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The map label for this gene is edd [H]

Identifier: 87199912

GI number: 87199912

Start: 2007263

End: 2009083

Strand: Direct

Name: edd [H]

Synonym: Saro_1895

Alternate gene names: 87199912

Gene position: 2007263-2009083 (Clockwise)

Preceding gene: 87199911

Following gene: 87199913

Centisome position: 56.36

GC content: 65.62

Gene sequence:

>1821_bases
ATGGCGATGAACCCAACTGTCGAGCGCGTCACCCAGCGCATCATCGAGCGTTCGCGCAGCACCCGCGCCGCATATCTCGA
TCTTGTGGAACGTTCGCGCGACCAGGGGCTCAACCGGCCCAGGCTTTCGTGCGGCAACCTGGCCCACGGCTTTGCCGCAT
CGGGCGAGGACAAGCCGGCGATCAAGTCGGGCAAGGCGATGAACATCGGCATCGTCACTGCCTACAACGATATGCTTTCG
GCGCATCAGCCGTATGGCCGCTATCCCGAGCAGATCAAGATATTCGCCCGGGAAGTGGGCGCGACGGCGCAGGTTGCAGG
CGGCGTTCCAGCGATGTGCGATGGCGTCACGCAGGGCCAGGATTCGATGGAGCTGTCGCTCTTCAGCCGCGACGTGATCG
CAATGGCGACGACAGTCGGGCTAAGCCACGCCATGTTCGAAGGCGCGCTCCTGCTCGGAATCTGCGACAAGATCGTGCCC
GGGCTGCTGATCGGCAGCCTGCGCTTTGGCCACCTGCCGACCATTCTCGTGCCGGCGGGCCCCATGCCGACAGGCCTTCC
CAACAAGGAGAAGGTCCGTATCCGCCAGCTATATGCAGAGGGCAAGGTCGGTCGCGACGAACTGCTCGAAAGCGAGAGCG
CCAGCTATCACTCCGCCGGCACGTGCACCTTCTATGGCACGGCCAACTCCAACCAGATGATGATGGAGATGATGGGGCTG
CACATGCCCGGCTCCAGCTTCGTCCTGCCCGGCACGAAGATCCGTCAGGAACTGACGCGGGCGGCGACGCATCGCATCGC
CCAGATTGGTTGGGATGGCGACGATTATCGTCCTCTCGGCAGGTGCGTCGACGAGAAGGCCATCGTCAATGCGATCGTCG
GCCTGCTGGCAACAGGTGGCTCGACCAACCACGTGATCCACCTGCCGGCCATCGCGCGGGCCGCCGGCATCCAGATAGAC
TGGAACGACATGGACGACCTGTCGCGCGTCGTCCCGCTTATCGCCAGCGTCTATCCCAATGGCGCGGGCGACGTGAACTA
CTTCGCAGCGGCGGGCGGCATGCCCTATGTGATCCGCGAGCTGATCGGGTCCGGCCTTGCCCATCCGGATATCCTGACGG
TCTACGGCCAGTCGCTGGAGGAAGGCGCCCAGCAGCCTGTCATGGAAGGCGACAACCTGCGCTGGGATCCGGCGCCCGAG
GTTTCGGGAGACGACAGCATGCTGCGCCCTGTTTCGGCGCCGTTCCAGCCCGAAGGCGGCTTCAGGTTGCTGAAAGGCAA
CCTCGGCCGGGGTACGATCAAGGTCAGCGCGGTCGATCCCTCACGCTGGACGATCGAGGCGCCTTGCCGGGTGTTCGAGG
ACCAAAATGCCGTGCTCGACGCGTTCAAGGCCGGCGAACTGGAGCGTGACGTCATCGTTGTCGTACGCTTCCAGGGGCCT
GCCGCAAACGGCATGCCCGAACTGCACAAGCTGACCCCGCCGCTTGGCGTCCTGCAGGATCGCGGGTTCAAGGTCGCGCT
CGTCACCGATGGCCGTATGTCGGGCGCTTCGGGCAAGGTGCCTGCCGCAATCCATGTCTCGCCCGAAGCCAAGCTCGGTG
GCCCGCTGGCAAGGCTGCGCGACGGCGACGTGGTGCGGGTATGCGCCAACAGCGGCGAGCTTGTCGCGGTCGTGCCCGCC
GAGGAGTGGAGCGCGCGCGAGGAAGCAGTTGCCCCGGCTAGTGCTCCCGGCGTAGGCCGCGAACTCTTCGCGCTCATGCG
GCAGCATTCCGATCCCGCCGAGCGCGGCGGATCGGCGATGCTCGCGGCGGCGGGGCTCTGA

Upstream 100 bases:

>100_bases
AGGCGCTGCTTGAGCGCGTCATTGCCGGCGACGATGGCTATCCCGTCGCCGATTTCCTGCGTGGCTATGGCCCGCCGGTC
ACGATCTACTGGAGCGAATG

Downstream 100 bases:

>100_bases
AGGATATATCCATCCGGCTGACAGAGGCCGATCTGGGGGACAGGATGCAGGTAGTTGCCGTCGATATTGGCGGAACCCAC
GCCCGCTTCGCGATTGCCGA

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MAMNPTVERVTQRIIERSRSTRAAYLDLVERSRDQGLNRPRLSCGNLAHGFAASGEDKPAIKSGKAMNIGIVTAYNDMLS
AHQPYGRYPEQIKIFAREVGATAQVAGGVPAMCDGVTQGQDSMELSLFSRDVIAMATTVGLSHAMFEGALLLGICDKIVP
GLLIGSLRFGHLPTILVPAGPMPTGLPNKEKVRIRQLYAEGKVGRDELLESESASYHSAGTCTFYGTANSNQMMMEMMGL
HMPGSSFVLPGTKIRQELTRAATHRIAQIGWDGDDYRPLGRCVDEKAIVNAIVGLLATGGSTNHVIHLPAIARAAGIQID
WNDMDDLSRVVPLIASVYPNGAGDVNYFAAAGGMPYVIRELIGSGLAHPDILTVYGQSLEEGAQQPVMEGDNLRWDPAPE
VSGDDSMLRPVSAPFQPEGGFRLLKGNLGRGTIKVSAVDPSRWTIEAPCRVFEDQNAVLDAFKAGELERDVIVVVRFQGP
AANGMPELHKLTPPLGVLQDRGFKVALVTDGRMSGASGKVPAAIHVSPEAKLGGPLARLRDGDVVRVCANSGELVAVVPA
EEWSAREEAVAPASAPGVGRELFALMRQHSDPAERGGSAMLAAAGL

Sequences:

>Translated_606_residues
MAMNPTVERVTQRIIERSRSTRAAYLDLVERSRDQGLNRPRLSCGNLAHGFAASGEDKPAIKSGKAMNIGIVTAYNDMLS
AHQPYGRYPEQIKIFAREVGATAQVAGGVPAMCDGVTQGQDSMELSLFSRDVIAMATTVGLSHAMFEGALLLGICDKIVP
GLLIGSLRFGHLPTILVPAGPMPTGLPNKEKVRIRQLYAEGKVGRDELLESESASYHSAGTCTFYGTANSNQMMMEMMGL
HMPGSSFVLPGTKIRQELTRAATHRIAQIGWDGDDYRPLGRCVDEKAIVNAIVGLLATGGSTNHVIHLPAIARAAGIQID
WNDMDDLSRVVPLIASVYPNGAGDVNYFAAAGGMPYVIRELIGSGLAHPDILTVYGQSLEEGAQQPVMEGDNLRWDPAPE
VSGDDSMLRPVSAPFQPEGGFRLLKGNLGRGTIKVSAVDPSRWTIEAPCRVFEDQNAVLDAFKAGELERDVIVVVRFQGP
AANGMPELHKLTPPLGVLQDRGFKVALVTDGRMSGASGKVPAAIHVSPEAKLGGPLARLRDGDVVRVCANSGELVAVVPA
EEWSAREEAVAPASAPGVGRELFALMRQHSDPAERGGSAMLAAAGL
>Mature_605_residues
AMNPTVERVTQRIIERSRSTRAAYLDLVERSRDQGLNRPRLSCGNLAHGFAASGEDKPAIKSGKAMNIGIVTAYNDMLSA
HQPYGRYPEQIKIFAREVGATAQVAGGVPAMCDGVTQGQDSMELSLFSRDVIAMATTVGLSHAMFEGALLLGICDKIVPG
LLIGSLRFGHLPTILVPAGPMPTGLPNKEKVRIRQLYAEGKVGRDELLESESASYHSAGTCTFYGTANSNQMMMEMMGLH
MPGSSFVLPGTKIRQELTRAATHRIAQIGWDGDDYRPLGRCVDEKAIVNAIVGLLATGGSTNHVIHLPAIARAAGIQIDW
NDMDDLSRVVPLIASVYPNGAGDVNYFAAAGGMPYVIRELIGSGLAHPDILTVYGQSLEEGAQQPVMEGDNLRWDPAPEV
SGDDSMLRPVSAPFQPEGGFRLLKGNLGRGTIKVSAVDPSRWTIEAPCRVFEDQNAVLDAFKAGELERDVIVVVRFQGPA
ANGMPELHKLTPPLGVLQDRGFKVALVTDGRMSGASGKVPAAIHVSPEAKLGGPLARLRDGDVVRVCANSGELVAVVPAE
EWSAREEAVAPASAPGVGRELFALMRQHSDPAERGGSAMLAAAGL

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=601, Percent_Identity=58.7354409317804, Blast_Score=715, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=551, Percent_Identity=28.8566243194192, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1786464, Length=514, Percent_Identity=31.7120622568093, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI2367371, Length=539, Percent_Identity=30.0556586270872, Blast_Score=163, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322476, Length=481, Percent_Identity=29.7297297297297, Blast_Score=174, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64478; Mature: 64346

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMNPTVERVTQRIIERSRSTRAAYLDLVERSRDQGLNRPRLSCGNLAHGFAASGEDKPA
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
IKSGKAMNIGIVTAYNDMLSAHQPYGRYPEQIKIFAREVGATAQVAGGVPAMCDGVTQGQ
CCCCCEEEEEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHCCCCCHHHCCCCCCC
DSMELSLFSRDVIAMATTVGLSHAMFEGALLLGICDKIVPGLLIGSLRFGHLPTILVPAG
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
PMPTGLPNKEKVRIRQLYAEGKVGRDELLESESASYHSAGTCTFYGTANSNQMMMEMMGL
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHCC
HMPGSSFVLPGTKIRQELTRAATHRIAQIGWDGDDYRPLGRCVDEKAIVNAIVGLLATGG
CCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
STNHVIHLPAIARAAGIQIDWNDMDDLSRVVPLIASVYPNGAGDVNYFAAAGGMPYVIRE
CCCEEEECCHHHHHHCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHH
LIGSGLAHPDILTVYGQSLEEGAQQPVMEGDNLRWDPAPEVSGDDSMLRPVSAPFQPEGG
HHHCCCCCCCHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCC
FRLLKGNLGRGTIKVSAVDPSRWTIEAPCRVFEDQNAVLDAFKAGELERDVIVVVRFQGP
CEEEECCCCCCEEEEEEECCCCEEEECCHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCC
AANGMPELHKLTPPLGVLQDRGFKVALVTDGRMSGASGKVPAAIHVSPEAKLGGPLARLR
CCCCCCHHHHCCCCHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHCC
DGDVVRVCANSGELVAVVPAEEWSAREEAVAPASAPGVGRELFALMRQHSDPAERGGSAM
CCCEEEEECCCCCEEEEEECHHHCCHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHCCCEE
LAAAGL
EEECCC
>Mature Secondary Structure 
AMNPTVERVTQRIIERSRSTRAAYLDLVERSRDQGLNRPRLSCGNLAHGFAASGEDKPA
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
IKSGKAMNIGIVTAYNDMLSAHQPYGRYPEQIKIFAREVGATAQVAGGVPAMCDGVTQGQ
CCCCCEEEEEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHCCCCCHHHCCCCCCC
DSMELSLFSRDVIAMATTVGLSHAMFEGALLLGICDKIVPGLLIGSLRFGHLPTILVPAG
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
PMPTGLPNKEKVRIRQLYAEGKVGRDELLESESASYHSAGTCTFYGTANSNQMMMEMMGL
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHCC
HMPGSSFVLPGTKIRQELTRAATHRIAQIGWDGDDYRPLGRCVDEKAIVNAIVGLLATGG
CCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
STNHVIHLPAIARAAGIQIDWNDMDDLSRVVPLIASVYPNGAGDVNYFAAAGGMPYVIRE
CCCEEEECCHHHHHHCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHH
LIGSGLAHPDILTVYGQSLEEGAQQPVMEGDNLRWDPAPEVSGDDSMLRPVSAPFQPEGG
HHHCCCCCCCHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCC
FRLLKGNLGRGTIKVSAVDPSRWTIEAPCRVFEDQNAVLDAFKAGELERDVIVVVRFQGP
CEEEECCCCCCEEEEEEECCCCEEEECCHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCC
AANGMPELHKLTPPLGVLQDRGFKVALVTDGRMSGASGKVPAAIHVSPEAKLGGPLARLR
CCCCCCHHHHCCCCHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHCC
DGDVVRVCANSGELVAVVPAEEWSAREEAVAPASAPGVGRELFALMRQHSDPAERGGSAM
CCCEEEEECCCCCEEEEEECHHHCCHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHCCCEE
LAAAGL
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254282 [H]