Click here to switch to the map view.

The map label for this gene is tsaA [H]

Identifier: 88608779

GI number: 88608779

Start: 485636

End: 486238

Strand: Reverse

Name: tsaA [H]

Synonym: NSE_0559

Alternate gene names: 88608779

Gene position: 486238-485636 (Counterclockwise)

Preceding gene: 88608733

Following gene: 88608277

Centisome position: 56.6

GC content: 42.95

Gene sequence:

>603_bases
ATGTCTACTTTAGTTGGTAAGAAAGCGTTTGATTTCACAGCAAAGGCTGTACTCAAGAACGGTTCTTTTTGTGATGATTT
TAATCTTCAGCGTGAATTGTCTGGCAAATACGGGGTGCTCTTCTTTTATCCATTGGATTTTACTTTTGTCTGTCCAACGG
AGATTATTGCTTTCAGTAATAGGATTCCTGCGTTTATCGAGAGAAATGCGGTTGTTGTAGGTGTTAGTGTTGACTCCCAT
TTTTCGCACTTTGCCTGGCGCAGCTTGCCTGTAAAAGATGGTGGAATAGGCAGTATTGGTTACACTCTGGTCTCAGACAT
AACAAAGTCTATTTCACGTGACTACCAGGTTTTGCTAGACGATGCAGTTGCTCTTCGTGGTACATTTATCATAGATCCGA
ATTTTGTTATCAGAGTTGCTCATGTTAATGACCTGAACGTGGGTCGGAACGTCGATGAGGTTCTCCGTACTTTGGATGCG
CTCAAGTATAGTGACGAAAATGGAGAGGTTTGTCCGGCAGGTTGGAGCAAGGGCAAAGAAGCGATAAAGGCGACGCATGA
GAGTATTTCCGATTATCTAGCTTCCAATAGGGATGAGCTTTGA

Upstream 100 bases:

>100_bases
TTTTAGATCGCTTATGTATCTGAAACAAAAAATTTTTAGGATACTTTAAGCTTCAAAGTAAATGGTATACAATCCCCTTC
TTGGAGGTGGTCTTATTGGT

Downstream 100 bases:

>100_bases
CTAAAGATGTGTGATGCTCTTGAAAGCGATGTAATAATAATCGGGTCTGGGCCAGCCGGGTGTACGGCTGGGATATACGC
GGCACGTGCATCTCTTAGCG

Product: anti-oxidant AhpCTSA family protein

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MSTLVGKKAFDFTAKAVLKNGSFCDDFNLQRELSGKYGVLFFYPLDFTFVCPTEIIAFSNRIPAFIERNAVVVGVSVDSH
FSHFAWRSLPVKDGGIGSIGYTLVSDITKSISRDYQVLLDDAVALRGTFIIDPNFVIRVAHVNDLNVGRNVDEVLRTLDA
LKYSDENGEVCPAGWSKGKEAIKATHESISDYLASNRDEL

Sequences:

>Translated_200_residues
MSTLVGKKAFDFTAKAVLKNGSFCDDFNLQRELSGKYGVLFFYPLDFTFVCPTEIIAFSNRIPAFIERNAVVVGVSVDSH
FSHFAWRSLPVKDGGIGSIGYTLVSDITKSISRDYQVLLDDAVALRGTFIIDPNFVIRVAHVNDLNVGRNVDEVLRTLDA
LKYSDENGEVCPAGWSKGKEAIKATHESISDYLASNRDEL
>Mature_199_residues
STLVGKKAFDFTAKAVLKNGSFCDDFNLQRELSGKYGVLFFYPLDFTFVCPTEIIAFSNRIPAFIERNAVVVGVSVDSHF
SHFAWRSLPVKDGGIGSIGYTLVSDITKSISRDYQVLLDDAVALRGTFIIDPNFVIRVAHVNDLNVGRNVDEVLRTLDAL
KYSDENGEVCPAGWSKGKEAIKATHESISDYLASNRDEL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=194, Percent_Identity=48.9690721649485, Blast_Score=191, Evalue=3e-49,
Organism=Homo sapiens, GI32455266, Length=194, Percent_Identity=48.9690721649485, Blast_Score=191, Evalue=3e-49,
Organism=Homo sapiens, GI32455264, Length=194, Percent_Identity=48.9690721649485, Blast_Score=191, Evalue=3e-49,
Organism=Homo sapiens, GI32189392, Length=193, Percent_Identity=51.8134715025907, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI5802974, Length=190, Percent_Identity=53.1578947368421, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI32483377, Length=183, Percent_Identity=54.0983606557377, Blast_Score=187, Evalue=4e-48,
Organism=Homo sapiens, GI5453549, Length=149, Percent_Identity=56.3758389261745, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=59.7560975609756, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4758638, Length=186, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1786822, Length=182, Percent_Identity=34.0659340659341, Blast_Score=117, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI32565831, Length=194, Percent_Identity=48.4536082474227, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI193204376, Length=194, Percent_Identity=48.4536082474227, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17554494, Length=164, Percent_Identity=47.5609756097561, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6323613, Length=199, Percent_Identity=48.7437185929648, Blast_Score=172, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6320661, Length=194, Percent_Identity=44.3298969072165, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319407, Length=159, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17738015, Length=195, Percent_Identity=52.3076923076923, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24656348, Length=163, Percent_Identity=55.2147239263804, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17864676, Length=163, Percent_Identity=55.2147239263804, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17157991, Length=191, Percent_Identity=46.5968586387435, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24641739, Length=191, Percent_Identity=46.5968586387435, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=44.7368421052632, Blast_Score=160, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24581278, Length=157, Percent_Identity=26.7515923566879, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17975518, Length=157, Percent_Identity=31.8471337579618, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24652434, Length=157, Percent_Identity=31.8471337579618, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24652436, Length=157, Percent_Identity=31.8471337579618, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22122; Mature: 21991

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00014 ER_TARGET

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLVGKKAFDFTAKAVLKNGSFCDDFNLQRELSGKYGVLFFYPLDFTFVCPTEIIAFSN
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCEEEECHHHHHHHCC
RIPAFIERNAVVVGVSVDSHFSHFAWRSLPVKDGGIGSIGYTLVSDITKSISRDYQVLLD
CCCCEEECCEEEEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DAVALRGTFIIDPNFVIRVAHVNDLNVGRNVDEVLRTLDALKYSDENGEVCPAGWSKGKE
HHHHHCEEEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
AIKATHESISDYLASNRDEL
HHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STLVGKKAFDFTAKAVLKNGSFCDDFNLQRELSGKYGVLFFYPLDFTFVCPTEIIAFSN
CCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCEEEECHHHHHHHCC
RIPAFIERNAVVVGVSVDSHFSHFAWRSLPVKDGGIGSIGYTLVSDITKSISRDYQVLLD
CCCCEEECCEEEEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DAVALRGTFIIDPNFVIRVAHVNDLNVGRNVDEVLRTLDALKYSDENGEVCPAGWSKGKE
HHHHHCEEEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
AIKATHESISDYLASNRDEL
HHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]