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The map label for this gene is trpC

Identifier: 87200040

GI number: 87200040

Start: 2157759

End: 2158547

Strand: Direct

Name: trpC

Synonym: Saro_2024

Alternate gene names: 87200040

Gene position: 2157759-2158547 (Clockwise)

Preceding gene: 87200039

Following gene: 87200043

Centisome position: 60.58

GC content: 66.03

Gene sequence:

>789_bases
ATGACCGACAAGCTCACCGAAATCTGCGATACCAAGCGCAATGAAGTCGCCGCCCGCAAGGGCGCTGTCACCGTCAGCGA
ACTCACCGCCCGCGCCAGCGAACAGAGCGCGCCGCGCGGCTTCGAAAAAGCCCTGCGCGGCAAGGCCGCCGAAGGCTTCG
CGCTCATCGCCGAAATCAAGAAGGCCAGCCCCTCCAAGGGTCTGATCCGCCCGGATTTCCGTCCGGCCGATCACGCCCGC
GCCTATCAGGCCGGCGGCGCGGCCTGCCTCTCGGTCCTCACCGATGCACCCTATTTCCAGGGCCACGAGGATTTCCTCGT
CGAAGCGCGCGCAGCCTGCACGCTCCCGGTGATCCGCAAGGATTTCATGGTCGATCCATGGCAGTGCCTTGAAGCGCGCG
CCATCGGCGCCGACGCCATCCTCATCATCGTCGCCGCCCTGTCCGACCAGCAGATGGCCGAAATCGAGGCCGCGGCCCTC
GAACAGGGCATGGATGCACTTGTCGAAGTCCACAACGAGGAAGAGATGGAGCGCGCCGCCCGCCTGCGGTCGCGCCTGAT
CGGGGTCAACAACCGCGATCTCAAGCGCTTCGTGACCGACCTCGCCACGACCGAACGCCTCGCCCCCCTCGCTCCGGATG
GCACCCTGCTGGTTGCCGAAAGCGGTATCAACACCCACGCCGACTTGCTTCGCCTCGAAAAGTGCGGCGCCCGCACGTTT
CTCGTCGGCGAAAGCCTGATGCGCCAGGCCGACGTCGAAGCGGCAACGCGCGGACTGTTGTTCGGTTAG

Upstream 100 bases:

>100_bases
AATAGTGTCCCCGTCGCCATTCATGTCGAGCGGAGTCGAGGCACACTGGCGCAAATCGGTTCTCGACTTCGCGCGAACCC
GGCGGCAAAGGGGGATCGCA

Downstream 100 bases:

>100_bases
TTCAGGCGCACCGGTCCGGCCCCCTGCTCCGCGTCGAGCAGTCGCTGGACCTGCCGGTAGAACGCCTCGCGCTCCTCGGG
TTGCGGCCCTGCGCTGGCGC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MTDKLTEICDTKRNEVAARKGAVTVSELTARASEQSAPRGFEKALRGKAAEGFALIAEIKKASPSKGLIRPDFRPADHAR
AYQAGGAACLSVLTDAPYFQGHEDFLVEARAACTLPVIRKDFMVDPWQCLEARAIGADAILIIVAALSDQQMAEIEAAAL
EQGMDALVEVHNEEEMERAARLRSRLIGVNNRDLKRFVTDLATTERLAPLAPDGTLLVAESGINTHADLLRLEKCGARTF
LVGESLMRQADVEAATRGLLFG

Sequences:

>Translated_262_residues
MTDKLTEICDTKRNEVAARKGAVTVSELTARASEQSAPRGFEKALRGKAAEGFALIAEIKKASPSKGLIRPDFRPADHAR
AYQAGGAACLSVLTDAPYFQGHEDFLVEARAACTLPVIRKDFMVDPWQCLEARAIGADAILIIVAALSDQQMAEIEAAAL
EQGMDALVEVHNEEEMERAARLRSRLIGVNNRDLKRFVTDLATTERLAPLAPDGTLLVAESGINTHADLLRLEKCGARTF
LVGESLMRQADVEAATRGLLFG
>Mature_261_residues
TDKLTEICDTKRNEVAARKGAVTVSELTARASEQSAPRGFEKALRGKAAEGFALIAEIKKASPSKGLIRPDFRPADHARA
YQAGGAACLSVLTDAPYFQGHEDFLVEARAACTLPVIRKDFMVDPWQCLEARAIGADAILIIVAALSDQQMAEIEAAALE
QGMDALVEVHNEEEMERAARLRSRLIGVNNRDLKRFVTDLATTERLAPLAPDGTLLVAESGINTHADLLRLEKCGARTFL
VGESLMRQADVEAATRGLLFG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=262, Percent_Identity=40.8396946564886, Blast_Score=168, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=208, Percent_Identity=40.8653846153846, Blast_Score=148, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_NOVAD (Q2G6R0)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497297.1
- HSSP:   Q56319
- ProteinModelPortal:   Q2G6R0
- SMR:   Q2G6R0
- STRING:   Q2G6R0
- GeneID:   3917345
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_2024
- NMPDR:   fig|48935.1.peg.2291
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- ProtClustDB:   PRK00278
- BioCyc:   NARO279238:SARO_2024-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28344; Mature: 28213

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKLTEICDTKRNEVAARKGAVTVSELTARASEQSAPRGFEKALRGKAAEGFALIAEIK
CCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHH
KASPSKGLIRPDFRPADHARAYQAGGAACLSVLTDAPYFQGHEDFLVEARAACTLPVIRK
HCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
DFMVDPWQCLEARAIGADAILIIVAALSDQQMAEIEAAALEQGMDALVEVHNEEEMERAA
HHCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RLRSRLIGVNNRDLKRFVTDLATTERLAPLAPDGTLLVAESGINTHADLLRLEKCGARTF
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEE
LVGESLMRQADVEAATRGLLFG
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDKLTEICDTKRNEVAARKGAVTVSELTARASEQSAPRGFEKALRGKAAEGFALIAEIK
CCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHH
KASPSKGLIRPDFRPADHARAYQAGGAACLSVLTDAPYFQGHEDFLVEARAACTLPVIRK
HCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
DFMVDPWQCLEARAIGADAILIIVAALSDQQMAEIEAAALEQGMDALVEVHNEEEMERAA
HHCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RLRSRLIGVNNRDLKRFVTDLATTERLAPLAPDGTLLVAESGINTHADLLRLEKCGARTF
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEE
LVGESLMRQADVEAATRGLLFG
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA