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The map label for this gene is degP [H]

Identifier: 88608224

GI number: 88608224

Start: 133504

End: 134925

Strand: Direct

Name: degP [H]

Synonym: NSE_0166

Alternate gene names: 88608224

Gene position: 133504-134925 (Clockwise)

Preceding gene: 88608777

Following gene: 88608539

Centisome position: 15.54

GC content: 44.59

Gene sequence:

>1422_bases
ATGAGAAGAAATAGGTTTTATGAGATATTTTTCCTAGCTGTACTTTTGAACTGTTCTTTTGCTGCTGGGGCTGTGCCATC
TGAGGGATTTTCTGATGTTGTCTCAAGGCTTGCTCCTGCGGTTGTGAATATTTCCAGCGAATACAGGTTAAGGATGGATA
ACCAGGGTCTGTGTGGTAACCCGGCTATTTTGGAAGAGTTTTCTGAATTTTGTGAGCGCCTTAAGCCGTTTTTTCGCAAC
AAGAATCCGGGTAAGAAGTATGGGACATCTTTGGGTTCTGGCTTTTTGATTTCCGATGATGGGCTTATAGTTACGAATTA
TCATGTCATTGCGAATGCTGATAAAATCAGGGTCGTTCTGAGTCAGTGTAGTGAAGCGTGCCAACAGTATGAGGCTACGG
TGATTGGGTATGATAAAAAAACCGACCTTGCTGCGCTAAAAATTTCTGGAGTAAGTGGTCTTCCATATTTGCGTTTTGGT
GATTCGTCTAAAATGAGGCCCGGGGACTGGGTGATAGCAGTTGGTAATCCTTTTGGTTTAGGGGGCTCTGTCAGTGCTGG
AATTGTTTCAGCGATCAGTAGAGAGATCGGTCTATCTCAGAACAGCGATTTTATACAGACGGACGTTGTGCTCAATTCTG
GTAATTCTGGAGGACCGCTTTGTAATGCAAAGGGTGAAGTAATTGGTGTAAATACGGCTGCTGTGTATTCTAATGGTGGA
AGTGCAGGGATTGGTTTTGCCGTGCCATCGAATGTTGCGAAGCCAGTGATAGAAGCTCTAGCTAAGGGTAAGCAGATTCA
GCGTGGATGGATAGGGATTGTCATCCAAGAGATCACAAACGAAACAAAAGACTCACTTGGTGGAGACTTATCCGGTGTTC
TGGTGGCGAGTGTTGAAAAAGATGGACCTGCGTATAAAGCTGGGATGAGGGTTGGAGACGTTATTACAGCTGTGAACGGG
GAGAAAATTAGCGGTTCAAGGAGATTAGTAAGGGAAGTTTCCGGGCGGAGAATAGGTGATACAATAGAACTGTCTGTAGT
CAGGGATGCTCTTAAAAATAAGGAGACGGTGTCTTTGAAGGTAAAAATTGAAAAAACACCGCAAAGGTATGCAGACGATG
GGGCATCGCAGTTAGAGGTCATAGGATTAGTGGTTTCCAATCTGACTGATACGATTAGAAATTCGTTTGGGCTTGGTGCT
AGCATTGAAGGGGTGGTGGTCTTGGCCGTTGATCCTGACAAAGAGAGTTTTCTCAAAGCTGGGGATATAATTATTGGGGT
TGGTACCAACAGGCAGATTTCTACTGTCCAGGAGTTTAAACAGCACATAGACGAAGCAAAGAAAAAGGGGCAAAGGTCGC
TCCTAATGCTGATAAATCGTGGTAAGCAGACGATCTTTGCGGCTGTAGGCTTGGATAACTAG

Upstream 100 bases:

>100_bases
TACAGGACGATAATTGCCTACAGGAAGGTTTTTAGTCGGGGTAATACAAAATTTATTATCAACTCGAGTGATGAGTTTTT
GGCTACATTGAAGGATGTTA

Downstream 100 bases:

>100_bases
TTCTACCTCTAATGCGGCGGCAGACATTCGTACATCTTAGAGTACGAAGCGATTATTCGCTCTTGAGGGCAGTAACCAAA
CCTAGGAGAATTGTTGATCT

Product: periplasmic serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MRRNRFYEIFFLAVLLNCSFAAGAVPSEGFSDVVSRLAPAVVNISSEYRLRMDNQGLCGNPAILEEFSEFCERLKPFFRN
KNPGKKYGTSLGSGFLISDDGLIVTNYHVIANADKIRVVLSQCSEACQQYEATVIGYDKKTDLAALKISGVSGLPYLRFG
DSSKMRPGDWVIAVGNPFGLGGSVSAGIVSAISREIGLSQNSDFIQTDVVLNSGNSGGPLCNAKGEVIGVNTAAVYSNGG
SAGIGFAVPSNVAKPVIEALAKGKQIQRGWIGIVIQEITNETKDSLGGDLSGVLVASVEKDGPAYKAGMRVGDVITAVNG
EKISGSRRLVREVSGRRIGDTIELSVVRDALKNKETVSLKVKIEKTPQRYADDGASQLEVIGLVVSNLTDTIRNSFGLGA
SIEGVVVLAVDPDKESFLKAGDIIIGVGTNRQISTVQEFKQHIDEAKKKGQRSLLMLINRGKQTIFAAVGLDN

Sequences:

>Translated_473_residues
MRRNRFYEIFFLAVLLNCSFAAGAVPSEGFSDVVSRLAPAVVNISSEYRLRMDNQGLCGNPAILEEFSEFCERLKPFFRN
KNPGKKYGTSLGSGFLISDDGLIVTNYHVIANADKIRVVLSQCSEACQQYEATVIGYDKKTDLAALKISGVSGLPYLRFG
DSSKMRPGDWVIAVGNPFGLGGSVSAGIVSAISREIGLSQNSDFIQTDVVLNSGNSGGPLCNAKGEVIGVNTAAVYSNGG
SAGIGFAVPSNVAKPVIEALAKGKQIQRGWIGIVIQEITNETKDSLGGDLSGVLVASVEKDGPAYKAGMRVGDVITAVNG
EKISGSRRLVREVSGRRIGDTIELSVVRDALKNKETVSLKVKIEKTPQRYADDGASQLEVIGLVVSNLTDTIRNSFGLGA
SIEGVVVLAVDPDKESFLKAGDIIIGVGTNRQISTVQEFKQHIDEAKKKGQRSLLMLINRGKQTIFAAVGLDN
>Mature_473_residues
MRRNRFYEIFFLAVLLNCSFAAGAVPSEGFSDVVSRLAPAVVNISSEYRLRMDNQGLCGNPAILEEFSEFCERLKPFFRN
KNPGKKYGTSLGSGFLISDDGLIVTNYHVIANADKIRVVLSQCSEACQQYEATVIGYDKKTDLAALKISGVSGLPYLRFG
DSSKMRPGDWVIAVGNPFGLGGSVSAGIVSAISREIGLSQNSDFIQTDVVLNSGNSGGPLCNAKGEVIGVNTAAVYSNGG
SAGIGFAVPSNVAKPVIEALAKGKQIQRGWIGIVIQEITNETKDSLGGDLSGVLVASVEKDGPAYKAGMRVGDVITAVNG
EKISGSRRLVREVSGRRIGDTIELSVVRDALKNKETVSLKVKIEKTPQRYADDGASQLEVIGLVVSNLTDTIRNSFGLGA
SIEGVVVLAVDPDKESFLKAGDIIIGVGTNRQISTVQEFKQHIDEAKKKGQRSLLMLINRGKQTIFAAVGLDN

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=310, Percent_Identity=38.0645161290323, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI22129776, Length=319, Percent_Identity=37.3040752351097, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI7019477, Length=357, Percent_Identity=34.1736694677871, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI24308541, Length=273, Percent_Identity=36.996336996337, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI1786356, Length=477, Percent_Identity=32.2851153039832, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1789629, Length=448, Percent_Identity=32.1428571428571, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1789630, Length=284, Percent_Identity=38.3802816901408, Blast_Score=169, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24646839, Length=266, Percent_Identity=35.7142857142857, Blast_Score=145, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50386; Mature: 50386

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRNRFYEIFFLAVLLNCSFAAGAVPSEGFSDVVSRLAPAVVNISSEYRLRMDNQGLCGN
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEECCCCCCCC
PAILEEFSEFCERLKPFFRNKNPGKKYGTSLGSGFLISDDGLIVTNYHVIANADKIRVVL
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEECCCEEEEEEEEEECCHHHHHHH
SQCSEACQQYEATVIGYDKKTDLAALKISGVSGLPYLRFGDSSKMRPGDWVIAVGNPFGL
HHHHHHHHHHCCEEEECCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCEEEECCCCCCC
GGSVSAGIVSAISREIGLSQNSDFIQTDVVLNSGNSGGPLCNAKGEVIGVNTAAVYSNGG
CCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEEEEEEECCC
SAGIGFAVPSNVAKPVIEALAKGKQIQRGWIGIVIQEITNETKDSLGGDLSGVLVASVEK
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
DGPAYKAGMRVGDVITAVNGEKISGSRRLVREVSGRRIGDTIELSVVRDALKNKETVSLK
CCCHHHHCCCHHHEEEECCCCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCEEEEE
VKIEKTPQRYADDGASQLEVIGLVVSNLTDTIRNSFGLGASIEGVVVLAVDPDKESFLKA
EEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHCC
GDIIIGVGTNRQISTVQEFKQHIDEAKKKGQRSLLMLINRGKQTIFAAVGLDN
CCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCEEEEEEEECCC
>Mature Secondary Structure
MRRNRFYEIFFLAVLLNCSFAAGAVPSEGFSDVVSRLAPAVVNISSEYRLRMDNQGLCGN
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEECCCCCCCC
PAILEEFSEFCERLKPFFRNKNPGKKYGTSLGSGFLISDDGLIVTNYHVIANADKIRVVL
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEECCCEEEEEEEEEECCHHHHHHH
SQCSEACQQYEATVIGYDKKTDLAALKISGVSGLPYLRFGDSSKMRPGDWVIAVGNPFGL
HHHHHHHHHHCCEEEECCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCEEEECCCCCCC
GGSVSAGIVSAISREIGLSQNSDFIQTDVVLNSGNSGGPLCNAKGEVIGVNTAAVYSNGG
CCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEEEEEEECCC
SAGIGFAVPSNVAKPVIEALAKGKQIQRGWIGIVIQEITNETKDSLGGDLSGVLVASVEK
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
DGPAYKAGMRVGDVITAVNGEKISGSRRLVREVSGRRIGDTIELSVVRDALKNKETVSLK
CCCHHHHCCCHHHEEEECCCCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCEEEEE
VKIEKTPQRYADDGASQLEVIGLVVSNLTDTIRNSFGLGASIEGVVVLAVDPDKESFLKA
EEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHCC
GDIIIGVGTNRQISTVQEFKQHIDEAKKKGQRSLLMLINRGKQTIFAAVGLDN
CCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]