Click here to switch to the map view.

The map label for this gene is guaA [C]

Identifier: 87200619

GI number: 87200619

Start: 2817653

End: 2818495

Strand: Direct

Name: guaA [C]

Synonym: Saro_2606

Alternate gene names: 87200619

Gene position: 2817653-2818495 (Clockwise)

Preceding gene: 87200618

Following gene: 87200621

Centisome position: 79.11

GC content: 65.6

Gene sequence:

>843_bases
ATGACCCGATTGCTGCTGCTCGAAGGAAACACCGCCGACAAGCGCGCCAGGGGGCGCGAACTGGGCGTGCGCAGTTCGAG
CGAGATCTACGCACAGGCGATTGCCGCGCATTTCCCCCGGATCGAACTGGACGTGCTGAACGGCGCCGACGAAGGCGAGG
CGATTCCCCACGACCGATCCTGGGCCGACTACGACGGGTTCGTCGTCACCGGCTCGTCGCTGCACGCATACGACCGGGAA
TTTGCGGTCACCAACCAGATCGCCCTCGTGGCCCAGGCGGCCGAACATGGACTGCCGATCTTCGGTTCGTGCTGGGGATT
GCAGATCGCGGTCATGGCGGCGGGCGGAGAGGTGGCCTACAATCCGAGGGGTCGCGAGGTAGGCTTCGCGCGCAAGATCG
CGCTCAACGATGCCGGGCGCGCCCATCCCATGTTCGGCGCGAAGCAGCACGTTTTCGATGCGCCCTGCATCCACTACGAC
GAAGTCGTGCGGATGCCCGATGGCGCCACGCTGCTCGCGTCCAACGGCCACAGTCTGGTGCAGGCCGCGGTGATCCCGCT
GGGTCAGAGTGAAGTCTGGGCAGTGCAATACCATCCCGAATTCGACCTCGCGCAGCTCGTCCAGCTCTACACCCTCTATG
CCGCCGACATGATCGCGCAGGGCTTCTTTTCCAACGAGGCCGAACTCGTCGCCTACCGCGACAAGATCGCGCGGTTGGCG
CAGGATCCGACCGATGCAGGGCTGGCGTGGCAACTGGGCATCGACGCCGACGTGCTGGACCCGCGGCAGCGCGCGGCGGA
GATCATCGCCTGGATCGAGAGCCGAGTCCTGAACGGCACCTAA

Upstream 100 bases:

>100_bases
TCCACCGCTGGAGCGGCATCTCGCCCCACGCCTGGCGGGCACGGCTGAACCAGACCGCGCACTGAAACCCCAAGACAAGT
CACTATCCAAGGCCGATCCC

Downstream 100 bases:

>100_bases
AAGCACCTAAAGGCACCTGGATGCACACGGGACAACGGAAAGGGGGCCTCGCGCCCCCTTTCCTGTACCCTAGTTCCAGC
CGCCGTCCGGCTTGTCGAAC

Product: glutamine amidotransferase class-I

Products: AMP; L-Glutamate; GMP; H+; Diphosphate [C]

Alternate protein names: Glutamine Amidotransferase; Class I Glutamine Amidotransferase Family Protein; GMP Synthase; Glutamine Amidotransferase Class I; Glutamine Amidotransferase Class-I Family; Glutamine Amidotransferase Protein; Guanosine Monophosphate Synthetase; Class I Glutamine Amidotransferase; Glutamine-Hydrolyzing GMP Synthase; GMP Synthase Family Protein

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTRLLLLEGNTADKRARGRELGVRSSSEIYAQAIAAHFPRIELDVLNGADEGEAIPHDRSWADYDGFVVTGSSLHAYDRE
FAVTNQIALVAQAAEHGLPIFGSCWGLQIAVMAAGGEVAYNPRGREVGFARKIALNDAGRAHPMFGAKQHVFDAPCIHYD
EVVRMPDGATLLASNGHSLVQAAVIPLGQSEVWAVQYHPEFDLAQLVQLYTLYAADMIAQGFFSNEAELVAYRDKIARLA
QDPTDAGLAWQLGIDADVLDPRQRAAEIIAWIESRVLNGT

Sequences:

>Translated_280_residues
MTRLLLLEGNTADKRARGRELGVRSSSEIYAQAIAAHFPRIELDVLNGADEGEAIPHDRSWADYDGFVVTGSSLHAYDRE
FAVTNQIALVAQAAEHGLPIFGSCWGLQIAVMAAGGEVAYNPRGREVGFARKIALNDAGRAHPMFGAKQHVFDAPCIHYD
EVVRMPDGATLLASNGHSLVQAAVIPLGQSEVWAVQYHPEFDLAQLVQLYTLYAADMIAQGFFSNEAELVAYRDKIARLA
QDPTDAGLAWQLGIDADVLDPRQRAAEIIAWIESRVLNGT
>Mature_279_residues
TRLLLLEGNTADKRARGRELGVRSSSEIYAQAIAAHFPRIELDVLNGADEGEAIPHDRSWADYDGFVVTGSSLHAYDREF
AVTNQIALVAQAAEHGLPIFGSCWGLQIAVMAAGGEVAYNPRGREVGFARKIALNDAGRAHPMFGAKQHVFDAPCIHYDE
VVRMPDGATLLASNGHSLVQAAVIPLGQSEVWAVQYHPEFDLAQLVQLYTLYAADMIAQGFFSNEAELVAYRDKIARLAQ
DPTDAGLAWQLGIDADVLDPRQRAAEIIAWIESRVLNGT

Specific function: Catalyzes The Synthesis Of Gmp From Xmp. [C]

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 6.3.5.2 [C]

Molecular weight: Translated: 30496; Mature: 30364

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLLLLEGNTADKRARGRELGVRSSSEIYAQAIAAHFPRIELDVLNGADEGEAIPHDRS
CCEEEEEECCCCHHHHCCHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
WADYDGFVVTGSSLHAYDREFAVTNQIALVAQAAEHGLPIFGSCWGLQIAVMAAGGEVAY
CCCCCCEEEECCCCCCCCCCHHHHHHHHHEEHHHHCCCCEEECCCCEEEEEEEECCEEEE
NPRGREVGFARKIALNDAGRAHPMFGAKQHVFDAPCIHYDEVVRMPDGATLLASNGHSLV
CCCCCCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCHHHEEECCCCCEEEECCCCCEE
QAAVIPLGQSEVWAVQYHPEFDLAQLVQLYTLYAADMIAQGFFSNEAELVAYRDKIARLA
HEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
QDPTDAGLAWQLGIDADVLDPRQRAAEIIAWIESRVLNGT
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRLLLLEGNTADKRARGRELGVRSSSEIYAQAIAAHFPRIELDVLNGADEGEAIPHDRS
CEEEEEECCCCHHHHCCHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
WADYDGFVVTGSSLHAYDREFAVTNQIALVAQAAEHGLPIFGSCWGLQIAVMAAGGEVAY
CCCCCCEEEECCCCCCCCCCHHHHHHHHHEEHHHHCCCCEEECCCCEEEEEEEECCEEEE
NPRGREVGFARKIALNDAGRAHPMFGAKQHVFDAPCIHYDEVVRMPDGATLLASNGHSLV
CCCCCCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCHHHEEECCCCCEEEECCCCCEE
QAAVIPLGQSEVWAVQYHPEFDLAQLVQLYTLYAADMIAQGFFSNEAELVAYRDKIARLA
HEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
QDPTDAGLAWQLGIDADVLDPRQRAAEIIAWIESRVLNGT
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1 {NH4+}} 0.42 {6-thioXMP}} 0.53 {ATP}} 2 {1-ribosyl-4,6-dihydroxypyrazolo[3,4-d]-pyrimidine} 0.058 {XMP}} 0.029 {XMP}} 0.35 {8-azaXMP}} [C]

Substrates: ATP; L-Glutamine; H2O; Xanthosine 5'-phosphate [C]

Specific reaction: ATP + L-Glutamine + H2O + Xanthosine 5'-phosphate --> AMP + L-Glutamate + GMP + (2) H+ + Diphosphate [C]

General reaction: Amination [C]

Inhibitor: 1, N6-Ethenoadenosine; 1-Methyl adenosine 5'-phosphate 5'-phosphate; 2', 3'-Dihydroadenosine; 2'-Deoxyadenosine; 2, 6-Diaminopurine ribonucleoside; 2-Amino-6-methyl thiopurine ribonucleoside; 2-Fluoroadenosine; 3'-Deoxyadenosine; 5'-Azido-5'-deoxyadenosin

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA