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The map label for this gene is hflK

Identifier: 88608650

GI number: 88608650

Start: 131617

End: 132660

Strand: Direct

Name: hflK

Synonym: NSE_0164

Alternate gene names: 88608650

Gene position: 131617-132660 (Clockwise)

Preceding gene: 88608520

Following gene: 88608777

Centisome position: 15.32

GC content: 43.68

Gene sequence:

>1044_bases
ATGACATTAGCTAGATATGACAACCCTTGGGGTTCTGACGACGAACCACCACGGAGGACGAGAGCAACTCGCAGAAATGT
TTACGATATAGAGGGACTTTTACTGTCTGTTCGTGGTAAGTTTTTCCGTCGTGGAGGATCAAGGTTTAGTTGGTGGTTCA
TCTTATGTCTCCTTAGTTTGTTTGGCATCCTTTGGGTTTTGTCGGGCTTTTATGTTGTTAACCCTGAGGAGCAGGCGGTG
GAACTTACCTTTGGTAAGTATACAGGGATGGCGGATCCGGGTCTCAGGTACCATTTTCCTTTCCCGATTGGTCGTGTCGA
TAAGGTAAAGGTAGCTGCTATAAATCGTAACGAAATAGGTTATTCCTCTGGCAAGAAAGGGGAAGGTGAGGGCATAATGC
TCACAGGTGATGAGAATATTCTCGACGCAAATTTCGAGGTTCAATGGCGGATAAAGGACGCCTATAAGTTTCTGTATAAA
GTCAGGGATTATGGGTTTGGGTTGAGTGTCAAAGGTGCTGCCGAAAGTGCCATGAGGGATGCAATTGGACAAAATGAGAT
ATCCTTTATTTTGAGAGGTGAAGGCAGAGCAAAAATCGCTTCAGATACGAAAAAACAATTGCAAGAAATTCTTGATGGTT
ATGATATGGGTGTCGAGATACTTTCAATCCAAATGAAAAAAGTTGACCCCCCTGAGAAAGTGATAGATGCTTTCCGTGAT
GTGCAGAGCGCTCGTGCTGATAAGGAAAGGGAAATCAACCAAGCCTACTCCTATAGGAACGACGCTTTACCTAGAGCTCG
TGGTGAGGCTGAGGTTGCTCTGCAAGGTGCACAAGCCTACAAGATAGAAGCTATAAATCGCGCTGTGGGTGACACGAAGA
GGTTCATCGAAATTTATAACCAGTATAGAGTTAACCCCGACATAACAAAGATGAGAATGCGAATTGAAATGCTCGAAGAG
GTTTATAAGAACACCGAGAAAATCATTGCTGATGATAGCAATATATTCAAGTTCTTCGATTTACAGAAGGGTGGTGTCAA
ATGA

Upstream 100 bases:

>100_bases
AGGCTTTTTAAGGTGGGATTATAGCCTTTTTTATCCTTGAAGCAAGAGTGAAAATCAATTAGATTTAATTAATCGTGGTG
GTCTAGAGAGAAAATATAGG

Downstream 100 bases:

>100_bases
GAGGAGTTTTAGCAGTTGTTATAGGCTTTTTTTTGCTGTTGAATCTCAGCGTGTTTGTGGTTCCCGAGGGGTATAAAGCT
ATAGTTTTACAGTTCGGTGA

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTLARYDNPWGSDDEPPRRTRATRRNVYDIEGLLLSVRGKFFRRGGSRFSWWFILCLLSLFGILWVLSGFYVVNPEEQAV
ELTFGKYTGMADPGLRYHFPFPIGRVDKVKVAAINRNEIGYSSGKKGEGEGIMLTGDENILDANFEVQWRIKDAYKFLYK
VRDYGFGLSVKGAAESAMRDAIGQNEISFILRGEGRAKIASDTKKQLQEILDGYDMGVEILSIQMKKVDPPEKVIDAFRD
VQSARADKEREINQAYSYRNDALPRARGEAEVALQGAQAYKIEAINRAVGDTKRFIEIYNQYRVNPDITKMRMRIEMLEE
VYKNTEKIIADDSNIFKFFDLQKGGVK

Sequences:

>Translated_347_residues
MTLARYDNPWGSDDEPPRRTRATRRNVYDIEGLLLSVRGKFFRRGGSRFSWWFILCLLSLFGILWVLSGFYVVNPEEQAV
ELTFGKYTGMADPGLRYHFPFPIGRVDKVKVAAINRNEIGYSSGKKGEGEGIMLTGDENILDANFEVQWRIKDAYKFLYK
VRDYGFGLSVKGAAESAMRDAIGQNEISFILRGEGRAKIASDTKKQLQEILDGYDMGVEILSIQMKKVDPPEKVIDAFRD
VQSARADKEREINQAYSYRNDALPRARGEAEVALQGAQAYKIEAINRAVGDTKRFIEIYNQYRVNPDITKMRMRIEMLEE
VYKNTEKIIADDSNIFKFFDLQKGGVK
>Mature_346_residues
TLARYDNPWGSDDEPPRRTRATRRNVYDIEGLLLSVRGKFFRRGGSRFSWWFILCLLSLFGILWVLSGFYVVNPEEQAVE
LTFGKYTGMADPGLRYHFPFPIGRVDKVKVAAINRNEIGYSSGKKGEGEGIMLTGDENILDANFEVQWRIKDAYKFLYKV
RDYGFGLSVKGAAESAMRDAIGQNEISFILRGEGRAKIASDTKKQLQEILDGYDMGVEILSIQMKKVDPPEKVIDAFRDV
QSARADKEREINQAYSYRNDALPRARGEAEVALQGAQAYKIEAINRAVGDTKRFIEIYNQYRVNPDITKMRMRIEMLEEV
YKNTEKIIADDSNIFKFFDLQKGGVK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=282, Percent_Identity=35.8156028368794, Blast_Score=169, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 39689; Mature: 39558

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLARYDNPWGSDDEPPRRTRATRRNVYDIEGLLLSVRGKFFRRGGSRFSWWFILCLLSL
CCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
FGILWVLSGFYVVNPEEQAVELTFGKYTGMADPGLRYHFPFPIGRVDKVKVAAINRNEIG
HHHHHHHCCEEEECCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCEEEEEEECCCCCC
YSSGKKGEGEGIMLTGDENILDANFEVQWRIKDAYKFLYKVRDYGFGLSVKGAAESAMRD
CCCCCCCCCCEEEEECCCCEEECCCEEEEEEHHHHHHHHHHHHCCCCEEECHHHHHHHHH
AIGQNEISFILRGEGRAKIASDTKKQLQEILDGYDMGVEILSIQMKKVDPPEKVIDAFRD
HCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHH
VQSARADKEREINQAYSYRNDALPRARGEAEVALQGAQAYKIEAINRAVGDTKRFIEIYN
HHHHHCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHH
QYRVNPDITKMRMRIEMLEEVYKNTEKIIADDSNIFKFFDLQKGGVK
HHCCCCCHHHHHHHHHHHHHHHHCHHHEECCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
TLARYDNPWGSDDEPPRRTRATRRNVYDIEGLLLSVRGKFFRRGGSRFSWWFILCLLSL
CCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
FGILWVLSGFYVVNPEEQAVELTFGKYTGMADPGLRYHFPFPIGRVDKVKVAAINRNEIG
HHHHHHHCCEEEECCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCEEEEEEECCCCCC
YSSGKKGEGEGIMLTGDENILDANFEVQWRIKDAYKFLYKVRDYGFGLSVKGAAESAMRD
CCCCCCCCCCEEEEECCCCEEECCCEEEEEEHHHHHHHHHHHHCCCCEEECHHHHHHHHH
AIGQNEISFILRGEGRAKIASDTKKQLQEILDGYDMGVEILSIQMKKVDPPEKVIDAFRD
HCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHH
VQSARADKEREINQAYSYRNDALPRARGEAEVALQGAQAYKIEAINRAVGDTKRFIEIYN
HHHHHCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHH
QYRVNPDITKMRMRIEMLEEVYKNTEKIIADDSNIFKFFDLQKGGVK
HHCCCCCHHHHHHHHHHHHHHHHCHHHEECCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]