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The map label for this gene is argH

Identifier: 87200690

GI number: 87200690

Start: 2914921

End: 2916330

Strand: Reverse

Name: argH

Synonym: Saro_2677

Alternate gene names: 87200690

Gene position: 2916330-2914921 (Counterclockwise)

Preceding gene: 87200695

Following gene: 87200689

Centisome position: 81.88

GC content: 68.37

Gene sequence:

>1410_bases
ATGAGCGGCAATTCGGGCTCCAACCAGATGTGGGGCGGGCGCTTCGCAGGCGGTCCCTCGGCGATCATGCGCGAGATCAA
CGCCTCGATTCCCTTCGACAAGGCGTTGTGGCGGCAGGACATCGCCGCGTCAAAGGCCCATGTGGACATGCTGGGCGCGC
AAGGGATCGTCTCGGCCGAGGATGCGGCGCTGATCGCCAGTGGGCTCGATCAGGTGGCAGCGGAGTACGAGGCCAACGGG
GTGCCCGAGAACTGGGACCTCGAGGACATCCACATGACCACCGAGAGCCGCCTTGCCGAACTGATCGGCCCGGCGGCGGG
GCGCCTGCACACCGCGCGCAGCCGCAACGACCAGGTGGCGACCGACTTTCGCCTGTGGGTTCGCGACGCGATGGACCAGG
CCGAGCTGGGCCTGAAGCAGTTGCAGGTCGCGCTGGTGAGCCGCGCGGGCGAGCATGCCGCTTCGATCATGCCCGGCTTC
ACGCACCTGCAGACCGCGCAGCCGGTGACGCTGGGCCACCACCTGATGGCCTATTACGAGATGATCGGGCGCGACCGTTC
GCGCTTTGCCGATGCGCGGGTGCGCATGAACCGCAGCCCGCTCGGCTCGGCGGCGCTGGCCGGCACCGGCTTTCCCATCG
ACCGCTTCCGCACTGCCGAGGCGCTGGGCTTCGATGGGCCGACTGACAACAGCCTCGATTCGGTGTCGGACCGCGACTTC
GCGTTGGACTACCTGATGGCCGCCGCGCAGTGCTCGCTGCACCTGTCGCGGCTGGCCGAGGAATTCATCATCTGGGCGAG
CCAGCCCTTCGGCTTCGTGACGCTGCCCGACAGCCTTTCGACCGGCAGCAGCATCATGCCGCAGAAGAAGAACCCCGACG
CGGCCGAACTGGTGCGCGGCCATTCGGGCCGGATCGTCGGCTGCCTGACCGCGCTGATGATCACGATGAAGGGCCTGCCG
CTGGCCTATTCCAAGGACATGCAGGACGACAAGCCGCCGGTGTTCGAGGCCGCCAGCCTGCTGGCGCTGTCCATCGCGGC
AATGACCGGGATGGTGGCCGAGGCGAAGTTCCGGACCGACCGCATGCGCGCCGCCGCCGAGCTTGGCTATGCCACGGCGA
CCGACCTTGCCGACTGGCTGGTGCGGCAGGCCAACATCCCGTTCCGCGAGGCGCACCACATCACCGGTTCCGCGGTGAAG
CTGGCCGAATCGCGCGGGATAGCGCTCGACCAGCTTTCGATCGAGGACCTCAAGGCGATCGACGAGCGCATCGACGAGCG
CGTCTATGCGGCTCTGTCGGTCGAGGCGAGCGTGGCGGCGCGTTGCAGCCATGGCGGAACCGCGCCGGACGAGGTAAGGA
AGCGCGTGGCCCAGGCGCGCGTGGCGCTGGGGCTGGAGGAATCGGCTTGA

Upstream 100 bases:

>100_bases
CGGTTGCGAGTCGGGCGCGGCTTGCCTATCGCACCCCGCGACGGCGAGCGCCGCCATCAGCAGAAGCAATTTTGGCGACA
ATGGGAACGGGCGGACGGAC

Downstream 100 bases:

>100_bases
GATTTCGGCGGGACATTCTGCTGGTCGGCTTTGGCGCACTCGCTCTGGCGGGCTGTGGCAATCGGGCCGAGCTGAAGCTG
GCGCCCGACCAGACGCCGCC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSGNSGSNQMWGGRFAGGPSAIMREINASIPFDKALWRQDIAASKAHVDMLGAQGIVSAEDAALIASGLDQVAAEYEANG
VPENWDLEDIHMTTESRLAELIGPAAGRLHTARSRNDQVATDFRLWVRDAMDQAELGLKQLQVALVSRAGEHAASIMPGF
THLQTAQPVTLGHHLMAYYEMIGRDRSRFADARVRMNRSPLGSAALAGTGFPIDRFRTAEALGFDGPTDNSLDSVSDRDF
ALDYLMAAAQCSLHLSRLAEEFIIWASQPFGFVTLPDSLSTGSSIMPQKKNPDAAELVRGHSGRIVGCLTALMITMKGLP
LAYSKDMQDDKPPVFEAASLLALSIAAMTGMVAEAKFRTDRMRAAAELGYATATDLADWLVRQANIPFREAHHITGSAVK
LAESRGIALDQLSIEDLKAIDERIDERVYAALSVEASVAARCSHGGTAPDEVRKRVAQARVALGLEESA

Sequences:

>Translated_469_residues
MSGNSGSNQMWGGRFAGGPSAIMREINASIPFDKALWRQDIAASKAHVDMLGAQGIVSAEDAALIASGLDQVAAEYEANG
VPENWDLEDIHMTTESRLAELIGPAAGRLHTARSRNDQVATDFRLWVRDAMDQAELGLKQLQVALVSRAGEHAASIMPGF
THLQTAQPVTLGHHLMAYYEMIGRDRSRFADARVRMNRSPLGSAALAGTGFPIDRFRTAEALGFDGPTDNSLDSVSDRDF
ALDYLMAAAQCSLHLSRLAEEFIIWASQPFGFVTLPDSLSTGSSIMPQKKNPDAAELVRGHSGRIVGCLTALMITMKGLP
LAYSKDMQDDKPPVFEAASLLALSIAAMTGMVAEAKFRTDRMRAAAELGYATATDLADWLVRQANIPFREAHHITGSAVK
LAESRGIALDQLSIEDLKAIDERIDERVYAALSVEASVAARCSHGGTAPDEVRKRVAQARVALGLEESA
>Mature_468_residues
SGNSGSNQMWGGRFAGGPSAIMREINASIPFDKALWRQDIAASKAHVDMLGAQGIVSAEDAALIASGLDQVAAEYEANGV
PENWDLEDIHMTTESRLAELIGPAAGRLHTARSRNDQVATDFRLWVRDAMDQAELGLKQLQVALVSRAGEHAASIMPGFT
HLQTAQPVTLGHHLMAYYEMIGRDRSRFADARVRMNRSPLGSAALAGTGFPIDRFRTAEALGFDGPTDNSLDSVSDRDFA
LDYLMAAAQCSLHLSRLAEEFIIWASQPFGFVTLPDSLSTGSSIMPQKKNPDAAELVRGHSGRIVGCLTALMITMKGLPL
AYSKDMQDDKPPVFEAASLLALSIAAMTGMVAEAKFRTDRMRAAAELGYATATDLADWLVRQANIPFREAHHITGSAVKL
AESRGIALDQLSIEDLKAIDERIDERVYAALSVEASVAARCSHGGTAPDEVRKRVAQARVALGLEESA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=459, Percent_Identity=41.3943355119826, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI68303542, Length=459, Percent_Identity=41.3943355119826, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI68303549, Length=459, Percent_Identity=39.4335511982571, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI68303547, Length=459, Percent_Identity=39.2156862745098, Blast_Score=323, Evalue=2e-88,
Organism=Escherichia coli, GI1790398, Length=459, Percent_Identity=45.3159041394335, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6321806, Length=461, Percent_Identity=40.7809110629067, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221473854, Length=454, Percent_Identity=38.9867841409692, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI78706858, Length=454, Percent_Identity=38.9867841409692, Blast_Score=320, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_NOVAD (Q2G4W0)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497947.1
- ProteinModelPortal:   Q2G4W0
- SMR:   Q2G4W0
- STRING:   Q2G4W0
- GeneID:   3918451
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_2677
- NMPDR:   fig|48935.1.peg.1116
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   Q2G4W0
- ProtClustDB:   PRK00855
- BioCyc:   NARO279238:SARO_2677-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50490; Mature: 50359

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGNSGSNQMWGGRFAGGPSAIMREINASIPFDKALWRQDIAASKAHVDMLGAQGIVSAE
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
DAALIASGLDQVAAEYEANGVPENWDLEDIHMTTESRLAELIGPAAGRLHTARSRNDQVA
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHEECCHHHHHHHHHCCHHHHHHHHCCCCCCHH
TDFRLWVRDAMDQAELGLKQLQVALVSRAGEHAASIMPGFTHLQTAQPVTLGHHLMAYYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHCCCCCHHHHHHHHHHHH
MIGRDRSRFADARVRMNRSPLGSAALAGTGFPIDRFRTAEALGFDGPTDNSLDSVSDRDF
HHCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHH
ALDYLMAAAQCSLHLSRLAEEFIIWASQPFGFVTLPDSLSTGSSIMPQKKNPDAAELVRG
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCC
HSGRIVGCLTALMITMKGLPLAYSKDMQDDKPPVFEAASLLALSIAAMTGMVAEAKFRTD
CCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMRAAAELGYATATDLADWLVRQANIPFREAHHITGSAVKLAESRGIALDQLSIEDLKAI
HHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCEEECCCHHHHHHH
DERIDERVYAALSVEASVAARCSHGGTAPDEVRKRVAQARVALGLEESA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SGNSGSNQMWGGRFAGGPSAIMREINASIPFDKALWRQDIAASKAHVDMLGAQGIVSAE
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
DAALIASGLDQVAAEYEANGVPENWDLEDIHMTTESRLAELIGPAAGRLHTARSRNDQVA
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHEECCHHHHHHHHHCCHHHHHHHHCCCCCCHH
TDFRLWVRDAMDQAELGLKQLQVALVSRAGEHAASIMPGFTHLQTAQPVTLGHHLMAYYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHCCCCCHHHHHHHHHHHH
MIGRDRSRFADARVRMNRSPLGSAALAGTGFPIDRFRTAEALGFDGPTDNSLDSVSDRDF
HHCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHH
ALDYLMAAAQCSLHLSRLAEEFIIWASQPFGFVTLPDSLSTGSSIMPQKKNPDAAELVRG
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCC
HSGRIVGCLTALMITMKGLPLAYSKDMQDDKPPVFEAASLLALSIAAMTGMVAEAKFRTD
CCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMRAAAELGYATATDLADWLVRQANIPFREAHHITGSAVKLAESRGIALDQLSIEDLKAI
HHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCEEECCCHHHHHHH
DERIDERVYAALSVEASVAARCSHGGTAPDEVRKRVAQARVALGLEESA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA