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The map label for this gene is cysG [H]

Identifier: 87200977

GI number: 87200977

Start: 3181951

End: 3182730

Strand: Reverse

Name: cysG [H]

Synonym: Saro_2965

Alternate gene names: 87200977

Gene position: 3182730-3181951 (Counterclockwise)

Preceding gene: 87200978

Following gene: 87200971

Centisome position: 89.36

GC content: 70.9

Gene sequence:

>780_bases
ATGAACGACTTTCCGGCGGGAATGGTCTGGCTGGTCGGTGCGGGACCCGGCGATCCCGAACTGCTGACGCGCAAGGCCGA
ACGGCTGATCGGCAGAGCCAGCGTCGTGTTCTTCGATGCTCTTGTCGGCCGCGAGGTGCTCGACCTGGCCAGCCCGGGCG
CGCGGCTCGTCGACGTGGGAAAGCGCTCCGGCCGCCACTCGAAGGACCAGCGCACGATCGATGCCCTGATCGTCGAGGCC
GCGCTCTCCGGGGAACGGGTGGTGCGCCTGAAGGGCGGCGATCCGTCGATCTTCGGCCGCGCAACCGAGGAACTGGAAGC
GTGCCGATCCGCGGGCGTGGTGGTTGCCGTCTGTCCGGGCGTGACGGCGGCCAGCGCGGCAGCTGCCGGGCTCTCGCGCT
CGCTCACCCTGCGCGGACTGGCGCGCAAGCTGGTCTTCGTTACCGCCCATGCGCGCGCGGGCGATACGCTGGACCTTGAC
TGGGCAGCGCTGGCGGACCCGGGTGCGACGCTGGCGATCTACATGGGCAAGTCAGCAGCCGGCGCGATCGCTCGGGGGTT
GCAGGGGACGGGCATGGCGGGCGAAACGCCGGTGGCGCTGGTCGAGAATGCCAGCCTTCCCGACGAACGCCGGATCGTGA
CGCGACTGGACCTGCTGGAGCTTGCCGCGCGGACGCTGGGCGACGGGCCGGCGCTGCTCCTGATCGGGGAAGCAATGCGT
ACGCCCGGTCGCCGTGCCGTGGCTGCGGCCGCGCAAGCCATGGAAAGGGAGACGCCGTGA

Upstream 100 bases:

>100_bases
TCGCGGGATGCACCCGCGCCGGATCGAATTGCGGAAGCTGCCGCCCGGCCATCGCCCGGATGCTCGACGAGATGAACCTG
GATACACAGGAGGCTGCGGA

Downstream 100 bases:

>100_bases
TGGCCCTGATGCGCAAGTTGCTGGCCTTGTTCGGCGCGTCGAACTGCGATCTTTGCGGGCAGGTGTGGACTGCCGACACA
AGGTCCGCCGGAAAGTGTCC

Product: uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNDFPAGMVWLVGAGPGDPELLTRKAERLIGRASVVFFDALVGREVLDLASPGARLVDVGKRSGRHSKDQRTIDALIVEA
ALSGERVVRLKGGDPSIFGRATEELEACRSAGVVVAVCPGVTAASAAAAGLSRSLTLRGLARKLVFVTAHARAGDTLDLD
WAALADPGATLAIYMGKSAAGAIARGLQGTGMAGETPVALVENASLPDERRIVTRLDLLELAARTLGDGPALLLIGEAMR
TPGRRAVAAAAQAMERETP

Sequences:

>Translated_259_residues
MNDFPAGMVWLVGAGPGDPELLTRKAERLIGRASVVFFDALVGREVLDLASPGARLVDVGKRSGRHSKDQRTIDALIVEA
ALSGERVVRLKGGDPSIFGRATEELEACRSAGVVVAVCPGVTAASAAAAGLSRSLTLRGLARKLVFVTAHARAGDTLDLD
WAALADPGATLAIYMGKSAAGAIARGLQGTGMAGETPVALVENASLPDERRIVTRLDLLELAARTLGDGPALLLIGEAMR
TPGRRAVAAAAQAMERETP
>Mature_259_residues
MNDFPAGMVWLVGAGPGDPELLTRKAERLIGRASVVFFDALVGREVLDLASPGARLVDVGKRSGRHSKDQRTIDALIVEA
ALSGERVVRLKGGDPSIFGRATEELEACRSAGVVVAVCPGVTAASAAAAGLSRSLTLRGLARKLVFVTAHARAGDTLDLD
WAALADPGATLAIYMGKSAAGAIARGLQGTGMAGETPVALVENASLPDERRIVTRLDLLELAARTLGDGPALLLIGEAMR
TPGRRAVAAAAQAMERETP

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=231, Percent_Identity=44.5887445887446, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322922, Length=235, Percent_Identity=31.063829787234, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 26764; Mature: 26764

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDFPAGMVWLVGAGPGDPELLTRKAERLIGRASVVFFDALVGREVLDLASPGARLVDVG
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
KRSGRHSKDQRTIDALIVEAALSGERVVRLKGGDPSIFGRATEELEACRSAGVVVAVCPG
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCEEEEECCC
VTAASAAAAGLSRSLTLRGLARKLVFVTAHARAGDTLDLDWAALADPGATLAIYMGKSAA
CHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHCCCCCEEEEEECCCHH
GAIARGLQGTGMAGETPVALVENASLPDERRIVTRLDLLELAARTLGDGPALLLIGEAMR
HHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHC
TPGRRAVAAAAQAMERETP
CCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNDFPAGMVWLVGAGPGDPELLTRKAERLIGRASVVFFDALVGREVLDLASPGARLVDVG
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
KRSGRHSKDQRTIDALIVEAALSGERVVRLKGGDPSIFGRATEELEACRSAGVVVAVCPG
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCEEEEECCC
VTAASAAAAGLSRSLTLRGLARKLVFVTAHARAGDTLDLDWAALADPGATLAIYMGKSAA
CHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHCCCCCEEEEEECCCHH
GAIARGLQGTGMAGETPVALVENASLPDERRIVTRLDLLELAARTLGDGPALLLIGEAMR
HHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHC
TPGRRAVAAAAQAMERETP
CCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA