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The map label for this gene is phbA [H]

Identifier: 87199244

GI number: 87199244

Start: 1274354

End: 1275568

Strand: Reverse

Name: phbA [H]

Synonym: Saro_1222

Alternate gene names: 87199244

Gene position: 1275568-1274354 (Counterclockwise)

Preceding gene: 87199245

Following gene: 87199243

Centisome position: 35.81

GC content: 67.57

Gene sequence:

>1215_bases
ATGACCCAGCTTCGCCACGCCGCCATCGTCGCCCCCATCCGCACCGCCGTGGGCAAGTTCGGCGGCTCGCTGTCGCCTCT
CACCGCCGGGCAACTGGGCGCAACGATCCTCACGGCGCTGATGGACCGCACAAGGATCGACCCCGCGCGCGTCGATGACG
TGATCTTCGCGCAGGGTTACGGCAACGGCGAGGCGCCGTGCATCTCGCACTGGTCGTGGCTGCTCGCGGGCCTGCCCGAG
GAAGTTCCCGGCTACCAGCTCGATCGCCGCTGCGGCTCGGGCCTCCAGTCGATCGTCAATGCGGCGATGATGGTGCAGAC
CGGGGTTTCCGACGTCGTCGTGGCGGGCGGCGTGGAATCGATGTCCAACGTCGAGCACTATACCACTGACGTCCGCAAGG
GCGTGCGCGCGGGCTCGCTGACCCTTCACGACCGCCTTACCCGTGGCCGCGTGATGAGCCAGCCGATCGAGCGCTATGGC
GTGATCAGCGGCATGATCGAGACGGCGGAAAACCTCGCCAAGGACTTTGCCATCACCCGCGAAGCCTGCGACGCCTATGC
CGTGCGCAGCCACCAGCGCGCGGCTGCTGCATGGGCCAACGGCCTGTTCGACGACGAACTCGTTCCGGTCTCCATCCCCC
AGAAAAAGGGCGACCCCGTTCTCTTCGCCCACGACGAGGGTTACCGTGCCGACGCCAGCATGGAAACGCTTGGCAAGCTG
CGCCCCCTCGAAGGCGGCGTCGTGACGGCAGGCAACGCCAGCCAGCAGAACGACGCGGCCGCCGCCTGCCTCGTCGTCGC
GGAAGACAAGCTCGCCGAACTCGGCCTCGAACCCATCGCGTGGTTCCATTCCTGGGCGGCAGCGGGCTGCGATCCGAGCC
GCATGGGCTATGGCCCTGTCCCCGCTACCGAGCGCCTGTTCGCCCGCAACGGCCTGACGTGGAACGACATCGACCTCATC
GAACTGAACGAGGCCTTCGCCCCTCAGGTTCTCGCCTGCCTCAAGGGCTGGGGCTGGTCGGACGACGACAGCCGCCACGA
GATGCTGAACGTCAATGGCTCGGGCATCAGCCTCGGCCATCCCATCGGCGCCACCGGCGGGCGCATCCTCGCCAACCTTA
CGCGCGAATTGAAGCGGCGCGGCGGGCGCTATGGCCTTGAAACCATGTGCATTGGTGGCGGTCAGGGAATCGCGGCGGTG
TTCGAGGCGGCCTGA

Upstream 100 bases:

>100_bases
CACGCTGATCGACCGGGGCGTGGTGGCACGATCCGACAAAGACCAATGATCAATCCCCCTCCCGTTCCCGTAGAGCGGAT
GTCGTGAAGGATTTACCGTG

Downstream 100 bases:

>100_bases
TGATCCTCTCGCCGTACGACAGCGAAGACCACGGCGAAATCCGTGAGGGCGTTCGCAAGCTATGCGCCCAGTTTCCGGGC
GAGTACTGGCGCAAGCTCGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTQLRHAAIVAPIRTAVGKFGGSLSPLTAGQLGATILTALMDRTRIDPARVDDVIFAQGYGNGEAPCISHWSWLLAGLPE
EVPGYQLDRRCGSGLQSIVNAAMMVQTGVSDVVVAGGVESMSNVEHYTTDVRKGVRAGSLTLHDRLTRGRVMSQPIERYG
VISGMIETAENLAKDFAITREACDAYAVRSHQRAAAAWANGLFDDELVPVSIPQKKGDPVLFAHDEGYRADASMETLGKL
RPLEGGVVTAGNASQQNDAAAACLVVAEDKLAELGLEPIAWFHSWAAAGCDPSRMGYGPVPATERLFARNGLTWNDIDLI
ELNEAFAPQVLACLKGWGWSDDDSRHEMLNVNGSGISLGHPIGATGGRILANLTRELKRRGGRYGLETMCIGGGQGIAAV
FEAA

Sequences:

>Translated_404_residues
MTQLRHAAIVAPIRTAVGKFGGSLSPLTAGQLGATILTALMDRTRIDPARVDDVIFAQGYGNGEAPCISHWSWLLAGLPE
EVPGYQLDRRCGSGLQSIVNAAMMVQTGVSDVVVAGGVESMSNVEHYTTDVRKGVRAGSLTLHDRLTRGRVMSQPIERYG
VISGMIETAENLAKDFAITREACDAYAVRSHQRAAAAWANGLFDDELVPVSIPQKKGDPVLFAHDEGYRADASMETLGKL
RPLEGGVVTAGNASQQNDAAAACLVVAEDKLAELGLEPIAWFHSWAAAGCDPSRMGYGPVPATERLFARNGLTWNDIDLI
ELNEAFAPQVLACLKGWGWSDDDSRHEMLNVNGSGISLGHPIGATGGRILANLTRELKRRGGRYGLETMCIGGGQGIAAV
FEAA
>Mature_403_residues
TQLRHAAIVAPIRTAVGKFGGSLSPLTAGQLGATILTALMDRTRIDPARVDDVIFAQGYGNGEAPCISHWSWLLAGLPEE
VPGYQLDRRCGSGLQSIVNAAMMVQTGVSDVVVAGGVESMSNVEHYTTDVRKGVRAGSLTLHDRLTRGRVMSQPIERYGV
ISGMIETAENLAKDFAITREACDAYAVRSHQRAAAAWANGLFDDELVPVSIPQKKGDPVLFAHDEGYRADASMETLGKLR
PLEGGVVTAGNASQQNDAAAACLVVAEDKLAELGLEPIAWFHSWAAAGCDPSRMGYGPVPATERLFARNGLTWNDIDLIE
LNEAFAPQVLACLKGWGWSDDDSRHEMLNVNGSGISLGHPIGATGGRILANLTRELKRRGGRYGLETMCIGGGQGIAAVF
EAA

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=407, Percent_Identity=39.8034398034398, Blast_Score=271, Evalue=8e-73,
Organism=Homo sapiens, GI148539872, Length=401, Percent_Identity=36.6583541147132, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=36, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=35.6435643564356, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=32.4766355140187, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=25.8312020460358, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1788554, Length=403, Percent_Identity=43.424317617866, Blast_Score=284, Evalue=9e-78,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=42.4019607843137, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=41.5422885572139, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI48994986, Length=412, Percent_Identity=37.621359223301, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=33.8028169014084, Blast_Score=191, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI133906874, Length=398, Percent_Identity=39.4472361809045, Blast_Score=259, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI25147385, Length=394, Percent_Identity=32.741116751269, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=31.4214463840399, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=29.4811320754717, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=25.1908396946565, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=33.9066339066339, Blast_Score=196, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=33.5820895522388, Blast_Score=196, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24655093, Length=396, Percent_Identity=41.4141414141414, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17648125, Length=400, Percent_Identity=39.75, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24640423, Length=398, Percent_Identity=35.678391959799, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17137578, Length=432, Percent_Identity=29.8611111111111, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42965; Mature: 42834

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLRHAAIVAPIRTAVGKFGGSLSPLTAGQLGATILTALMDRTRIDPARVDDVIFAQGY
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEECCC
GNGEAPCISHWSWLLAGLPEEVPGYQLDRRCGSGLQSIVNAAMMVQTGVSDVVVAGGVES
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHH
MSNVEHYTTDVRKGVRAGSLTLHDRLTRGRVMSQPIERYGVISGMIETAENLAKDFAITR
HHHHHHHHHHHHHCCCCCCEEHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EACDAYAVRSHQRAAAAWANGLFDDELVPVSIPQKKGDPVLFAHDEGYRADASMETLGKL
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHCC
RPLEGGVVTAGNASQQNDAAAACLVVAEDKLAELGLEPIAWFHSWAAAGCDPSRMGYGPV
CCCCCCEEECCCCCCCCCHHEEEEEEEHHHHHHCCCHHHHHHHHHHHCCCCHHHCCCCCC
PATERLFARNGLTWNDIDLIELNEAFAPQVLACLKGWGWSDDDSRHEMLNVNGSGISLGH
CHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEECCC
PIGATGGRILANLTRELKRRGGRYGLETMCIGGGQGIAAVFEAA
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHEECC
>Mature Secondary Structure 
TQLRHAAIVAPIRTAVGKFGGSLSPLTAGQLGATILTALMDRTRIDPARVDDVIFAQGY
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEECCC
GNGEAPCISHWSWLLAGLPEEVPGYQLDRRCGSGLQSIVNAAMMVQTGVSDVVVAGGVES
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHH
MSNVEHYTTDVRKGVRAGSLTLHDRLTRGRVMSQPIERYGVISGMIETAENLAKDFAITR
HHHHHHHHHHHHHCCCCCCEEHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EACDAYAVRSHQRAAAAWANGLFDDELVPVSIPQKKGDPVLFAHDEGYRADASMETLGKL
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHCC
RPLEGGVVTAGNASQQNDAAAACLVVAEDKLAELGLEPIAWFHSWAAAGCDPSRMGYGPV
CCCCCCEEECCCCCCCCCHHEEEEEEEHHHHHHCCCHHHHHHHHHHHCCCCHHHCCCCCC
PATERLFARNGLTWNDIDLIELNEAFAPQVLACLKGWGWSDDDSRHEMLNVNGSGISLGH
CHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEECCC
PIGATGGRILANLTRELKRRGGRYGLETMCIGGGQGIAAVFEAA
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7763384 [H]