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The map label for this gene is bioF [C]

Identifier: 87198742

GI number: 87198742

Start: 757565

End: 758713

Strand: Reverse

Name: bioF [C]

Synonym: Saro_0718

Alternate gene names: 87198742

Gene position: 758713-757565 (Counterclockwise)

Preceding gene: 87198743

Following gene: 87198741

Centisome position: 21.3

GC content: 66.32

Gene sequence:

>1149_bases
ATGGCCGAAAGCACCACCCGCACCGGCAACCTGTGGTCGGCGCACACCGCCGACCTTGCAGCGCTTGGCGAAAAGGCGCG
CCTGCGCTCGCTCGCTCCGCGGCGCGGGGTGGACTTCGCATCGAACGACTACCTCGCCATGTCCTCCTCGCCCCGACTGG
CAGGGGCAGTGCAGGAAGCCGTGACGCGGGGTGTGCCGTTGGGTTCGGGTGGATCGAGGCTGCTGCGAGGCAATGATCCC
GAACACGAGTTGCTGGAGACGGAAGCCGCCCGCTTCTTCGGCTCGGAAAGCGCCCTGTTCTTCTCGTCAGGCTACGCCGC
CAATGTTGCACTGCTTTCCACTCTTCCGCAGCGCGGTGACCTGATTATCTATGACGAACTGGTCCATGCCTCAATGCACG
AGGGCCTGCGCCTGACGCGCGCCACCAGCGTCAGTGCCGCCCACAACGATCCGCAGAGCTTCGACGATGCTGCGCTTGAC
TGGCGCGCCAAGGGCAACACCGGCCGCGTCTGGCTCGCGTTCGAGACGCTCTATTCCATGGACGGCGACATGGCACCGGT
TGCCGAGATGGCGCAGATCGCGGAACGCCACGACGCGGTCATGCTGATCGACGAAGCCCACGCGACGGGCGTGTTCGGCG
TCGATGGACGCGGCCTTGCCGCCAGCCTTGACGGGCGGGCCGATACCATTGTTCTGCGCACTTGCGGCAAAGCCATGGGC
TGTGAAGGTGCCCTCGTCCTGGCGCCGCGTGTCGTCCGCGACTTCCTCGTCAATCGGGGCCGTCCTTTCATCTTCTCGAC
CGCTCCTTCACCGCTCGTATGCGCCGCAGTGCGCGAGGCGATGCGCATGATGGCAGACGAGCCCGAGCGCCGCGAGAACT
TGCGTACGCTCGTAGCCCACGCCGAACGTGCACTCGTCCGCCACGGCGCCGAACCAACAGGTTCGCAGATCCTTCCGCTA
ATCCTGGGCGAAGACGCGCGCACCATGGCAGTCGCCGCTTCTCTCCAGGCAAGCGGTTTCGACGTGCGCGGCATCCGCCC
ACCCACAGTGCCGCAAGGCACCAGCCGCCTGCGCATCTCGCTGACGCTCAACGCCACGCGCGACGACGTCGATGCGCTTG
GCACAGCACTGGAAGAGGCGCTGCGATGA

Upstream 100 bases:

>100_bases
CCGCCATGTTCAAGCGCCTCGGTCTCAAGCCGATGGAAGGCGAGGAACCCATGCGGGCGATGAAGTCCGTCGGAGGCTGC
TCCGGAGGCTGCGCGGCGTA

Downstream 100 bases:

>100_bases
CCGCTTTCGTCGTCACCGGCACAGACACGGGCGTCGGCAAGACGATCTTTTCCGCCGCGCTGACAGGCGCGCTTAACGCG
CATTACTGGAAGCCTGTCCA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MAESTTRTGNLWSAHTADLAALGEKARLRSLAPRRGVDFASNDYLAMSSSPRLAGAVQEAVTRGVPLGSGGSRLLRGNDP
EHELLETEAARFFGSESALFFSSGYAANVALLSTLPQRGDLIIYDELVHASMHEGLRLTRATSVSAAHNDPQSFDDAALD
WRAKGNTGRVWLAFETLYSMDGDMAPVAEMAQIAERHDAVMLIDEAHATGVFGVDGRGLAASLDGRADTIVLRTCGKAMG
CEGALVLAPRVVRDFLVNRGRPFIFSTAPSPLVCAAVREAMRMMADEPERRENLRTLVAHAERALVRHGAEPTGSQILPL
ILGEDARTMAVAASLQASGFDVRGIRPPTVPQGTSRLRISLTLNATRDDVDALGTALEEALR

Sequences:

>Translated_382_residues
MAESTTRTGNLWSAHTADLAALGEKARLRSLAPRRGVDFASNDYLAMSSSPRLAGAVQEAVTRGVPLGSGGSRLLRGNDP
EHELLETEAARFFGSESALFFSSGYAANVALLSTLPQRGDLIIYDELVHASMHEGLRLTRATSVSAAHNDPQSFDDAALD
WRAKGNTGRVWLAFETLYSMDGDMAPVAEMAQIAERHDAVMLIDEAHATGVFGVDGRGLAASLDGRADTIVLRTCGKAMG
CEGALVLAPRVVRDFLVNRGRPFIFSTAPSPLVCAAVREAMRMMADEPERRENLRTLVAHAERALVRHGAEPTGSQILPL
ILGEDARTMAVAASLQASGFDVRGIRPPTVPQGTSRLRISLTLNATRDDVDALGTALEEALR
>Mature_381_residues
AESTTRTGNLWSAHTADLAALGEKARLRSLAPRRGVDFASNDYLAMSSSPRLAGAVQEAVTRGVPLGSGGSRLLRGNDPE
HELLETEAARFFGSESALFFSSGYAANVALLSTLPQRGDLIIYDELVHASMHEGLRLTRATSVSAAHNDPQSFDDAALDW
RAKGNTGRVWLAFETLYSMDGDMAPVAEMAQIAERHDAVMLIDEAHATGVFGVDGRGLAASLDGRADTIVLRTCGKAMGC
EGALVLAPRVVRDFLVNRGRPFIFSTAPSPLVCAAVREAMRMMADEPERRENLRTLVAHAERALVRHGAEPTGSQILPLI
LGEDARTMAVAASLQASGFDVRGIRPPTVPQGTSRLRISLTLNATRDDVDALGTALEEALR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977444, Length=364, Percent_Identity=32.6923076923077, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI83977442, Length=364, Percent_Identity=32.6923076923077, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI83977440, Length=364, Percent_Identity=32.6923076923077, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI7657118, Length=353, Percent_Identity=30.8781869688385, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI284448556, Length=353, Percent_Identity=30.8781869688385, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI4502025, Length=348, Percent_Identity=31.8965517241379, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI40316939, Length=348, Percent_Identity=31.8965517241379, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI4758668, Length=365, Percent_Identity=28.4931506849315, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI119220554, Length=362, Percent_Identity=24.0331491712707, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI5454084, Length=266, Percent_Identity=25.5639097744361, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=35.8166189111748, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1790046, Length=340, Percent_Identity=31.4705882352941, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71994529, Length=346, Percent_Identity=31.2138728323699, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32566772, Length=363, Percent_Identity=23.1404958677686, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982617, Length=296, Percent_Identity=23.6486486486486, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982625, Length=303, Percent_Identity=24.0924092409241, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17560914, Length=315, Percent_Identity=23.8095238095238, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17560912, Length=315, Percent_Identity=23.8095238095238, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=372, Percent_Identity=30.9139784946237, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6320267, Length=356, Percent_Identity=26.4044943820225, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323954, Length=269, Percent_Identity=23.4200743494424, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24662918, Length=347, Percent_Identity=29.1066282420749, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI17137420, Length=352, Percent_Identity=33.2386363636364, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17136286, Length=365, Percent_Identity=24.9315068493151, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24653280, Length=270, Percent_Identity=24.8148148148148, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24653276, Length=270, Percent_Identity=24.8148148148148, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24653278, Length=270, Percent_Identity=24.8148148148148, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 40856; Mature: 40725

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESTTRTGNLWSAHTADLAALGEKARLRSLAPRRGVDFASNDYLAMSSSPRLAGAVQEA
CCCCCCCCCCCCCCHHHHHHHHCHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHH
VTRGVPLGSGGSRLLRGNDPEHELLETEAARFFGSESALFFSSGYAANVALLSTLPQRGD
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCC
LIIYDELVHASMHEGLRLTRATSVSAAHNDPQSFDDAALDWRAKGNTGRVWLAFETLYSM
EEEEHHHHHHHHHCCEEEEHHCCCCCCCCCCCCCCCHHCEEEECCCCCEEEEEEEHHHHC
DGDMAPVAEMAQIAERHDAVMLIDEAHATGVFGVDGRGLAASLDGRADTIVLRTCGKAMG
CCCCCHHHHHHHHHHHCCEEEEEECCCCCEEEECCCCCCEEECCCCCCEEEEEECCHHCC
CEGALVLAPRVVRDFLVNRGRPFIFSTAPSPLVCAAVREAMRMMADEPERRENLRTLVAH
CCCEEEECHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AERALVRHGAEPTGSQILPLILGEDARTMAVAASLQASGFDVRGIRPPTVPQGTSRLRIS
HHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEEEE
LTLNATRDDVDALGTALEEALR
EEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AESTTRTGNLWSAHTADLAALGEKARLRSLAPRRGVDFASNDYLAMSSSPRLAGAVQEA
CCCCCCCCCCCCCHHHHHHHHCHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHH
VTRGVPLGSGGSRLLRGNDPEHELLETEAARFFGSESALFFSSGYAANVALLSTLPQRGD
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCC
LIIYDELVHASMHEGLRLTRATSVSAAHNDPQSFDDAALDWRAKGNTGRVWLAFETLYSM
EEEEHHHHHHHHHCCEEEEHHCCCCCCCCCCCCCCCHHCEEEECCCCCEEEEEEEHHHHC
DGDMAPVAEMAQIAERHDAVMLIDEAHATGVFGVDGRGLAASLDGRADTIVLRTCGKAMG
CCCCCHHHHHHHHHHHCCEEEEEECCCCCEEEECCCCCCEEECCCCCCEEEEEECCHHCC
CEGALVLAPRVVRDFLVNRGRPFIFSTAPSPLVCAAVREAMRMMADEPERRENLRTLVAH
CCCEEEECHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AERALVRHGAEPTGSQILPLILGEDARTMAVAASLQASGFDVRGIRPPTVPQGTSRLRIS
HHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEEEE
LTLNATRDDVDALGTALEEALR
EEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA