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The map label for this gene is ribA [H]

Identifier: 88607347

GI number: 88607347

Start: 1381745

End: 1382836

Strand: Reverse

Name: ribA [H]

Synonym: APH_1314

Alternate gene names: 88607347

Gene position: 1382836-1381745 (Counterclockwise)

Preceding gene: 88607743

Following gene: 88607844

Centisome position: 93.99

GC content: 41.94

Gene sequence:

>1092_bases
ATGTTTGGCCCAATTGGCAATTTTTTTGGTTTGGGGAACAATTTATTGAGTCGAGCTGTAAATGAAATACGGCGTTGTGC
TCCAGTTATTCTCCACGAAGATGATAAATATTTGTTGGTTTTCGCTAGCGAGTTATTAGAGGAGCCATCTCTTGCCGTGT
TCAAGTCTTTTTCAGACAATGTATATATCCTCCTCACGGCACAGCGAGCATCGTATGTAACAACGAACGATAAGTTATCA
CGAGTAGGAGCTAACACCCTGTCACTCGCAGATATAAGAACTCTTATGAGTGGTTTACCAGAAGAGACACGTAGTGTACC
TGTCGAAGAGAGCTTGAGTCCACTAGATAGTCTAGCAATAGACCTAGTAAAGATGGCAAAATTGCTACCATCAGCGCTAG
TGATAGATATGGGATTTGGGAACATAGAAGAGATGTACGATTGGTGCAAATGTAATGGAATATTGCATTTAGCCGGAAAG
GCGCTAACAGACTACACACAGGAGTACGTCTTACAAGAAGTGTGTCGATCTGATCTATATCTCCAGGATTCACTTAAATC
AAAGATCATAGTGTATCGGTCTAAAATTGGTGAGCCAGAACATTACGCAATAGTTATAGGTGAGCCAGCAATTGAAAACA
TTGTAGTGAGGCTGCACTCTTCGTGTTACACAGGAGACCTATTGGGGAGTCTATCGTGTGACTGTCGCAGTCAGTTACTC
ACAGCAGTAAAGCTTTTGGCTGAACAGGCTGGGGGTATCATTCTTTACATTTCTCAAGAAGGTCGCGGAATTGGTCTTGC
TAACAAAATCAGGGCATACAGTTTGCAGATGCAGAATTCCCTAGATACAGTGGATGCTAACAGGTTTCTAGGATTTGATG
ACGATGAACGCATATTCTTACCTGCAGCCATGATTTTAAGGAACCTGGGAGTATCGAGTCTCCAGTTGCTAACCAATAAT
CCTCACAAAGTGCAGGAGATAGGTAAGTATGGATTTGATGTGACGAAAACTATCCCTTTTCACATGGAGATCAACGAATA
TAACGGAAATTATATTAAAACCAAGCAGACCCGTTTGGGGCATACAAACTAG

Upstream 100 bases:

>100_bases
TTATGGTGGAAATGGTAGACACGCAGCGTTGAGGTCGCTGTGGCTATATCAGCCTTGGAAGTTCAAGTCTTCTTAACCGC
ACCATTTCATGAGTCTCAAA

Downstream 100 bases:

>100_bases
GATCGACGGCGGATCTCCATAATGCCTTATGTACAAGATGATGATGGCTCAAGGCAGGCTGAATTCCATGTAGCGCCGAC
AAGACCTAGATTGTCGATGG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MFGPIGNFFGLGNNLLSRAVNEIRRCAPVILHEDDKYLLVFASELLEEPSLAVFKSFSDNVYILLTAQRASYVTTNDKLS
RVGANTLSLADIRTLMSGLPEETRSVPVEESLSPLDSLAIDLVKMAKLLPSALVIDMGFGNIEEMYDWCKCNGILHLAGK
ALTDYTQEYVLQEVCRSDLYLQDSLKSKIIVYRSKIGEPEHYAIVIGEPAIENIVVRLHSSCYTGDLLGSLSCDCRSQLL
TAVKLLAEQAGGIILYISQEGRGIGLANKIRAYSLQMQNSLDTVDANRFLGFDDDERIFLPAAMILRNLGVSSLQLLTNN
PHKVQEIGKYGFDVTKTIPFHMEINEYNGNYIKTKQTRLGHTN

Sequences:

>Translated_363_residues
MFGPIGNFFGLGNNLLSRAVNEIRRCAPVILHEDDKYLLVFASELLEEPSLAVFKSFSDNVYILLTAQRASYVTTNDKLS
RVGANTLSLADIRTLMSGLPEETRSVPVEESLSPLDSLAIDLVKMAKLLPSALVIDMGFGNIEEMYDWCKCNGILHLAGK
ALTDYTQEYVLQEVCRSDLYLQDSLKSKIIVYRSKIGEPEHYAIVIGEPAIENIVVRLHSSCYTGDLLGSLSCDCRSQLL
TAVKLLAEQAGGIILYISQEGRGIGLANKIRAYSLQMQNSLDTVDANRFLGFDDDERIFLPAAMILRNLGVSSLQLLTNN
PHKVQEIGKYGFDVTKTIPFHMEINEYNGNYIKTKQTRLGHTN
>Mature_363_residues
MFGPIGNFFGLGNNLLSRAVNEIRRCAPVILHEDDKYLLVFASELLEEPSLAVFKSFSDNVYILLTAQRASYVTTNDKLS
RVGANTLSLADIRTLMSGLPEETRSVPVEESLSPLDSLAIDLVKMAKLLPSALVIDMGFGNIEEMYDWCKCNGILHLAGK
ALTDYTQEYVLQEVCRSDLYLQDSLKSKIIVYRSKIGEPEHYAIVIGEPAIENIVVRLHSSCYTGDLLGSLSCDCRSQLL
TAVKLLAEQAGGIILYISQEGRGIGLANKIRAYSLQMQNSLDTVDANRFLGFDDDERIFLPAAMILRNLGVSSLQLLTNN
PHKVQEIGKYGFDVTKTIPFHMEINEYNGNYIKTKQTRLGHTN

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=163, Percent_Identity=46.0122699386503, Blast_Score=137, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6319438, Length=174, Percent_Identity=36.2068965517241, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 40353; Mature: 40353

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGPIGNFFGLGNNLLSRAVNEIRRCAPVILHEDDKYLLVFASELLEEPSLAVFKSFSDN
CCCCCCHHHHCCHHHHHHHHHHHHHHCCEEEECCCCEEEEEEHHHHCCCCHHHHHCCCCC
VYILLTAQRASYVTTNDKLSRVGANTLSLADIRTLMSGLPEETRSVPVEESLSPLDSLAI
EEEEEEECCCCEEECCCHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHCCHHHHHHH
DLVKMAKLLPSALVIDMGFGNIEEMYDWCKCNGILHLAGKALTDYTQEYVLQEVCRSDLY
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCE
LQDSLKSKIIVYRSKIGEPEHYAIVIGEPAIENIVVRLHSSCYTGDLLGSLSCDCRSQLL
EHHHHHCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHH
TAVKLLAEQAGGIILYISQEGRGIGLANKIRAYSLQMQNSLDTVDANRFLGFDDDERIFL
HHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHEEHHHCCCCCCCCCCCCCCCCCCCEEH
PAAMILRNLGVSSLQLLTNNPHKVQEIGKYGFDVTKTIPFHMEINEYNGNYIKTKQTRLG
HHHHHHHHCCHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEEEEEECCCCCEEEEECCCCC
HTN
CCC
>Mature Secondary Structure
MFGPIGNFFGLGNNLLSRAVNEIRRCAPVILHEDDKYLLVFASELLEEPSLAVFKSFSDN
CCCCCCHHHHCCHHHHHHHHHHHHHHCCEEEECCCCEEEEEEHHHHCCCCHHHHHCCCCC
VYILLTAQRASYVTTNDKLSRVGANTLSLADIRTLMSGLPEETRSVPVEESLSPLDSLAI
EEEEEEECCCCEEECCCHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHCCHHHHHHH
DLVKMAKLLPSALVIDMGFGNIEEMYDWCKCNGILHLAGKALTDYTQEYVLQEVCRSDLY
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCE
LQDSLKSKIIVYRSKIGEPEHYAIVIGEPAIENIVVRLHSSCYTGDLLGSLSCDCRSQLL
EHHHHHCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHH
TAVKLLAEQAGGIILYISQEGRGIGLANKIRAYSLQMQNSLDTVDANRFLGFDDDERIFL
HHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHEEHHHCCCCCCCCCCCCCCCCCCCEEH
PAAMILRNLGVSSLQLLTNNPHKVQEIGKYGFDVTKTIPFHMEINEYNGNYIKTKQTRLG
HHHHHHHHCCHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEEEEEECCCCCEEEEECCCCC
HTN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7883178 [H]