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The map label for this gene is polA [H]

Identifier: 88607131

GI number: 88607131

Start: 1159453

End: 1160067

Strand: Reverse

Name: polA [H]

Synonym: APH_1098

Alternate gene names: 88607131

Gene position: 1160067-1159453 (Counterclockwise)

Preceding gene: 88607685

Following gene: 88607712

Centisome position: 78.85

GC content: 46.18

Gene sequence:

>615_bases
ATGGCTGTATTCGTGCATCGCAATGATTTGCCACATGACGTGGATCTAGGCGATATGGTTGCTGTAGATACGGAAACCAT
GGGTTTGGTTTGTCGGCGGGATAGGGTATGTTTAGTGCAGCTATCAGCGGGTAACGGCGATGCGCATCTTGTAAAGTTTG
ATGGTGATTATAGTGCTCCTAATCTCAGGAAAGTGATATCGGATCCCGGTGTTCTGAAGATTTTTCACTTTGCGAGGTTT
GACGTTGCTGCGATTAGGCATGGTTTTGGGATGTGGGCAACGCCTTGTTACTGCACCAAGATAGCGTCGAGGTTAGTTAG
GACTTATACCAACCATCACGGTCTTAAGGATTTATGCTATGAGCTTCTTGGGGTCAAAATTAATAAGGCTCAGCAGTCAT
CTGATTGGGGCAGGGAGGTTTTGACCGCAGAGCAACTGAGTTACGCAGCGGCAGATGTCATTTACTTACATGCGATCAAA
AAGAAGTTGGACATGATGCTAGAGCGTGAGGAGAAGCAGGAGTTGGCAGAAGCGTGTTTTAAATTTGTTCCTGTTCGTGC
GGAATTGGATCTGTTAGGCTGGGATGGTGTAGATATATTCAGTCATCAGACATAG

Upstream 100 bases:

>100_bases
GAGCAAAATCGGGATTATGCGGAAGAAGCCTAGTTTTGTGGATTGTTTTTTTCAGGGTGTGTGATAGAGTTGAGCCCTGT
AGGTAGGAACGGGGTTTTGC

Downstream 100 bases:

>100_bases
GGCTGTTCGGTGGTATCAGTGGGTGTATTACGCCTTCTGTTGTGCTTGTCGTATTGACATTATTCTGGATTATGTTTAGA
ATGCGCAACTTTGGGAAGTA

Product: 3''-5'' exonuclease family protein

Products: NA

Alternate protein names: POL I [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MAVFVHRNDLPHDVDLGDMVAVDTETMGLVCRRDRVCLVQLSAGNGDAHLVKFDGDYSAPNLRKVISDPGVLKIFHFARF
DVAAIRHGFGMWATPCYCTKIASRLVRTYTNHHGLKDLCYELLGVKINKAQQSSDWGREVLTAEQLSYAAADVIYLHAIK
KKLDMMLEREEKQELAEACFKFVPVRAELDLLGWDGVDIFSHQT

Sequences:

>Translated_204_residues
MAVFVHRNDLPHDVDLGDMVAVDTETMGLVCRRDRVCLVQLSAGNGDAHLVKFDGDYSAPNLRKVISDPGVLKIFHFARF
DVAAIRHGFGMWATPCYCTKIASRLVRTYTNHHGLKDLCYELLGVKINKAQQSSDWGREVLTAEQLSYAAADVIYLHAIK
KKLDMMLEREEKQELAEACFKFVPVRAELDLLGWDGVDIFSHQT
>Mature_203_residues
AVFVHRNDLPHDVDLGDMVAVDTETMGLVCRRDRVCLVQLSAGNGDAHLVKFDGDYSAPNLRKVISDPGVLKIFHFARFD
VAAIRHGFGMWATPCYCTKIASRLVRTYTNHHGLKDLCYELLGVKINKAQQSSDWGREVLTAEQLSYAAADVIYLHAIKK
KLDMMLEREEKQELAEACFKFVPVRAELDLLGWDGVDIFSHQT

Specific function: Cleaves Multimeric tRNA Precursor At The Spacer Region. [C]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 3'-5' exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR019760
- InterPro:   IPR001098
- InterPro:   IPR002298
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00476 DNA_pol_A [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 22997; Mature: 22866

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVFVHRNDLPHDVDLGDMVAVDTETMGLVCRRDRVCLVQLSAGNGDAHLVKFDGDYSAP
CEEEEECCCCCCCCCCCCEEEECCHHHHHEECCCCEEEEEEECCCCCEEEEEECCCCCCC
NLRKVISDPGVLKIFHFARFDVAAIRHGFGMWATPCYCTKIASRLVRTYTNHHGLKDLCY
HHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
ELLGVKINKAQQSSDWGREVLTAEQLSYAAADVIYLHAIKKKLDMMLEREEKQELAEACF
HHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFVPVRAELDLLGWDGVDIFSHQT
HHCCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
AVFVHRNDLPHDVDLGDMVAVDTETMGLVCRRDRVCLVQLSAGNGDAHLVKFDGDYSAP
EEEEECCCCCCCCCCCCEEEECCHHHHHEECCCCEEEEEEECCCCCEEEEEECCCCCCC
NLRKVISDPGVLKIFHFARFDVAAIRHGFGMWATPCYCTKIASRLVRTYTNHHGLKDLCY
HHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
ELLGVKINKAQQSSDWGREVLTAEQLSYAAADVIYLHAIKKKLDMMLEREEKQELAEACF
HHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFVPVRAELDLLGWDGVDIFSHQT
HHCCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]