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The map label for this gene is fadA [H]

Identifier: 87198889

GI number: 87198889

Start: 920716

End: 921891

Strand: Reverse

Name: fadA [H]

Synonym: Saro_0867

Alternate gene names: 87198889

Gene position: 921891-920716 (Counterclockwise)

Preceding gene: 87198890

Following gene: 87198887

Centisome position: 25.88

GC content: 67.01

Gene sequence:

>1176_bases
ATGCGTGACGCCGTAATCGTATCCGCCGCTCGCACGCCTATCGGGCGCGCCTACAAGGGCGCCTTCAATGCCACTCCCGG
CGCGACGCTGGGCGCGCTTTCGCTGGAAGCCGCCGTGGCGCGGGCGGGGATCGACCCTGCCGAGGTCGACGACGTGCTGT
GGGGCGCGGCGCTCCAGCAGGGCGCCCAGGCCGGCAACATCGCGCGCCAGGTGGCGCTGCGCGCAGGCCTGCCGATCACC
ACTTCGGGCATGAGCATGGATCGCCAGTGCTCGTCGGGTCTGATGACCATCGCCACCGCTTCGAAGCAGGTGATCATCGA
CCGCATGGACGTGGTTGCCGCCGGCGGCCAGGAATCGATCAGCCTCGTCCAGACCAAGGACATGCGCGTCGCCCCGGACA
AGAGCCTGATGGCGATGCACAAGGCGATCTACATGCCGATGCTGCAGACCGCAGAGATCGTCGGCCAGCGCTATGGCATC
AGCCGCGAGGCCTGCGACGAATATGCCCTGCAATCGCAGCAGCGCACCGCCGCCGCGCAGGCCGCGGGCAAGTTCGATGA
CGAGATCGTCGCCGTGGACACGACGATGGGCGTCCAGAACAAGGAAACCGGCGAAGTCACCTTCCAGGACGTTCACCTGA
CCAAGGACGAAGGTAATCGTCCCTCGACCACGATCGAGAACCTCCAGGCGCTGAAGCCGGTGATCGAGGGCGGCATCGTG
ACGGCGGGCAACGCCAGCCAGCTATCGGACGGTTCCGCGGCGGTCGTCGTGATGGAAGCGGCGCTGGCGGCAAAGAAGGG
CCTGGCCCCGCTCGGACGCTATGTCGGCATGGCCGTTGCCGGGACCGAGCCCGACGAGATGGGCATCGGCCCGGTCTTCG
CGATCCCCAAGCTGCTCCAGCGCTTCGGGCTGAAGATGGACGACATCGGCCTGTGGGAGCTGAACGAAGCCTTCGCGGTG
CAGGTGCTTTACTGCCGCGACAAGCTGGGCATCCCCAATGACCTGCTCAACGTCAACGGCGGCTCGATCTCGATCGGCCA
CCCTTATGGCATGACCGGCGCGCGCTGCACCGGCCACGCGCTGATCGAAGGCAAGCGTCGCGGCGCGAAGTACGTGGTGG
TCACCATGTGCGTCGGCGGCGGCATGGGCGCGGCGGGACTTTTCGAAGTCCTCTGA

Upstream 100 bases:

>100_bases
TCAAGCGCGAACTGCGCGACAAATTCGGCGGGAATCCGATCCTCGCCGCGACCTCCCTGGAAAAGGCCCCTGCCCCAACA
CGTTCTCAAGGAGCATGAAC

Downstream 100 bases:

>100_bases
CGCCAGGAACAGGAAAGCCCCGGACGTTGCGGCGTCCGGGGCTTCCGGGGAGCGAGGGTCTTGCGAACCCTCAGAACTTG
ACCGTACCGGTCAACCAGAA

Product: Acetyl-CoA C-acyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MRDAVIVSAARTPIGRAYKGAFNATPGATLGALSLEAAVARAGIDPAEVDDVLWGAALQQGAQAGNIARQVALRAGLPIT
TSGMSMDRQCSSGLMTIATASKQVIIDRMDVVAAGGQESISLVQTKDMRVAPDKSLMAMHKAIYMPMLQTAEIVGQRYGI
SREACDEYALQSQQRTAAAQAAGKFDDEIVAVDTTMGVQNKETGEVTFQDVHLTKDEGNRPSTTIENLQALKPVIEGGIV
TAGNASQLSDGSAAVVVMEAALAAKKGLAPLGRYVGMAVAGTEPDEMGIGPVFAIPKLLQRFGLKMDDIGLWELNEAFAV
QVLYCRDKLGIPNDLLNVNGGSISIGHPYGMTGARCTGHALIEGKRRGAKYVVVTMCVGGGMGAAGLFEVL

Sequences:

>Translated_391_residues
MRDAVIVSAARTPIGRAYKGAFNATPGATLGALSLEAAVARAGIDPAEVDDVLWGAALQQGAQAGNIARQVALRAGLPIT
TSGMSMDRQCSSGLMTIATASKQVIIDRMDVVAAGGQESISLVQTKDMRVAPDKSLMAMHKAIYMPMLQTAEIVGQRYGI
SREACDEYALQSQQRTAAAQAAGKFDDEIVAVDTTMGVQNKETGEVTFQDVHLTKDEGNRPSTTIENLQALKPVIEGGIV
TAGNASQLSDGSAAVVVMEAALAAKKGLAPLGRYVGMAVAGTEPDEMGIGPVFAIPKLLQRFGLKMDDIGLWELNEAFAV
QVLYCRDKLGIPNDLLNVNGGSISIGHPYGMTGARCTGHALIEGKRRGAKYVVVTMCVGGGMGAAGLFEVL
>Mature_391_residues
MRDAVIVSAARTPIGRAYKGAFNATPGATLGALSLEAAVARAGIDPAEVDDVLWGAALQQGAQAGNIARQVALRAGLPIT
TSGMSMDRQCSSGLMTIATASKQVIIDRMDVVAAGGQESISLVQTKDMRVAPDKSLMAMHKAIYMPMLQTAEIVGQRYGI
SREACDEYALQSQQRTAAAQAAGKFDDEIVAVDTTMGVQNKETGEVTFQDVHLTKDEGNRPSTTIENLQALKPVIEGGIV
TAGNASQLSDGSAAVVVMEAALAAKKGLAPLGRYVGMAVAGTEPDEMGIGPVFAIPKLLQRFGLKMDDIGLWELNEAFAV
QVLYCRDKLGIPNDLLNVNGGSISIGHPYGMTGARCTGHALIEGKRRGAKYVVVTMCVGGGMGAAGLFEVL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=39.0547263681592, Blast_Score=261, Evalue=7e-70,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=42.7848101265823, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI4557237, Length=407, Percent_Identity=36.6093366093366, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=36.0201511335013, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI4504327, Length=444, Percent_Identity=29.7297297297297, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=31.6195372750643, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=41.1192214111922, Blast_Score=249, Evalue=1e-67,
Organism=Escherichia coli, GI1788554, Length=409, Percent_Identity=39.6088019559902, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=37.3134328358209, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=36.1111111111111, Blast_Score=217, Evalue=8e-58,
Organism=Escherichia coli, GI1788683, Length=418, Percent_Identity=31.1004784688995, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI133906874, Length=397, Percent_Identity=37.0277078085642, Blast_Score=233, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17535921, Length=408, Percent_Identity=35.0490196078431, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI25147385, Length=401, Percent_Identity=33.1670822942643, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=444, Percent_Identity=30.1801801801802, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=388, Percent_Identity=28.8659793814433, Blast_Score=144, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=36.6161616161616, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=417, Percent_Identity=31.4148681055156, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=39.7022332506204, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24640423, Length=402, Percent_Identity=36.81592039801, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI17648125, Length=398, Percent_Identity=35.678391959799, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI17137578, Length=437, Percent_Identity=29.9771167048055, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40826; Mature: 40826

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAVIVSAARTPIGRAYKGAFNATPGATLGALSLEAAVARAGIDPAEVDDVLWGAALQQ
CCCCEEEEECCCCCCHHHCCCCCCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GAQAGNIARQVALRAGLPITTSGMSMDRQCSSGLMTIATASKQVIIDRMDVVAAGGQESI
CCHHHHHHHHHHHHCCCCEEECCCCCCHHHHCCEEEEEECCCHHHHHHHHHEECCCCCCE
SLVQTKDMRVAPDKSLMAMHKAIYMPMLQTAEIVGQRYGISREACDEYALQSQQRTAAAQ
EEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AAGKFDDEIVAVDTTMGVQNKETGEVTFQDVHLTKDEGNRPSTTIENLQALKPVIEGGIV
HCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEE
TAGNASQLSDGSAAVVVMEAALAAKKGLAPLGRYVGMAVAGTEPDEMGIGPVFAIPKLLQ
ECCCCCCCCCCCEEEEEHHHHHHHHCCCHHHHHHHCEEEECCCCHHCCCCHHHHHHHHHH
RFGLKMDDIGLWELNEAFAVQVLYCRDKLGIPNDLLNVNGGSISIGHPYGMTGARCTGHA
HHCCCCCCCCEEECCHHHEEEEEEEECCCCCCHHHEECCCCEEEECCCCCCCCCCCCCHH
LIEGKRRGAKYVVVTMCVGGGMGAAGLFEVL
EEECCCCCCCEEEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure
MRDAVIVSAARTPIGRAYKGAFNATPGATLGALSLEAAVARAGIDPAEVDDVLWGAALQQ
CCCCEEEEECCCCCCHHHCCCCCCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GAQAGNIARQVALRAGLPITTSGMSMDRQCSSGLMTIATASKQVIIDRMDVVAAGGQESI
CCHHHHHHHHHHHHCCCCEEECCCCCCHHHHCCEEEEEECCCHHHHHHHHHEECCCCCCE
SLVQTKDMRVAPDKSLMAMHKAIYMPMLQTAEIVGQRYGISREACDEYALQSQQRTAAAQ
EEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AAGKFDDEIVAVDTTMGVQNKETGEVTFQDVHLTKDEGNRPSTTIENLQALKPVIEGGIV
HCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEE
TAGNASQLSDGSAAVVVMEAALAAKKGLAPLGRYVGMAVAGTEPDEMGIGPVFAIPKLLQ
ECCCCCCCCCCCEEEEEHHHHHHHHCCCHHHHHHHCEEEECCCCHHCCCCHHHHHHHHHH
RFGLKMDDIGLWELNEAFAVQVLYCRDKLGIPNDLLNVNGGSISIGHPYGMTGARCTGHA
HHCCCCCCCCEEECCHHHEEEEEEEECCCCCCHHHEECCCCEEEECCCCCCCCCCCCCHH
LIEGKRRGAKYVVVTMCVGGGMGAAGLFEVL
EEECCCCCCCEEEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]