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The map label for this gene is adk

Identifier: 89053104

GI number: 89053104

Start: 588511

End: 589086

Strand: Direct

Name: adk

Synonym: Jann_0613

Alternate gene names: 89053104

Gene position: 588511-589086 (Clockwise)

Preceding gene: 89053103

Following gene: 89053105

Centisome position: 13.63

GC content: 61.11

Gene sequence:

>576_bases
ATGAACATTATTCTGCTTGGCCCGCCTGGCGCGGGCAAAGGAACCCAGGCCGGTATCCTTGTGAAGGACCGCGGCATGGT
GCAGCTGTCCACTGGCGATATGCTGCGCGCGGCGCGCACCAGTGGCACCGAGATGGGCAATCTTGTCGCCGGTGTCATGG
ATCGCGGAGAGCTTGTGACCGACGAGATCGTCATCGGCCTGATCCGGGAACAGTTGGAAGCTGGTGGCTCTGGTTTCATC
TTCGACGGCTTTCCCCGCACATTGGCCCAAGCCGACGCGCTGGCGGATCTGCTGGCCGAAGTTGGCCAGACGCTGGACCA
TGTGATCGCGATGGAAGTGAACGATGAGGCCCTGGTGGGTCGTATCGTCAACCGCGCCAAGGAGGCCGCGGCCGCAGGGC
AGCCAGTCCGCGCGGATGACAACGAGGAAAGCCTGAAGATCCGTCTGATGGAATACTACAAGAAGACCTCGCCGCTGCTT
GGATATTACCACGCGAAAGAGCAATTGCGTTGGGTCCCCGGTCTGGGGGCAATTGACGACGTTGCCAAGGGCATCGCGGA
CGTTCTGGACGCTTAA

Upstream 100 bases:

>100_bases
CTCATCTGCTGGCCCACCAATACGAAGGCCTGCTGGAGAAGTCCCAGCTGCGCGGTCGTAAGAGTGGATCGAAGAAACCG
CGTAAAGGACCGGCGCGTCG

Downstream 100 bases:

>100_bases
CTTGTCTGAAACCGGTTTTGTGCTTATATTAAGTGGGTGGAAGTTAACTTTATGGAGGCGAATAATGATCGCACGTGAAG
GATATCTTGACTAACACCAT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MNIILLGPPGAGKGTQAGILVKDRGMVQLSTGDMLRAARTSGTEMGNLVAGVMDRGELVTDEIVIGLIREQLEAGGSGFI
FDGFPRTLAQADALADLLAEVGQTLDHVIAMEVNDEALVGRIVNRAKEAAAAGQPVRADDNEESLKIRLMEYYKKTSPLL
GYYHAKEQLRWVPGLGAIDDVAKGIADVLDA

Sequences:

>Translated_191_residues
MNIILLGPPGAGKGTQAGILVKDRGMVQLSTGDMLRAARTSGTEMGNLVAGVMDRGELVTDEIVIGLIREQLEAGGSGFI
FDGFPRTLAQADALADLLAEVGQTLDHVIAMEVNDEALVGRIVNRAKEAAAAGQPVRADDNEESLKIRLMEYYKKTSPLL
GYYHAKEQLRWVPGLGAIDDVAKGIADVLDA
>Mature_191_residues
MNIILLGPPGAGKGTQAGILVKDRGMVQLSTGDMLRAARTSGTEMGNLVAGVMDRGELVTDEIVIGLIREQLEAGGSGFI
FDGFPRTLAQADALADLLAEVGQTLDHVIAMEVNDEALVGRIVNRAKEAAAAGQPVRADDNEESLKIRLMEYYKKTSPLL
GYYHAKEQLRWVPGLGAIDDVAKGIADVLDA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=186, Percent_Identity=43.010752688172, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI7524346, Length=186, Percent_Identity=43.010752688172, Blast_Score=144, Evalue=3e-35,
Organism=Homo sapiens, GI4502011, Length=193, Percent_Identity=34.1968911917098, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI28144899, Length=192, Percent_Identity=31.7708333333333, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI28144897, Length=192, Percent_Identity=31.7708333333333, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI7706497, Length=201, Percent_Identity=28.8557213930348, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI19923437, Length=185, Percent_Identity=31.3513513513514, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI310110345, Length=185, Percent_Identity=30.2702702702703, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI53832003, Length=185, Percent_Identity=30.2702702702703, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI8051579, Length=185, Percent_Identity=30.2702702702703, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI53832001, Length=185, Percent_Identity=30.2702702702703, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1786680, Length=186, Percent_Identity=45.1612903225806, Blast_Score=149, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17552384, Length=208, Percent_Identity=38.4615384615385, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=192, Percent_Identity=33.8541666666667, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17533833, Length=194, Percent_Identity=32.9896907216495, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=194, Percent_Identity=30.4123711340206, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25147457, Length=195, Percent_Identity=29.2307692307692, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17537943, Length=211, Percent_Identity=26.5402843601896, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=214, Percent_Identity=37.3831775700935, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322828, Length=192, Percent_Identity=31.7708333333333, Blast_Score=107, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321018, Length=184, Percent_Identity=33.1521739130435, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=40.5660377358491, Blast_Score=139, Evalue=8e-34,
Organism=Drosophila melanogaster, GI17737899, Length=185, Percent_Identity=31.8918918918919, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24645822, Length=185, Percent_Identity=31.8918918918919, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24663208, Length=167, Percent_Identity=35.3293413173653, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17647141, Length=167, Percent_Identity=35.3293413173653, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI221459597, Length=172, Percent_Identity=30.8139534883721, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356893, Length=172, Percent_Identity=30.8139534883721, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_JANSC (Q28UT2)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_508555.1
- HSSP:   P16304
- ProteinModelPortal:   Q28UT2
- SMR:   Q28UT2
- STRING:   Q28UT2
- GeneID:   3933055
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_0613
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   TRLMEYY
- ProtClustDB:   PRK00279
- BioCyc:   JSP290400:JANN_0613-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20287; Mature: 20287

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIILLGPPGAGKGTQAGILVKDRGMVQLSTGDMLRAARTSGTEMGNLVAGVMDRGELVT
CEEEEECCCCCCCCCCCEEEEECCCEEEECCCHHHHHHHCCCCHHHHHHHHHHCCCCHHH
DEIVIGLIREQLEAGGSGFIFDGFPRTLAQADALADLLAEVGQTLDHVIAMEVNDEALVG
HHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHH
RIVNRAKEAAAAGQPVRADDNEESLKIRLMEYYKKTSPLLGYYHAKEQLRWVPGLGAIDD
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHH
VAKGIADVLDA
HHHHHHHHHCC
>Mature Secondary Structure
MNIILLGPPGAGKGTQAGILVKDRGMVQLSTGDMLRAARTSGTEMGNLVAGVMDRGELVT
CEEEEECCCCCCCCCCCEEEEECCCEEEECCCHHHHHHHCCCCHHHHHHHHHHCCCCHHH
DEIVIGLIREQLEAGGSGFIFDGFPRTLAQADALADLLAEVGQTLDHVIAMEVNDEALVG
HHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHH
RIVNRAKEAAAAGQPVRADDNEESLKIRLMEYYKKTSPLLGYYHAKEQLRWVPGLGAIDD
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHH
VAKGIADVLDA
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA