BacMap

Definition	Anaplasma phagocytophilum HZ, complete genome.
Accession	NC_007797
Length	1,471,282

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The map label for this gene is znuC

Identifier: 88607812

GI number: 88607812

Start: 1041848

End: 1042510

Strand: Direct

Name: znuC

Synonym: APH_0983

Alternate gene names: 88607812

Gene position: 1041848-1042510 (Clockwise)

Preceding gene: 88607919

Following gene: 88607065

Centisome position: 70.81

GC content: 41.03

Gene sequence:

>663_bases
ATGCTTGTTGTTGACAGTATAACCTTGTTCTATGGAAATAGGAAGGTAATAGATAATGTCAGCTTCTCTATACGTCCCGG
TGAAATTATCACAATCCTCGGTCCTAATGGCGGAGGAAAAACATCTTTGGTGAGAGTACTAGTAGGCATTAATCAAGACT
ATATAGGTACCATTCACTATACCAAAAGACCTATCATCGCATATATGCCGCAGAATTTTAAAGTTAACAGTTTCATGCCT
ATGACGGTAGAGTACCTGTTGCTAAGTGCATGTTGGGGCAGAGGAATATCCCTAGACCTACGGGCGGTTATACAGTATGT
AGACATCTCAAAACTGCTTACTAGACAGATATCAGAGCTCTCAGCCGGAGAGATACAGTTAGTACTCCTTGCAAGGTGTA
TGGTTATGAAACCTGATCTGATCGTGCTTGATGAACCGGTCAGTTGTATGGACGTTGAGGCAAAGAACAATTTCTATCGG
TTGATAGGTAAGTTGGTATCTAAGTATAATATAAGTATCATCATGACATCTCATGATCTGCACTGCGTTATGGCTTGCTC
AGATCGTGTAATCTGCATAAATCGCTCCATACGCTGTGAAGGAACTCCTGAGGAGATCACTGAGAGTGCAAAATTTATGA
GCGTATTTCCAGAGAATGTTTAG

Upstream 100 bases:

>100_bases
GCAGGAGAAGTGCCACCAATAGCGAAATAATATGTATTCTGGTCAGCATATCAAGGAACCTGTCACACGCGTCGCGGGGC
TTCAGAAGAGTGTTCTACCC

Downstream 100 bases:

>100_bases
TTCTATCAGCGGGCTAGCTAGACTATGCAAGATAGGGGCCACACTACTGCGATATGGAATTATTCCTAATGCTGGCATAT
TTTCAAACAGAAAGCATAAA

Product: putative cation ABC transporter, ATP-binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MLVVDSITLFYGNRKVIDNVSFSIRPGEIITILGPNGGGKTSLVRVLVGINQDYIGTIHYTKRPIIAYMPQNFKVNSFMP
MTVEYLLLSACWGRGISLDLRAVIQYVDISKLLTRQISELSAGEIQLVLLARCMVMKPDLIVLDEPVSCMDVEAKNNFYR
LIGKLVSKYNISIIMTSHDLHCVMACSDRVICINRSIRCEGTPEEITESAKFMSVFPENV

Sequences:

>Translated_220_residues
MLVVDSITLFYGNRKVIDNVSFSIRPGEIITILGPNGGGKTSLVRVLVGINQDYIGTIHYTKRPIIAYMPQNFKVNSFMP
MTVEYLLLSACWGRGISLDLRAVIQYVDISKLLTRQISELSAGEIQLVLLARCMVMKPDLIVLDEPVSCMDVEAKNNFYR
LIGKLVSKYNISIIMTSHDLHCVMACSDRVICINRSIRCEGTPEEITESAKFMSVFPENV
>Mature_220_residues
MLVVDSITLFYGNRKVIDNVSFSIRPGEIITILGPNGGGKTSLVRVLVGINQDYIGTIHYTKRPIIAYMPQNFKVNSFMP
MTVEYLLLSACWGRGISLDLRAVIQYVDISKLLTRQISELSAGEIQLVLLARCMVMKPDLIVLDEPVSCMDVEAKNNFYR
LIGKLVSKYNISIIMTSHDLHCVMACSDRVICINRSIRCEGTPEEITESAKFMSVFPENV

Specific function: Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system

COG id: COG1121

COG function: function code P; ABC-type Mn/Zn transport systems, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI27262624, Length=206, Percent_Identity=28.6407766990291, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI27262626, Length=206, Percent_Identity=28.6407766990291, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI153792144, Length=215, Percent_Identity=22.3255813953488, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI27881501, Length=206, Percent_Identity=23.7864077669903, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI30795238, Length=206, Percent_Identity=23.7864077669903, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI27436953, Length=199, Percent_Identity=27.6381909547739, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI108773784, Length=192, Percent_Identity=27.6041666666667, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI108773782, Length=192, Percent_Identity=27.6041666666667, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788165, Length=217, Percent_Identity=36.8663594470046, Blast_Score=160, Evalue=5e-41,
Organism=Escherichia coli, GI1789864, Length=247, Percent_Identity=28.7449392712551, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI87081709, Length=230, Percent_Identity=26.5217391304348, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787712, Length=205, Percent_Identity=28.780487804878, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87081791, Length=236, Percent_Identity=28.3898305084746, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790739, Length=236, Percent_Identity=26.6949152542373, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787370, Length=218, Percent_Identity=28.4403669724771, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789991, Length=245, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1789593, Length=234, Percent_Identity=26.4957264957265, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI87082267, Length=225, Percent_Identity=25.7777777777778, Blast_Score=81, Evalue=4e-17,
Organism=Escherichia coli, GI1786698, Length=207, Percent_Identity=27.0531400966184, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1790190, Length=219, Percent_Identity=29.2237442922374, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787500, Length=201, Percent_Identity=25.8706467661692, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789672, Length=232, Percent_Identity=25.4310344827586, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081782, Length=215, Percent_Identity=24.1860465116279, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787089, Length=209, Percent_Identity=27.7511961722488, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786253, Length=227, Percent_Identity=26.431718061674, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789032, Length=215, Percent_Identity=29.7674418604651, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786975, Length=208, Percent_Identity=25.9615384615385, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788506, Length=219, Percent_Identity=26.9406392694064, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1787041, Length=207, Percent_Identity=25.6038647342995, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786703, Length=206, Percent_Identity=23.3009708737864, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1786563, Length=203, Percent_Identity=22.6600985221675, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1787758, Length=183, Percent_Identity=26.775956284153, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790525, Length=230, Percent_Identity=25.6521739130435, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI48994943, Length=229, Percent_Identity=24.8908296943231, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1789751, Length=206, Percent_Identity=22.3300970873786, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790467, Length=228, Percent_Identity=22.8070175438596, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI48995001, Length=208, Percent_Identity=27.4038461538462, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87082268, Length=162, Percent_Identity=30.2469135802469, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788472, Length=197, Percent_Identity=23.8578680203046, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788897, Length=206, Percent_Identity=24.2718446601942, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786345, Length=215, Percent_Identity=24.1860465116279, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788540, Length=195, Percent_Identity=24.6153846153846, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17565586, Length=219, Percent_Identity=25.5707762557078, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17555800, Length=205, Percent_Identity=25.8536585365854, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574150, Length=220, Percent_Identity=26.8181818181818, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI116007328, Length=220, Percent_Identity=26.8181818181818, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221512771, Length=228, Percent_Identity=26.7543859649123, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666836, Length=210, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573573, Length=217, Percent_Identity=24.8847926267281, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573571, Length=217, Percent_Identity=24.8847926267281, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24661270, Length=200, Percent_Identity=26.5, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355589, Length=200, Percent_Identity=26.5, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ZNUC_ANAPZ (Q2GJA5)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505546.1
- ProteinModelPortal:   Q2GJA5
- SMR:   Q2GJA5
- STRING:   Q2GJA5
- GeneID:   3930678
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0983
- NMPDR:   fig|212042.5.peg.928
- TIGR:   APH_0983
- eggNOG:   COG1121
- HOGENOM:   HBG758042
- PhylomeDB:   Q2GJA5
- ProtClustDB:   CLSK749566
- BioCyc:   APHA212042:APH_0983-MONOMER
- HAMAP:   MF_01725
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017882
- InterPro:   IPR003593
- SMART:   SM00382

Pfam domain/function: PF00005 ABC_tran

EC number: NA

Molecular weight: Translated: 24658; Mature: 24658

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51298 ZNUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVVDSITLFYGNRKVIDNVSFSIRPGEIITILGPNGGGKTSLVRVLVGINQDYIGTIHY
CEEEEEEEEEECCEEEECCCEEEECCCCEEEEECCCCCCHHHHHHHEECCCCCCEEEEEE
TKRPIIAYMPQNFKVNSFMPMTVEYLLLSACWGRGISLDLRAVIQYVDISKLLTRQISEL
CCCCEEEECCCCEEECCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHC
SAGEIQLVLLARCMVMKPDLIVLDEPVSCMDVEAKNNFYRLIGKLVSKYNISIIMTSHDL
CCCCEEHHHHHHHHHCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHCCEEEEEECCCC
HCVMACSDRVICINRSIRCEGTPEEITESAKFMSVFPENV
EEEEECCCCEEEECCEEECCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLVVDSITLFYGNRKVIDNVSFSIRPGEIITILGPNGGGKTSLVRVLVGINQDYIGTIHY
CEEEEEEEEEECCEEEECCCEEEECCCCEEEEECCCCCCHHHHHHHEECCCCCCEEEEEE
TKRPIIAYMPQNFKVNSFMPMTVEYLLLSACWGRGISLDLRAVIQYVDISKLLTRQISEL
CCCCEEEECCCCEEECCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHC
SAGEIQLVLLARCMVMKPDLIVLDEPVSCMDVEAKNNFYRLIGKLVSKYNISIIMTSHDL
CCCCEEHHHHHHHHHCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHCCEEEEEECCCC
HCVMACSDRVICINRSIRCEGTPEEITESAKFMSVFPENV
EEEEECCCCEEEECCEEECCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA