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The map label for this gene is pgi

Identifier: 87199826

GI number: 87199826

Start: 1907699

End: 1909222

Strand: Direct

Name: pgi

Synonym: Saro_1809

Alternate gene names: 87199826

Gene position: 1907699-1909222 (Clockwise)

Preceding gene: 87199820

Following gene: 87199827

Centisome position: 53.56

GC content: 66.73

Gene sequence:

>1524_bases
ATGACGGTTGCCGAAGCGGAAACGTACTGGACGGCGCTGGCCGGGCTGCCGCGCCCGACGCTCAAGGAGCTGTTCTCCGA
TGCCGGCCGTCTCGATCGCTACGCCGCTACGCTCGACCTGCCGGGCGGCCCGATCCGCTTCGACTGGTCCAAGACGCACC
TCTCCGCCGAAGTGGAAGCGGTGTTCGCCGCGCTTGCATCGGCGATGGACTTCGAAGGCCGCCGCGCCGCGCTGATCGAG
GGCGCGAAAATCAACAACACCGAAGGCCGCGCGGCCGAGCACACCGCTCAGCGCGGCATCGGCAACGAGGCCAGCGTCGA
GGAAGCCGAGGCGCTCCACGCCCGCATGCGCATGCTGGTCGACGCGATCCACGCCGGTGCGCTTGGCGAAGTGCGCAGCC
TGATCCACATTGGCATCGGCGGTTCGGCGCTCGGGCCGGCGCTGGCGATCGACGCACTGACCCGCGACGGCGCGAAGGTG
GCCGTCCACGTCGTGTCGAACATCGACGGCTGCGCGCTCGAAGCCGCTATGAAGGCCTGCGATCCGGCAACGACGATGAT
CGCCGTTGCCTCCAAGACCTTCACCACGACCGAGACGATGACCAACGCTGCCTCGGCGCTTGAATGGCTGCGCGAGAACG
GCGTTGCCGATCCCTATGGCCAGGTCGTTGCGCTCACCGCCGCGCCCGAGAAGGCGGTCGAGTGGGGCGTCGACGAAACC
CGCGTCCTGCCGTTCTCCGAAACCGTGGGCGGGCGTTACTCGCTGTGGTCGTCGATCGGTTTCCCGGTCGCGATGGCGCT
GGGGTGGGAAGGCTTCGCCGCGTTCCTCGACGGTGCGGCGGCTATCGATCGCCATTTCATCGACGCAGACCTGGCCGGCA
ACGTCGTCGTTCGCGCCGCCTTTGCCGATCTCTATTACACTCAGGTTCGCGGGTGCCAGACGCGTGCGGTCTTCGCCTAT
GACGAACGCCTCGCGCTTCTGCCGGACTATCTCCAGCAGCTCGAAATGGAATCAAACGGCAAGCGCGTCCTCGCCGATGG
CTCTCCACTTACACGGCCAAGCGCGCCGGTTACCTGGGGCGGCGTCGGGACCGATGCACAGCATGCCGTGTTCCAGCTCC
TGCACCAGGGTACGCACTTGATTCCGGTCGATTTCCTTGCCGTCAAGACGCAGGGCCACGACCTCGACCCGGCGCATCAC
CAGATCCTGCTTTCCAACTGCTTCGCCCAGGGTGCTGCGCTCATGGCCGGCAAGGCGAGCGATGACGGCGCGCGTGCCTA
TCCCGGCGACCGTCCTTCCGCGACGATCCTGTGCGACGATCTCAACCCCGCGACGCTCGGCGCGCTGATCGCCTTCCACG
AGCATCGCACGTTCGTCTCTGCGGTGATGCTCGGCATCAATCCCTTCGACCAGTTCGGCGTCGAACTGGGCAAGGCCATT
GCCAAGCAGATCGAGTCTGGCGGCGGCGAAGGCTTCGATCCGTCGACCGAAGCACTCCTGGCAGCGGTTGGCCTCGCCGG
CTGA

Upstream 100 bases:

>100_bases
GTCTGCACAGCTTGCCGCACGATGAACCGCGGCTTGGCGGGCGGGAACGTACCGGGCATAGGGCCATTGCGCGAAAGCGA
GATCACGAAGGGGAATTGCG

Downstream 100 bases:

>100_bases
TAGTTAGGCGCACTAACCGATTTTCTCGAAACCCTCTGGTCTTGGCGAAGGCCAGAGGCCATATGCGCTCCTCGACAAGG
AGTATGCCATGGCTGAGCAG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MTVAEAETYWTALAGLPRPTLKELFSDAGRLDRYAATLDLPGGPIRFDWSKTHLSAEVEAVFAALASAMDFEGRRAALIE
GAKINNTEGRAAEHTAQRGIGNEASVEEAEALHARMRMLVDAIHAGALGEVRSLIHIGIGGSALGPALAIDALTRDGAKV
AVHVVSNIDGCALEAAMKACDPATTMIAVASKTFTTTETMTNAASALEWLRENGVADPYGQVVALTAAPEKAVEWGVDET
RVLPFSETVGGRYSLWSSIGFPVAMALGWEGFAAFLDGAAAIDRHFIDADLAGNVVVRAAFADLYYTQVRGCQTRAVFAY
DERLALLPDYLQQLEMESNGKRVLADGSPLTRPSAPVTWGGVGTDAQHAVFQLLHQGTHLIPVDFLAVKTQGHDLDPAHH
QILLSNCFAQGAALMAGKASDDGARAYPGDRPSATILCDDLNPATLGALIAFHEHRTFVSAVMLGINPFDQFGVELGKAI
AKQIESGGGEGFDPSTEALLAAVGLAG

Sequences:

>Translated_507_residues
MTVAEAETYWTALAGLPRPTLKELFSDAGRLDRYAATLDLPGGPIRFDWSKTHLSAEVEAVFAALASAMDFEGRRAALIE
GAKINNTEGRAAEHTAQRGIGNEASVEEAEALHARMRMLVDAIHAGALGEVRSLIHIGIGGSALGPALAIDALTRDGAKV
AVHVVSNIDGCALEAAMKACDPATTMIAVASKTFTTTETMTNAASALEWLRENGVADPYGQVVALTAAPEKAVEWGVDET
RVLPFSETVGGRYSLWSSIGFPVAMALGWEGFAAFLDGAAAIDRHFIDADLAGNVVVRAAFADLYYTQVRGCQTRAVFAY
DERLALLPDYLQQLEMESNGKRVLADGSPLTRPSAPVTWGGVGTDAQHAVFQLLHQGTHLIPVDFLAVKTQGHDLDPAHH
QILLSNCFAQGAALMAGKASDDGARAYPGDRPSATILCDDLNPATLGALIAFHEHRTFVSAVMLGINPFDQFGVELGKAI
AKQIESGGGEGFDPSTEALLAAVGLAG
>Mature_506_residues
TVAEAETYWTALAGLPRPTLKELFSDAGRLDRYAATLDLPGGPIRFDWSKTHLSAEVEAVFAALASAMDFEGRRAALIEG
AKINNTEGRAAEHTAQRGIGNEASVEEAEALHARMRMLVDAIHAGALGEVRSLIHIGIGGSALGPALAIDALTRDGAKVA
VHVVSNIDGCALEAAMKACDPATTMIAVASKTFTTTETMTNAASALEWLRENGVADPYGQVVALTAAPEKAVEWGVDETR
VLPFSETVGGRYSLWSSIGFPVAMALGWEGFAAFLDGAAAIDRHFIDADLAGNVVVRAAFADLYYTQVRGCQTRAVFAYD
ERLALLPDYLQQLEMESNGKRVLADGSPLTRPSAPVTWGGVGTDAQHAVFQLLHQGTHLIPVDFLAVKTQGHDLDPAHHQ
ILLSNCFAQGAALMAGKASDDGARAYPGDRPSATILCDDLNPATLGALIAFHEHRTFVSAVMLGINPFDQFGVELGKAIA
KQIESGGGEGFDPSTEALLAAVGLAG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=526, Percent_Identity=35.9315589353612, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI296080693, Length=514, Percent_Identity=35.6031128404669, Blast_Score=305, Evalue=7e-83,
Organism=Escherichia coli, GI1790457, Length=499, Percent_Identity=37.4749498997996, Blast_Score=320, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI71996703, Length=500, Percent_Identity=38, Blast_Score=326, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI71996708, Length=500, Percent_Identity=38, Blast_Score=326, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6319673, Length=491, Percent_Identity=38.0855397148676, Blast_Score=333, Evalue=4e-92,
Organism=Drosophila melanogaster, GI24651916, Length=503, Percent_Identity=39.3638170974155, Blast_Score=342, Evalue=5e-94,
Organism=Drosophila melanogaster, GI24651914, Length=503, Percent_Identity=39.3638170974155, Blast_Score=342, Evalue=5e-94,
Organism=Drosophila melanogaster, GI17737445, Length=503, Percent_Identity=39.3638170974155, Blast_Score=342, Evalue=5e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_NOVAD (Q2G7C4)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497083.1
- HSSP:   Q3TEE7
- ProteinModelPortal:   Q2G7C4
- SMR:   Q2G7C4
- STRING:   Q2G7C4
- GeneID:   3918368
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1809
- NMPDR:   fig|48935.1.peg.1343
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   LGKGVYQ
- PhylomeDB:   Q2G7C4
- ProtClustDB:   PRK00179
- BioCyc:   NARO279238:SARO_1809-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 53415; Mature: 53284

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 337-337 ACT_SITE 368-368 ACT_SITE 478-478

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAEAETYWTALAGLPRPTLKELFSDAGRLDRYAATLDLPGGPIRFDWSKTHLSAEVEA
CCCCCHHHHHHHHHCCCCHHHHHHHHHHCHHHHEEEEEECCCCCEEECCCHHHHHHHHHH
VFAALASAMDFEGRRAALIEGAKINNTEGRAAEHTAQRGIGNEASVEEAEALHARMRMLV
HHHHHHHHHCCCCCEEEEEECCEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
DAIHAGALGEVRSLIHIGIGGSALGPALAIDALTRDGAKVAVHVVSNIDGCALEAAMKAC
HHHHCCCHHHHHHHHEECCCCCHHCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHC
DPATTMIAVASKTFTTTETMTNAASALEWLRENGVADPYGQVVALTAAPEKAVEWGVDET
CCHHHHEEECCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHCCCCCC
RVLPFSETVGGRYSLWSSIGFPVAMALGWEGFAAFLDGAAAIDRHFIDADLAGNVVVRAA
EEECCHHHCCCCHHHHHHCCCHHHHHHCHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHH
FADLYYTQVRGCQTRAVFAYDERLALLPDYLQQLEMESNGKRVLADGSPLTRPSAPVTWG
HHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEC
GVGTDAQHAVFQLLHQGTHLIPVDFLAVKTQGHDLDPAHHQILLSNCFAQGAALMAGKAS
CCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCC
DDGARAYPGDRPSATILCDDLNPATLGALIAFHEHRTFVSAVMLGINPFDQFGVELGKAI
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AKQIESGGGEGFDPSTEALLAAVGLAG
HHHHHCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TVAEAETYWTALAGLPRPTLKELFSDAGRLDRYAATLDLPGGPIRFDWSKTHLSAEVEA
CCCCHHHHHHHHHCCCCHHHHHHHHHHCHHHHEEEEEECCCCCEEECCCHHHHHHHHHH
VFAALASAMDFEGRRAALIEGAKINNTEGRAAEHTAQRGIGNEASVEEAEALHARMRMLV
HHHHHHHHHCCCCCEEEEEECCEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
DAIHAGALGEVRSLIHIGIGGSALGPALAIDALTRDGAKVAVHVVSNIDGCALEAAMKAC
HHHHCCCHHHHHHHHEECCCCCHHCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHC
DPATTMIAVASKTFTTTETMTNAASALEWLRENGVADPYGQVVALTAAPEKAVEWGVDET
CCHHHHEEECCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHCCCCCC
RVLPFSETVGGRYSLWSSIGFPVAMALGWEGFAAFLDGAAAIDRHFIDADLAGNVVVRAA
EEECCHHHCCCCHHHHHHCCCHHHHHHCHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHH
FADLYYTQVRGCQTRAVFAYDERLALLPDYLQQLEMESNGKRVLADGSPLTRPSAPVTWG
HHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEC
GVGTDAQHAVFQLLHQGTHLIPVDFLAVKTQGHDLDPAHHQILLSNCFAQGAALMAGKAS
CCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCC
DDGARAYPGDRPSATILCDDLNPATLGALIAFHEHRTFVSAVMLGINPFDQFGVELGKAI
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AKQIESGGGEGFDPSTEALLAAVGLAG
HHHHHCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA