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The map label for this gene is hppA

Identifier: 87199089

GI number: 87199089

Start: 1110255

End: 1112408

Strand: Reverse

Name: hppA

Synonym: Saro_1067

Alternate gene names: 87199089

Gene position: 1112408-1110255 (Counterclockwise)

Preceding gene: 87199090

Following gene: 87199088

Centisome position: 31.23

GC content: 64.02

Gene sequence:

>2154_bases
GTGGTCCGGGAGATAAAGGGGGATGCCAACGTGAACCTAGTCGTATTATCGATAATACTCGGGTTACTTGCCGTCGTTTA
TGGCTTCGTGACCAGCCGCCAGGTGCTTGGCGCACCGGCCGGCAATTCCAAGATGCAGGAAATCGCCGCCGCCATCCAGG
AAGGCGCGCAAGCCTACCTCAAGCGCCAGTACACCACGATCGCCATAGTCGGCGTGGTCGTTGCCGTGATCATCGCGGCT
ACGCTGGGCACGATCTCGGCAACGGGCTTCGTGATCGGCGCAGTGCTTTCGGGCGTTGCGGGCTTCATCGGGATGAACAT
CTCTGTTCGCTCGAACGTGCGAACGGCGGCCGCAGCGCAGAATGGGCTTCAGGCCGGTCTCACGCTGGCATTCCGTGCAG
GGGCGATCACCGGCATGCTGGTGGCGGGCCTTGCCCTGCTCGCCATCGCGGTGTTCTACCACTACCTGACCGACATTGCC
GGTTACACCGTAGGCGGCGACGATCGCACCGTGGTGGACGGGCTGGTTGCGCTGGCCTTCGGCGCATCGCTGATCTCCAT
TTTCGCACGTCTGGGCGGTGGCATCTTCACCAAGGCTGCTGACGTCGGCGCCGACCTCGTCGGCAAGGTGGAAGCAGGCA
TCCCCGAAGACGATCCGCGCAACCCCGCCGTCATCGCCGACAACGTGGGCGACAACGTCGGCGACTGCGCCGGCATGGCC
GCCGACCTGTTCGAGACCTACGTCGTGACCGTGGGCGCAACGATGGTTCTGACCGCGCTGCTGCTCAAGGGCCTCGGCGC
TGCCCTCGCCCCGATGATGGCGCTTCCGTTGCTGATCGGCGGCGTGTGCATCGTCACCTCGATCATCGGCACCTACTTCG
TGAAGCTGGGTTCGTCGAACAACATCATGGGCGCGATGTACAAGGGCTTCCTTGTCACCGCCGTGCTCTCTGTCGGTGCG
ATCTGGTGGGCCATTTCCTATGCGCTGGGCGACATGGAAACCTCGATGTCGTACACCATCCTCGACAACACGGTGACCTT
CTCGGGCCGCGTGCTGTTCTACTGCTCGCTGCTCGGTCTGGTCATCACCGGCCTGATCATCTGGATCACCGAGTACTATA
CCGGCACCAACTACCGCCCGGTGCGCTCCATCGCCAAGTCGTCGGAAACCGGCCACGGCACCAACGTCATCCAGGGACTG
GCCATCAGCCTTGAATCGACCGCGATGCCGACGATCGTGATTTGCGCCGGCATCATCATTGCCTACCAGCTCGCCGGGCT
GATCGGCATTGCCTATGCGGCAACCGCGATGCTGGCTCTGGCCGGCATGGTCGTCGCGCTGGATGCCTACGGTCCTGTCA
CCGACAACGCAGGCGGCATTGCCGAAATGGCAGGCCTCGACGATTCGGTCCGTGAAAAGACCGACGCGCTCGATGCGGTG
GGCAACACCACCAAGGCCGTGACCAAGGGCTACGCGATCGGATCGGCCGGCCTTGCCGCGCTCGTCCTGTTCGCTGCCTA
CACCACCGACCTTCGCGAGTTCTTCCCGAACCTCGCGGTCAGCTTCAGCCTCGAGAACCCCTATGTCATCGTCGGGCTGC
TGCTCGGCGCTCTCCTGCCGTACCTGTTCGGTGCGATGGGCATGACCGCAGTGGGCCGCGCGGCGGGCGATGTGGTGATC
GACGTGCGTGACCAGTTCCGCGAAAATCCGGGTATCATGGCGGGCACTTCGAAGCCCGACTACGCCCGCACCGTCGACCT
CGTGACCAAGGCCGCGATCAAGGAAATGATCGTGCCTTCGCTGCTGCCGGTACTGGCGCCGATCGCGGTATACTTCGTGA
TCGCCGCGGTTGGGGGGCAGGCCAACGGCTTCGCCGCGCTTGGCGCACTGCTGCTCGGCGTTATCGTCGGCGGCCTGTTC
GTCGCAATCTCGATGACCTCGGGCGGCGGCGCGTGGGACAATGCCAAGAAGTACATCGAGGACGGCAACCACGGCGGCAA
GGGTTCGGACGCGCACAAGGCGGCCGTGACCGGCGATACCGTGGGCGACCCGTACAAAGACACTGCCGGCCCGGCAGTGA
ACCCGATGATCAAGATTACCAACATCGTCGCGCTGCTTCTGCTCGCGGCGCTGGCAGCACACGCGGCGGGGTAA

Upstream 100 bases:

>100_bases
CACGATTAAAAACCGACTGGCGCACCGCATCGAAGGACTTGCGGGGCGGGAATAAACCTATAGCTTCCGCCCGACCCGCA
ACGACGGGGACGGATCATTC

Downstream 100 bases:

>100_bases
CACCGCCGAACGCCCCGAGTTGGGGAGAAGGAACCCCGTCCGGCTTCATCCGGGCGGGGTTTTTCCTTGCCCTCGAAACG
GGAACAGCCATCACAATCAG

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MVREIKGDANVNLVVLSIILGLLAVVYGFVTSRQVLGAPAGNSKMQEIAAAIQEGAQAYLKRQYTTIAIVGVVVAVIIAA
TLGTISATGFVIGAVLSGVAGFIGMNISVRSNVRTAAAAQNGLQAGLTLAFRAGAITGMLVAGLALLAIAVFYHYLTDIA
GYTVGGDDRTVVDGLVALAFGASLISIFARLGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMA
ADLFETYVVTVGATMVLTALLLKGLGAALAPMMALPLLIGGVCIVTSIIGTYFVKLGSSNNIMGAMYKGFLVTAVLSVGA
IWWAISYALGDMETSMSYTILDNTVTFSGRVLFYCSLLGLVITGLIIWITEYYTGTNYRPVRSIAKSSETGHGTNVIQGL
AISLESTAMPTIVICAGIIIAYQLAGLIGIAYAATAMLALAGMVVALDAYGPVTDNAGGIAEMAGLDDSVREKTDALDAV
GNTTKAVTKGYAIGSAGLAALVLFAAYTTDLREFFPNLAVSFSLENPYVIVGLLLGALLPYLFGAMGMTAVGRAAGDVVI
DVRDQFRENPGIMAGTSKPDYARTVDLVTKAAIKEMIVPSLLPVLAPIAVYFVIAAVGGQANGFAALGALLLGVIVGGLF
VAISMTSGGGAWDNAKKYIEDGNHGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAALAAHAAG

Sequences:

>Translated_717_residues
MVREIKGDANVNLVVLSIILGLLAVVYGFVTSRQVLGAPAGNSKMQEIAAAIQEGAQAYLKRQYTTIAIVGVVVAVIIAA
TLGTISATGFVIGAVLSGVAGFIGMNISVRSNVRTAAAAQNGLQAGLTLAFRAGAITGMLVAGLALLAIAVFYHYLTDIA
GYTVGGDDRTVVDGLVALAFGASLISIFARLGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMA
ADLFETYVVTVGATMVLTALLLKGLGAALAPMMALPLLIGGVCIVTSIIGTYFVKLGSSNNIMGAMYKGFLVTAVLSVGA
IWWAISYALGDMETSMSYTILDNTVTFSGRVLFYCSLLGLVITGLIIWITEYYTGTNYRPVRSIAKSSETGHGTNVIQGL
AISLESTAMPTIVICAGIIIAYQLAGLIGIAYAATAMLALAGMVVALDAYGPVTDNAGGIAEMAGLDDSVREKTDALDAV
GNTTKAVTKGYAIGSAGLAALVLFAAYTTDLREFFPNLAVSFSLENPYVIVGLLLGALLPYLFGAMGMTAVGRAAGDVVI
DVRDQFRENPGIMAGTSKPDYARTVDLVTKAAIKEMIVPSLLPVLAPIAVYFVIAAVGGQANGFAALGALLLGVIVGGLF
VAISMTSGGGAWDNAKKYIEDGNHGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAALAAHAAG
>Mature_717_residues
MVREIKGDANVNLVVLSIILGLLAVVYGFVTSRQVLGAPAGNSKMQEIAAAIQEGAQAYLKRQYTTIAIVGVVVAVIIAA
TLGTISATGFVIGAVLSGVAGFIGMNISVRSNVRTAAAAQNGLQAGLTLAFRAGAITGMLVAGLALLAIAVFYHYLTDIA
GYTVGGDDRTVVDGLVALAFGASLISIFARLGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMA
ADLFETYVVTVGATMVLTALLLKGLGAALAPMMALPLLIGGVCIVTSIIGTYFVKLGSSNNIMGAMYKGFLVTAVLSVGA
IWWAISYALGDMETSMSYTILDNTVTFSGRVLFYCSLLGLVITGLIIWITEYYTGTNYRPVRSIAKSSETGHGTNVIQGL
AISLESTAMPTIVICAGIIIAYQLAGLIGIAYAATAMLALAGMVVALDAYGPVTDNAGGIAEMAGLDDSVREKTDALDAV
GNTTKAVTKGYAIGSAGLAALVLFAAYTTDLREFFPNLAVSFSLENPYVIVGLLLGALLPYLFGAMGMTAVGRAAGDVVI
DVRDQFRENPGIMAGTSKPDYARTVDLVTKAAIKEMIVPSLLPVLAPIAVYFVIAAVGGQANGFAALGALLLGVIVGGLF
VAISMTSGGGAWDNAKKYIEDGNHGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAALAAHAAG

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 73149; Mature: 73149

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVREIKGDANVNLVVLSIILGLLAVVYGFVTSRQVLGAPAGNSKMQEIAAAIQEGAQAYL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KRQYTTIAIVGVVVAVIIAATLGTISATGFVIGAVLSGVAGFIGMNISVRSNVRTAAAAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHH
NGLQAGLTLAFRAGAITGMLVAGLALLAIAVFYHYLTDIAGYTVGGDDRTVVDGLVALAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
GASLISIFARLGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMA
HHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHH
ADLFETYVVTVGATMVLTALLLKGLGAALAPMMALPLLIGGVCIVTSIIGTYFVKLGSSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NIMGAMYKGFLVTAVLSVGAIWWAISYALGDMETSMSYTILDNTVTFSGRVLFYCSLLGL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEECCHHHHHHHHHHH
VITGLIIWITEYYTGTNYRPVRSIAKSSETGHGTNVIQGLAISLESTAMPTIVICAGIII
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHEEHHCCCHHHHHHHHHHH
AYQLAGLIGIAYAATAMLALAGMVVALDAYGPVTDNAGGIAEMAGLDDSVREKTDALDAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHH
GNTTKAVTKGYAIGSAGLAALVLFAAYTTDLREFFPNLAVSFSLENPYVIVGLLLGALLP
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHH
YLFGAMGMTAVGRAAGDVVIDVRDQFRENPGIMAGTSKPDYARTVDLVTKAAIKEMIVPS
HHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LLPVLAPIAVYFVIAAVGGQANGFAALGALLLGVIVGGLFVAISMTSGGGAWDNAKKYIE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHH
DGNHGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAALAAHAAG
CCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVREIKGDANVNLVVLSIILGLLAVVYGFVTSRQVLGAPAGNSKMQEIAAAIQEGAQAYL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KRQYTTIAIVGVVVAVIIAATLGTISATGFVIGAVLSGVAGFIGMNISVRSNVRTAAAAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHH
NGLQAGLTLAFRAGAITGMLVAGLALLAIAVFYHYLTDIAGYTVGGDDRTVVDGLVALAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
GASLISIFARLGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMA
HHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHH
ADLFETYVVTVGATMVLTALLLKGLGAALAPMMALPLLIGGVCIVTSIIGTYFVKLGSSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NIMGAMYKGFLVTAVLSVGAIWWAISYALGDMETSMSYTILDNTVTFSGRVLFYCSLLGL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEECCHHHHHHHHHHH
VITGLIIWITEYYTGTNYRPVRSIAKSSETGHGTNVIQGLAISLESTAMPTIVICAGIII
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHEEHHCCCHHHHHHHHHHH
AYQLAGLIGIAYAATAMLALAGMVVALDAYGPVTDNAGGIAEMAGLDDSVREKTDALDAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHH
GNTTKAVTKGYAIGSAGLAALVLFAAYTTDLREFFPNLAVSFSLENPYVIVGLLLGALLP
CCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHH
YLFGAMGMTAVGRAAGDVVIDVRDQFRENPGIMAGTSKPDYARTVDLVTKAAIKEMIVPS
HHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LLPVLAPIAVYFVIAAVGGQANGFAALGALLLGVIVGGLFVAISMTSGGGAWDNAKKYIE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHH
DGNHGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAALAAHAAG
CCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]