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The map label for this gene is f1pep1 [H]

Identifier: 87200537

GI number: 87200537

Start: 2725475

End: 2727619

Strand: Reverse

Name: f1pep1 [H]

Synonym: Saro_2524

Alternate gene names: 87200537

Gene position: 2727619-2725475 (Counterclockwise)

Preceding gene: 87200538

Following gene: 87200536

Centisome position: 76.58

GC content: 68.07

Gene sequence:

>2145_bases
ATGTCCGAGGAAGCCGCGCTGCCCGCCGCTTCGGTCGCGACCGCCGGCCAACCTGCCGCTGCGGCACGGCTGTTCCTCCC
GCGCGGTGCCTATCCCGAGACGCGGCGCGATGGGCTGGTGGAGCAGGTCTTCGGGCAGCGCGTTGCCGATCCGTACCGCT
GGCTGGAGGCAGACCCGCGCGGCGACGCGGGCGTTGCGGGCTGGATCGCGCGGCAGAACGCGCTATCCGCCGATTACCTG
GCGAAGCTGCCGGGCCGCGAGCGCCTGGCAACGCGCATCCGCGCGCTGTTCGACTTCGAACGATACGGCCTGCCCCGCAA
GGCCGGGCGCAGCTATTTCTACACGCGCAATACCGGGCTCCAGAACCAGTCCGCACTGTGGGTCCGGCGCGGGCTGGACG
GCGAACAGCGTCTGCTGGTCGACCCCAACCTGTGGAGCGCGGACGGGTCGCTGGCGCTGGCCCAGTGGGAGCCATCGCCT
TCGGGGCGCTACCTTGCCATCGCGGAACAGGAGGCCGGGAGTGACTGGCGGACGCTGCGCGTGGTCGAGGTGAGCAGCGG
GCGCGTGCTGGACGAGCGCGTCGATTGGGCGAACGACACCGAGATCGCGTGGGTGGGCGACGAAGGCTTCCTCTATTCGC
GCTTCCCCGCGCCCGGGCAGGGCGAGGATGCGCGGGCGCCGCGGTTCGGCAAGGCGGTGTGGTTCCACCGCGTCGGCACG
GCGCAGGACCGCGACGAACAGGTCTTTGCCACGCCCGATCATCCCGAATGGAGCCACAAGGCATTGGTGACGAGCGACGG
GCGCTGGGCCGTCGTCGTCAGCGAGATCAGCACAGACAAGCGCAATGCCGTCCACCTCATCCGCCTGACCGGGCGGGAGC
GGGGGACGTGGAAGGCCGAGGCATTGGTGCCCGATATTGCGGATCACTGGAAGCTGGTGGCCGGCATCGGCGAGAGGCTG
TGGTTTCTGACCGACCGGGGTGCGCCGAACTATCATCTCGTGCGGGTGGACCTGTCGCGGCCGCAGGAGGGGTGGCAGGT
GGTGGTGCCGCAGCGGGGCAATACGCTGGAAGGTGCGCGGATGATCGGCGACCGCTTCCTCCTTTCCTACCTTCGCGACG
GGCAGAGCGTCGCGGTGATGACTGACCGCAAGGGCCGGCCCGGAAAGGCGATCACGCTGAACGGGATCGGCACGGCGAGC
GGCTTTGGCGGAAGGCCCGGGGACACGGAAACCTTCTATCAGTTCACCAGCTTCAACATGCCGCCTGCGGTCTATCGCAT
GGACTTGCGCACCGGCGCGGTAACGCCCTTCGCGGTGCCGCGCATGGCGTTCGACCCGGCGGACTACGATGTGGAACAAC
GCCAGTTTACGTCGAAGGACGGGACAAAGGTTCCGATCTACATCGTTCGCAAGCGCGTGCTGGCGGCTGCGGACAAACCC
CTGCCGACACTGCTCTACGGGTACGGCGGCTTCGACATTTCGCTGACGCCGGCCTATTCGCCGGTGCGGATGGCGTGGCT
GGAAGCGGGCGGGGCGTTCGCGCTGGCCAACATCCGGGGCGGCGGCGAGTTCGGGCGGAGCTGGTACGAGGCCGGCCGGC
GCGAGAACAAGCAGAACAGCTTCGACGACTTCATCGCCGCCGGCGAATTCCTGATCCGCGAAGGCATTGCCGGGAAAGGG
CAACTGGCGATCCAGGGGGCATCGAACGGCGGGTTGCTGGTAGGCGCCGTCGTCAACCAGAGGCCGGACCTGTTCGCCGC
GGCAAACCCCGACGTGGGCGTGATGGACATGCTGCGCTTCGACCGATTCACTTCCGGGCGGTTCTGGGTCGACGATTATG
GCCGGCCGGACCGCGAGGAGGACTGGCGGACGCTGCGCGCATATTCGCCCTATCACAACATTGCGACCGGCAAGCCCTAC
CCGGCTATCCTGGTGACCACGGCAGACAACGACGACCGCGTCGTGCCGGCGCACAGTTTCAAGTACGTGGCGGCTCTCCA
GGCCGGCGACATTGGCGAAAAGCCCCATCTCTTGCGCGTGGAAAGCCGCGCGGGGCATGGCGCGGGCAAGCCCGTCGACA
AGGTGATCGGCGCCGGGGCGGATGTGATGGCATTTCTCGCCTATTGGACCGGGCTTTCGCTCTGA

Upstream 100 bases:

>100_bases
TGGCAGTGCTAAGGCGATGGCAACGATGGTCTGGGAGATGGACAGGAAACGGCGGATTGCCGCGTGGGCGTTGCTGCTGC
TCGCGGGATCGCGGCATGCG

Downstream 100 bases:

>100_bases
AATCCAAAAGTGCGTTTTGTTAAGGTTGTGAGGTGTTTTTCTGAACAACTCCTGTCATGCCGGTTCAGCGTCGTCTCACG
GCGAATCAGGCATTCCTTCA

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 714; Mature: 713

Protein sequence:

>714_residues
MSEEAALPAASVATAGQPAAAARLFLPRGAYPETRRDGLVEQVFGQRVADPYRWLEADPRGDAGVAGWIARQNALSADYL
AKLPGRERLATRIRALFDFERYGLPRKAGRSYFYTRNTGLQNQSALWVRRGLDGEQRLLVDPNLWSADGSLALAQWEPSP
SGRYLAIAEQEAGSDWRTLRVVEVSSGRVLDERVDWANDTEIAWVGDEGFLYSRFPAPGQGEDARAPRFGKAVWFHRVGT
AQDRDEQVFATPDHPEWSHKALVTSDGRWAVVVSEISTDKRNAVHLIRLTGRERGTWKAEALVPDIADHWKLVAGIGERL
WFLTDRGAPNYHLVRVDLSRPQEGWQVVVPQRGNTLEGARMIGDRFLLSYLRDGQSVAVMTDRKGRPGKAITLNGIGTAS
GFGGRPGDTETFYQFTSFNMPPAVYRMDLRTGAVTPFAVPRMAFDPADYDVEQRQFTSKDGTKVPIYIVRKRVLAAADKP
LPTLLYGYGGFDISLTPAYSPVRMAWLEAGGAFALANIRGGGEFGRSWYEAGRRENKQNSFDDFIAAGEFLIREGIAGKG
QLAIQGASNGGLLVGAVVNQRPDLFAAANPDVGVMDMLRFDRFTSGRFWVDDYGRPDREEDWRTLRAYSPYHNIATGKPY
PAILVTTADNDDRVVPAHSFKYVAALQAGDIGEKPHLLRVESRAGHGAGKPVDKVIGAGADVMAFLAYWTGLSL

Sequences:

>Translated_714_residues
MSEEAALPAASVATAGQPAAAARLFLPRGAYPETRRDGLVEQVFGQRVADPYRWLEADPRGDAGVAGWIARQNALSADYL
AKLPGRERLATRIRALFDFERYGLPRKAGRSYFYTRNTGLQNQSALWVRRGLDGEQRLLVDPNLWSADGSLALAQWEPSP
SGRYLAIAEQEAGSDWRTLRVVEVSSGRVLDERVDWANDTEIAWVGDEGFLYSRFPAPGQGEDARAPRFGKAVWFHRVGT
AQDRDEQVFATPDHPEWSHKALVTSDGRWAVVVSEISTDKRNAVHLIRLTGRERGTWKAEALVPDIADHWKLVAGIGERL
WFLTDRGAPNYHLVRVDLSRPQEGWQVVVPQRGNTLEGARMIGDRFLLSYLRDGQSVAVMTDRKGRPGKAITLNGIGTAS
GFGGRPGDTETFYQFTSFNMPPAVYRMDLRTGAVTPFAVPRMAFDPADYDVEQRQFTSKDGTKVPIYIVRKRVLAAADKP
LPTLLYGYGGFDISLTPAYSPVRMAWLEAGGAFALANIRGGGEFGRSWYEAGRRENKQNSFDDFIAAGEFLIREGIAGKG
QLAIQGASNGGLLVGAVVNQRPDLFAAANPDVGVMDMLRFDRFTSGRFWVDDYGRPDREEDWRTLRAYSPYHNIATGKPY
PAILVTTADNDDRVVPAHSFKYVAALQAGDIGEKPHLLRVESRAGHGAGKPVDKVIGAGADVMAFLAYWTGLSL
>Mature_713_residues
SEEAALPAASVATAGQPAAAARLFLPRGAYPETRRDGLVEQVFGQRVADPYRWLEADPRGDAGVAGWIARQNALSADYLA
KLPGRERLATRIRALFDFERYGLPRKAGRSYFYTRNTGLQNQSALWVRRGLDGEQRLLVDPNLWSADGSLALAQWEPSPS
GRYLAIAEQEAGSDWRTLRVVEVSSGRVLDERVDWANDTEIAWVGDEGFLYSRFPAPGQGEDARAPRFGKAVWFHRVGTA
QDRDEQVFATPDHPEWSHKALVTSDGRWAVVVSEISTDKRNAVHLIRLTGRERGTWKAEALVPDIADHWKLVAGIGERLW
FLTDRGAPNYHLVRVDLSRPQEGWQVVVPQRGNTLEGARMIGDRFLLSYLRDGQSVAVMTDRKGRPGKAITLNGIGTASG
FGGRPGDTETFYQFTSFNMPPAVYRMDLRTGAVTPFAVPRMAFDPADYDVEQRQFTSKDGTKVPIYIVRKRVLAAADKPL
PTLLYGYGGFDISLTPAYSPVRMAWLEAGGAFALANIRGGGEFGRSWYEAGRRENKQNSFDDFIAAGEFLIREGIAGKGQ
LAIQGASNGGLLVGAVVNQRPDLFAAANPDVGVMDMLRFDRFTSGRFWVDDYGRPDREEDWRTLRAYSPYHNIATGKPYP
AILVTTADNDDRVVPAHSFKYVAALQAGDIGEKPHLLRVESRAGHGAGKPVDKVIGAGADVMAFLAYWTGLSL

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=700, Percent_Identity=38.1428571428571, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI284172438, Length=544, Percent_Identity=23.3455882352941, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI284172431, Length=544, Percent_Identity=23.3455882352941, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI284172420, Length=549, Percent_Identity=23.6794171220401, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI284172413, Length=549, Percent_Identity=23.6794171220401, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI70778815, Length=549, Percent_Identity=23.6794171220401, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI108860686, Length=226, Percent_Identity=29.2035398230088, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI108860692, Length=225, Percent_Identity=28.8888888888889, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1788150, Length=713, Percent_Identity=24.6844319775596, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24583414, Length=704, Percent_Identity=37.7840909090909, Blast_Score=480, Evalue=1e-135,
Organism=Drosophila melanogaster, GI221510989, Length=707, Percent_Identity=35.6435643564356, Blast_Score=456, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 78767; Mature: 78636

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEAALPAASVATAGQPAAAARLFLPRGAYPETRRDGLVEQVFGQRVADPYRWLEADPR
CCCCCCCCCHHHHCCCCCHHHEEEEECCCCCCCHHHCCHHHHHHHHHHCCHHHHHCCCCC
GDAGVAGWIARQNALSADYLAKLPGRERLATRIRALFDFERYGLPRKAGRSYFYTRNTGL
CCCCHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCEEEEECCCC
QNQSALWVRRGLDGEQRLLVDPNLWSADGSLALAQWEPSPSGRYLAIAEQEAGSDWRTLR
CCCCEEEEECCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCEEEE
VVEVSSGRVLDERVDWANDTEIAWVGDEGFLYSRFPAPGQGEDARAPRFGKAVWFHRVGT
EEEECCCCEEHHHCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCEEEEEECCC
AQDRDEQVFATPDHPEWSHKALVTSDGRWAVVVSEISTDKRNAVHLIRLTGRERGTWKAE
CCCCCCEEEECCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCEEEEEEECCCCCCEEHH
ALVPDIADHWKLVAGIGERLWFLTDRGAPNYHLVRVDLSRPQEGWQVVVPQRGNTLEGAR
HHCCCHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCHHH
MIGDRFLLSYLRDGQSVAVMTDRKGRPGKAITLNGIGTASGFGGRPGDTETFYQFTSFNM
HHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCHHEEEEECCCC
PPAVYRMDLRTGAVTPFAVPRMAFDPADYDVEQRQFTSKDGTKVPIYIVRKRVLAAADKP
CHHHEEEECCCCCCCCCCCCCEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
LPTLLYGYGGFDISLTPAYSPVRMAWLEAGGAFALANIRGGGEFGRSWYEAGRRENKQNS
CCEEEEECCCEEEEECCCCCCCEEEEEECCCEEEEEEECCCHHHHHHHHHHHHHCCCCCC
FDDFIAAGEFLIREGIAGKGQLAIQGASNGGLLVGAVVNQRPDLFAAANPDVGVMDMLRF
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEECCCCCCHHHHHHH
DRFTSGRFWVDDYGRPDREEDWRTLRAYSPYHNIATGKPYPAILVTTADNDDRVVPAHSF
HCCCCCEEEECCCCCCCCHHHHHHHEECCCCCCCCCCCCCCEEEEEECCCCCEEECCCCC
KYVAALQAGDIGEKPHLLRVESRAGHGAGKPVDKVIGAGADVMAFLAYWTGLSL
EEEEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEEAALPAASVATAGQPAAAARLFLPRGAYPETRRDGLVEQVFGQRVADPYRWLEADPR
CCCCCCCCHHHHCCCCCHHHEEEEECCCCCCCHHHCCHHHHHHHHHHCCHHHHHCCCCC
GDAGVAGWIARQNALSADYLAKLPGRERLATRIRALFDFERYGLPRKAGRSYFYTRNTGL
CCCCHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCEEEEECCCC
QNQSALWVRRGLDGEQRLLVDPNLWSADGSLALAQWEPSPSGRYLAIAEQEAGSDWRTLR
CCCCEEEEECCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCEEEE
VVEVSSGRVLDERVDWANDTEIAWVGDEGFLYSRFPAPGQGEDARAPRFGKAVWFHRVGT
EEEECCCCEEHHHCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCEEEEEECCC
AQDRDEQVFATPDHPEWSHKALVTSDGRWAVVVSEISTDKRNAVHLIRLTGRERGTWKAE
CCCCCCEEEECCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCEEEEEEECCCCCCEEHH
ALVPDIADHWKLVAGIGERLWFLTDRGAPNYHLVRVDLSRPQEGWQVVVPQRGNTLEGAR
HHCCCHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCHHH
MIGDRFLLSYLRDGQSVAVMTDRKGRPGKAITLNGIGTASGFGGRPGDTETFYQFTSFNM
HHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCHHEEEEECCCC
PPAVYRMDLRTGAVTPFAVPRMAFDPADYDVEQRQFTSKDGTKVPIYIVRKRVLAAADKP
CHHHEEEECCCCCCCCCCCCCEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
LPTLLYGYGGFDISLTPAYSPVRMAWLEAGGAFALANIRGGGEFGRSWYEAGRRENKQNS
CCEEEEECCCEEEEECCCCCCCEEEEEECCCEEEEEEECCCHHHHHHHHHHHHHCCCCCC
FDDFIAAGEFLIREGIAGKGQLAIQGASNGGLLVGAVVNQRPDLFAAANPDVGVMDMLRF
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEECCCCCCHHHHHHH
DRFTSGRFWVDDYGRPDREEDWRTLRAYSPYHNIATGKPYPAILVTTADNDDRVVPAHSF
HCCCCCEEEECCCCCCCCHHHHHHHEECCCCCCCCCCCCCCEEEEEECCCCCEEECCCCC
KYVAALQAGDIGEKPHLLRVESRAGHGAGKPVDKVIGAGADVMAFLAYWTGLSL
EEEEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]