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The map label for this gene is sucD

Identifier: 88608406

GI number: 88608406

Start: 212197

End: 213069

Strand: Reverse

Name: sucD

Synonym: NSE_0250

Alternate gene names: 88608406

Gene position: 213069-212197 (Counterclockwise)

Preceding gene: 88608589

Following gene: 88608284

Centisome position: 24.8

GC content: 44.9

Gene sequence:

>873_bases
ATGGCGATTTTAGTTAACAAAGAAACACGGGTTATCTGCCAAGGATTTACAGGCCATCAGGGTACTTTTCATTCTGAACA
GGCTATTGAATACGGCACAAAAATGGTTGGTGGTGTAACGCCCGGTAAGGGAGGTCAAATGCACCTTGGGCTACCGGTCT
TTAACACTGTATACCATGCAAGAAAAGAGACTGGAGCAAATGCAACCGTAATATATGTTCCGGCACCGTTTGCGATGGAC
GCAATTCTTGAAGCAATTGATGCAGAGATAGAACTGATCGTGTGTATAACAGAGGGAATTCCTGTTCAAGACATGATGCG
CGTTAAGAGCGCATTAAGTAACTCTAAAAGTCTGTTGATAGGCCCAAACTGCCCGGGCATCATAACGCCTGGTGAATGCA
AGATAGGTATAATGCCGGGATATATCCACAAGCGTGGAAAAATAGGCATTGTCTCTCGCTCTGGAACACTCACCTATGAA
GCGGTTGCACAGACAACACAAATGGGTCTCGGACAATCCACGTGCATTGGTGTGGGTGGTGATCCAGTAAAAGGGCTCGA
TTTCGTGGATTGTGTGAAAATGTTCTTGGACGATCCAGAAACTGAAGCAATTATCATGATTGGTGAAATTGGTGGTTCAG
CTGAGGAAAAGGCTTGTGCATTGCTGAAATCATCGCAAAGTAAAAAACCAACAGTTGGTTTTATTGCCGGTGCTACTGCT
CCTCCTGGAAGGAGGATGGGCCATGCTGGGGCAATTATTTCGAGTAGCGATGAGTCTGCAGAAAGTAAGATAAAAGTAAT
GAAAGACGCAGGAATTGTAATTGCGGAAACCCCAGCTCTGATAGGAAAAACGGTTGCAGATCTCATAGCATAA

Upstream 100 bases:

>100_bases
GAATAAAGATTATTGAGGGCTCCGGACTGAATATTGTGACCGCCTCCGAACTTGATGATGCGGCACAAAAAATCGTAAAA
CTGACAAGGAAGGAAATTTA

Downstream 100 bases:

>100_bases
GTATTTTTGACGGTGTCAAAAGATACGGGATACTGGTTTTCTAGAGTTTTATCTCGTTAGGATAAATTGGTTTTGTTCTA
GGCCGGGTGTTTTCTATCTG

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MAILVNKETRVICQGFTGHQGTFHSEQAIEYGTKMVGGVTPGKGGQMHLGLPVFNTVYHARKETGANATVIYVPAPFAMD
AILEAIDAEIELIVCITEGIPVQDMMRVKSALSNSKSLLIGPNCPGIITPGECKIGIMPGYIHKRGKIGIVSRSGTLTYE
AVAQTTQMGLGQSTCIGVGGDPVKGLDFVDCVKMFLDDPETEAIIMIGEIGGSAEEKACALLKSSQSKKPTVGFIAGATA
PPGRRMGHAGAIISSSDESAESKIKVMKDAGIVIAETPALIGKTVADLIA

Sequences:

>Translated_290_residues
MAILVNKETRVICQGFTGHQGTFHSEQAIEYGTKMVGGVTPGKGGQMHLGLPVFNTVYHARKETGANATVIYVPAPFAMD
AILEAIDAEIELIVCITEGIPVQDMMRVKSALSNSKSLLIGPNCPGIITPGECKIGIMPGYIHKRGKIGIVSRSGTLTYE
AVAQTTQMGLGQSTCIGVGGDPVKGLDFVDCVKMFLDDPETEAIIMIGEIGGSAEEKACALLKSSQSKKPTVGFIAGATA
PPGRRMGHAGAIISSSDESAESKIKVMKDAGIVIAETPALIGKTVADLIA
>Mature_289_residues
AILVNKETRVICQGFTGHQGTFHSEQAIEYGTKMVGGVTPGKGGQMHLGLPVFNTVYHARKETGANATVIYVPAPFAMDA
ILEAIDAEIELIVCITEGIPVQDMMRVKSALSNSKSLLIGPNCPGIITPGECKIGIMPGYIHKRGKIGIVSRSGTLTYEA
VAQTTQMGLGQSTCIGVGGDPVKGLDFVDCVKMFLDDPETEAIIMIGEIGGSAEEKACALLKSSQSKKPTVGFIAGATAP
PGRRMGHAGAIISSSDESAESKIKVMKDAGIVIAETPALIGKTVADLIA

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=287, Percent_Identity=66.8989547038328, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI38569423, Length=263, Percent_Identity=28.8973384030418, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI38569421, Length=263, Percent_Identity=28.8973384030418, Blast_Score=98, Evalue=9e-21,
Organism=Escherichia coli, GI1786949, Length=289, Percent_Identity=64.7058823529412, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1786513, Length=184, Percent_Identity=28.2608695652174, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17550194, Length=286, Percent_Identity=63.6363636363636, Blast_Score=356, Evalue=9e-99,
Organism=Caenorhabditis elegans, GI17553126, Length=284, Percent_Identity=63.3802816901408, Blast_Score=350, Evalue=7e-97,
Organism=Caenorhabditis elegans, GI17551266, Length=254, Percent_Identity=27.1653543307087, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17557344, Length=254, Percent_Identity=26.7716535433071, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324716, Length=296, Percent_Identity=54.0540540540541, Blast_Score=298, Evalue=9e-82,
Organism=Drosophila melanogaster, GI28574296, Length=282, Percent_Identity=64.8936170212766, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI21356559, Length=287, Percent_Identity=57.4912891986063, Blast_Score=333, Evalue=7e-92,
Organism=Drosophila melanogaster, GI281363475, Length=255, Percent_Identity=29.4117647058824, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281363473, Length=255, Percent_Identity=29.4117647058824, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281363477, Length=255, Percent_Identity=29.4117647058824, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30230; Mature: 30098

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVNKETRVICQGFTGHQGTFHSEQAIEYGTKMVGGVTPGKGGQMHLGLPVFNTVYHA
CEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHH
RKETGANATVIYVPAPFAMDAILEAIDAEIELIVCITEGIPVQDMMRVKSALSNSKSLLI
HHHCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
GPNCPGIITPGECKIGIMPGYIHKRGKIGIVSRSGTLTYEAVAQTTQMGLGQSTCIGVGG
CCCCCCEECCCCEEEEEECCCEECCCCEEEEECCCCEEHHHHHHHHHHCCCCCEEEECCC
DPVKGLDFVDCVKMFLDDPETEAIIMIGEIGGSAEEKACALLKSSQSKKPTVGFIAGATA
CCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEECCCC
PPGRRMGHAGAIISSSDESAESKIKVMKDAGIVIAETPALIGKTVADLIA
CCCCCCCCCCEEEECCCCCCHHHEEEEECCCEEEEECCHHHHHHHHHHHC
>Mature Secondary Structure 
AILVNKETRVICQGFTGHQGTFHSEQAIEYGTKMVGGVTPGKGGQMHLGLPVFNTVYHA
EEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHH
RKETGANATVIYVPAPFAMDAILEAIDAEIELIVCITEGIPVQDMMRVKSALSNSKSLLI
HHHCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
GPNCPGIITPGECKIGIMPGYIHKRGKIGIVSRSGTLTYEAVAQTTQMGLGQSTCIGVGG
CCCCCCEECCCCEEEEEECCCEECCCCEEEEECCCCEEHHHHHHHHHHCCCCCEEEECCC
DPVKGLDFVDCVKMFLDDPETEAIIMIGEIGGSAEEKACALLKSSQSKKPTVGFIAGATA
CCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEECCCC
PPGRRMGHAGAIISSSDESAESKIKVMKDAGIVIAETPALIGKTVADLIA
CCCCCCCCCCEEEECCCCCCHHHEEEEECCCEEEEECCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]