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The map label for this gene is parC [H]

Identifier: 87200806

GI number: 87200806

Start: 3015091

End: 3017376

Strand: Reverse

Name: parC [H]

Synonym: Saro_2793

Alternate gene names: 87200806

Gene position: 3017376-3015091 (Counterclockwise)

Preceding gene: 87200807

Following gene: 87200805

Centisome position: 84.72

GC content: 65.35

Gene sequence:

>2286_bases
ATGGCGACCGATACGACAGAACCCGATCCGTTCGACGCAATCGTCGATGCTCCGTTCGATTCCGCGCTGTCGGAACGCTA
CCTCGTCTATGCGCTGTCGACGATCACCGCGCGCTCGCTGCCCGACCTGCGCGACGGTCTGAAGCCGGTGCACCGCCGCC
TGCTGTGGGCGATGCGGCAACTGAAGCTGGATCCGGCGCAGGCGTTCAAGAAATCGGCCCGCGTGGTCGGCGACGTCATC
GGCAAGTATCACCCCCATGGCGATGCCAGCGTCTATGACGCGATGGTCCGCCTCGCGCAGGACTGGGCGCTGCGCTATCC
GCTGGTCGAGGGGCAGGGCAACTTCGGCAACATCGACGGCGATAACGCCGCGGCCTATCGCTATACCGAAGCCAGGCTGA
CGAAGACGGCGATCCAGCTCATGTCCGGGCTGGACGAGGGCACCGTCGACTTCGTGCCCACCTACAACGGCGAGGAGGAA
GAGCCGGAAATCTTTCCGGGCCTGTTCCCGAACCTGCTGGCCAATGGATCGAGCGGCATCGCGGTGGGCATGGCCACCAA
CATCCCGAGCCACAACGTGGCCGAGATCATCGATGCGACGCTGCTGCTGATCGACAATCCGCATGCCGAGCACGCCCAGT
TGATGGAAGTGTTCCACGGGCCCGACCTGCCGACGGGCGGCGTCATCGTCGACAGTCCGGCGGTGATTTCCAACGCCTAT
GAAACCGGACGCGGCGCGATCCGGGTGCGCGGGCGCTTTTCGACGGGCCGCGACGAGGCTGGCAACTGGGAAGAGAGCGG
CATCGAGAAGCTGGGCGGCGGGCAGTGGCAGCTCGTGGTCTCGGAAATCCCCTACATGGTGCAGAAGGGCAAGCTGATCG
AGCAGATTGCCCAGCTCATCGCCGACAAGAAGCTGCCGATCCTCGAGGACATCCGCGACGAGAGCGACGAGCAGATCCGG
CTGGTGCTGATCCCCAAGAGCCGAAATGTCGACCCCGACCTGCTCAAGGAATCGCTCTACCGACTGACCGACCTTGAAAC
GCGGTTCGGGCTCAACCTCAACGTGCTGGATTCGCGGCGGACGCCCGGCGTGCTGGGGCTGAAGCTGGTATTGCAGGAGT
GGGTGATCTCGCAGATCGACATCCTGCTGCGGCGTTCGCGCCATCGGCTGGACAAGATCGCCTCGCGGCTCGAGCTGCTC
GAAGGCTATATCATTGCCTATCTCAACCTCGACCGGATCATCGAGATCATCCGCACCGAGGACGAGCCCAAGCCGGTGAT
GATGGCCGAGTTCGAGCTGACCGACCGCCAGGCCGAGGCGATCCTCAACATGCGGCTGCGATCCCTGCGCAAGCTCGAGG
AAATGGAGCTGCGCAAGGAACGCGATGCCCTGCTGGCAGAGCAAGAGGAGCTGCAGAAGCTGCTCGACAGTCCGGCGCGC
CAGCGCACCCGGCTGAAGCGCGACCTGGCGGCGCTGCGCAAGGACTATGCCGAGGACACCGCGCTGGGACGGCGGCGCAC
GACGATTGCCGAAGCCGCGCCGACGCGCGAGTTCAGCATGGACGCGATGATCGAGAAGGAGCCGGTGACGGTGATCCTTT
CGGCCAAGGGCTGGATCAGGGCGGCCAAGGGGCATGTGCCGCTCGATGGCGATTTCAAGTTCAAGGAAGGCGATGGCCCG
GCCTTCGCACTTCACTGCCAGACCACGGACAAGCTGCTGGTGGCGGTGGACAACGGGCGGTTCTACACGCTGGGGGCCGA
CAAGCTGCCGGGCGCGCGGGGCTTTGGCGAGCCTATCAGGACGATGGTGGACATCGATCCGGATGCGCAGATCGTTTCGG
TCCTGCCCTACAAGCCCAAGGGGCAACTGCTGCTCGCGGCGAACACCGGGCGCGGCTTTGCCGCCGAGATGGACGAACTG
CTGGCCGAGACGCGAAAGGGGCGCGGGGTGGTTTCAACCAAGCCGGGCGTCAAGCTTGCCGTGGTGCGCGAGATCGCGCC
CGAGCACGATCACGTCGCGGTGATCGGCGAGAACCGCAAGCTGGTGATCTTCGCGCTTTCGGAAGTGCCGCTGCTCGCCA
AGGGGCAGGGCGTCACGCTGCAGCGCTACAAGGACGGCGAGATGTCGGACGTGATCACGCTGCGGCTCGAAGATGGGCTT
ACCTGGGCGATGGGCGGCGAGAGCGGACGGACGCGGGTGGAGAAGGATCTGCTGCCGTGGAAGGTTGCGCGCGGCGCCGC
GGGGCGCCTGCCGCCGAACGGGTTTCCGCGAGATAACCGGTTCTGA

Upstream 100 bases:

>100_bases
CGACAATCCCCGGAAAATCCGCCCGCCCTCCGCAATTGCGGGGGATCGCGCGGCTCTGCGACTTTCGCTCCGCCGGGCGT
GTTGCTAAGCCGTTCCGACC

Downstream 100 bases:

>100_bases
GAAGGTAGTGGGACCAGGGGTTTGCCAGCCAGAACTGTCGGGTCTGGCGTTGTAGCTGACCGGCAAGCGCGTGCGCGTTG
ATGCTTGCGTCGTTTAATGG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 761; Mature: 760

Protein sequence:

>761_residues
MATDTTEPDPFDAIVDAPFDSALSERYLVYALSTITARSLPDLRDGLKPVHRRLLWAMRQLKLDPAQAFKKSARVVGDVI
GKYHPHGDASVYDAMVRLAQDWALRYPLVEGQGNFGNIDGDNAAAYRYTEARLTKTAIQLMSGLDEGTVDFVPTYNGEEE
EPEIFPGLFPNLLANGSSGIAVGMATNIPSHNVAEIIDATLLLIDNPHAEHAQLMEVFHGPDLPTGGVIVDSPAVISNAY
ETGRGAIRVRGRFSTGRDEAGNWEESGIEKLGGGQWQLVVSEIPYMVQKGKLIEQIAQLIADKKLPILEDIRDESDEQIR
LVLIPKSRNVDPDLLKESLYRLTDLETRFGLNLNVLDSRRTPGVLGLKLVLQEWVISQIDILLRRSRHRLDKIASRLELL
EGYIIAYLNLDRIIEIIRTEDEPKPVMMAEFELTDRQAEAILNMRLRSLRKLEEMELRKERDALLAEQEELQKLLDSPAR
QRTRLKRDLAALRKDYAEDTALGRRRTTIAEAAPTREFSMDAMIEKEPVTVILSAKGWIRAAKGHVPLDGDFKFKEGDGP
AFALHCQTTDKLLVAVDNGRFYTLGADKLPGARGFGEPIRTMVDIDPDAQIVSVLPYKPKGQLLLAANTGRGFAAEMDEL
LAETRKGRGVVSTKPGVKLAVVREIAPEHDHVAVIGENRKLVIFALSEVPLLAKGQGVTLQRYKDGEMSDVITLRLEDGL
TWAMGGESGRTRVEKDLLPWKVARGAAGRLPPNGFPRDNRF

Sequences:

>Translated_761_residues
MATDTTEPDPFDAIVDAPFDSALSERYLVYALSTITARSLPDLRDGLKPVHRRLLWAMRQLKLDPAQAFKKSARVVGDVI
GKYHPHGDASVYDAMVRLAQDWALRYPLVEGQGNFGNIDGDNAAAYRYTEARLTKTAIQLMSGLDEGTVDFVPTYNGEEE
EPEIFPGLFPNLLANGSSGIAVGMATNIPSHNVAEIIDATLLLIDNPHAEHAQLMEVFHGPDLPTGGVIVDSPAVISNAY
ETGRGAIRVRGRFSTGRDEAGNWEESGIEKLGGGQWQLVVSEIPYMVQKGKLIEQIAQLIADKKLPILEDIRDESDEQIR
LVLIPKSRNVDPDLLKESLYRLTDLETRFGLNLNVLDSRRTPGVLGLKLVLQEWVISQIDILLRRSRHRLDKIASRLELL
EGYIIAYLNLDRIIEIIRTEDEPKPVMMAEFELTDRQAEAILNMRLRSLRKLEEMELRKERDALLAEQEELQKLLDSPAR
QRTRLKRDLAALRKDYAEDTALGRRRTTIAEAAPTREFSMDAMIEKEPVTVILSAKGWIRAAKGHVPLDGDFKFKEGDGP
AFALHCQTTDKLLVAVDNGRFYTLGADKLPGARGFGEPIRTMVDIDPDAQIVSVLPYKPKGQLLLAANTGRGFAAEMDEL
LAETRKGRGVVSTKPGVKLAVVREIAPEHDHVAVIGENRKLVIFALSEVPLLAKGQGVTLQRYKDGEMSDVITLRLEDGL
TWAMGGESGRTRVEKDLLPWKVARGAAGRLPPNGFPRDNRF
>Mature_760_residues
ATDTTEPDPFDAIVDAPFDSALSERYLVYALSTITARSLPDLRDGLKPVHRRLLWAMRQLKLDPAQAFKKSARVVGDVIG
KYHPHGDASVYDAMVRLAQDWALRYPLVEGQGNFGNIDGDNAAAYRYTEARLTKTAIQLMSGLDEGTVDFVPTYNGEEEE
PEIFPGLFPNLLANGSSGIAVGMATNIPSHNVAEIIDATLLLIDNPHAEHAQLMEVFHGPDLPTGGVIVDSPAVISNAYE
TGRGAIRVRGRFSTGRDEAGNWEESGIEKLGGGQWQLVVSEIPYMVQKGKLIEQIAQLIADKKLPILEDIRDESDEQIRL
VLIPKSRNVDPDLLKESLYRLTDLETRFGLNLNVLDSRRTPGVLGLKLVLQEWVISQIDILLRRSRHRLDKIASRLELLE
GYIIAYLNLDRIIEIIRTEDEPKPVMMAEFELTDRQAEAILNMRLRSLRKLEEMELRKERDALLAEQEELQKLLDSPARQ
RTRLKRDLAALRKDYAEDTALGRRRTTIAEAAPTREFSMDAMIEKEPVTVILSAKGWIRAAKGHVPLDGDFKFKEGDGPA
FALHCQTTDKLLVAVDNGRFYTLGADKLPGARGFGEPIRTMVDIDPDAQIVSVLPYKPKGQLLLAANTGRGFAAEMDELL
AETRKGRGVVSTKPGVKLAVVREIAPEHDHVAVIGENRKLVIFALSEVPLLAKGQGVTLQRYKDGEMSDVITLRLEDGLT
WAMGGESGRTRVEKDLLPWKVARGAAGRLPPNGFPRDNRF

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=184, Percent_Identity=30.4347826086957, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI19913408, Length=189, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789396, Length=697, Percent_Identity=39.8852223816356, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI1788562, Length=776, Percent_Identity=35.9536082474227, Blast_Score=402, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17535065, Length=206, Percent_Identity=31.5533980582524, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=189, Percent_Identity=31.2169312169312, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=281, Percent_Identity=27.4021352313167, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=216, Percent_Identity=27.3148148148148, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17136538, Length=184, Percent_Identity=29.8913043478261, Blast_Score=67, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.3

Molecular weight: Translated: 84565; Mature: 84434

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDTTEPDPFDAIVDAPFDSALSERYLVYALSTITARSLPDLRDGLKPVHRRLLWAMRQ
CCCCCCCCCCCHHHHCCCCHHHHHHHEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LKLDPAQAFKKSARVVGDVIGKYHPHGDASVYDAMVRLAQDWALRYPLVEGQGNFGNIDG
HCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCC
DNAAAYRYTEARLTKTAIQLMSGLDEGTVDFVPTYNGEEEEPEIFPGLFPNLLANGSSGI
CCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCE
AVGMATNIPSHNVAEIIDATLLLIDNPHAEHAQLMEVFHGPDLPTGGVIVDSPAVISNAY
EEEEECCCCCCHHHHHHCEEEEEEECCCHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHH
ETGRGAIRVRGRFSTGRDEAGNWEESGIEKLGGGQWQLVVSEIPYMVQKGKLIEQIAQLI
HCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEHHHCCHHHHCCHHHHHHHHHH
ADKKLPILEDIRDESDEQIRLVLIPKSRNVDPDLLKESLYRLTDLETRFGLNLNVLDSRR
CCCCCCHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHCCEEEEECCCC
TPGVLGLKLVLQEWVISQIDILLRRSRHRLDKIASRLELLEGYIIAYLNLDRIIEIIRTE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHCC
DEPKPVMMAEFELTDRQAEAILNMRLRSLRKLEEMELRKERDALLAEQEELQKLLDSPAR
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
QRTRLKRDLAALRKDYAEDTALGRRRTTIAEAAPTREFSMDAMIEKEPVTVILSAKGWIR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCCEE
AAKGHVPLDGDFKFKEGDGPAFALHCQTTDKLLVAVDNGRFYTLGADKLPGARGFGEPIR
ECCCCCCCCCCEEEECCCCCEEEEEECCCCEEEEEEECCEEEEECCCCCCCCCCCCCHHH
TMVDIDPDAQIVSVLPYKPKGQLLLAANTGRGFAAEMDELLAETRKGRGVVSTKPGVKLA
HEEECCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCEEE
VVREIAPEHDHVAVIGENRKLVIFALSEVPLLAKGQGVTLQRYKDGEMSDVITLRLEDGL
EEHHHCCCCCCEEEEECCCEEEEEEECCCCEEECCCCCEEEEECCCCCCCEEEEEEECCE
TWAMGGESGRTRVEKDLLPWKVARGAAGRLPPNGFPRDNRF
EEEECCCCCCCHHHHHCCCHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATDTTEPDPFDAIVDAPFDSALSERYLVYALSTITARSLPDLRDGLKPVHRRLLWAMRQ
CCCCCCCCCCHHHHCCCCHHHHHHHEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LKLDPAQAFKKSARVVGDVIGKYHPHGDASVYDAMVRLAQDWALRYPLVEGQGNFGNIDG
HCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCC
DNAAAYRYTEARLTKTAIQLMSGLDEGTVDFVPTYNGEEEEPEIFPGLFPNLLANGSSGI
CCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCE
AVGMATNIPSHNVAEIIDATLLLIDNPHAEHAQLMEVFHGPDLPTGGVIVDSPAVISNAY
EEEEECCCCCCHHHHHHCEEEEEEECCCHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHH
ETGRGAIRVRGRFSTGRDEAGNWEESGIEKLGGGQWQLVVSEIPYMVQKGKLIEQIAQLI
HCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEHHHCCHHHHCCHHHHHHHHHH
ADKKLPILEDIRDESDEQIRLVLIPKSRNVDPDLLKESLYRLTDLETRFGLNLNVLDSRR
CCCCCCHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHCCEEEEECCCC
TPGVLGLKLVLQEWVISQIDILLRRSRHRLDKIASRLELLEGYIIAYLNLDRIIEIIRTE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHCC
DEPKPVMMAEFELTDRQAEAILNMRLRSLRKLEEMELRKERDALLAEQEELQKLLDSPAR
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
QRTRLKRDLAALRKDYAEDTALGRRRTTIAEAAPTREFSMDAMIEKEPVTVILSAKGWIR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCCEE
AAKGHVPLDGDFKFKEGDGPAFALHCQTTDKLLVAVDNGRFYTLGADKLPGARGFGEPIR
ECCCCCCCCCCEEEECCCCCEEEEEECCCCEEEEEEECCEEEEECCCCCCCCCCCCCHHH
TMVDIDPDAQIVSVLPYKPKGQLLLAANTGRGFAAEMDELLAETRKGRGVVSTKPGVKLA
HEEECCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCEEE
VVREIAPEHDHVAVIGENRKLVIFALSEVPLLAKGQGVTLQRYKDGEMSDVITLRLEDGL
EEHHHCCCCCCEEEEECCCEEEEEEECCCCEEECCCCCEEEEECCCCCCCEEEEEEECCE
TWAMGGESGRTRVEKDLLPWKVARGAAGRLPPNGFPRDNRF
EEEECCCCCCCHHHHHCCCHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]