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The map label for this gene is gyaR [H]

Identifier: 87200322

GI number: 87200322

Start: 2448208

End: 2449227

Strand: Direct

Name: gyaR [H]

Synonym: Saro_2308

Alternate gene names: 87200322

Gene position: 2448208-2449227 (Clockwise)

Preceding gene: 87200320

Following gene: 87200323

Centisome position: 68.74

GC content: 68.33

Gene sequence:

>1020_bases
ATGCCCAGTTCCGCCGACTATCGCCCGACCCGCCGCGTCGAAGGCAAGCCCCGCGTCTTCGTGACGCGCCGTCTCCTGCC
TGAAACCGAAGCCCGCATGGCCGAACTGTTCGATGTCGTCCTCAACAGCGATGACCGGCCGCTCGGCCGCGCCGAACTCG
TCGCCGCGATGCAGGACGCCCATGTCCTCGTGCCCACGGTCACCGACCGGATCGACGCCTCCATGATTGCCGAGGCAGGC
CCGCAACTCGGCCTCATCGCCAATTTCGGCGCCGGCACGGAACACATCGACCTTGCCGCCGCCCGTGCCCGCAAGATCAT
CGTCACCAATACGCCCGGCGTCTTTACCGACGACACGGCGGACATGACGATCGCCCTCATCATCTCGGTCACCCGCCGCC
TCAACTACGGCGGCCGCGTGCTGCGCGCGGGCAAGTGGGAAGGCTGGGCGCCTTCGACGATGCTCGGCCACCGCCTTGCG
GGCAAGACACTCGCCATAGTCGGCATGGGCCGCATCGGCCAGGCCGTCGCCCACCGCGCGCGCGCCTTCGGGCTCAATGT
CGCCTATCACAGCCGCCATCGCCTGCCCGAAGCGCTGGAGACGATGTTCGGCGCCCGCTATGTGGCCGATCTCGACACCC
TGGTGGCCGAGGCCGACATCCTCACCCTGCACTGCCCCGCCACGCCCGAAACCAGTCACCTGATCGACGCGCGCCGCATC
GCCCTGATGAAGCCCGAGTCCTATCTGGTGAACACCGCGCGCGGCCAGCTCGTCGAGGAAGAGGCGCTGATCGCCGCCCT
TTCCGAAGGCCGCATCGGCGGCGCCGGCCTCGACGTGTTCGAACATGAGCCCCAGGTCGATGCTCGTCTGCTCGCACATC
ACAACGTCGCGATCCTGCCGCACATGGGCAGCGCCACCTTCGAGGGCCGAATCGCCTCGGGCGACAAGGTCGTCGCCAAC
GTGCGCTTCTGGGCCGATGGCCACCGCCCGCCCGACCAGGTGCTCGAAGGACTGGTCTGA

Upstream 100 bases:

>100_bases
AAATGGCCCATCAGGGCAACACCCTGGTGCAGCCTGTCCACCGCCGCAGACGTACCCGCCGCTTGACCGCCTCCCGCCGC
TCGGCCTAGCTTGGCGCGGC

Downstream 100 bases:

>100_bases
CGCGCCGCGAACCAGGCCAGAAACTGGAACGCTTGCACCAGTACCCTTCGTTTCGCACAACAATCGTACGCACGTTCCCT
TGTACACGGCAGCATTGTTG

Product: glycolate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MPSSADYRPTRRVEGKPRVFVTRRLLPETEARMAELFDVVLNSDDRPLGRAELVAAMQDAHVLVPTVTDRIDASMIAEAG
PQLGLIANFGAGTEHIDLAAARARKIIVTNTPGVFTDDTADMTIALIISVTRRLNYGGRVLRAGKWEGWAPSTMLGHRLA
GKTLAIVGMGRIGQAVAHRARAFGLNVAYHSRHRLPEALETMFGARYVADLDTLVAEADILTLHCPATPETSHLIDARRI
ALMKPESYLVNTARGQLVEEEALIAALSEGRIGGAGLDVFEHEPQVDARLLAHHNVAILPHMGSATFEGRIASGDKVVAN
VRFWADGHRPPDQVLEGLV

Sequences:

