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The map label for this gene is ffh

Identifier: 88608106

GI number: 88608106

Start: 469013

End: 470362

Strand: Reverse

Name: ffh

Synonym: NSE_0540

Alternate gene names: 88608106

Gene position: 470362-469013 (Counterclockwise)

Preceding gene: 88608516

Following gene: 88608743

Centisome position: 54.76

GC content: 40.96

Gene sequence:

>1350_bases
ATGTTTGATTCACTTTCTAAAAAAATTGGTGGTGCACTGGATGGAATAAAGAATAGAGGGGTGATTACCGAAAAGGAGTT
TGACGATTTTGTTCGGAAGTTGCGTCTGACGTTTCTCGAGGCAGATGTTAGTCTGCCTGTCACTAAACAGTTTATCGCAA
ATGTAAGGGAATCGGTTATTGGAAAGTCTCGTGTGAAAGGGATCTCGACACCAGCGGTAATTGGAAGTGTTGTAAAAGAG
GAATTAGTAAAAATTTTGGGAGGTGAATCACAGAAATTTGAATTCCCGAAATTTGGGAAACAGATATTGATGTTTGTTGG
TTTACAGGGAGTTGGGAAGACTACAACTGCAGCAAAGTTAGCTCTGTTGATTCGGAAAAAATTTAAAAAAAATATTCTTT
TATCTTCTGTAGATATCTATAGGCCTGCAGCGAGGAAACAGCTTGAAATTCTTGCAAAGCAAATTGACGTTGATACTGTT
CCTATAGTGGAAGGTGAGGATGTCGATGCGATCGTAAAGAAAACATTAGATTTATTTAATAATAGCCATGAAGGTTATGA
TGTGCTTATGGTTGACACTGCCGGACGTTCGCAAATTGATTCTGTGCTTATGGAAGAGCTAAAAGTGATTAAGAATCGCT
TACAGCCCTCCGAGATATTTCAGGTTCTAGATGCGATGATGGGGCAAGATTCACTTAATGTTGCGAGGACATTTCACTCA
GAGATCGGTACAACTGGGGTAATAGTGAGCAGGCTAGACAGCGATGCGCGGGTTGGTTCAGTGCTTTCAGTTAGGCAATC
TGTTGGTCTTCCTATTAGATTTTGTGGCGCTGGAGAGAGGGTTAATGATTTAGAAGAATTTCACCCGGAACGTATGGCAG
GAAGAATAATGGGAGCTGGGGATATTGCCTCCCTAGTTGAATATGCCTCGTCTGAAGTTGGTGAAGAAAGAATAGGTTCT
ATAAGAAAAAGAATCGAAGCTGGTAAGTTCGATTATGATGATCTTGTGTTGCAGTTGAAAAGCATTGACAAGCTTGGCGG
AATAGCTAAACTCTTACGTTTTATTCCCGGAATTAATAAAGTTCCGACGGAGCATCTTGTCGATGATACAACCCTGAAGA
AAAATCTGGCCATGATAGGCAGTATGACAAAGAGGGAAAGAGCGTGTCTCGATTCCATCAACCAGTCACGCAAATCACGC
ATAGCGAGTGGGGCAGGAGTTAAGATATACGAAGTGAACAAGTTAATAAAAAACTTTGAGAAAGCTCGCCTGCTCGCCCT
AAAAATAGGAAAAGTAGGTGCAACAAATGAGAAATCCATACACGACCTCAACGAACTACTCAGGAAATAA

Upstream 100 bases:

>100_bases
AACGACCTGTAGTTGTTTAGACTCCTTGTCGCTTAGTATTGTGATTTTTTTAATGAGCATCGTTGTTGTATTGTTTCTCT
TTGCAGGGGTTTGATTTCTT

Downstream 100 bases:

>100_bases
GGAAAACAGGAAGGGAGGGGCCCCCCTTTTCTGGCCCCCAGAGAAATAGTACACGGGGAATCAGAAGTAAAAAGCGATCC
CCGAGTCCGCCTATCGCTTA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFDSLSKKIGGALDGIKNRGVITEKEFDDFVRKLRLTFLEADVSLPVTKQFIANVRESVIGKSRVKGISTPAVIGSVVKE
ELVKILGGESQKFEFPKFGKQILMFVGLQGVGKTTTAAKLALLIRKKFKKNILLSSVDIYRPAARKQLEILAKQIDVDTV
PIVEGEDVDAIVKKTLDLFNNSHEGYDVLMVDTAGRSQIDSVLMEELKVIKNRLQPSEIFQVLDAMMGQDSLNVARTFHS
EIGTTGVIVSRLDSDARVGSVLSVRQSVGLPIRFCGAGERVNDLEEFHPERMAGRIMGAGDIASLVEYASSEVGEERIGS
IRKRIEAGKFDYDDLVLQLKSIDKLGGIAKLLRFIPGINKVPTEHLVDDTTLKKNLAMIGSMTKRERACLDSINQSRKSR
IASGAGVKIYEVNKLIKNFEKARLLALKIGKVGATNEKSIHDLNELLRK

Sequences:

>Translated_449_residues
MFDSLSKKIGGALDGIKNRGVITEKEFDDFVRKLRLTFLEADVSLPVTKQFIANVRESVIGKSRVKGISTPAVIGSVVKE
ELVKILGGESQKFEFPKFGKQILMFVGLQGVGKTTTAAKLALLIRKKFKKNILLSSVDIYRPAARKQLEILAKQIDVDTV
PIVEGEDVDAIVKKTLDLFNNSHEGYDVLMVDTAGRSQIDSVLMEELKVIKNRLQPSEIFQVLDAMMGQDSLNVARTFHS
EIGTTGVIVSRLDSDARVGSVLSVRQSVGLPIRFCGAGERVNDLEEFHPERMAGRIMGAGDIASLVEYASSEVGEERIGS
IRKRIEAGKFDYDDLVLQLKSIDKLGGIAKLLRFIPGINKVPTEHLVDDTTLKKNLAMIGSMTKRERACLDSINQSRKSR
IASGAGVKIYEVNKLIKNFEKARLLALKIGKVGATNEKSIHDLNELLRK
>Mature_449_residues
MFDSLSKKIGGALDGIKNRGVITEKEFDDFVRKLRLTFLEADVSLPVTKQFIANVRESVIGKSRVKGISTPAVIGSVVKE
ELVKILGGESQKFEFPKFGKQILMFVGLQGVGKTTTAAKLALLIRKKFKKNILLSSVDIYRPAARKQLEILAKQIDVDTV
PIVEGEDVDAIVKKTLDLFNNSHEGYDVLMVDTAGRSQIDSVLMEELKVIKNRLQPSEIFQVLDAMMGQDSLNVARTFHS
EIGTTGVIVSRLDSDARVGSVLSVRQSVGLPIRFCGAGERVNDLEEFHPERMAGRIMGAGDIASLVEYASSEVGEERIGS
IRKRIEAGKFDYDDLVLQLKSIDKLGGIAKLLRFIPGINKVPTEHLVDDTTLKKNLAMIGSMTKRERACLDSINQSRKSR
IASGAGVKIYEVNKLIKNFEKARLLALKIGKVGATNEKSIHDLNELLRK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=440, Percent_Identity=29.7727272727273, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI226371618, Length=378, Percent_Identity=30.1587301587302, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI89061728, Length=137, Percent_Identity=33.5766423357664, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI23308697, Length=325, Percent_Identity=23.6923076923077, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI295424842, Length=325, Percent_Identity=23.6923076923077, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1788963, Length=423, Percent_Identity=39.9527186761229, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI1789874, Length=253, Percent_Identity=33.596837944664, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17539958, Length=438, Percent_Identity=29.2237442922374, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI193206261, Length=310, Percent_Identity=24.5161290322581, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325345, Length=432, Percent_Identity=29.1666666666667, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320498, Length=247, Percent_Identity=29.9595141700405, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647949, Length=440, Percent_Identity=29.3181818181818, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24641198, Length=299, Percent_Identity=23.7458193979933, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49508; Mature: 49508

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDSLSKKIGGALDGIKNRGVITEKEFDDFVRKLRLTFLEADVSLPVTKQFIANVRESVI
CCCHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GKSRVKGISTPAVIGSVVKEELVKILGGESQKFEFPKFGKQILMFVGLQGVGKTTTAAKL
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHH
ALLIRKKFKKNILLSSVDIYRPAARKQLEILAKQIDVDTVPIVEGEDVDAIVKKTLDLFN
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
NSHEGYDVLMVDTAGRSQIDSVLMEELKVIKNRLQPSEIFQVLDAMMGQDSLNVARTFHS
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHH
EIGTTGVIVSRLDSDARVGSVLSVRQSVGLPIRFCGAGERVNDLEEFHPERMAGRIMGAG
HHCCHHHHHHHCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHCHHHHHHHHCCCH
DIASLVEYASSEVGEERIGSIRKRIEAGKFDYDDLVLQLKSIDKLGGIAKLLRFIPGINK
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VPTEHLVDDTTLKKNLAMIGSMTKRERACLDSINQSRKSRIASGAGVKIYEVNKLIKNFE
CCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHH
KARLLALKIGKVGATNEKSIHDLNELLRK
HHHHHHHHHCCCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MFDSLSKKIGGALDGIKNRGVITEKEFDDFVRKLRLTFLEADVSLPVTKQFIANVRESVI
CCCHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GKSRVKGISTPAVIGSVVKEELVKILGGESQKFEFPKFGKQILMFVGLQGVGKTTTAAKL
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHH
ALLIRKKFKKNILLSSVDIYRPAARKQLEILAKQIDVDTVPIVEGEDVDAIVKKTLDLFN
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
NSHEGYDVLMVDTAGRSQIDSVLMEELKVIKNRLQPSEIFQVLDAMMGQDSLNVARTFHS
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHH
EIGTTGVIVSRLDSDARVGSVLSVRQSVGLPIRFCGAGERVNDLEEFHPERMAGRIMGAG
HHCCHHHHHHHCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHCHHHHHHHHCCCH
DIASLVEYASSEVGEERIGSIRKRIEAGKFDYDDLVLQLKSIDKLGGIAKLLRFIPGINK
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VPTEHLVDDTTLKKNLAMIGSMTKRERACLDSINQSRKSRIASGAGVKIYEVNKLIKNFE
CCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHH
KARLLALKIGKVGATNEKSIHDLNELLRK
HHHHHHHHHCCCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]