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The map label for this gene is parC [H]

Identifier: 89053044

GI number: 89053044

Start: 540378

End: 542705

Strand: Direct

Name: parC [H]

Synonym: Jann_0553

Alternate gene names: 89053044

Gene position: 540378-542705 (Clockwise)

Preceding gene: 89053039

Following gene: 89053045

Centisome position: 12.51

GC content: 62.33

Gene sequence:

>2328_bases
ATGAGCAGTGATGATGACACACAAGATGACCGCCCCGATCCCGGGCCTGGGTCCGCATCCATTTCGGAGCCGTTGAGCCG
TGCCATCGGCTCGCGGTATCTTCAGTATGCATTGTCCACGATCATGCACCGCGCTCTGCCTGACGCGCGCGACGGGTTGA
AGCCGGTTCACCGCCGTATTCTTTATGCGATGCGAGAGCTGCGGCTCGCCTCCAACGGGGGCTTTCGGAAGTCCGCCAAG
ATTTCTGGCGATGTGATGGGCAATTACCACCCCCACGGCGATGCCGCGATTTACGATGCGATGGCGCGCCTGGCGCAGGA
TTTCGTCATTCGCTACCCGCTGGTCGATGGGCAAGGCAACTTCGGCAATATCGACGGCGATAACCCCGCCGCCGCTCGCT
ACACGGAAGCGCGCATGACCGCCGTGGCCGAGGCGCTGCTGGAGGGCCTGTCAGAGGACGCGGTCAATTTCCGCGACAAT
TACGACGGCACCCTGCAAGAGCCCGAAGTCCTGCCCGCACAGGTCCCAAACCTTCTGGCCAACGGCTCCAGCGGGATCGC
TGTGGGCATGGCAACGAACATCCCGCCCCACAATCTGGACGAGTTGATCGCCGCCTGTCTGCACCTGATCAAAACCCCCG
ATGCCCGCGATGAGACGTTGCTGAACTACGTCCAGGGCCCAGATTTCCCGACCGGCGGCGTCATCGTCGAGCCGCGCGAG
AGCATGGCCGAGACCTACCGCACCGGCAAAGGCGGCTTCCGCGTGCGGGCGACGCATGAGATCGAGGATCTGGGTCGCGG
CCAATGGCAGATCGTTGTCACGGAAATCCCCTATCAGGTCCAGAAATCCAAGCTGATCGAGAAACTGGCCGAGCTGATCC
AGCTGAAGAAGATGCCGATCCTCGCCGATGTGCGCGATGAGAGTGCCGATGATATTCGCATCGTGCTGGAACCGCGCTCC
AAAACCGTGGACCCCGATGTGCTGATGGCCGCGCTCTACCGGCAGTCCGATCTTGAGAACCGTTTTTCATTGAACATGAA
CGTGCTGATCGATGGCCGCACGCCCAAAGTCTGCTCTCTTAAAGAGGTGCTGCGCGCGTTCCTCGACCACCGCCAGGACG
TGCTGATGCGCCGGTCCCGTCATCGGATGGCGCAGATCGACCACCGTCTTGAAGTGTTGGAAGGGTTCCTGATTGCGTTC
CTGAACCTCGACCGTGTGATCGATATCATCCGTTACGACGACAGCCCCAAAGCCGCGTTGATGCGCGAGGATTGGGGCCA
GGATTTCGTCCGTGCGATGTCCGAGGCCGACTACGTGTCCCCCAAACCTGGCGAAGGGGAGCTGACGGAAGTTCAGGTCG
AAGCGATCCTCAACATGCGCCTGCGCAGCTTGCGTCGTCTGGAAGAGATGGAGTTGCAGGCCGAGCGTGATCGGTTGATG
GAAGAACGCGCGGGGCTGGAAGATTTGCTGGCCGAAGAAAGCCTCCAATGGGGCCGTATTGCCGAGGAACTGCGCGAGGT
GCGCAAGAAGTTCGGCTCCCGCGCGGATGGCGGCGCGCGGCGCACGCAATTTGCCGAGGCGGGCAACATCGAAGAAGTCT
CCCTTGAGGCGATGATCGAGCGCGAGCCTGTCACAATCGTCTGCTCTCAGATGGGCTGGATCCGCGCCATGAAGGGCCAT
GTGGACCTCAGCCAAGAGATGAAGTTCCGCGACGGCGACGGCCCGCGTTTTGCGATCCATGCAGAGACGACGGATAAGCT
GCTGATCCTCGGCTCCCAGGGTCGCGTCTACACGCTCGGGGCCAATGGTCTGCCCGGCGGGCGGGGTTTGGGAGAGCCTT
TGCGCCTGATGGTGGACCTGCCAAACGAGGTGCAGATCGTCGATCTGTTCGTGCACCATCCGGGCGCAAAGCGTCTGATG
GCGTCCAGTGCGGGCGATGGGTTCCTCGTGGCAGAGGAAGATATCCTCGCCCAGACCCGCTCCGGCAAGCAGGTGCTGAA
CGTGAAGGACGGTGTCACGGCCAGCGTTTGCCGCGCCGTCGCCCCGGAGGATGACCACGTGGCCGTCGTCGGAGAGAACC
GTAAACTGTTGGTCTTCCCCCTGACGGAACTGCCCGAGATGGGGCGTGGCAAGGGCGTGCGATTGCAAAAATACAAAGAC
GGTGGCCTTTCGGATGCGCGTACCTTCCGGCTGGAGGACGGTCTTGTGTGGCTGGATCCCGCGGGCCGGACCCGCACCGA
GGTTGAGCTTGGGGAATGGGCGGCCAAGCGCGCAGGGGCAGGTCGCATGGCGCCCCGTGGGTTCCCCCGCGACAACCAAT
TTAACTAG

Upstream 100 bases:

>100_bases
TTCCACGATTCGAAAATACCCGATTCTCCCAAAACAACTGGTTAATTGCCGTTATTGTTCCTTGTTCGGCAGCAGTGCGC
CGGGTAAGCACATGATCTAG

Downstream 100 bases:

>100_bases
GCGTCGCGCCATGTGGGAAGGCGGAAAACCGCCGTGCGGGCCTTTTGGTAACACTTCGTCTCACCTGGCATGCAACGCCT
TTACCCCAGACCGCCGCGAC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 775; Mature: 774

Protein sequence:

>775_residues
MSSDDDTQDDRPDPGPGSASISEPLSRAIGSRYLQYALSTIMHRALPDARDGLKPVHRRILYAMRELRLASNGGFRKSAK
ISGDVMGNYHPHGDAAIYDAMARLAQDFVIRYPLVDGQGNFGNIDGDNPAAARYTEARMTAVAEALLEGLSEDAVNFRDN
YDGTLQEPEVLPAQVPNLLANGSSGIAVGMATNIPPHNLDELIAACLHLIKTPDARDETLLNYVQGPDFPTGGVIVEPRE
SMAETYRTGKGGFRVRATHEIEDLGRGQWQIVVTEIPYQVQKSKLIEKLAELIQLKKMPILADVRDESADDIRIVLEPRS
KTVDPDVLMAALYRQSDLENRFSLNMNVLIDGRTPKVCSLKEVLRAFLDHRQDVLMRRSRHRMAQIDHRLEVLEGFLIAF
LNLDRVIDIIRYDDSPKAALMREDWGQDFVRAMSEADYVSPKPGEGELTEVQVEAILNMRLRSLRRLEEMELQAERDRLM
EERAGLEDLLAEESLQWGRIAEELREVRKKFGSRADGGARRTQFAEAGNIEEVSLEAMIEREPVTIVCSQMGWIRAMKGH
VDLSQEMKFRDGDGPRFAIHAETTDKLLILGSQGRVYTLGANGLPGGRGLGEPLRLMVDLPNEVQIVDLFVHHPGAKRLM
ASSAGDGFLVAEEDILAQTRSGKQVLNVKDGVTASVCRAVAPEDDHVAVVGENRKLLVFPLTELPEMGRGKGVRLQKYKD
GGLSDARTFRLEDGLVWLDPAGRTRTEVELGEWAAKRAGAGRMAPRGFPRDNQFN

Sequences:

>Translated_775_residues
MSSDDDTQDDRPDPGPGSASISEPLSRAIGSRYLQYALSTIMHRALPDARDGLKPVHRRILYAMRELRLASNGGFRKSAK
ISGDVMGNYHPHGDAAIYDAMARLAQDFVIRYPLVDGQGNFGNIDGDNPAAARYTEARMTAVAEALLEGLSEDAVNFRDN
YDGTLQEPEVLPAQVPNLLANGSSGIAVGMATNIPPHNLDELIAACLHLIKTPDARDETLLNYVQGPDFPTGGVIVEPRE
SMAETYRTGKGGFRVRATHEIEDLGRGQWQIVVTEIPYQVQKSKLIEKLAELIQLKKMPILADVRDESADDIRIVLEPRS
KTVDPDVLMAALYRQSDLENRFSLNMNVLIDGRTPKVCSLKEVLRAFLDHRQDVLMRRSRHRMAQIDHRLEVLEGFLIAF
LNLDRVIDIIRYDDSPKAALMREDWGQDFVRAMSEADYVSPKPGEGELTEVQVEAILNMRLRSLRRLEEMELQAERDRLM
EERAGLEDLLAEESLQWGRIAEELREVRKKFGSRADGGARRTQFAEAGNIEEVSLEAMIEREPVTIVCSQMGWIRAMKGH
VDLSQEMKFRDGDGPRFAIHAETTDKLLILGSQGRVYTLGANGLPGGRGLGEPLRLMVDLPNEVQIVDLFVHHPGAKRLM
ASSAGDGFLVAEEDILAQTRSGKQVLNVKDGVTASVCRAVAPEDDHVAVVGENRKLLVFPLTELPEMGRGKGVRLQKYKD
GGLSDARTFRLEDGLVWLDPAGRTRTEVELGEWAAKRAGAGRMAPRGFPRDNQFN
>Mature_774_residues
SSDDDTQDDRPDPGPGSASISEPLSRAIGSRYLQYALSTIMHRALPDARDGLKPVHRRILYAMRELRLASNGGFRKSAKI
SGDVMGNYHPHGDAAIYDAMARLAQDFVIRYPLVDGQGNFGNIDGDNPAAARYTEARMTAVAEALLEGLSEDAVNFRDNY
DGTLQEPEVLPAQVPNLLANGSSGIAVGMATNIPPHNLDELIAACLHLIKTPDARDETLLNYVQGPDFPTGGVIVEPRES
MAETYRTGKGGFRVRATHEIEDLGRGQWQIVVTEIPYQVQKSKLIEKLAELIQLKKMPILADVRDESADDIRIVLEPRSK
TVDPDVLMAALYRQSDLENRFSLNMNVLIDGRTPKVCSLKEVLRAFLDHRQDVLMRRSRHRMAQIDHRLEVLEGFLIAFL
NLDRVIDIIRYDDSPKAALMREDWGQDFVRAMSEADYVSPKPGEGELTEVQVEAILNMRLRSLRRLEEMELQAERDRLME
ERAGLEDLLAEESLQWGRIAEELREVRKKFGSRADGGARRTQFAEAGNIEEVSLEAMIEREPVTIVCSQMGWIRAMKGHV
DLSQEMKFRDGDGPRFAIHAETTDKLLILGSQGRVYTLGANGLPGGRGLGEPLRLMVDLPNEVQIVDLFVHHPGAKRLMA
SSAGDGFLVAEEDILAQTRSGKQVLNVKDGVTASVCRAVAPEDDHVAVVGENRKLLVFPLTELPEMGRGKGVRLQKYKDG
GLSDARTFRLEDGLVWLDPAGRTRTEVELGEWAAKRAGAGRMAPRGFPRDNQFN

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=485, Percent_Identity=23.0927835051546, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI19913406, Length=343, Percent_Identity=24.198250728863, Blast_Score=67, Evalue=8e-11,
Organism=Escherichia coli, GI1789396, Length=712, Percent_Identity=40.3089887640449, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1788562, Length=649, Percent_Identity=41.4483821263482, Blast_Score=446, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17535065, Length=415, Percent_Identity=25.7831325301205, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=390, Percent_Identity=26.1538461538462, Blast_Score=80, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=380, Percent_Identity=23.6842105263158, Blast_Score=79, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=416, Percent_Identity=25.2403846153846, Blast_Score=91, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 86148; Mature: 86017

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDDDTQDDRPDPGPGSASISEPLSRAIGSRYLQYALSTIMHRALPDARDGLKPVHRRI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHH
LYAMRELRLASNGGFRKSAKISGDVMGNYHPHGDAAIYDAMARLAQDFVIRYPLVDGQGN
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCC
FGNIDGDNPAAARYTEARMTAVAEALLEGLSEDAVNFRDNYDGTLQEPEVLPAQVPNLLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
NGSSGIAVGMATNIPPHNLDELIAACLHLIKTPDARDETLLNYVQGPDFPTGGVIVEPRE
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCHH
SMAETYRTGKGGFRVRATHEIEDLGRGQWQIVVTEIPYQVQKSKLIEKLAELIQLKKMPI
HHHHHHHCCCCCEEEEEECCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCC
LADVRDESADDIRIVLEPRSKTVDPDVLMAALYRQSDLENRFSLNMNVLIDGRTPKVCSL
EEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCHHHH
KEVLRAFLDHRQDVLMRRSRHRMAQIDHRLEVLEGFLIAFLNLDRVIDIIRYDDSPKAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
MREDWGQDFVRAMSEADYVSPKPGEGELTEVQVEAILNMRLRSLRRLEEMELQAERDRLM
HHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EERAGLEDLLAEESLQWGRIAEELREVRKKFGSRADGGARRTQFAEAGNIEEVSLEAMIE
HHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHC
REPVTIVCSQMGWIRAMKGHVDLSQEMKFRDGDGPRFAIHAETTDKLLILGSQGRVYTLG
CCCEEEEECHHHHHHHHHCCCCCHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCEEEEC
ANGLPGGRGLGEPLRLMVDLPNEVQIVDLFVHHPGAKRLMASSAGDGFLVAEEDILAQTR
CCCCCCCCCCCCCHHEEEECCCCEEEEEEEEECCCHHHHHHCCCCCCEEEECHHHHHHCC
SGKQVLNVKDGVTASVCRAVAPEDDHVAVVGENRKLLVFPLTELPEMGRGKGVRLQKYKD
CCCEEEECCCCCHHHHHHHCCCCCCCEEEEECCCEEEEEEHHHCCCCCCCCCEEEEEECC
GGLSDARTFRLEDGLVWLDPAGRTRTEVELGEWAAKRAGAGRMAPRGFPRDNQFN
CCCCCCEEEEEECCEEEECCCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSDDDTQDDRPDPGPGSASISEPLSRAIGSRYLQYALSTIMHRALPDARDGLKPVHRRI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHH
LYAMRELRLASNGGFRKSAKISGDVMGNYHPHGDAAIYDAMARLAQDFVIRYPLVDGQGN
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCC
FGNIDGDNPAAARYTEARMTAVAEALLEGLSEDAVNFRDNYDGTLQEPEVLPAQVPNLLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
NGSSGIAVGMATNIPPHNLDELIAACLHLIKTPDARDETLLNYVQGPDFPTGGVIVEPRE
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCHH
SMAETYRTGKGGFRVRATHEIEDLGRGQWQIVVTEIPYQVQKSKLIEKLAELIQLKKMPI
HHHHHHHCCCCCEEEEEECCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCC
LADVRDESADDIRIVLEPRSKTVDPDVLMAALYRQSDLENRFSLNMNVLIDGRTPKVCSL
EEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCHHHH
KEVLRAFLDHRQDVLMRRSRHRMAQIDHRLEVLEGFLIAFLNLDRVIDIIRYDDSPKAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
MREDWGQDFVRAMSEADYVSPKPGEGELTEVQVEAILNMRLRSLRRLEEMELQAERDRLM
HHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EERAGLEDLLAEESLQWGRIAEELREVRKKFGSRADGGARRTQFAEAGNIEEVSLEAMIE
HHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHC
REPVTIVCSQMGWIRAMKGHVDLSQEMKFRDGDGPRFAIHAETTDKLLILGSQGRVYTLG
CCCEEEEECHHHHHHHHHCCCCCHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCEEEEC
ANGLPGGRGLGEPLRLMVDLPNEVQIVDLFVHHPGAKRLMASSAGDGFLVAEEDILAQTR
CCCCCCCCCCCCCHHEEEECCCCEEEEEEEEECCCHHHHHHCCCCCCEEEECHHHHHHCC
SGKQVLNVKDGVTASVCRAVAPEDDHVAVVGENRKLLVFPLTELPEMGRGKGVRLQKYKD
CCCEEEECCCCCHHHHHHHCCCCCCCEEEEECCCEEEEEEHHHCCCCCCCCCEEEEEECC
GGLSDARTFRLEDGLVWLDPAGRTRTEVELGEWAAKRAGAGRMAPRGFPRDNQFN
CCCCCCEEEEEECCEEEECCCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]