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The map label for this gene is sufS [H]

Identifier: 87198225

GI number: 87198225

Start: 205411

End: 206622

Strand: Direct

Name: sufS [H]

Synonym: Saro_0199

Alternate gene names: 87198225

Gene position: 205411-206622 (Clockwise)

Preceding gene: 87198224

Following gene: 87198226

Centisome position: 5.77

GC content: 68.4

Gene sequence:

>1212_bases
GTGAGCGTGGACACGATCACGCGCGGCGCGCAATGGCCGGGCCTGCTGAATCCCGACGGCAGCCGCTGGCACTATCTCGA
CACCGCAGCCACCGCGCAGAAGCCGCAGGTGGTGATCGACGCGGTAACTCGCGCCCTCGGCGCCGACTACGCCACCGTCC
ATCGCGGCGTCTATGCCCGCTCGGCCGACATGACGCTCGCCTTCGAGGCCGCGCGCCGCAAGGTGGCGGGGCTGGTCAAC
GGCGATGAAGGCGAGATCGTCTTCACGCGCGGCGCAACCGAGGCGATCAACCTCGTCGCGCAGACCTGGGGCCAGGCAAA
CCTCAAGGCGGGCGACCGCATCCTGCTCTCCACGCTCGAGCATCATTCGAACATCGTACCTTGGCAGTTGCTGCGCGACC
GGACCGGAGTCGAGATCGACGTCTGCCCGTTGACCGAGGACGGCCGCATCGACCTTGCCGCGGCGGAGCGCATCCTGACC
CCCGCGCACAAGCTTGTCGCTCTTGCCCATGTGTCGAACGTGCTCGGTTCTGTGCTCGACGTGGCGCAGGCGGTCCGGCT
GGCGCGTGCGGTCGGGGCGAAGATCCTGCTCGACGGCTGCCAGGCGGTGCCGCGCCTCGCTGTCGACGTGAAGGCGATGG
ACGCTGATTTCTACGTCTTTTCCGCCCACAAGCTCTATGGCCCGACCGGCATAGGCGCGCTTTGGGCCAAGGCCGCGATT
CTCGACGCCATGCCGCCGTGGCAGGGCGGCGGGGCGATGATCGACCGCGTCACTTTCGAGCGCACGACCTATGCCCCCGC
GCCGCAGCGTTTCGAAGCCGGCACCCCGGCCATCGTCGAGGCCATCGGCTTCGGCGCGGCGGTGGACTTCGTGCAGGCAC
AGGGCCTCGATGCGATCCACGCCCATGAAGTCGCGCTCGTGGCCAAGGCCCGCGAGGCGCTCGGGCGGATGAACTCCGTC
CGCCTGTTCGGGCCCGAGGACAGCGCCGGCATCGTCAGCTTCGCCATCGAGGGCGTGCACCCGCACGATCTCGGCACGAT
CCTCGACGAGGAAGGCGTGGCGATCCGTGCCGGGCACCACTGCGCGCAGCCATTGATGGACCACCTTGGCGTTCCCGCCA
CGGCCCGGGCCAGCTTCGGCATCTACAGCGATGAAAGCGATATCGCCGCCCTCGTGCGCGGCATCGAAAGGACCAAGAGG
ATATTCGGATGA

Upstream 100 bases:

>100_bases
AGAAGCTCATGCTCCAGGCCTTCATCGCCGAGGCCTTCGTCGGCGCGGCCGACGAGGAGGTCCTGACAGATGCCGCGCTC
AAGGCGCTGGAGGCTGTGCT

Downstream 100 bases:

>100_bases
GCAGCGAAGATCCCAAATTCGCCGTCGAGGAAGTCGAAGCGGTGGCTGCCCCCCGGCGTGCCTTCGTCGAGGACGCGGTC
GAAGAGACCCCCGCCGAGAA

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSVDTITRGAQWPGLLNPDGSRWHYLDTAATAQKPQVVIDAVTRALGADYATVHRGVYARSADMTLAFEAARRKVAGLVN
GDEGEIVFTRGATEAINLVAQTWGQANLKAGDRILLSTLEHHSNIVPWQLLRDRTGVEIDVCPLTEDGRIDLAAAERILT
PAHKLVALAHVSNVLGSVLDVAQAVRLARAVGAKILLDGCQAVPRLAVDVKAMDADFYVFSAHKLYGPTGIGALWAKAAI
LDAMPPWQGGGAMIDRVTFERTTYAPAPQRFEAGTPAIVEAIGFGAAVDFVQAQGLDAIHAHEVALVAKAREALGRMNSV
RLFGPEDSAGIVSFAIEGVHPHDLGTILDEEGVAIRAGHHCAQPLMDHLGVPATARASFGIYSDESDIAALVRGIERTKR
IFG

Sequences:

>Translated_403_residues
MSVDTITRGAQWPGLLNPDGSRWHYLDTAATAQKPQVVIDAVTRALGADYATVHRGVYARSADMTLAFEAARRKVAGLVN
GDEGEIVFTRGATEAINLVAQTWGQANLKAGDRILLSTLEHHSNIVPWQLLRDRTGVEIDVCPLTEDGRIDLAAAERILT
PAHKLVALAHVSNVLGSVLDVAQAVRLARAVGAKILLDGCQAVPRLAVDVKAMDADFYVFSAHKLYGPTGIGALWAKAAI
LDAMPPWQGGGAMIDRVTFERTTYAPAPQRFEAGTPAIVEAIGFGAAVDFVQAQGLDAIHAHEVALVAKAREALGRMNSV
RLFGPEDSAGIVSFAIEGVHPHDLGTILDEEGVAIRAGHHCAQPLMDHLGVPATARASFGIYSDESDIAALVRGIERTKR
IFG
>Mature_402_residues
SVDTITRGAQWPGLLNPDGSRWHYLDTAATAQKPQVVIDAVTRALGADYATVHRGVYARSADMTLAFEAARRKVAGLVNG
DEGEIVFTRGATEAINLVAQTWGQANLKAGDRILLSTLEHHSNIVPWQLLRDRTGVEIDVCPLTEDGRIDLAAAERILTP
AHKLVALAHVSNVLGSVLDVAQAVRLARAVGAKILLDGCQAVPRLAVDVKAMDADFYVFSAHKLYGPTGIGALWAKAAIL
DAMPPWQGGGAMIDRVTFERTTYAPAPQRFEAGTPAIVEAIGFGAAVDFVQAQGLDAIHAHEVALVAKAREALGRMNSVR
LFGPEDSAGIVSFAIEGVHPHDLGTILDEEGVAIRAGHHCAQPLMDHLGVPATARASFGIYSDESDIAALVRGIERTKRI
FG

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=271, Percent_Identity=28.4132841328413, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI156713448, Length=332, Percent_Identity=25, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1787970, Length=381, Percent_Identity=47.244094488189, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1789175, Length=379, Percent_Identity=41.1609498680739, Blast_Score=307, Evalue=6e-85,
Organism=Escherichia coli, GI48994898, Length=221, Percent_Identity=32.579185520362, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=222, Percent_Identity=27.9279279279279, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI193211090, Length=396, Percent_Identity=25.2525252525253, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319831, Length=389, Percent_Identity=25.9640102827763, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20129463, Length=295, Percent_Identity=30.1694915254237, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 42899; Mature: 42768

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDTITRGAQWPGLLNPDGSRWHYLDTAATAQKPQVVIDAVTRALGADYATVHRGVYAR
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHCCCEEC
SADMTLAFEAARRKVAGLVNGDEGEIVFTRGATEAINLVAQTWGQANLKAGDRILLSTLE
CCCCEEHHHHHHHHHHHCEECCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
HHSNIVPWQLLRDRTGVEIDVCPLTEDGRIDLAAAERILTPAHKLVALAHVSNVLGSVLD
HHCCCCCHHHHHCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAQAVRLARAVGAKILLDGCQAVPRLAVDVKAMDADFYVFSAHKLYGPTGIGALWAKAAI
HHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEEECCCEEEEEEHHHCCCCCHHHHHHHHHH
LDAMPPWQGGGAMIDRVTFERTTYAPAPQRFEAGTPAIVEAIGFGAAVDFVQAQGLDAIH
HHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCHHH
AHEVALVAKAREALGRMNSVRLFGPEDSAGIVSFAIEGVHPHDLGTILDEEGVAIRAGHH
HHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCHHHHHCCCCCCEEECCCH
CAQPLMDHLGVPATARASFGIYSDESDIAALVRGIERTKRIFG
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVDTITRGAQWPGLLNPDGSRWHYLDTAATAQKPQVVIDAVTRALGADYATVHRGVYAR
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHCCCEEC
SADMTLAFEAARRKVAGLVNGDEGEIVFTRGATEAINLVAQTWGQANLKAGDRILLSTLE
CCCCEEHHHHHHHHHHHCEECCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
HHSNIVPWQLLRDRTGVEIDVCPLTEDGRIDLAAAERILTPAHKLVALAHVSNVLGSVLD
HHCCCCCHHHHHCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAQAVRLARAVGAKILLDGCQAVPRLAVDVKAMDADFYVFSAHKLYGPTGIGALWAKAAI
HHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEEECCCEEEEEEHHHCCCCCHHHHHHHHHH
LDAMPPWQGGGAMIDRVTFERTTYAPAPQRFEAGTPAIVEAIGFGAAVDFVQAQGLDAIH
HHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCHHH
AHEVALVAKAREALGRMNSVRLFGPEDSAGIVSFAIEGVHPHDLGTILDEEGVAIRAGHH
HHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCHHHHHCCCCCCEEECCCH
CAQPLMDHLGVPATARASFGIYSDESDIAALVRGIERTKRIFG
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11251816 [H]