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The map label for this gene is ubiB [H]

Identifier: 88607065

GI number: 88607065

Start: 1042503

End: 1043954

Strand: Direct

Name: ubiB [H]

Synonym: APH_0984

Alternate gene names: 88607065

Gene position: 1042503-1043954 (Clockwise)

Preceding gene: 88607812

Following gene: 88606784

Centisome position: 70.86

GC content: 41.32

Gene sequence:

>1452_bases
ATGTTTAGTTCTATCAGCGGGCTAGCTAGACTATGCAAGATAGGGGCCACACTACTGCGATATGGAATTATTCCTAATGC
TGGCATATTTTCAAACAGAAAGCATAAAAAGAACTATGGAGAAAGAGTGCATTTATGCCTCCGCAGCCTGGGTCCTACGT
TTATAAAATTTGGACAATTTCTAGCTTCTAGAGCAGATATAGTGGGGGAAGAAGTCGCGGGAAACTTACTCACGTTGTGC
GACAAGCTCACACCATTCCCCTATAGCCAAGTAGTTTCTATAATAGAAAGCCAGTTTCACAAGAAAATGGATGAGATTTT
CTTGGAGTTTGATGAAGAACCAGTTGCTGCAGCGTCAATAGCTCAGGTGCATAGAGCACGGACATTGGACGGAGAGCTGA
AAGCTGTCAAAGTGCTTCGGCCGGGTATAGAAGCATCATTTCGCGCAGATATAGCTCTGATGCGTAAGATCGCAGATATT
TCAAGTGCTCTGGGTATACTCAGTAGATTCAAATTGCCTCAGCTAGTGGAGATGTTCTCAGATATCTGTAAGCTAGAGTT
GGATCTTCGCTTTGAAGCCGCAAGTGCTGATGAACTAAGGGAAAATTTACGGGCTGAGTCTTCAGACTTCTACGTACCCA
AAGTAGACTGGAAACACACAAGCAGAAGGGTGCTAACATTACAATGGGTAGAAGGAACCCCTATATACAGAGTAGATGAG
CTTCAGAACAAAGAATTGTTGGCTAAAAATCTGATAATAGCCTTCTGTAATCAAGTATACAGAGACGGATTTTTCCATGC
AGATATGCATCCTGGCAATCTCATGGTTGATGCAAACAGCAGAATAATTGTGGTAGATTTCGGGATTATGGGGAGGCTTG
ATGAAGAAACATGCTTCTATATAACTGAAATACTTGTGGGGTTTATCAATCGAGACTACCGCAGAGTAGCTGCCGCACAC
TTTGACGCAGGGTATGTTCCTGAAAGGTTTGATCAATTCGTTACAGCTTGCCGTTCAATATGGGAGCCTATAGCTGATGT
AGATGATACTAAGAATTTTTCTACAGCTTCTTTACTTGCACAGCTCTTCAAAATTACCGCAGATTTTGACATGTGCGTAC
AACCTAAGCTGTTATTATTACAGAAGTCTATGGTTCTGGTAGAAGGTATTTGTAGACAACTAGTTCCTGAAATGAACTTT
TGGAAAATTGCAGAACTGTGGGTCAAAGATCATTATGAGAATATAGGATATGTAGAAAGACTTAAGCAGTGCAAGGCATA
TAGATCGATGATGAATATTGGGTTACTCGTTTCTAAGATTGACAGAAGCCTCGATATAGTTATCTCACACGGGCAAGCAG
CGAATGCGCGCAAGAGTGGTGGCATTACCAAATCAACGTTTTGTTTAACTCTAGTTATCGCGTTTCTGACACTGATTATT
CTTTTTAAGTAA

Upstream 100 bases:

>100_bases
TGCTCAGATCGTGTAATCTGCATAAATCGCTCCATACGCTGTGAAGGAACTCCTGAGGAGATCACTGAGAGTGCAAAATT
TATGAGCGTATTTCCAGAGA

Downstream 100 bases:

>100_bases
TACTTTATGTATTAGTGTGTATCATACAAAATATCCCCTAATTATCTCACTAACAATTAGCACCCTAAGAGGCCGTACTC
CTAGCGCCTTTACAGAGCAC

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MFSSISGLARLCKIGATLLRYGIIPNAGIFSNRKHKKNYGERVHLCLRSLGPTFIKFGQFLASRADIVGEEVAGNLLTLC
DKLTPFPYSQVVSIIESQFHKKMDEIFLEFDEEPVAAASIAQVHRARTLDGELKAVKVLRPGIEASFRADIALMRKIADI
SSALGILSRFKLPQLVEMFSDICKLELDLRFEAASADELRENLRAESSDFYVPKVDWKHTSRRVLTLQWVEGTPIYRVDE
LQNKELLAKNLIIAFCNQVYRDGFFHADMHPGNLMVDANSRIIVVDFGIMGRLDEETCFYITEILVGFINRDYRRVAAAH
FDAGYVPERFDQFVTACRSIWEPIADVDDTKNFSTASLLAQLFKITADFDMCVQPKLLLLQKSMVLVEGICRQLVPEMNF
WKIAELWVKDHYENIGYVERLKQCKAYRSMMNIGLLVSKIDRSLDIVISHGQAANARKSGGITKSTFCLTLVIAFLTLII
LFK

Sequences:

>Translated_483_residues
MFSSISGLARLCKIGATLLRYGIIPNAGIFSNRKHKKNYGERVHLCLRSLGPTFIKFGQFLASRADIVGEEVAGNLLTLC
DKLTPFPYSQVVSIIESQFHKKMDEIFLEFDEEPVAAASIAQVHRARTLDGELKAVKVLRPGIEASFRADIALMRKIADI
SSALGILSRFKLPQLVEMFSDICKLELDLRFEAASADELRENLRAESSDFYVPKVDWKHTSRRVLTLQWVEGTPIYRVDE
LQNKELLAKNLIIAFCNQVYRDGFFHADMHPGNLMVDANSRIIVVDFGIMGRLDEETCFYITEILVGFINRDYRRVAAAH
FDAGYVPERFDQFVTACRSIWEPIADVDDTKNFSTASLLAQLFKITADFDMCVQPKLLLLQKSMVLVEGICRQLVPEMNF
WKIAELWVKDHYENIGYVERLKQCKAYRSMMNIGLLVSKIDRSLDIVISHGQAANARKSGGITKSTFCLTLVIAFLTLII
LFK
>Mature_483_residues
MFSSISGLARLCKIGATLLRYGIIPNAGIFSNRKHKKNYGERVHLCLRSLGPTFIKFGQFLASRADIVGEEVAGNLLTLC
DKLTPFPYSQVVSIIESQFHKKMDEIFLEFDEEPVAAASIAQVHRARTLDGELKAVKVLRPGIEASFRADIALMRKIADI
SSALGILSRFKLPQLVEMFSDICKLELDLRFEAASADELRENLRAESSDFYVPKVDWKHTSRRVLTLQWVEGTPIYRVDE
LQNKELLAKNLIIAFCNQVYRDGFFHADMHPGNLMVDANSRIIVVDFGIMGRLDEETCFYITEILVGFINRDYRRVAAAH
FDAGYVPERFDQFVTACRSIWEPIADVDDTKNFSTASLLAQLFKITADFDMCVQPKLLLLQKSMVLVEGICRQLVPEMNF
WKIAELWVKDHYENIGYVERLKQCKAYRSMMNIGLLVSKIDRSLDIVISHGQAANARKSGGITKSTFCLTLVIAFLTLII
LFK

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=364, Percent_Identity=27.4725274725275, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI41393593, Length=272, Percent_Identity=29.7794117647059, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI217035081, Length=341, Percent_Identity=27.5659824046921, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI27363457, Length=303, Percent_Identity=25.4125412541254, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI217416386, Length=303, Percent_Identity=25.4125412541254, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI34147522, Length=236, Percent_Identity=25.8474576271186, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI32261307, Length=335, Percent_Identity=22.089552238806, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI2367309, Length=435, Percent_Identity=36.551724137931, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17559152, Length=306, Percent_Identity=25.8169934640523, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32565180, Length=214, Percent_Identity=30.3738317757009, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325148, Length=433, Percent_Identity=22.8637413394919, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323282, Length=268, Percent_Identity=23.134328358209, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321319, Length=314, Percent_Identity=22.6114649681529, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24662575, Length=297, Percent_Identity=32.3232323232323, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI22024280, Length=383, Percent_Identity=24.8041775456919, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI18859849, Length=331, Percent_Identity=27.190332326284, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 54762; Mature: 54762

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSSISGLARLCKIGATLLRYGIIPNAGIFSNRKHKKNYGERVHLCLRSLGPTFIKFGQF
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHH
LASRADIVGEEVAGNLLTLCDKLTPFPYSQVVSIIESQFHKKMDEIFLEFDEEPVAAASI
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AQVHRARTLDGELKAVKVLRPGIEASFRADIALMRKIADISSALGILSRFKLPQLVEMFS
HHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DICKLELDLRFEAASADELRENLRAESSDFYVPKVDWKHTSRRVLTLQWVEGTPIYRVDE
HHHHEEHEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEHHH
LQNKELLAKNLIIAFCNQVYRDGFFHADMHPGNLMVDANSRIIVVDFGIMGRLDEETCFY
HCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCEEEEEECCCCCCCCCHHHHH
ITEILVGFINRDYRRVAAAHFDAGYVPERFDQFVTACRSIWEPIADVDDTKNFSTASLLA
HHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
QLFKITADFDMCVQPKLLLLQKSMVLVEGICRQLVPEMNFWKIAELWVKDHYENIGYVER
HHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHH
LKQCKAYRSMMNIGLLVSKIDRSLDIVISHGQAANARKSGGITKSTFCLTLVIAFLTLII
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHH
LFK
HCC
>Mature Secondary Structure
MFSSISGLARLCKIGATLLRYGIIPNAGIFSNRKHKKNYGERVHLCLRSLGPTFIKFGQF
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHH
LASRADIVGEEVAGNLLTLCDKLTPFPYSQVVSIIESQFHKKMDEIFLEFDEEPVAAASI
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AQVHRARTLDGELKAVKVLRPGIEASFRADIALMRKIADISSALGILSRFKLPQLVEMFS
HHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DICKLELDLRFEAASADELRENLRAESSDFYVPKVDWKHTSRRVLTLQWVEGTPIYRVDE
HHHHEEHEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEHHH
LQNKELLAKNLIIAFCNQVYRDGFFHADMHPGNLMVDANSRIIVVDFGIMGRLDEETCFY
HCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCEEEEEECCCCCCCCCHHHHH
ITEILVGFINRDYRRVAAAHFDAGYVPERFDQFVTACRSIWEPIADVDDTKNFSTASLLA
HHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
QLFKITADFDMCVQPKLLLLQKSMVLVEGICRQLVPEMNFWKIAELWVKDHYENIGYVER
HHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHH
LKQCKAYRSMMNIGLLVSKIDRSLDIVISHGQAANARKSGGITKSTFCLTLVIAFLTLII
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHH
LFK
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA