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The map label for this gene is der [H]

Identifier: 88608743

GI number: 88608743

Start: 461878

End: 463299

Strand: Reverse

Name: der [H]

Synonym: NSE_0536

Alternate gene names: 88608743

Gene position: 463299-461878 (Counterclockwise)

Preceding gene: 88608106

Following gene: 88608423

Centisome position: 53.93

GC content: 38.47

Gene sequence:

>1422_bases
ATGCAGTCTACCTTTAGAGTTTCCATAGTTGGAAAGGCAAATGTTGGTAAATCAACATTGTTTAATAAGATGGCCAAGGA
AAAACGTTCAATTACTATGGATAGAAAAGGAGTCACTCGTGATGTGGTTGTCAGAAGAATTTCACTAAGTGATGGGAAAT
CGCTTCTTCTACTTGATACTGCAGGCTTCAATCCACAACATCCAGAAACAGTTGAAAGGACTGAATATGCGATAAAGGAA
AGCGATATGGTTCTTTTCGTGATTGACAATAAAATCGATTCCGAGGATATGCTTTTTGCCAATTGGCTTAGAAGGAATGC
TGGAAACAGTAAAATAGTTTTGGTTTGCAATAAGAGTGATCGTAAAGATAGAGATGATTGCTCACTTTTTGGCTTTCAGA
ATGTTTTTCTAATATCTGCCGAGCATTCGTTAGGTCTCAGGGAGCTCATTTCCTACATAGAGTCCTTTATACCGGAGCAA
TTAGATACTCCGAAAAATGGCTCTGAAGAACAAAGGAGAATTAAAGTCGCTATTTTAGGTCAGCCAAACGTTGGTAAATC
TAGTTTGATGAACAAGTTTGTAGGTAAAGATCGTGTCCTCGTGCTACCAATAGCAGGTACTACAAGGGATCCAATAAGTG
ATGAGCTTCAGTGGAAATGCACAACCTTTGAACTTGTTGATACCGCCGGTTTGAGAAAAAAACAAAGAGTCACTGACGGA
TTAGAAAAAATATGCAATTCAAGGGCTTTACGTACTTCAGCAGAGAGTGATGTGGTGATTTTTATGTGCGACATATCAAA
TTTTACGTTGGAACGTCAGGATTTTCTTCTTATGAATAGGATCCTAGAACAAGGTAAACCAATGATACTTGTGGGGAATA
AGAAAGATGCAGTCGATGCTATTGAACTTGAAAATATCAAGGACTTTATTAGTCTGCAAGCGCAAAAATTAATTGCTTCG
CAGATACCGATATTTTTTATTTCCTGTCTACATGAGGGCGATTTTTCCTACATACTAGACGAATGTAGGAGGCTGCATGA
CGACTCGAAGCGAAATATTTCAACGCATCGATTAAATATGTGGCTCCAAGAAATTGTACGTCGCCACCCACATCCTATGG
TGAACTCCAAGGCAGTAAAGCTTAAATATATAAAGAAATTACTAAATAAATTTGTTTTTGTACTAAGTGCAAATCGCCCT
GAACTTGTCGCTGAGTCATATTTAAATTATGTGAGGAACTCCCTTATTAGAGACTTTCGGATTTGCGGTATTCCAGTGAC
CCTCACTTTAAAAAAGAACACCAATCCATACGTAGAAAGCAAACCTCCTGAACAAAAAAACATGGAATTGATATCCAGAA
GAGGATCGGCATCTGGTTCTGGACCTACCCATCGTAAGAGCAGCATGAGAAAGTCCTCATAA

Upstream 100 bases:

>100_bases
TCTTGCCCTCTCCTTCTTTGGGTTTTATTCGGCTATATTGCTATTTAGATGTATTCCATACAAATTGACATCTACACTTT
CTCCTTGTGTTGTCTTTAAC

Downstream 100 bases:

>100_bases
GATAATGCCGCGCAAATAGCCTTATGGATGGCACCAGACGATCAATAAGATATCAAGACGGTCCCGTTTTTAGAGACCAA
ACATAGAGCGAATTTTGCTA

Product: putative GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MQSTFRVSIVGKANVGKSTLFNKMAKEKRSITMDRKGVTRDVVVRRISLSDGKSLLLLDTAGFNPQHPETVERTEYAIKE
SDMVLFVIDNKIDSEDMLFANWLRRNAGNSKIVLVCNKSDRKDRDDCSLFGFQNVFLISAEHSLGLRELISYIESFIPEQ
LDTPKNGSEEQRRIKVAILGQPNVGKSSLMNKFVGKDRVLVLPIAGTTRDPISDELQWKCTTFELVDTAGLRKKQRVTDG
LEKICNSRALRTSAESDVVIFMCDISNFTLERQDFLLMNRILEQGKPMILVGNKKDAVDAIELENIKDFISLQAQKLIAS
QIPIFFISCLHEGDFSYILDECRRLHDDSKRNISTHRLNMWLQEIVRRHPHPMVNSKAVKLKYIKKLLNKFVFVLSANRP
ELVAESYLNYVRNSLIRDFRICGIPVTLTLKKNTNPYVESKPPEQKNMELISRRGSASGSGPTHRKSSMRKSS

Sequences:

>Translated_473_residues
MQSTFRVSIVGKANVGKSTLFNKMAKEKRSITMDRKGVTRDVVVRRISLSDGKSLLLLDTAGFNPQHPETVERTEYAIKE
SDMVLFVIDNKIDSEDMLFANWLRRNAGNSKIVLVCNKSDRKDRDDCSLFGFQNVFLISAEHSLGLRELISYIESFIPEQ
LDTPKNGSEEQRRIKVAILGQPNVGKSSLMNKFVGKDRVLVLPIAGTTRDPISDELQWKCTTFELVDTAGLRKKQRVTDG
LEKICNSRALRTSAESDVVIFMCDISNFTLERQDFLLMNRILEQGKPMILVGNKKDAVDAIELENIKDFISLQAQKLIAS
QIPIFFISCLHEGDFSYILDECRRLHDDSKRNISTHRLNMWLQEIVRRHPHPMVNSKAVKLKYIKKLLNKFVFVLSANRP
ELVAESYLNYVRNSLIRDFRICGIPVTLTLKKNTNPYVESKPPEQKNMELISRRGSASGSGPTHRKSSMRKSS
>Mature_473_residues
MQSTFRVSIVGKANVGKSTLFNKMAKEKRSITMDRKGVTRDVVVRRISLSDGKSLLLLDTAGFNPQHPETVERTEYAIKE
SDMVLFVIDNKIDSEDMLFANWLRRNAGNSKIVLVCNKSDRKDRDDCSLFGFQNVFLISAEHSLGLRELISYIESFIPEQ
LDTPKNGSEEQRRIKVAILGQPNVGKSSLMNKFVGKDRVLVLPIAGTTRDPISDELQWKCTTFELVDTAGLRKKQRVTDG
LEKICNSRALRTSAESDVVIFMCDISNFTLERQDFLLMNRILEQGKPMILVGNKKDAVDAIELENIKDFISLQAQKLIAS
QIPIFFISCLHEGDFSYILDECRRLHDDSKRNISTHRLNMWLQEIVRRHPHPMVNSKAVKLKYIKKLLNKFVFVLSANRP
ELVAESYLNYVRNSLIRDFRICGIPVTLTLKKNTNPYVESKPPEQKNMELISRRGSASGSGPTHRKSSMRKSS

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis [H]

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain [H]

Homologues:

Organism=Escherichia coli, GI87082120, Length=470, Percent_Identity=29.3617021276596, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI2367268, Length=100, Percent_Identity=39, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323665, Length=161, Percent_Identity=34.1614906832298, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 53874; Mature: 53874

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSTFRVSIVGKANVGKSTLFNKMAKEKRSITMDRKGVTRDVVVRRISLSDGKSLLLLDT
CCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEEECCCCCEEEEEEE
AGFNPQHPETVERTEYAIKESDMVLFVIDNKIDSEDMLFANWLRRNAGNSKIVLVCNKSD
CCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCC
RKDRDDCSLFGFQNVFLISAEHSLGLRELISYIESFIPEQLDTPKNGSEEQRRIKVAILG
CCCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCEEEEEEEEC
QPNVGKSSLMNKFVGKDRVLVLPIAGTTRDPISDELQWKCTTFELVDTAGLRKKQRVTDG
CCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEEEEEHHCCCCCHHHHHHHH
LEKICNSRALRTSAESDVVIFMCDISNFTLERQDFLLMNRILEQGKPMILVGNKKDAVDA
HHHHHCCHHHCCCCCCCEEEEEEECCCCEECHHHHHHHHHHHHCCCCEEEECCCCCCCHH
IELENIKDFISLQAQKLIASQIPIFFISCLHEGDFSYILDECRRLHDDSKRNISTHRLNM
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHH
WLQEIVRRHPHPMVNSKAVKLKYIKKLLNKFVFVLSANRPELVAESYLNYVRNSLIRDFR
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHE
ICGIPVTLTLKKNTNPYVESKPPEQKNMELISRRGSASGSGPTHRKSSMRKSS
EECCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MQSTFRVSIVGKANVGKSTLFNKMAKEKRSITMDRKGVTRDVVVRRISLSDGKSLLLLDT
CCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEEECCCCCEEEEEEE
AGFNPQHPETVERTEYAIKESDMVLFVIDNKIDSEDMLFANWLRRNAGNSKIVLVCNKSD
CCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCC
RKDRDDCSLFGFQNVFLISAEHSLGLRELISYIESFIPEQLDTPKNGSEEQRRIKVAILG
CCCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCEEEEEEEEC
QPNVGKSSLMNKFVGKDRVLVLPIAGTTRDPISDELQWKCTTFELVDTAGLRKKQRVTDG
CCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEEEEEHHCCCCCHHHHHHHH
LEKICNSRALRTSAESDVVIFMCDISNFTLERQDFLLMNRILEQGKPMILVGNKKDAVDA
HHHHHCCHHHCCCCCCCEEEEEEECCCCEECHHHHHHHHHHHHCCCCEEEECCCCCCCHH
IELENIKDFISLQAQKLIASQIPIFFISCLHEGDFSYILDECRRLHDDSKRNISTHRLNM
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHH
WLQEIVRRHPHPMVNSKAVKLKYIKKLLNKFVFVLSANRPELVAESYLNYVRNSLIRDFR
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHE
ICGIPVTLTLKKNTNPYVESKPPEQKNMELISRRGSASGSGPTHRKSSMRKSS
EECCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]