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The map label for this gene is cytR [H]

Identifier: 87199341

GI number: 87199341

Start: 1363722

End: 1364750

Strand: Reverse

Name: cytR [H]

Synonym: Saro_1320

Alternate gene names: 87199341

Gene position: 1364750-1363722 (Counterclockwise)

Preceding gene: 87199342

Following gene: 87199332

Centisome position: 38.32

GC content: 67.64

Gene sequence:

>1029_bases
ATGCCGAGCGACAGGAAGATCATCCGCGTAACGTCGTTCGACGTGGCCGAAGCGGCGGGCGTCAGCCAGTCCACCGTCAG
CCGCGCACTGGCAGGCGACACGTCGATCAGCGAGCCGACGCGCCAGCGCGTGATCGAAGCGGCACGCCGCCTGAACTACC
AGGTGGACGAGAACGCGGCACGCCTGCGCCGGGGCCGCACCGGCACACTCGCGGTCGTGATGATCTGCCGCGAGGCGCAG
GACCGCAAGGATATCAACCCGTTCTACTTCTCGCTCCTGGGCAGCACCTGCGCGGCTGCATCGGCGCGCGGATACGAAAC
GCTGGTCTCGTTCCAGGATGCTCCCGAAAACTTCTGGGGCCACTTCCAGGAGCGGCGCAAGGCCGATGGCATGATCGTGA
TCGGCACGACGACCAACACGGCGGCGTGGGACTATTTCCGCGACATGCCGGAAGGCACGCACTGGACCTGCTGGGGCTCA
CCCGACAACGACATGCCCTGGGTGCGCAGTGACAACCTTTCGGGCGCCACGCTGGCGACGCGCCACCTGCTGGTGCGCGG
CTATCGCCAGATCGTGTGCATCGGCTCGGCCACCTCGCCCCAGCGCCAGTTCCAGGAACGGTATGAAGGCTACGCCGAGG
CCATGCGCTCGGCCGGGCTCGAACCGCGCCTGCAACAGGTCGAGAGCGGCCTCGCACGCGAGGAACAGGGCCGCCGCGCG
GCGATAGCGCTGGCGGAAAGCGGAGAGCAGTTCGACGCCATCTTCGCGGTCTGCGACGAGATGGCGCTGGGCGCGCTCAA
GGAACTGACCGCGCGTGGCTATGCCGTGCCGGACCAGGTCGGGATCATCGGCTTCGACGGCATCCGCGCCGGCGCATGGT
CGACCCCACCCCTCACCTCGATCGAACCCGATTTCCAGATGGCCGGCGGATTGCTGGTCGAACAGCTGCTGGCAAAGATC
AACGGGACCGAAGGCTCGGGCCGGCGCGTGCCGGTAAGGCTGGTTATCCGGGGCTCAACACGGCCCTGA

Upstream 100 bases:

>100_bases
GGTCTTCGCCCGTCGACACATTTGCCGCCCTGCGCGCCGCCAAGGATACTTTCCGCTGACGCCGATCCTGCTAAAGGGGT
GTTGACCGGGGGAAAGCCTA

Downstream 100 bases:

>100_bases
GCCGCACCGGCCGGCGGCCCCGCCGCAGAAGCCGCGCCCCTTCCCGACCCAGCCAGATTTCCACGAGAGGTGCTTCGCGC
GCATTGCGGGCCGTTCGCGC

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MPSDRKIIRVTSFDVAEAAGVSQSTVSRALAGDTSISEPTRQRVIEAARRLNYQVDENAARLRRGRTGTLAVVMICREAQ
DRKDINPFYFSLLGSTCAAASARGYETLVSFQDAPENFWGHFQERRKADGMIVIGTTTNTAAWDYFRDMPEGTHWTCWGS
PDNDMPWVRSDNLSGATLATRHLLVRGYRQIVCIGSATSPQRQFQERYEGYAEAMRSAGLEPRLQQVESGLAREEQGRRA
AIALAESGEQFDAIFAVCDEMALGALKELTARGYAVPDQVGIIGFDGIRAGAWSTPPLTSIEPDFQMAGGLLVEQLLAKI
NGTEGSGRRVPVRLVIRGSTRP

Sequences:

>Translated_342_residues
MPSDRKIIRVTSFDVAEAAGVSQSTVSRALAGDTSISEPTRQRVIEAARRLNYQVDENAARLRRGRTGTLAVVMICREAQ
DRKDINPFYFSLLGSTCAAASARGYETLVSFQDAPENFWGHFQERRKADGMIVIGTTTNTAAWDYFRDMPEGTHWTCWGS
PDNDMPWVRSDNLSGATLATRHLLVRGYRQIVCIGSATSPQRQFQERYEGYAEAMRSAGLEPRLQQVESGLAREEQGRRA
AIALAESGEQFDAIFAVCDEMALGALKELTARGYAVPDQVGIIGFDGIRAGAWSTPPLTSIEPDFQMAGGLLVEQLLAKI
NGTEGSGRRVPVRLVIRGSTRP
>Mature_341_residues
PSDRKIIRVTSFDVAEAAGVSQSTVSRALAGDTSISEPTRQRVIEAARRLNYQVDENAARLRRGRTGTLAVVMICREAQD
RKDINPFYFSLLGSTCAAASARGYETLVSFQDAPENFWGHFQERRKADGMIVIGTTTNTAAWDYFRDMPEGTHWTCWGSP
DNDMPWVRSDNLSGATLATRHLLVRGYRQIVCIGSATSPQRQFQERYEGYAEAMRSAGLEPRLQQVESGLAREEQGRRAA
IALAESGEQFDAIFAVCDEMALGALKELTARGYAVPDQVGIIGFDGIRAGAWSTPPLTSIEPDFQMAGGLLVEQLLAKIN
GTEGSGRRVPVRLVIRGSTRP

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=351, Percent_Identity=30.7692307692308, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1790194, Length=317, Percent_Identity=29.3375394321767, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1788474, Length=295, Percent_Identity=30.1694915254237, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789068, Length=304, Percent_Identity=28.6184210526316, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789202, Length=308, Percent_Identity=28.2467532467532, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787948, Length=320, Percent_Identity=25.3125, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787580, Length=326, Percent_Identity=24.5398773006135, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787906, Length=346, Percent_Identity=26.878612716763, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994940, Length=324, Percent_Identity=27.4691358024691, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786540, Length=349, Percent_Identity=25.7879656160458, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37554; Mature: 37423

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSDRKIIRVTSFDVAEAAGVSQSTVSRALAGDTSISEPTRQRVIEAARRLNYQVDENAA
CCCCCCEEEEECCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHH
RLRRGRTGTLAVVMICREAQDRKDINPFYFSLLGSTCAAASARGYETLVSFQDAPENFWG
HHHCCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHH
HFQERRKADGMIVIGTTTNTAAWDYFRDMPEGTHWTCWGSPDNDMPWVRSDNLSGATLAT
HHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEECCCCCCHHHHH
RHLLVRGYRQIVCIGSATSPQRQFQERYEGYAEAMRSAGLEPRLQQVESGLAREEQGRRA
HHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEE
AIALAESGEQFDAIFAVCDEMALGALKELTARGYAVPDQVGIIGFDGIRAGAWSTPPLTS
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCC
IEPDFQMAGGLLVEQLLAKINGTEGSGRRVPVRLVIRGSTRP
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCC
>Mature Secondary Structure 
PSDRKIIRVTSFDVAEAAGVSQSTVSRALAGDTSISEPTRQRVIEAARRLNYQVDENAA
CCCCCEEEEECCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHH
RLRRGRTGTLAVVMICREAQDRKDINPFYFSLLGSTCAAASARGYETLVSFQDAPENFWG
HHHCCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHH
HFQERRKADGMIVIGTTTNTAAWDYFRDMPEGTHWTCWGSPDNDMPWVRSDNLSGATLAT
HHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEECCCCCCHHHHH
RHLLVRGYRQIVCIGSATSPQRQFQERYEGYAEAMRSAGLEPRLQQVESGLAREEQGRRA
HHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEE
AIALAESGEQFDAIFAVCDEMALGALKELTARGYAVPDQVGIIGFDGIRAGAWSTPPLTS
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCC
IEPDFQMAGGLLVEQLLAKINGTEGSGRRVPVRLVIRGSTRP
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]