPATRDNAFLRAILVIGDAPEMTESYRDFTDGAPEVETVAAN
DDELAFWLYSSGSTGQPKGVRHVHGALKATCETFGDQVLGIREDDVVYSVAKMFFAYGLGNAVSFPQSVGATTVLFGGRP
TPPVVFDILAKHRPSILCAVPTLFAALVQAADGAPKHGLRLCTSAGEALPRDVGEGWDRLTGVEIVDGVGSTEMLHIFLS
NAPGDCVYGTSGTAVPGYELRLVNEHDEELADGEVGELLVRGPSSADGYWNRRAKSQATFEGMWTRTGDKYERKDGRYIY
CGRTDDMFKVSGIWVSPFEVESALVDHASVLEAAVVARADEAGLDKPAAFVVLTEGAEVPEAEALKAFVKDKIGMWKYPR
WVEIVEDLPKTATGKIQRFKLRA

Sequences:

>Translated_503_residues
MANAATFFVDRHMAEGRADKPAFVEADGKERVLTYGQLHVESGRFAGALGRHGVRREERIAMIVRDQIEWPVVFWGAMKA
GAIPVPLNTLLSSDVYETILTDSRASILVVSEEMWEVVEPATRDNAFLRAILVIGDAPEMTESYRDFTDGAPEVETVAAN
DDELAFWLYSSGSTGQPKGVRHVHGALKATCETFGDQVLGIREDDVVYSVAKMFFAYGLGNAVSFPQSVGATTVLFGGRP
TPPVVFDILAKHRPSILCAVPTLFAALVQAADGAPKHGLRLCTSAGEALPRDVGEGWDRLTGVEIVDGVGSTEMLHIFLS
NAPGDCVYGTSGTAVPGYELRLVNEHDEELADGEVGELLVRGPSSADGYWNRRAKSQATFEGMWTRTGDKYERKDGRYIY
CGRTDDMFKVSGIWVSPFEVESALVDHASVLEAAVVARADEAGLDKPAAFVVLTEGAEVPEAEALKAFVKDKIGMWKYPR
WVEIVEDLPKTATGKIQRFKLRA
>Mature_502_residues
ANAATFFVDRHMAEGRADKPAFVEADGKERVLTYGQLHVESGRFAGALGRHGVRREERIAMIVRDQIEWPVVFWGAMKAG
AIPVPLNTLLSSDVYETILTDSRASILVVSEEMWEVVEPATRDNAFLRAILVIGDAPEMTESYRDFTDGAPEVETVAAND
DELAFWLYSSGSTGQPKGVRHVHGALKATCETFGDQVLGIREDDVVYSVAKMFFAYGLGNAVSFPQSVGATTVLFGGRPT
PPVVFDILAKHRPSILCAVPTLFAALVQAADGAPKHGLRLCTSAGEALPRDVGEGWDRLTGVEIVDGVGSTEMLHIFLSN
APGDCVYGTSGTAVPGYELRLVNEHDEELADGEVGELLVRGPSSADGYWNRRAKSQATFEGMWTRTGDKYERKDGRYIYC
GRTDDMFKVSGIWVSPFEVESALVDHASVLEAAVVARADEAGLDKPAAFVVLTEGAEVPEAEALKAFVKDKIGMWKYPRW
VEIVEDLPKTATGKIQRFKLRA

Specific function: Catalyzes the ligation of 4-hydroxybenzoate, benzoate or cyclohex-1,4-dienecarboxylate and CoA at the expense of ATP. The enzyme shows low activity towards cyclo-2,5-dienecarboxylate, 4- fluorobenzoate, 4-chlorobenzoate and 2-methoxybenzoate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. Benzoate-CoA ligase subfamily [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=506, Percent_Identity=30.2371541501976, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI42544132, Length=512, Percent_Identity=27.5390625, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI187761345, Length=529, Percent_Identity=28.7334593572779, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI187761343, Length=529, Percent_Identity=28.7334593572779, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI122937307, Length=505, Percent_Identity=28.9108910891089, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI58082049, Length=514, Percent_Identity=27.431906614786, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI157311624, Length=514, Percent_Identity=27.0428015564202, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI157311622, Length=514, Percent_Identity=27.0428015564202, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI115511026, Length=525, Percent_Identity=26.8571428571429, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI8923896, Length=568, Percent_Identity=27.4647887323944, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI253970489, Length=581, Percent_Identity=26.8502581755594, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI13375727, Length=554, Percent_Identity=24.3682310469314, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI28416953, Length=549, Percent_Identity=24.408014571949, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI156151445, Length=513, Percent_Identity=24.5614035087719, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI42544134, Length=358, Percent_Identity=22.6256983240223, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI195947378, Length=418, Percent_Identity=24.1626794258373, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1788107, Length=523, Percent_Identity=28.8718929254302, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1790505, Length=543, Percent_Identity=27.0718232044199, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI145693145, Length=507, Percent_Identity=26.4299802761341, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI221142682, Length=483, Percent_Identity=25.879917184265, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1786810, Length=517, Percent_Identity=23.4042553191489, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1786529, Length=523, Percent_Identity=26.5774378585086, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789201, Length=360, Percent_Identity=24.7222222222222, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786801, Length=485, Percent_Identity=24.5360824742268, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788595, Length=376, Percent_Identity=27.3936170212766, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17531443, Length=502, Percent_Identity=24.5019920318725, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17538037, Length=523, Percent_Identity=26.5774378585086, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17559526, Length=524, Percent_Identity=26.1450381679389, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17557194, Length=524, Percent_Identity=25.1908396946565, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71982997, Length=567, Percent_Identity=26.63139329806, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71983001, Length=567, Percent_Identity=26.63139329806, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17558820, Length=519, Percent_Identity=25.2408477842004, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32563687, Length=509, Percent_Identity=24.5579567779961, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71996755, Length=489, Percent_Identity=23.9263803680982, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17560308, Length=513, Percent_Identity=24.1715399610136, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994703, Length=519, Percent_Identity=23.8921001926782, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71994694, Length=519, Percent_Identity=23.8921001926782, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71994690, Length=519, Percent_Identity=23.8921001926782, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17560140, Length=377, Percent_Identity=23.6074270557029, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=342, Percent_Identity=22.8070175438596, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319699, Length=474, Percent_Identity=24.8945147679325, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323182, Length=556, Percent_Identity=26.0791366906475, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319264, Length=558, Percent_Identity=27.5985663082437, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI18859661, Length=507, Percent_Identity=28.2051282051282, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24667955, Length=558, Percent_Identity=25.8064516129032, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI62472339, Length=529, Percent_Identity=26.0869565217391, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24581924, Length=504, Percent_Identity=26.1904761904762, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21355181, Length=512, Percent_Identity=24.21875, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24667959, Length=380, Percent_Identity=28.4210526315789, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922652, Length=509, Percent_Identity=25.147347740668, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24656500, Length=490, Percent_Identity=22.8571428571429, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648253, Length=495, Percent_Identity=24.8484848484848, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648255, Length=495, Percent_Identity=24.8484848484848, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21355225, Length=563, Percent_Identity=22.3801065719361, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24653035, Length=486, Percent_Identity=22.4279835390947, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648260, Length=355, Percent_Identity=25.0704225352113, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24648676, Length=388, Percent_Identity=26.8041237113402, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161076582, Length=489, Percent_Identity=21.6768916155419, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356441, Length=500, Percent_Identity=24, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281365686, Length=457, Percent_Identity=22.7571115973742, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21356947, Length=478, Percent_Identity=20.2928870292887, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873
- InterPro:   IPR011957 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.25; =6.2.1.27 [H]

Molecular weight: Translated: 54796; Mature: 54664

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANAATFFVDRHMAEGRADKPAFVEADGKERVLTYGQLHVESGRFAGALGRHGVRREERI
CCCCEEEEEHHHHHCCCCCCCCEEECCCCCEEEEEEEEEEECCCHHHHHHHCCCCHHHHH
AMIVRDQIEWPVVFWGAMKAGAIPVPLNTLLSSDVYETILTDSRASILVVSEEMWEVVEP
EEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHCC
ATRDNAFLRAILVIGDAPEMTESYRDFTDGAPEVETVAANDDELAFWLYSSGSTGQPKGV
CCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCH
RHVHGALKATCETFGDQVLGIREDDVVYSVAKMFFAYGLGNAVSFPQSVGATTVLFGGRP
HHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCCEEEEECCCC
TPPVVFDILAKHRPSILCAVPTLFAALVQAADGAPKHGLRLCTSAGEALPRDVGEGWDRL
CCHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHH
TGVEIVDGVGSTEMLHIFLSNAPGDCVYGTSGTAVPGYELRLVNEHDEELADGEVGELLV
CCCCEECCCCCCEEEEEEECCCCCCEEECCCCCCCCCEEEEEECCCCHHHCCCCCCEEEE
RGPSSADGYWNRRAKSQATFEGMWTRTGDKYERKDGRYIYCGRTDDMFKVSGIWVSPFEV
ECCCCCCCCHHHHHCCCCHHCEEECCCCCCHHCCCCCEEEECCCCCCEEECCEEECHHHH
ESALVDHASVLEAAVVARADEAGLDKPAAFVVLTEGAEVPEAEALKAFVKDKIGMWKYPR
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCH
WVEIVEDLPKTATGKIQRFKLRA
HHHHHHHCCCCCCCCEEEEEECC
>Mature Secondary Structure 
ANAATFFVDRHMAEGRADKPAFVEADGKERVLTYGQLHVESGRFAGALGRHGVRREERI
CCCEEEEEHHHHHCCCCCCCCEEECCCCCEEEEEEEEEEECCCHHHHHHHCCCCHHHHH
AMIVRDQIEWPVVFWGAMKAGAIPVPLNTLLSSDVYETILTDSRASILVVSEEMWEVVEP
EEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHCC
ATRDNAFLRAILVIGDAPEMTESYRDFTDGAPEVETVAANDDELAFWLYSSGSTGQPKGV
CCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCH
RHVHGALKATCETFGDQVLGIREDDVVYSVAKMFFAYGLGNAVSFPQSVGATTVLFGGRP
HHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCCEEEEECCCC
TPPVVFDILAKHRPSILCAVPTLFAALVQAADGAPKHGLRLCTSAGEALPRDVGEGWDRL
CCHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHH
TGVEIVDGVGSTEMLHIFLSNAPGDCVYGTSGTAVPGYELRLVNEHDEELADGEVGELLV
CCCCEECCCCCCEEEEEEECCCCCCEEECCCCCCCCCEEEEEECCCCHHHCCCCCCEEEE
RGPSSADGYWNRRAKSQATFEGMWTRTGDKYERKDGRYIYCGRTDDMFKVSGIWVSPFEV
ECCCCCCCCHHHHHCCCCHHCEEECCCCCCHHCCCCCEEEECCCCCCEEECCEEECHHHH
ESALVDHASVLEAAVVARADEAGLDKPAAFVVLTEGAEVPEAEALKAFVKDKIGMWKYPR
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCH
WVEIVEDLPKTATGKIQRFKLRA
HHHHHHHCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8300518 [H]