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The map label for this gene is gor [H]

Identifier: 87199827

GI number: 87199827

Start: 1909311

End: 1910672

Strand: Direct

Name: gor [H]

Synonym: Saro_1810

Alternate gene names: 87199827

Gene position: 1909311-1910672 (Clockwise)

Preceding gene: 87199826

Following gene: 87199828

Centisome position: 53.61

GC content: 64.54

Gene sequence:

>1362_bases
ATGGCTGAGCAGGAATTCGACTACGACCTCTTCGTGATCGGCGCGGGTTCGGGCGGGGTGCGCGCAAGCCGCATTGCCGC
AAGCCACGGCGCGCGCGTGGCGGTCGCGGAAGAATACAGGGTCGGCGGCACCTGCGTCATTCGGGGCTGCGTGCCCAAGA
AGCTGCTGGTCTACGGATCGCACTTCGCCGAAGAACTGCAGGACGCGGCCAACTATGGCTGGACGGTCGAGAAGATGAGC
TTCGACTGGCCGACGTTACGTGACGCGGTGCTCAAGGACGTCGACCGGCTCAACACCGCCTACACGTCGACCCTCGAGAA
CAACAAGGTAGAGCGCTTCCTCGAACGCGCGACCGTAACCGGCCCCAACACGGTCAGGCTGGGGGGAAGCGGCCGCGAGA
TCAGCGCGCGCTACATCCTCGTCGCGACGGGCGCATGGCCGGTCATGCCGGACTTCCCCGGCAACGAGCACTGCATTACC
TCGAACGAGGTGTTTCATCTCGAAAACCTGCCGAAGCGCGTGGTGATTTCCGGGGCGGGCTACATCGCGATGGAATTCGC
CGGAATCTTCAACGCCCTTGGCTGTCACGTAACGGTGGTCAATCGCAGCGAGACGATCCTGCGCGGCTACGATGAATCGC
TGCGCGACCGCCTGCTTCAGATCACCATGGCGCGCGGCATCGAGTACAAGTTCAACTGCCCGTTCGAAAAGGTCGAGAAG
CAGGCGGACGGCTCCCTGCAGGTCTTCCTCGCCGGGCAGCCCGATCCTCTCGCCGCCGACATCGTGCTGGTCGCCACCGG
CCGCCTTCCCAAGACCGATGGCCTCGGCCTCGAGACCGCCGGGATCGAGCTTGGCGCGCAGGGCGAAATTCCGGTCGACG
ATCACGGCCGCACCGCCTGCGACAGCATCTACGCGGTCGGTGACGTAACGAACCGCGTCCAGCTTACCCCGATCGCCATC
CGCGAAGGCCATGCCTTTGCCGACCGCGTGTTCGGCGGCAAGGATACCTCCGTCAGCTACGACTGCATCCCCAGCGCCGT
GTTCTCGCAGCCGCCGCTGGCCGGTGTCGGGCTCACCGAAAGCCAGGCCCGGCAGGCGTTCGGCGGCAACATCAAGGTCT
ATTCGTCAGACTTCCGACCGATGAAGAACATCTTCGGCCACCGTCCCGAACGCGGCCTCTACAAGATGATCGTCGAGGCC
ACGAGCGAGAGGGTCCTCGGCATTCACATGATCGGTCCAGAAGCGCCCGAAATTCTCCAGGCCGCGGCAATCGCGGTCAA
GGCCGGGCTGACCAAGGCCGATTTCGACGCGACCGTGGCGCTCCATCCATCGATGGCGGAAGAACTCGTCCTGATGCGCT
GA

Upstream 100 bases:

>100_bases
CTCGCCGGCTGATAGTTAGGCGCACTAACCGATTTTCTCGAAACCCTCTGGTCTTGGCGAAGGCCAGAGGCCATATGCGC
TCCTCGACAAGGAGTATGCC

Downstream 100 bases:

>100_bases
GCGGGCCGGTTGCAAGCCGCAACCGCCATGATACCCTGCCTTCCACCAATCCAGGGGGAGGGCAGGCGTGGAGCTATCGG
GAAAGACCGTGCTGGTGACC

Product: NADPH-glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MAEQEFDYDLFVIGAGSGGVRASRIAASHGARVAVAEEYRVGGTCVIRGCVPKKLLVYGSHFAEELQDAANYGWTVEKMS
FDWPTLRDAVLKDVDRLNTAYTSTLENNKVERFLERATVTGPNTVRLGGSGREISARYILVATGAWPVMPDFPGNEHCIT
SNEVFHLENLPKRVVISGAGYIAMEFAGIFNALGCHVTVVNRSETILRGYDESLRDRLLQITMARGIEYKFNCPFEKVEK
QADGSLQVFLAGQPDPLAADIVLVATGRLPKTDGLGLETAGIELGAQGEIPVDDHGRTACDSIYAVGDVTNRVQLTPIAI
REGHAFADRVFGGKDTSVSYDCIPSAVFSQPPLAGVGLTESQARQAFGGNIKVYSSDFRPMKNIFGHRPERGLYKMIVEA
TSERVLGIHMIGPEAPEILQAAAIAVKAGLTKADFDATVALHPSMAEELVLMR

Sequences:

>Translated_453_residues
MAEQEFDYDLFVIGAGSGGVRASRIAASHGARVAVAEEYRVGGTCVIRGCVPKKLLVYGSHFAEELQDAANYGWTVEKMS
FDWPTLRDAVLKDVDRLNTAYTSTLENNKVERFLERATVTGPNTVRLGGSGREISARYILVATGAWPVMPDFPGNEHCIT
SNEVFHLENLPKRVVISGAGYIAMEFAGIFNALGCHVTVVNRSETILRGYDESLRDRLLQITMARGIEYKFNCPFEKVEK
QADGSLQVFLAGQPDPLAADIVLVATGRLPKTDGLGLETAGIELGAQGEIPVDDHGRTACDSIYAVGDVTNRVQLTPIAI
REGHAFADRVFGGKDTSVSYDCIPSAVFSQPPLAGVGLTESQARQAFGGNIKVYSSDFRPMKNIFGHRPERGLYKMIVEA
TSERVLGIHMIGPEAPEILQAAAIAVKAGLTKADFDATVALHPSMAEELVLMR
>Mature_452_residues
AEQEFDYDLFVIGAGSGGVRASRIAASHGARVAVAEEYRVGGTCVIRGCVPKKLLVYGSHFAEELQDAANYGWTVEKMSF
DWPTLRDAVLKDVDRLNTAYTSTLENNKVERFLERATVTGPNTVRLGGSGREISARYILVATGAWPVMPDFPGNEHCITS
NEVFHLENLPKRVVISGAGYIAMEFAGIFNALGCHVTVVNRSETILRGYDESLRDRLLQITMARGIEYKFNCPFEKVEKQ
ADGSLQVFLAGQPDPLAADIVLVATGRLPKTDGLGLETAGIELGAQGEIPVDDHGRTACDSIYAVGDVTNRVQLTPIAIR
EGHAFADRVFGGKDTSVSYDCIPSAVFSQPPLAGVGLTESQARQAFGGNIKVYSSDFRPMKNIFGHRPERGLYKMIVEAT
SERVLGIHMIGPEAPEILQAAAIAVKAGLTKADFDATVALHPSMAEELVLMR

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=39.7379912663755, Blast_Score=298, Evalue=8e-81,
Organism=Homo sapiens, GI33519430, Length=470, Percent_Identity=35.3191489361702, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI33519428, Length=470, Percent_Identity=35.3191489361702, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI33519426, Length=470, Percent_Identity=35.3191489361702, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI148277071, Length=470, Percent_Identity=35.3191489361702, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI148277065, Length=470, Percent_Identity=35.3191489361702, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI22035672, Length=471, Percent_Identity=35.244161358811, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI291045266, Length=472, Percent_Identity=31.7796610169492, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=30.3687635574837, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI291045268, Length=471, Percent_Identity=30.1486199575372, Blast_Score=182, Evalue=7e-46,
Organism=Escherichia coli, GI1789915, Length=432, Percent_Identity=38.6574074074074, Blast_Score=288, Evalue=7e-79,
Organism=Escherichia coli, GI1786307, Length=459, Percent_Identity=27.8867102396514, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI87081717, Length=450, Percent_Identity=28.6666666666667, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI87082354, Length=457, Percent_Identity=29.3216630196937, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=34.0425531914894, Blast_Score=257, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI71983429, Length=455, Percent_Identity=37.8021978021978, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI71983419, Length=455, Percent_Identity=37.8021978021978, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI71982272, Length=482, Percent_Identity=31.5352697095436, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI32565766, Length=455, Percent_Identity=31.8681318681319, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=37.1794871794872, Blast_Score=282, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6321091, Length=461, Percent_Identity=28.6334056399132, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=27.8723404255319, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24640553, Length=466, Percent_Identity=36.0515021459227, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI24640549, Length=466, Percent_Identity=36.0515021459227, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=35.8208955223881, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI17737741, Length=468, Percent_Identity=34.4017094017094, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI21358499, Length=457, Percent_Identity=30.4157549234136, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49053; Mature: 48922

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQEFDYDLFVIGAGSGGVRASRIAASHGARVAVAEEYRVGGTCVIRGCVPKKLLVYGS
CCCCCCCCEEEEEECCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCHHEECH
HFAEELQDAANYGWTVEKMSFDWPTLRDAVLKDVDRLNTAYTSTLENNKVERFLERATVT
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
GPNTVRLGGSGREISARYILVATGAWPVMPDFPGNEHCITSNEVFHLENLPKRVVISGAG
CCCEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCEECCCCEEEECCCCCEEEEECCC
YIAMEFAGIFNALGCHVTVVNRSETILRGYDESLRDRLLQITMARGIEYKFNCPFEKVEK
EEEHHHHHHHHCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHH
QADGSLQVFLAGQPDPLAADIVLVATGRLPKTDGLGLETAGIELGAQGEIPVDDHGRTAC
HCCCCEEEEECCCCCCCEEEEEEEEECCCCCCCCCCEEECCEEECCCCCCCCCCCCCHHH
DSIYAVGDVTNRVQLTPIAIREGHAFADRVFGGKDTSVSYDCIPSAVFSQPPLAGVGLTE
HHEEEECCCCCEEEEEEEEEECCCHHHHHHCCCCCCCEEHHCCCHHHHCCCCCCCCCCCH
SQARQAFGGNIKVYSSDFRPMKNIFGHRPERGLYKMIVEATSERVLGIHMIGPEAPEILQ
HHHHHHHCCCEEEEECCCCHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHH
AAAIAVKAGLTKADFDATVALHPSMAEELVLMR
HHHHHHHCCCCCCCCCEEEEECCHHHHHHEECC
>Mature Secondary Structure 
AEQEFDYDLFVIGAGSGGVRASRIAASHGARVAVAEEYRVGGTCVIRGCVPKKLLVYGS
CCCCCCCEEEEEECCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCHHEECH
HFAEELQDAANYGWTVEKMSFDWPTLRDAVLKDVDRLNTAYTSTLENNKVERFLERATVT
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
GPNTVRLGGSGREISARYILVATGAWPVMPDFPGNEHCITSNEVFHLENLPKRVVISGAG
CCCEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCEECCCCEEEECCCCCEEEEECCC
YIAMEFAGIFNALGCHVTVVNRSETILRGYDESLRDRLLQITMARGIEYKFNCPFEKVEK
EEEHHHHHHHHCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHH
QADGSLQVFLAGQPDPLAADIVLVATGRLPKTDGLGLETAGIELGAQGEIPVDDHGRTAC
HCCCCEEEEECCCCCCCEEEEEEEEECCCCCCCCCCEEECCEEECCCCCCCCCCCCCHHH
DSIYAVGDVTNRVQLTPIAIREGHAFADRVFGGKDTSVSYDCIPSAVFSQPPLAGVGLTE
HHEEEECCCCCEEEEEEEEEECCCHHHHHHCCCCCCCEEHHCCCHHHHCCCCCCCCCCCH
SQARQAFGGNIKVYSSDFRPMKNIFGHRPERGLYKMIVEATSERVLGIHMIGPEAPEILQ
HHHHHHHCCCEEEEECCCCHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHH
AAAIAVKAGLTKADFDATVALHPSMAEELVLMR
HHHHHHHCCCCCCCCCEEEEECCHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]