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The map label for this gene is gcvPA

Identifier: 87199869

GI number: 87199869

Start: 1951422

End: 1952780

Strand: Direct

Name: gcvPA

Synonym: Saro_1852

Alternate gene names: 87199869

Gene position: 1951422-1952780 (Clockwise)

Preceding gene: 87199868

Following gene: 87199870

Centisome position: 54.79

GC content: 67.03

Gene sequence:

>1359_bases
ATGCGTTATCTTCCCCTGACCGACGCCGACCGGAGCGCCATGCTCTCGGTCGTCGGCGCGGGTTCCGTCGACGAGCTGTT
CGCCGACGTTCCCGCCGAAGCGCGGCTTTCCGCGCCCATCGCCGGCCTGCCGAACCATGCCAGCGAGATGGCGGTCGAGC
GCCACATGGCGCGCCTTTCCGCCAACAACGTGACGGCCGGATCGGTGCCGTTCTTCCTCGGCGCTGGCGCTTATCGCCAC
CATGTCCCCGCCACCGTCGATCACATGATCCAGCGCGGCGAGTTCCTGACGGCATACACGCCCTACCAGCCCGAAATCGC
GCAAGGCACGCTCCAGGTCCTGTTCGAGTTCCAGACCCAGGTCGCGCGGCTGTTCGGCACCGATGTCGCCAACGCATCGC
TCTATGATGGCTCGACCGCGTGCTGGGAAGCGATTGCCATGGCAGGCCGCATCACCAAGCGCGGCAAGGCCCTGCTTTCG
GGCGGCCTGCACCCGCACTATGTCGAGACCGCGCGGACGATGGCCAGGTTCACCGGCGACGTTCTGGATACCAGCGCACC
GGTGCTTACCGCCGCGCCCGATGACGATGCGCTCGTCGCCAGGATCGATGGCGAGACTTCCTGCGTCGTCGTGCAGTACC
CGGACATTCTGGGACGCATCCCCGACCTGGCGAAGATCGCAGCCGCCGCGCAGGCGCAAGGCGCGCTTCTGATCACGGTC
GTCACCGAACCCGTCGCCCTTGGCGTCCTGCAAAGCCCGGGCAGCCTCGGCGCGGACATCGTCGTGGGCGAGGGGCAGTC
GCTTGGCGTCGGCCTCCAGTTCGGCGGGCCCTACCTTGGCCTGTTCGGTTGTCGCGAGAAGTACCTGCGCCAGATCCCGG
GCCGCCTCTGCGGCGAAACCGTGGATGCCGACGGCAAGCGAGGCTTCGTGCTTACGCTTTCCACGCGCGAGCAGCATATC
CGCCGCGAGAAGGCGACGAGCAACATCTGCACCAACTCCGGCCTTTGCGCGCTGGCGTTCTCGATCCACCTGACGCTGCT
TGGCGGTTCGGGCCTCGCCGACATGGCAAGGCTCAGCCACCTTGCCGCGCGCAAGACGGCGGCGGCGCTGGCGCAGGTAT
CCGGGATCGAAGTGGTCAACAGCCATTTCTTCAACGAGTTCACCGTGGCGCTGCCACACGACGCGCGGCAGATTGTCCGC
GATCTTGCCGACCGGCATGTCCTCGGCGGCGTTTCGCTCGGCCGTCTCTATCCACAGGAAGCGGCGCTGGCGAACGGCAT
GGTCGTTGCCGCCACCGAATGCACGACGGACGAGGATATCGCGGCCCTTGTTGCCGCGCTGAAGGAGGTGCTGGCATGA

Upstream 100 bases:

>100_bases
GAGGGCTGGCTGTGGAAGATGACCCTGGCCGATGCCGCCGAACTCGACGGCCTGATGGACGAGGCTGCCTATCAGGCCTA
CGTCGCGGAGCTTTGACACG

Downstream 100 bases:

>100_bases
ACGCGATCAACCCCACCGGTTGGCGCCCTTCGATGGGCGAGAACGTGCCTGCAGGCGGCGTCCAGACCTTTACCGGCAAC
CGCGCGTTGCAACTCGAGGA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MRYLPLTDADRSAMLSVVGAGSVDELFADVPAEARLSAPIAGLPNHASEMAVERHMARLSANNVTAGSVPFFLGAGAYRH
HVPATVDHMIQRGEFLTAYTPYQPEIAQGTLQVLFEFQTQVARLFGTDVANASLYDGSTACWEAIAMAGRITKRGKALLS
GGLHPHYVETARTMARFTGDVLDTSAPVLTAAPDDDALVARIDGETSCVVVQYPDILGRIPDLAKIAAAAQAQGALLITV
VTEPVALGVLQSPGSLGADIVVGEGQSLGVGLQFGGPYLGLFGCREKYLRQIPGRLCGETVDADGKRGFVLTLSTREQHI
RREKATSNICTNSGLCALAFSIHLTLLGGSGLADMARLSHLAARKTAAALAQVSGIEVVNSHFFNEFTVALPHDARQIVR
DLADRHVLGGVSLGRLYPQEAALANGMVVAATECTTDEDIAALVAALKEVLA

Sequences:

>Translated_452_residues
MRYLPLTDADRSAMLSVVGAGSVDELFADVPAEARLSAPIAGLPNHASEMAVERHMARLSANNVTAGSVPFFLGAGAYRH
HVPATVDHMIQRGEFLTAYTPYQPEIAQGTLQVLFEFQTQVARLFGTDVANASLYDGSTACWEAIAMAGRITKRGKALLS
GGLHPHYVETARTMARFTGDVLDTSAPVLTAAPDDDALVARIDGETSCVVVQYPDILGRIPDLAKIAAAAQAQGALLITV
VTEPVALGVLQSPGSLGADIVVGEGQSLGVGLQFGGPYLGLFGCREKYLRQIPGRLCGETVDADGKRGFVLTLSTREQHI
RREKATSNICTNSGLCALAFSIHLTLLGGSGLADMARLSHLAARKTAAALAQVSGIEVVNSHFFNEFTVALPHDARQIVR
DLADRHVLGGVSLGRLYPQEAALANGMVVAATECTTDEDIAALVAALKEVLA
>Mature_452_residues
MRYLPLTDADRSAMLSVVGAGSVDELFADVPAEARLSAPIAGLPNHASEMAVERHMARLSANNVTAGSVPFFLGAGAYRH
HVPATVDHMIQRGEFLTAYTPYQPEIAQGTLQVLFEFQTQVARLFGTDVANASLYDGSTACWEAIAMAGRITKRGKALLS
GGLHPHYVETARTMARFTGDVLDTSAPVLTAAPDDDALVARIDGETSCVVVQYPDILGRIPDLAKIAAAAQAQGALLITV
VTEPVALGVLQSPGSLGADIVVGEGQSLGVGLQFGGPYLGLFGCREKYLRQIPGRLCGETVDADGKRGFVLTLSTREQHI
RREKATSNICTNSGLCALAFSIHLTLLGGSGLADMARLSHLAARKTAAALAQVSGIEVVNSHFFNEFTVALPHDARQIVR
DLADRHVLGGVSLGRLYPQEAALANGMVVAATECTTDEDIAALVAALKEVLA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=408, Percent_Identity=34.3137254901961, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1789269, Length=399, Percent_Identity=33.3333333333333, Blast_Score=174, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17535605, Length=396, Percent_Identity=35.3535353535354, Blast_Score=200, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323843, Length=404, Percent_Identity=33.1683168316832, Blast_Score=190, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24645648, Length=408, Percent_Identity=37.7450980392157, Blast_Score=228, Evalue=6e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_NOVAD (Q2G781)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497126.1
- ProteinModelPortal:   Q2G781
- SMR:   Q2G781
- STRING:   Q2G781
- GeneID:   3918414
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1852
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   NARO279238:SARO_1852-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 47593; Mature: 47593

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLPLTDADRSAMLSVVGAGSVDELFADVPAEARLSAPIAGLPNHASEMAVERHMARLS
CCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHH
ANNVTAGSVPFFLGAGAYRHHVPATVDHMIQRGEFLTAYTPYQPEIAQGTLQVLFEFQTQ
CCCCCCCCCCHHHCCCCHHCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHH
VARLFGTDVANASLYDGSTACWEAIAMAGRITKRGKALLSGGLHPHYVETARTMARFTGD
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHH
VLDTSAPVLTAAPDDDALVARIDGETSCVVVQYPDILGRIPDLAKIAAAAQAQGALLITV
HHCCCCCEEEECCCCCCEEEEECCCCCEEEEECCHHHCCCCHHHHHHHHHHCCCCEEEEE
VTEPVALGVLQSPGSLGADIVVGEGQSLGVGLQFGGPYLGLFGCREKYLRQIPGRLCGET
ECCCHHHHEECCCCCCCCEEEEECCCCEEEEEEECCCEEHHHHHHHHHHHHCCHHHCCCC
VDADGKRGFVLTLSTREQHIRREKATSNICTNSGLCALAFSIHLTLLGGSGLADMARLSH
CCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHEEEEEEEEEEECCCCHHHHHHHHH
LAARKTAAALAQVSGIEVVNSHFFNEFTVALPHDARQIVRDLADRHVLGGVSLGRLYPQE
HHHHHHHHHHHHHCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHEECCCHHHHCCCHH
AALANGMVVAATECTTDEDIAALVAALKEVLA
HHHHCCEEEEEECCCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MRYLPLTDADRSAMLSVVGAGSVDELFADVPAEARLSAPIAGLPNHASEMAVERHMARLS
CCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHH
ANNVTAGSVPFFLGAGAYRHHVPATVDHMIQRGEFLTAYTPYQPEIAQGTLQVLFEFQTQ
CCCCCCCCCCHHHCCCCHHCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHH
VARLFGTDVANASLYDGSTACWEAIAMAGRITKRGKALLSGGLHPHYVETARTMARFTGD
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHH
VLDTSAPVLTAAPDDDALVARIDGETSCVVVQYPDILGRIPDLAKIAAAAQAQGALLITV
HHCCCCCEEEECCCCCCEEEEECCCCCEEEEECCHHHCCCCHHHHHHHHHHCCCCEEEEE
VTEPVALGVLQSPGSLGADIVVGEGQSLGVGLQFGGPYLGLFGCREKYLRQIPGRLCGET
ECCCHHHHEECCCCCCCCEEEEECCCCEEEEEEECCCEEHHHHHHHHHHHHCCHHHCCCC
VDADGKRGFVLTLSTREQHIRREKATSNICTNSGLCALAFSIHLTLLGGSGLADMARLSH
CCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHEEEEEEEEEEECCCCHHHHHHHHH
LAARKTAAALAQVSGIEVVNSHFFNEFTVALPHDARQIVRDLADRHVLGGVSLGRLYPQE
HHHHHHHHHHHHHCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHEECCCHHHHCCCHH
AALANGMVVAATECTTDEDIAALVAALKEVLA
HHHHCCEEEEEECCCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA