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The map label for this gene is ptrB [C]

Identifier: 87200538

GI number: 87200538

Start: 2727747

End: 2729882

Strand: Reverse

Name: ptrB [C]

Synonym: Saro_2525

Alternate gene names: 87200538

Gene position: 2729882-2727747 (Counterclockwise)

Preceding gene: 87200539

Following gene: 87200537

Centisome position: 76.65

GC content: 67.51

Gene sequence:

>2136_bases
ATGCCCTCGATCCGCCCCTTGCTCGCCGCCTCGGCGCTGGCCTGCCTCGCCATGTCCATGACGGCCGAGGCGGCGCCGGC
CGCGATGAAGTACCCGCAGACCGAGCGAGGCACCGTGGTCGAGACGGCCTTCGGCGAGAAGGTCGCCGATCCCTACCGCT
GGCTCGAGGCCGACGTCCGCGTGGATCCGAAGGTGGCCGCCTGGGTCGATGCCCAGAGCAGGTTCACCGACGCCTATCTC
AAGGCCTTGCCCGAGCGTCCGGCCTTCGAGCAAAGGCTGAAGACGCTGTTCGACTTCGAACGCTTCGGGCTTCCGGTGAA
GGCGGGTGATCTTCTGTTCTTCCGCCACAACTCCGGCCTCCAGAACCAGTCGGTGCTCTATGTGCGCAAGGCCGATGGCA
GCGGCGAGCGACGGGTGCTGATCGACCCCAACGGCTGGGCCAAGGACGGCGCGACCGCGCTCGACGACTGGCAGCCTTCG
CCCGACGGAACGAAGGTGGCGTATTCGGTTCAGGACGGCGGCTCGGACTGGCGCACGCTCAAGGTGATCGATGTCGCCAG
CGGGCAGGTGCTGTCCGATACGGTCGAGCACGTGAAGTTCTCGCACATCGCCTGGGCGGGCAACGAAGCGGTCGTCTATT
CGCGTTTCCCTGCGCCCAAGGCGGGCGAGGCGTTCCAGGCGGTCAGTTCCAACCAGTCGGTCTGGCTGCACAAGCTGGGT
ACGCCGCAGTCGGAGGACCGCCTGCTTCATGCCACGCCCGACAATCCCCGGCTCTACCATTCGGCCGAGACCACCCATGA
CCAGCGCTGGCTGGTGGTGTCGACCAGCACCGGCAGCGAGAAGGGCAACGCGGTCGGCCTCGCCCGGATAGGCGGCGACT
GGAAGGTCCAGCCGCTGGTGAGCACGCTTGCCGACGAGTGGTCGCTGATCGCCGGGATCGGGGACCGGCTGTGGTTCGTG
ACCAGCAAGGATGCGCCGCGCAAGAAGGTGGTCATGGTCGACATGTCGGGCGCCGCGCCGGTCACCACGACCGTCGTGCC
GGAAAGCGACGACGTGCTGGAAAGCGCGAAGGTCGTCGGGGATCGTCTGGTTCTCGGCTATCTGCGCGACGTCAAGGCCG
AACTGCGGTTGGCGACGCTCGACGGCAAGCCTGCCGGAACCCTTGCCCTGCCGGGCATCGGGAGCATCGGCGGCGTGGTC
GGGGAGCCGGGCGACCCGCAGGGCCACTTCGCGTTCTCGGGCTTCACCCAGCCCGCCACGATCTATGCCTTCGACGCTGG
CGATGCCGCGTCCGCCAAGGTCTGGGCGGCGCCGAAGCTGACCTTCGATCCGGCCCGGTTCGAGACGCGGCAGGTGTTCT
ATCCTTCGAAGGACGGAACCCGGATTCCGATGTTCGTTGTCCGCCGCAAGGACCTTGCCGGTCCGCTGCCGACGATCCTC
TATGGCTACGGCGGTTTCAACATTTCGGTCCTTCCGGCCTTTTCGGCGGGACGCATGGCCTGGCTCGATGCCGGCGGTGC
GTTCGCCGTCGCCAACATCCGGGGTGGGGGCGAGTATGGCGAGGCCTGGCATCTGGCCGGCAAGGGGCCGACCAAGCAGA
ACGTGTTCGACGATTTCATCGCCGCCGGGGAATGGCTGAAGGCCAACGGCGTCACGTCCGCCAATGGTCTTGCGGTCGAG
GGCGGGTCGAACGGAGGCCTGCTCGTCGGGGCGGTCGTCAACCAGCGGCCCGATCTGTTCGCGGCGGCGGTCCCCGCGGT
CGGCGTGATGGACATGCTGCGCTTCGACAAGTTCACTGCCGGGCGCGAATGGGTGTTCGATTACGGCTATCCGGAGAAGG
AGGAGGACTGGCGCCGCCTGCGCGCCTACTCGCCCTATCACAATATCGCGTCGGGCAAGGACTACCCGGCGATCCTCGTG
ACCACCGCCGATACCGACGACCGGGTGGTTCCGGGCCATAGCTTCAAGTACGCGGCGGCGCTCCAGGCGGCCTCGATCGG
CAGCAAGCCGCACCTCATCCGCATCGAGACGCGCGCGGGGCACGGATCGGGCAAGCCCGTCGCGAAGCTGATCGCCGAGA
ATGCCGACGTCTACGCCTTCGTCGCGCACTGGACGGGACTGACGCCGAAGGAGTGA

Upstream 100 bases:

>100_bases
GACAGTGTAAACCGTGTAAACCCCCTCGGCCGCACTTGCAGTTTCGCGGATCGAAGCTAGTTTCGCCGGCAACCGGAATG
ATCAAGCTGAAAGCCCCTCC

Downstream 100 bases:

>100_bases
CCTTCGAAACATCTCCCGCCGCTTCGCTGGCAGTGCTAAGGCGATGGCAACGATGGTCTGGGAGATGGACAGGAAACGGC
GGATTGCCGCGTGGGCGTTG

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: PE; Post-proline cleaving enzyme [H]

Number of amino acids: Translated: 711; Mature: 710

Protein sequence:

>711_residues
MPSIRPLLAASALACLAMSMTAEAAPAAMKYPQTERGTVVETAFGEKVADPYRWLEADVRVDPKVAAWVDAQSRFTDAYL
KALPERPAFEQRLKTLFDFERFGLPVKAGDLLFFRHNSGLQNQSVLYVRKADGSGERRVLIDPNGWAKDGATALDDWQPS
PDGTKVAYSVQDGGSDWRTLKVIDVASGQVLSDTVEHVKFSHIAWAGNEAVVYSRFPAPKAGEAFQAVSSNQSVWLHKLG
TPQSEDRLLHATPDNPRLYHSAETTHDQRWLVVSTSTGSEKGNAVGLARIGGDWKVQPLVSTLADEWSLIAGIGDRLWFV
TSKDAPRKKVVMVDMSGAAPVTTTVVPESDDVLESAKVVGDRLVLGYLRDVKAELRLATLDGKPAGTLALPGIGSIGGVV
GEPGDPQGHFAFSGFTQPATIYAFDAGDAASAKVWAAPKLTFDPARFETRQVFYPSKDGTRIPMFVVRRKDLAGPLPTIL
YGYGGFNISVLPAFSAGRMAWLDAGGAFAVANIRGGGEYGEAWHLAGKGPTKQNVFDDFIAAGEWLKANGVTSANGLAVE
GGSNGGLLVGAVVNQRPDLFAAAVPAVGVMDMLRFDKFTAGREWVFDYGYPEKEEDWRRLRAYSPYHNIASGKDYPAILV
TTADTDDRVVPGHSFKYAAALQAASIGSKPHLIRIETRAGHGSGKPVAKLIAENADVYAFVAHWTGLTPKE

Sequences:

>Translated_711_residues
MPSIRPLLAASALACLAMSMTAEAAPAAMKYPQTERGTVVETAFGEKVADPYRWLEADVRVDPKVAAWVDAQSRFTDAYL
KALPERPAFEQRLKTLFDFERFGLPVKAGDLLFFRHNSGLQNQSVLYVRKADGSGERRVLIDPNGWAKDGATALDDWQPS
PDGTKVAYSVQDGGSDWRTLKVIDVASGQVLSDTVEHVKFSHIAWAGNEAVVYSRFPAPKAGEAFQAVSSNQSVWLHKLG
TPQSEDRLLHATPDNPRLYHSAETTHDQRWLVVSTSTGSEKGNAVGLARIGGDWKVQPLVSTLADEWSLIAGIGDRLWFV
TSKDAPRKKVVMVDMSGAAPVTTTVVPESDDVLESAKVVGDRLVLGYLRDVKAELRLATLDGKPAGTLALPGIGSIGGVV
GEPGDPQGHFAFSGFTQPATIYAFDAGDAASAKVWAAPKLTFDPARFETRQVFYPSKDGTRIPMFVVRRKDLAGPLPTIL
YGYGGFNISVLPAFSAGRMAWLDAGGAFAVANIRGGGEYGEAWHLAGKGPTKQNVFDDFIAAGEWLKANGVTSANGLAVE
GGSNGGLLVGAVVNQRPDLFAAAVPAVGVMDMLRFDKFTAGREWVFDYGYPEKEEDWRRLRAYSPYHNIASGKDYPAILV
TTADTDDRVVPGHSFKYAAALQAASIGSKPHLIRIETRAGHGSGKPVAKLIAENADVYAFVAHWTGLTPKE
>Mature_710_residues
PSIRPLLAASALACLAMSMTAEAAPAAMKYPQTERGTVVETAFGEKVADPYRWLEADVRVDPKVAAWVDAQSRFTDAYLK
ALPERPAFEQRLKTLFDFERFGLPVKAGDLLFFRHNSGLQNQSVLYVRKADGSGERRVLIDPNGWAKDGATALDDWQPSP
DGTKVAYSVQDGGSDWRTLKVIDVASGQVLSDTVEHVKFSHIAWAGNEAVVYSRFPAPKAGEAFQAVSSNQSVWLHKLGT
PQSEDRLLHATPDNPRLYHSAETTHDQRWLVVSTSTGSEKGNAVGLARIGGDWKVQPLVSTLADEWSLIAGIGDRLWFVT
SKDAPRKKVVMVDMSGAAPVTTTVVPESDDVLESAKVVGDRLVLGYLRDVKAELRLATLDGKPAGTLALPGIGSIGGVVG
EPGDPQGHFAFSGFTQPATIYAFDAGDAASAKVWAAPKLTFDPARFETRQVFYPSKDGTRIPMFVVRRKDLAGPLPTILY
GYGGFNISVLPAFSAGRMAWLDAGGAFAVANIRGGGEYGEAWHLAGKGPTKQNVFDDFIAAGEWLKANGVTSANGLAVEG
GSNGGLLVGAVVNQRPDLFAAAVPAVGVMDMLRFDKFTAGREWVFDYGYPEKEEDWRRLRAYSPYHNIASGKDYPAILVT
TADTDDRVVPGHSFKYAAALQAASIGSKPHLIRIETRAGHGSGKPVAKLIAENADVYAFVAHWTGLTPKE

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=706, Percent_Identity=40.2266288951841, Blast_Score=482, Evalue=1e-136,
Organism=Homo sapiens, GI284172420, Length=615, Percent_Identity=23.4146341463415, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI284172413, Length=615, Percent_Identity=23.4146341463415, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI70778815, Length=615, Percent_Identity=23.4146341463415, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI284172438, Length=592, Percent_Identity=22.8040540540541, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI284172431, Length=592, Percent_Identity=22.8040540540541, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI108860686, Length=310, Percent_Identity=26.7741935483871, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI108860692, Length=214, Percent_Identity=28.5046728971963, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1788150, Length=688, Percent_Identity=23.9825581395349, Blast_Score=170, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24583414, Length=708, Percent_Identity=38.2768361581921, Blast_Score=474, Evalue=1e-133,
Organism=Drosophila melanogaster, GI221510989, Length=713, Percent_Identity=38.0084151472651, Blast_Score=463, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 76562; Mature: 76431

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSIRPLLAASALACLAMSMTAEAAPAAMKYPQTERGTVVETAFGEKVADPYRWLEADVR
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEECCCCHHCCCHHHHCCCCE
VDPKVAAWVDAQSRFTDAYLKALPERPAFEQRLKTLFDFERFGLPVKAGDLLFFRHNSGL
ECCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEECCCEEEEEECCCC
QNQSVLYVRKADGSGERRVLIDPNGWAKDGATALDDWQPSPDGTKVAYSVQDGGSDWRTL
CCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEE
KVIDVASGQVLSDTVEHVKFSHIAWAGNEAVVYSRFPAPKAGEAFQAVSSNQSVWLHKLG
EEEEECCCCHHHHHHHHHEEEEEEECCCCEEEEECCCCCCCCCHHHHHCCCCCEEEEECC
TPQSEDRLLHATPDNPRLYHSAETTHDQRWLVVSTSTGSEKGNAVGLARIGGDWKVQPLV
CCCCCCEEEEECCCCCEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCEEEHHHH
STLADEWSLIAGIGDRLWFVTSKDAPRKKVVMVDMSGAAPVTTTVVPESDDVLESAKVVG
HHHHHHHHEEECCCCEEEEEECCCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHH
DRLVLGYLRDVKAELRLATLDGKPAGTLALPGIGSIGGVVGEPGDPQGHFAFSGFTQPAT
HHHHHHHHHHCCEEEEEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCEE
IYAFDAGDAASAKVWAAPKLTFDPARFETRQVFYPSKDGTRIPMFVVRRKDLAGPLPTIL
EEEECCCCCCCCEEEECCCCEECCCCCCEEEEEECCCCCCCCCEEEEEEHHCCCCCCEEE
YGYGGFNISVLPAFSAGRMAWLDAGGAFAVANIRGGGEYGEAWHLAGKGPTKQNVFDDFI
EECCCCEEEEEECCCCCCEEEEECCCEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHH
AAGEWLKANGVTSANGLAVEGGSNGGLLVGAVVNQRPDLFAAAVPAVGVMDMLRFDKFTA
HCCCEEECCCCCCCCCEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
GREWVFDYGYPEKEEDWRRLRAYSPYHNIASGKDYPAILVTTADTDDRVVPGHSFKYAAA
CCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHH
LQAASIGSKPHLIRIETRAGHGSGKPVAKLIAENADVYAFVAHWTGLTPKE
HHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCC
>Mature Secondary Structure 
PSIRPLLAASALACLAMSMTAEAAPAAMKYPQTERGTVVETAFGEKVADPYRWLEADVR
CCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEECCCCHHCCCHHHHCCCCE
VDPKVAAWVDAQSRFTDAYLKALPERPAFEQRLKTLFDFERFGLPVKAGDLLFFRHNSGL
ECCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEECCCEEEEEECCCC
QNQSVLYVRKADGSGERRVLIDPNGWAKDGATALDDWQPSPDGTKVAYSVQDGGSDWRTL
CCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEE
KVIDVASGQVLSDTVEHVKFSHIAWAGNEAVVYSRFPAPKAGEAFQAVSSNQSVWLHKLG
EEEEECCCCHHHHHHHHHEEEEEEECCCCEEEEECCCCCCCCCHHHHHCCCCCEEEEECC
TPQSEDRLLHATPDNPRLYHSAETTHDQRWLVVSTSTGSEKGNAVGLARIGGDWKVQPLV
CCCCCCEEEEECCCCCEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCEEEHHHH
STLADEWSLIAGIGDRLWFVTSKDAPRKKVVMVDMSGAAPVTTTVVPESDDVLESAKVVG
HHHHHHHHEEECCCCEEEEEECCCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHH
DRLVLGYLRDVKAELRLATLDGKPAGTLALPGIGSIGGVVGEPGDPQGHFAFSGFTQPAT
HHHHHHHHHHCCEEEEEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCEE
IYAFDAGDAASAKVWAAPKLTFDPARFETRQVFYPSKDGTRIPMFVVRRKDLAGPLPTIL
EEEECCCCCCCCEEEECCCCEECCCCCCEEEEEECCCCCCCCCEEEEEEHHCCCCCCEEE
YGYGGFNISVLPAFSAGRMAWLDAGGAFAVANIRGGGEYGEAWHLAGKGPTKQNVFDDFI
EECCCCEEEEEECCCCCCEEEEECCCEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHH
AAGEWLKANGVTSANGLAVEGGSNGGLLVGAVVNQRPDLFAAAVPAVGVMDMLRFDKFTA
HCCCEEECCCCCCCCCEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
GREWVFDYGYPEKEEDWRRLRAYSPYHNIASGKDYPAILVTTADTDDRVVPGHSFKYAAA
CCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHH
LQAASIGSKPHLIRIETRAGHGSGKPVAKLIAENADVYAFVAHWTGLTPKE
HHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8370677 [H]