>Translated_339_residues
MPSSADYRPTRRVEGKPRVFVTRRLLPETEARMAELFDVVLNSDDRPLGRAELVAAMQDAHVLVPTVTDRIDASMIAEAG
PQLGLIANFGAGTEHIDLAAARARKIIVTNTPGVFTDDTADMTIALIISVTRRLNYGGRVLRAGKWEGWAPSTMLGHRLA
GKTLAIVGMGRIGQAVAHRARAFGLNVAYHSRHRLPEALETMFGARYVADLDTLVAEADILTLHCPATPETSHLIDARRI
ALMKPESYLVNTARGQLVEEEALIAALSEGRIGGAGLDVFEHEPQVDARLLAHHNVAILPHMGSATFEGRIASGDKVVAN
VRFWADGHRPPDQVLEGLV
>Mature_338_residues
PSSADYRPTRRVEGKPRVFVTRRLLPETEARMAELFDVVLNSDDRPLGRAELVAAMQDAHVLVPTVTDRIDASMIAEAGP
QLGLIANFGAGTEHIDLAAARARKIIVTNTPGVFTDDTADMTIALIISVTRRLNYGGRVLRAGKWEGWAPSTMLGHRLAG
KTLAIVGMGRIGQAVAHRARAFGLNVAYHSRHRLPEALETMFGARYVADLDTLVAEADILTLHCPATPETSHLIDARRIA
LMKPESYLVNTARGQLVEEEALIAALSEGRIGGAGLDVFEHEPQVDARLLAHHNVAILPHMGSATFEGRIASGDKVVANV
RFWADGHRPPDQVLEGLV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=307, Percent_Identity=34.5276872964169, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI23308577, Length=274, Percent_Identity=33.5766423357664, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI61743967, Length=206, Percent_Identity=40.2912621359223, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4557497, Length=206, Percent_Identity=40.2912621359223, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI145580578, Length=245, Percent_Identity=36.734693877551, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI4557499, Length=245, Percent_Identity=36.734693877551, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=36.734693877551, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI87082289, Length=309, Percent_Identity=39.1585760517799, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=29.7297297297297, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789279, Length=281, Percent_Identity=29.8932384341637, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788660, Length=266, Percent_Identity=27.8195488721804, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081824, Length=145, Percent_Identity=33.1034482758621, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=277, Percent_Identity=33.2129963898917, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=226, Percent_Identity=30.9734513274336, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=258, Percent_Identity=36.4341085271318, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320925, Length=283, Percent_Identity=33.9222614840989, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=279, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=329, Percent_Identity=29.483282674772, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=32.2147651006711, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=212, Percent_Identity=31.6037735849057, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324980, Length=205, Percent_Identity=29.2682926829268, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571528, Length=332, Percent_Identity=36.7469879518072, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI45552429, Length=295, Percent_Identity=33.5593220338983, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI28574286, Length=297, Percent_Identity=33.3333333333333, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI45551003, Length=295, Percent_Identity=33.5593220338983, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI28574284, Length=295, Percent_Identity=33.5593220338983, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24585514, Length=295, Percent_Identity=33.5593220338983, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI28574282, Length=295, Percent_Identity=33.5593220338983, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24646446, Length=211, Percent_Identity=40.7582938388626, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24646448, Length=211, Percent_Identity=40.7582938388626, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24646452, Length=211, Percent_Identity=40.7582938388626, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24646450, Length=211, Percent_Identity=40.7582938388626, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI62472511, Length=206, Percent_Identity=41.2621359223301, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI19921140, Length=250, Percent_Identity=33.2, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=32.0158102766798, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36752; Mature: 36620

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSADYRPTRRVEGKPRVFVTRRLLPETEARMAELFDVVLNSDDRPLGRAELVAAMQDA
CCCCCCCCCCCCCCCCCCEEEEEHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
HVLVPTVTDRIDASMIAEAGPQLGLIANFGAGTEHIDLAAARARKIIVTNTPGVFTDDTA
EEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCEECCCC
DMTIALIISVTRRLNYGGRVLRAGKWEGWAPSTMLGHRLAGKTLAIVGMGRIGQAVAHRA
CHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHH
RAFGLNVAYHSRHRLPEALETMFGARYVADLDTLVAEADILTLHCPATPETSHLIDARRI
HHHEEEEEEHHHHCCHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHH
ALMKPESYLVNTARGQLVEEEALIAALSEGRIGGAGLDVFEHEPQVDARLLAHHNVAILP
EEECCHHHEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHCCCEEEEE
HMGSATFEGRIASGDKVVANVRFWADGHRPPDQVLEGLV
CCCCCCCCCEECCCCEEEEEEEEEECCCCCHHHHHCCCC
>Mature Secondary Structure 
PSSADYRPTRRVEGKPRVFVTRRLLPETEARMAELFDVVLNSDDRPLGRAELVAAMQDA
CCCCCCCCCCCCCCCCCEEEEEHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
HVLVPTVTDRIDASMIAEAGPQLGLIANFGAGTEHIDLAAARARKIIVTNTPGVFTDDTA
EEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCEECCCC
DMTIALIISVTRRLNYGGRVLRAGKWEGWAPSTMLGHRLAGKTLAIVGMGRIGQAVAHRA
CHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHH
RAFGLNVAYHSRHRLPEALETMFGARYVADLDTLVAEADILTLHCPATPETSHLIDARRI
HHHEEEEEEHHHHCCHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHH
ALMKPESYLVNTARGQLVEEEALIAALSEGRIGGAGLDVFEHEPQVDARLLAHHNVAILP
EEECCHHHEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHCCCEEEEE
HMGSATFEGRIASGDKVVANVRFWADGHRPPDQVLEGLV
CCCCCCCCCEECCCCEEEEEEEEEECCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA