Click here to switch to the map view.

The map label for this gene is sdhB

Identifier: 88608423

GI number: 88608423

Start: 459627

End: 460391

Strand: Reverse

Name: sdhB

Synonym: NSE_0534

Alternate gene names: 88608423

Gene position: 460391-459627 (Counterclockwise)

Preceding gene: 88608743

Following gene: 88608730

Centisome position: 53.6

GC content: 41.83

Gene sequence:

>765_bases
ATGGCGCAGTTTAGGCTACCTGAAAATTCACGTATCGTTGAGGGGAAAGTTCATAATTCTCCTTCTTCTGATGCAAGAAA
GTTAGTCGTGTACAGATTCTCTCCTGGTGATGATAACCCGAGAAGAGATATCTATTACGTGAACCAGAAGGACTGTGCAC
CTATGATCTTAGATGCTCTCATCAAAGTGAAAGGTGAAATAGATCCTACTTTAACTTTCAGGCGCTCTTGTAGAGAGGGA
GTTTGTGGCTCATGTGCCATGAATATCGATGGGCGTAACACGCTTGCATGTACAAAACGCATGGATGAAATTAAGGGTGA
GATTCGAATTTATCCTCTTCCTCATATGAGAGTGTTAAAGGATTTGGTTACCGACCTTACCGTGTTTTTTCAGCATTATC
GTTCTATAAAGCCTTGGTTACACTCCGAAAAAAGTAATAATGGAAAAGAACACCTCCAGATGCCTGAGGAAAGAGAAAAA
CTCGCTGGGCTGCATGACTGCATTTTATGTGCCTGCTGTTCGACGAGTTGTCCAAGTTTTTGGTGGAATGGAGATAAGTA
TCTTGGTCCTGCTGCGTTGCTACAAGCCTATCGTTGGTTGGTTGATAGCAGAGATTCAAAAAAGAAGGAGAGGCTTGAGT
TTTTAGCGGATTCATTTAGGTTATATCGTTGTCATACAATCATGAATTGTGCACAGGCGTGTCCTAAAGGTCTGAATCCG
GCCAAAGCAATTGCTGAAATAAAGAAAATGATCGTTTTGGAGTGA

Upstream 100 bases:

>100_bases
AATCTCATTGTGTATTACAGGGTAACATCTAAACCGCGCTTTATTTACCTGTTTCTGATAAAATGTTAGGATCTCGTTCA
GGTTCATCACTTTTTATAGC

Downstream 100 bases:

>100_bases
TTTCGACTCCCCGTTTGTGTCGTTTTACATATCGGTCCTATCTTGTGCTTTGAGGTTATGTTTTCTCAGTGAAGCGGCCT
GCATGGACGTTTACAAGATA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MAQFRLPENSRIVEGKVHNSPSSDARKLVVYRFSPGDDNPRRDIYYVNQKDCAPMILDALIKVKGEIDPTLTFRRSCREG
VCGSCAMNIDGRNTLACTKRMDEIKGEIRIYPLPHMRVLKDLVTDLTVFFQHYRSIKPWLHSEKSNNGKEHLQMPEEREK
LAGLHDCILCACCSTSCPSFWWNGDKYLGPAALLQAYRWLVDSRDSKKKERLEFLADSFRLYRCHTIMNCAQACPKGLNP
AKAIAEIKKMIVLE

Sequences:

>Translated_254_residues
MAQFRLPENSRIVEGKVHNSPSSDARKLVVYRFSPGDDNPRRDIYYVNQKDCAPMILDALIKVKGEIDPTLTFRRSCREG
VCGSCAMNIDGRNTLACTKRMDEIKGEIRIYPLPHMRVLKDLVTDLTVFFQHYRSIKPWLHSEKSNNGKEHLQMPEEREK
LAGLHDCILCACCSTSCPSFWWNGDKYLGPAALLQAYRWLVDSRDSKKKERLEFLADSFRLYRCHTIMNCAQACPKGLNP
AKAIAEIKKMIVLE
>Mature_253_residues
AQFRLPENSRIVEGKVHNSPSSDARKLVVYRFSPGDDNPRRDIYYVNQKDCAPMILDALIKVKGEIDPTLTFRRSCREGV
CGSCAMNIDGRNTLACTKRMDEIKGEIRIYPLPHMRVLKDLVTDLTVFFQHYRSIKPWLHSEKSNNGKEHLQMPEEREKL
AGLHDCILCACCSTSCPSFWWNGDKYLGPAALLQAYRWLVDSRDSKKKERLEFLADSFRLYRCHTIMNCAQACPKGLNPA
KAIAEIKKMIVLE

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=232, Percent_Identity=63.3620689655172, Blast_Score=313, Evalue=1e-85,
Organism=Escherichia coli, GI1786943, Length=232, Percent_Identity=53.0172413793103, Blast_Score=255, Evalue=2e-69,
Organism=Escherichia coli, GI1790596, Length=224, Percent_Identity=33.0357142857143, Blast_Score=137, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17533915, Length=232, Percent_Identity=56.0344827586207, Blast_Score=281, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6322987, Length=228, Percent_Identity=60.5263157894737, Blast_Score=291, Evalue=6e-80,
Organism=Drosophila melanogaster, GI17137106, Length=233, Percent_Identity=57.5107296137339, Blast_Score=300, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24643156, Length=227, Percent_Identity=56.3876651982379, Blast_Score=290, Evalue=6e-79,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 29143; Mature: 29012

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
5.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQFRLPENSRIVEGKVHNSPSSDARKLVVYRFSPGDDNPRRDIYYVNQKDCAPMILDAL
CCCCCCCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHH
IKVKGEIDPTLTFRRSCREGVCGSCAMNIDGRNTLACTKRMDEIKGEIRIYPLPHMRVLK
HHHCCCCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHH
DLVTDLTVFFQHYRSIKPWLHSEKSNNGKEHLQMPEEREKLAGLHDCILCACCSTSCPSF
HHHHHHHHHHHHHHHHCHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
WWNGDKYLGPAALLQAYRWLVDSRDSKKKERLEFLADSFRLYRCHTIMNCAQACPKGLNP
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AKAIAEIKKMIVLE
HHHHHHHHHHHHCC
>Mature Secondary Structure 
AQFRLPENSRIVEGKVHNSPSSDARKLVVYRFSPGDDNPRRDIYYVNQKDCAPMILDAL
CCCCCCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHH
IKVKGEIDPTLTFRRSCREGVCGSCAMNIDGRNTLACTKRMDEIKGEIRIYPLPHMRVLK
HHHCCCCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHH
DLVTDLTVFFQHYRSIKPWLHSEKSNNGKEHLQMPEEREKLAGLHDCILCACCSTSCPSF
HHHHHHHHHHHHHHHHCHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
WWNGDKYLGPAALLQAYRWLVDSRDSKKKERLEFLADSFRLYRCHTIMNCAQACPKGLNP
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
AKAIAEIKKMIVLE
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA