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The map label for this gene is gcvPB [H]

Identifier: 87199870

GI number: 87199870

Start: 1952777

End: 1954336

Strand: Direct

Name: gcvPB [H]

Synonym: Saro_1853

Alternate gene names: 87199870

Gene position: 1952777-1954336 (Clockwise)

Preceding gene: 87199869

Following gene: 87199872

Centisome position: 54.83

GC content: 67.44

Gene sequence:

>1560_bases
ATGAACGCGATCAACCCCACCGGTTGGCGCCCTTCGATGGGCGAGAACGTGCCTGCAGGCGGCGTCCAGACCTTTACCGG
CAACCGCGCGTTGCAACTCGAGGAAGCGCTCATCTTCGAACTCGGCCAGGCCGACCGTTCGGGCGTGGACTTCCCCGAAA
CGGACGGGATCGACCTTTCCGCGCTGGGCCCGCTCGCCCGCGCTGAACGGCCGGACCTGCCGGGCCTGTCGGAGCCGGAG
GCCGTGCGCCACTACACCCGCCTTTCGCGCCAGAACTATGCGATCGATCTCGGGCTGTTTCCGCTCGGCTCGTGCACGAT
GAAGCACAATCCGCGCCTTGATGAAAAGGTCGCGCGCATGCCCGGCTTTGCCGATGTCCACCCGCTTCAGCCCGTCCAGA
CGGTGCAGGGCGCGCTTGGCGTCATCAACGAGCTGGCGCATTGGCTGATCGAACTGACCGGCATGCACGGCGTCGCCATG
ACGCCCAAGGCCGGTGCCCACGGCGAGCTGTGCGGGCTGCTGTGCATCCGCGCCGCGCTGGAAGCGAAGGGCGATCCGCG
CAACGTGATCCTTGTTCCCGAAAGCGCGCACGGCACCAACCCCGCCACCGCCGCCTTCGCCGGGTTCAAGGTCGAGAACA
TCCCAGCCACGCCCGATGGCCGCGTCGATACCGCCGCGCTCACCGCGCGCCTGGGGCCGGACATCGCCGGGGTGATGATC
ACCAACCCCAACACCTGTGGCCTGTTCGAGCGCGATCTCAAGGTCATTGCCGATGCGGTCCATGCCGCGGGCGGCTATGT
CTATTGCGACGGTGCGAACTTCAACGCGATCGTCGGGCGCGTTCGTCCGGGCGATCTCGGCGTCGACGCGATGCATATCA
ACCTGCACAAGACCTTCTCGACGCCCCACGGCGGCGGCGGTCCGGGTTCGGGACCGGTGGTCCTTTCCGAAGCGCTTTCG
CCCTTTGGTCCGTTGCCGTTCACGGCGCGGCAGGCGGACGGTTCGATCCGGCTGATCGAGGAGGAACACGCGCATGAGGA
ACACCCCCAGGCTTTCGGCCGGATGTGCGCGTTCCACGGCCAGATGGGCATGTTCACCCGTGCGCTCGCCTATATCCTGA
GCCACGGAGCGGACGGACTGCGCCAGGTTTCGGGCGATGCCGTGCTCAACGCCAACTATGTCCTGCGCAGCCTCGACGAC
GTTCTCGATGCTCCGTTCGGCGCGGCGGGCCCGTGCATGCACGAGGCATTGTTCTCGGACGACGGCTTTGCCGAAGGCTT
CTCGACGCTCGATCTTGCCAAGGGCCTGATCGACGAGGGCTATCACCCGATGACGGTGTACTTCCCGCTGGTCGTCCACG
GCGCGATGCTGGTTGAGCCGACCGAGACCGAGAGCAAGGCCGGGCTCGACCAGTTCATCGGCGCAATGCGCTCGCTGGCC
GAACGCGCGCGGGCAGGGGACGAGGCGCTCAAGTCGGCGCCGCATCTCGCGCCCCGGCGCCGGCTCGACGAAACGCTGGC
GGCGCGCAAGCCCAGGCTGGTCTGGTCCAGCCAGGCCTGA

Upstream 100 bases:

>100_bases
AGGAAGCGGCGCTGGCGAACGGCATGGTCGTTGCCGCCACCGAATGCACGACGGACGAGGATATCGCGGCCCTTGTTGCC
GCGCTGAAGGAGGTGCTGGC

Downstream 100 bases:

>100_bases
ACGACCTGACGGGAACGGAAAAGGGCCGCCCCGGCTTGCCGGGACGGCCCTTGTTTCCTGTCGGCATCTTGCCGGCGTCA
GTTGATGGCTTCCTCGCCTG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MNAINPTGWRPSMGENVPAGGVQTFTGNRALQLEEALIFELGQADRSGVDFPETDGIDLSALGPLARAERPDLPGLSEPE
AVRHYTRLSRQNYAIDLGLFPLGSCTMKHNPRLDEKVARMPGFADVHPLQPVQTVQGALGVINELAHWLIELTGMHGVAM
TPKAGAHGELCGLLCIRAALEAKGDPRNVILVPESAHGTNPATAAFAGFKVENIPATPDGRVDTAALTARLGPDIAGVMI
TNPNTCGLFERDLKVIADAVHAAGGYVYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFSTPHGGGGPGSGPVVLSEALS
PFGPLPFTARQADGSIRLIEEEHAHEEHPQAFGRMCAFHGQMGMFTRALAYILSHGADGLRQVSGDAVLNANYVLRSLDD
VLDAPFGAAGPCMHEALFSDDGFAEGFSTLDLAKGLIDEGYHPMTVYFPLVVHGAMLVEPTETESKAGLDQFIGAMRSLA
ERARAGDEALKSAPHLAPRRRLDETLAARKPRLVWSSQA

Sequences:

>Translated_519_residues
MNAINPTGWRPSMGENVPAGGVQTFTGNRALQLEEALIFELGQADRSGVDFPETDGIDLSALGPLARAERPDLPGLSEPE
AVRHYTRLSRQNYAIDLGLFPLGSCTMKHNPRLDEKVARMPGFADVHPLQPVQTVQGALGVINELAHWLIELTGMHGVAM
TPKAGAHGELCGLLCIRAALEAKGDPRNVILVPESAHGTNPATAAFAGFKVENIPATPDGRVDTAALTARLGPDIAGVMI
TNPNTCGLFERDLKVIADAVHAAGGYVYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFSTPHGGGGPGSGPVVLSEALS
PFGPLPFTARQADGSIRLIEEEHAHEEHPQAFGRMCAFHGQMGMFTRALAYILSHGADGLRQVSGDAVLNANYVLRSLDD
VLDAPFGAAGPCMHEALFSDDGFAEGFSTLDLAKGLIDEGYHPMTVYFPLVVHGAMLVEPTETESKAGLDQFIGAMRSLA
ERARAGDEALKSAPHLAPRRRLDETLAARKPRLVWSSQA
>Mature_519_residues
MNAINPTGWRPSMGENVPAGGVQTFTGNRALQLEEALIFELGQADRSGVDFPETDGIDLSALGPLARAERPDLPGLSEPE
AVRHYTRLSRQNYAIDLGLFPLGSCTMKHNPRLDEKVARMPGFADVHPLQPVQTVQGALGVINELAHWLIELTGMHGVAM
TPKAGAHGELCGLLCIRAALEAKGDPRNVILVPESAHGTNPATAAFAGFKVENIPATPDGRVDTAALTARLGPDIAGVMI
TNPNTCGLFERDLKVIADAVHAAGGYVYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFSTPHGGGGPGSGPVVLSEALS
PFGPLPFTARQADGSIRLIEEEHAHEEHPQAFGRMCAFHGQMGMFTRALAYILSHGADGLRQVSGDAVLNANYVLRSLDD
VLDAPFGAAGPCMHEALFSDDGFAEGFSTLDLAKGLIDEGYHPMTVYFPLVVHGAMLVEPTETESKAGLDQFIGAMRSLA
ERARAGDEALKSAPHLAPRRRLDETLAARKPRLVWSSQA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=435, Percent_Identity=39.0804597701149, Blast_Score=242, Evalue=8e-64,
Organism=Escherichia coli, GI1789269, Length=435, Percent_Identity=39.5402298850575, Blast_Score=259, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17535605, Length=437, Percent_Identity=37.5286041189931, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI32564013, Length=393, Percent_Identity=37.9134860050891, Blast_Score=223, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323843, Length=439, Percent_Identity=38.9521640091116, Blast_Score=254, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24645648, Length=437, Percent_Identity=37.7574370709382, Blast_Score=236, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 55131; Mature: 55131

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAINPTGWRPSMGENVPAGGVQTFTGNRALQLEEALIFELGQADRSGVDFPETDGIDLS
CCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCHH
ALGPLARAERPDLPGLSEPEAVRHYTRLSRQNYAIDLGLFPLGSCTMKHNPRLDEKVARM
HCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHC
PGFADVHPLQPVQTVQGALGVINELAHWLIELTGMHGVAMTPKAGAHGELCGLLCIRAAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHH
EAKGDPRNVILVPESAHGTNPATAAFAGFKVENIPATPDGRVDTAALTARLGPDIAGVMI
HCCCCCCEEEEEECCCCCCCCHHHHHCCCEECCCCCCCCCCCCHHHHHHHCCCCEEEEEE
TNPNTCGLFERDLKVIADAVHAAGGYVYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFS
ECCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCCEEEEEEEEEEEC
TPHGGGGPGSGPVVLSEALSPFGPLPFTARQADGSIRLIEEEHAHEEHPQAFGRMCAFHG
CCCCCCCCCCCCEEHHHHHCCCCCCCCCEECCCCCEEEEEHHHCCCCCHHHHHHHHHHCC
QMGMFTRALAYILSHGADGLRQVSGDAVLNANYVLRSLDDVLDAPFGAAGPCMHEALFSD
CHHHHHHHHHHHHHCCCHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
DGFAEGFSTLDLAKGLIDEGYHPMTVYFPLVVHGAMLVEPTETESKAGLDQFIGAMRSLA
CCHHHCHHHHHHHHHHHHCCCCCCEEEEHHHHCCEEEECCCCCHHHCCHHHHHHHHHHHH
ERARAGDEALKSAPHLAPRRRLDETLAARKPRLVWSSQA
HHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCCCEECCCC
>Mature Secondary Structure
MNAINPTGWRPSMGENVPAGGVQTFTGNRALQLEEALIFELGQADRSGVDFPETDGIDLS
CCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCHH
ALGPLARAERPDLPGLSEPEAVRHYTRLSRQNYAIDLGLFPLGSCTMKHNPRLDEKVARM
HCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHC
PGFADVHPLQPVQTVQGALGVINELAHWLIELTGMHGVAMTPKAGAHGELCGLLCIRAAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHH
EAKGDPRNVILVPESAHGTNPATAAFAGFKVENIPATPDGRVDTAALTARLGPDIAGVMI
HCCCCCCEEEEEECCCCCCCCHHHHHCCCEECCCCCCCCCCCCHHHHHHHCCCCEEEEEE
TNPNTCGLFERDLKVIADAVHAAGGYVYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFS
ECCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCCEEEEEEEEEEEC
TPHGGGGPGSGPVVLSEALSPFGPLPFTARQADGSIRLIEEEHAHEEHPQAFGRMCAFHG
CCCCCCCCCCCCEEHHHHHCCCCCCCCCEECCCCCEEEEEHHHCCCCCHHHHHHHHHHCC
QMGMFTRALAYILSHGADGLRQVSGDAVLNANYVLRSLDDVLDAPFGAAGPCMHEALFSD
CHHHHHHHHHHHHHCCCHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
DGFAEGFSTLDLAKGLIDEGYHPMTVYFPLVVHGAMLVEPTETESKAGLDQFIGAMRSLA
CCHHHCHHHHHHHHHHHHCCCCCCEEEEHHHHCCEEEECCCCCHHHCCHHHHHHHHHHHH
ERARAGDEALKSAPHLAPRRRLDETLAARKPRLVWSSQA
HHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]