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The map label for this gene is hflC

Identifier: 88608777

GI number: 88608777

Start: 132657

End: 133517

Strand: Direct

Name: hflC

Synonym: NSE_0165

Alternate gene names: 88608777

Gene position: 132657-133517 (Clockwise)

Preceding gene: 88608650

Following gene: 88608224

Centisome position: 15.44

GC content: 40.88

Gene sequence:

>861_bases
ATGAGAGGAGTTTTAGCAGTTGTTATAGGCTTTTTTTTGCTGTTGAATCTCAGCGTGTTTGTGGTTCCCGAGGGGTATAA
AGCTATAGTTTTACAGTTCGGTGAGGTGGTAACTGAAAAGCCACTTGAACCAGGTTTGCATTTTAAGATCCCGTTCATCA
ATAAAGTCATAGTGATCGATACTAGGATACAGGACTTATCATCCGATTCTAGGGAGGTCATCGCCGCTGATCAAAAGAGA
TTGATAGTTAGTTACTACGCGAAATATAAGATTATAGATCCCGTACAATTTTATCGCTCTACTAGGAGTATAGCTAATCT
TGAGAGTAGGTTGGCTCCAGTGGTTGAGGCAAATATGAGAGAACAGATAGGTCTGGTACCTCTTGTCAGTATTCTGACTG
AGGAGAGAGCAGATGTGATGAACAAGATAAAATTGCATTCTGGAAATGTTGCGTCAGATTTTGGGGTCGCTGTAGTAGAT
GTTCGCATCAAAAGGACTGACCTTCCGGAAGAAAATAGTGATGCGATCTTTAAAAGGATGCAAACAGAGCGAGAAAAAGA
AGCACGTGAAATAAGGGCACGGGGTTACCAAGAAGCGCAGAAAATAATCGCGAATGCTGATAGGGAGAAGAAAGTCATTC
TAACTGAAGCATATGCAAAGGCGCAATCGATCAAAGGTGAAGGTGATGCTGAGGCTGCTAAACTATACGCGGAGGCGTAT
GCAGTTGATCAAGATTTCTATAAGTTTTACAGGACGATAATTGCCTACAGGAAGGTTTTTAGTCGGGGTAATACAAAATT
TATTATCAACTCGAGTGATGAGTTTTTGGCTACATTGAAGGATGTTAATGAGAAGAAATAG

Upstream 100 bases:

>100_bases
GAATTGAAATGCTCGAAGAGGTTTATAAGAACACCGAGAAAATCATTGCTGATGATAGCAATATATTCAAGTTCTTCGAT
TTACAGAAGGGTGGTGTCAA

Downstream 100 bases:

>100_bases
GTTTTATGAGATATTTTTCCTAGCTGTACTTTTGAACTGTTCTTTTGCTGCTGGGGCTGTGCCATCTGAGGGATTTTCTG
ATGTTGTCTCAAGGCTTGCT

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MRGVLAVVIGFFLLLNLSVFVVPEGYKAIVLQFGEVVTEKPLEPGLHFKIPFINKVIVIDTRIQDLSSDSREVIAADQKR
LIVSYYAKYKIIDPVQFYRSTRSIANLESRLAPVVEANMREQIGLVPLVSILTEERADVMNKIKLHSGNVASDFGVAVVD
VRIKRTDLPEENSDAIFKRMQTEREKEAREIRARGYQEAQKIIANADREKKVILTEAYAKAQSIKGEGDAEAAKLYAEAY
AVDQDFYKFYRTIIAYRKVFSRGNTKFIINSSDEFLATLKDVNEKK

Sequences:

>Translated_286_residues
MRGVLAVVIGFFLLLNLSVFVVPEGYKAIVLQFGEVVTEKPLEPGLHFKIPFINKVIVIDTRIQDLSSDSREVIAADQKR
LIVSYYAKYKIIDPVQFYRSTRSIANLESRLAPVVEANMREQIGLVPLVSILTEERADVMNKIKLHSGNVASDFGVAVVD
VRIKRTDLPEENSDAIFKRMQTEREKEAREIRARGYQEAQKIIANADREKKVILTEAYAKAQSIKGEGDAEAAKLYAEAY
AVDQDFYKFYRTIIAYRKVFSRGNTKFIINSSDEFLATLKDVNEKK
>Mature_286_residues
MRGVLAVVIGFFLLLNLSVFVVPEGYKAIVLQFGEVVTEKPLEPGLHFKIPFINKVIVIDTRIQDLSSDSREVIAADQKR
LIVSYYAKYKIIDPVQFYRSTRSIANLESRLAPVVEANMREQIGLVPLVSILTEERADVMNKIKLHSGNVASDFGVAVVD
VRIKRTDLPEENSDAIFKRMQTEREKEAREIRARGYQEAQKIIANADREKKVILTEAYAKAQSIKGEGDAEAAKLYAEAY
AVDQDFYKFYRTIIAYRKVFSRGNTKFIINSSDEFLATLKDVNEKK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=303, Percent_Identity=36.963696369637, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1786697, Length=230, Percent_Identity=27.8260869565217, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 32463; Mature: 32463

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGVLAVVIGFFLLLNLSVFVVPEGYKAIVLQFGEVVTEKPLEPGLHFKIPFINKVIVID
CCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEE
TRIQDLSSDSREVIAADQKRLIVSYYAKYKIIDPVQFYRSTRSIANLESRLAPVVEANMR
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQIGLVPLVSILTEERADVMNKIKLHSGNVASDFGVAVVDVRIKRTDLPEENSDAIFKRM
HHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHH
QTEREKEAREIRARGYQEAQKIIANADREKKVILTEAYAKAQSIKGEGDAEAAKLYAEAY
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHH
AVDQDFYKFYRTIIAYRKVFSRGNTKFIINSSDEFLATLKDVNEKK
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCC
>Mature Secondary Structure
MRGVLAVVIGFFLLLNLSVFVVPEGYKAIVLQFGEVVTEKPLEPGLHFKIPFINKVIVID
CCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEE
TRIQDLSSDSREVIAADQKRLIVSYYAKYKIIDPVQFYRSTRSIANLESRLAPVVEANMR
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQIGLVPLVSILTEERADVMNKIKLHSGNVASDFGVAVVDVRIKRTDLPEENSDAIFKRM
HHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHH
QTEREKEAREIRARGYQEAQKIIANADREKKVILTEAYAKAQSIKGEGDAEAAKLYAEAY
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHH
AVDQDFYKFYRTIIAYRKVFSRGNTKFIINSSDEFLATLKDVNEKK
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]