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The map label for this gene is msrA2 [H]

Identifier: 87198184

GI number: 87198184

Start: 155613

End: 156290

Strand: Direct

Name: msrA2 [H]

Synonym: Saro_0158

Alternate gene names: 87198184

Gene position: 155613-156290 (Clockwise)

Preceding gene: 87198183

Following gene: 87198185

Centisome position: 4.37

GC content: 64.9

Gene sequence:

>678_bases
ATGAGGCGTCCGGTCCTAGCCGCTGCTCTGCTGGCCGGGATCGTCACCGCGTCCTGCCAGCAGACCGCGCAGGCAGAAGG
CGCCGTGGCGGCGCCCGAGGCTGCGGTTCAGGCGGACGAAGCGCCAGGCCGCAAGGTTGCGATCTTCGCAGGCGGTTGCT
TCTGGGGCGTCGAGGGGGTGTTCAGCCACGTCAAGGGCGTGACCAGCGTGGTCTCGGGCTACCATGGGGGCGAAAAGAAG
ACCGCGAGCTACGATGTCGTCGGCACCGGCCGGACCGGCCATGCCGAGGCTGTTCGGGTCACCTACGATCCGGCCAAGGT
GCGCTACGACCAGCTTCTCCGGATATTCTTCGCTGTCGTGACCGATCCGACGCAGTTGAACTACCAGGGGCCGGACGACG
GCACCCAGTATCGCAACGCTCTGGTGCCGATGGACAAGGAACAGGCACGCGTGGCGGCCGGATACCTGGCCCAGTTGAAG
CGGCTCGATCTCTGGAAGCGGCCCATCGTGACAGCAGTCGAGCCTTACAAGACGTTCTATCCGGCCGAGGGCTATCATCA
GGACTTCATGGCCAACAATCCCGACCACGGTTATATCCGCCGCTGGGATGCGCCCAAGGTCCAGGCGCTCAAGCGCATGT
TCCCCGATCTCTACAAGCCGGCCTTCACGCGGAACTGA

Upstream 100 bases:

>100_bases
ATGGCGATGTCCGTTGGCGCGACCGCCTGGGCCTCGGCGGACAGCGCCCCGGTCACGAACTCCGGCACGAGCCACGCCAC
CGGCCAGACCGGCCGCTGAG

Downstream 100 bases:

>100_bases
TTTGCGCATCCGCGCGGCGCTGCCTATCTAGAGGCCATGGCGGGGCATCACCATCATCATGATTTCGCGGGCGAGAAGCT
GGTAAAGGCGGCGCGCGACG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRRPVLAAALLAGIVTASCQQTAQAEGAVAAPEAAVQADEAPGRKVAIFAGGCFWGVEGVFSHVKGVTSVVSGYHGGEKK
TASYDVVGTGRTGHAEAVRVTYDPAKVRYDQLLRIFFAVVTDPTQLNYQGPDDGTQYRNALVPMDKEQARVAAGYLAQLK
RLDLWKRPIVTAVEPYKTFYPAEGYHQDFMANNPDHGYIRRWDAPKVQALKRMFPDLYKPAFTRN

Sequences:

>Translated_225_residues
MRRPVLAAALLAGIVTASCQQTAQAEGAVAAPEAAVQADEAPGRKVAIFAGGCFWGVEGVFSHVKGVTSVVSGYHGGEKK
TASYDVVGTGRTGHAEAVRVTYDPAKVRYDQLLRIFFAVVTDPTQLNYQGPDDGTQYRNALVPMDKEQARVAAGYLAQLK
RLDLWKRPIVTAVEPYKTFYPAEGYHQDFMANNPDHGYIRRWDAPKVQALKRMFPDLYKPAFTRN
>Mature_225_residues
MRRPVLAAALLAGIVTASCQQTAQAEGAVAAPEAAVQADEAPGRKVAIFAGGCFWGVEGVFSHVKGVTSVVSGYHGGEKK
TASYDVVGTGRTGHAEAVRVTYDPAKVRYDQLLRIFFAVVTDPTQLNYQGPDDGTQYRNALVPMDKEQARVAAGYLAQLK
RLDLWKRPIVTAVEPYKTFYPAEGYHQDFMANNPDHGYIRRWDAPKVQALKRMFPDLYKPAFTRN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=39.622641509434, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=39.622641509434, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI208609993, Length=111, Percent_Identity=39.6396396396396, Blast_Score=81, Evalue=8e-16,
Organism=Escherichia coli, GI1790665, Length=155, Percent_Identity=43.8709677419355, Blast_Score=123, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=35.5421686746988, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24664627, Length=153, Percent_Identity=30.718954248366, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664631, Length=153, Percent_Identity=30.0653594771242, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45553131, Length=145, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24708; Mature: 24708

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPVLAAALLAGIVTASCQQTAQAEGAVAAPEAAVQADEAPGRKVAIFAGGCFWGVEGV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEEEEECCHHHHHHHH
FSHVKGVTSVVSGYHGGEKKTASYDVVGTGRTGHAEAVRVTYDPAKVRYDQLLRIFFAVV
HHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCEEEEEECHHHHHHHHHHHHHHHHH
TDPTQLNYQGPDDGTQYRNALVPMDKEQARVAAGYLAQLKRLDLWKRPIVTAVEPYKTFY
CCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHCC
PAEGYHQDFMANNPDHGYIRRWDAPKVQALKRMFPDLYKPAFTRN
CCCCCCHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRRPVLAAALLAGIVTASCQQTAQAEGAVAAPEAAVQADEAPGRKVAIFAGGCFWGVEGV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEEEEECCHHHHHHHH
FSHVKGVTSVVSGYHGGEKKTASYDVVGTGRTGHAEAVRVTYDPAKVRYDQLLRIFFAVV
HHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCEEEEEECHHHHHHHHHHHHHHHHH
TDPTQLNYQGPDDGTQYRNALVPMDKEQARVAAGYLAQLKRLDLWKRPIVTAVEPYKTFY
CCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHCC
PAEGYHQDFMANNPDHGYIRRWDAPKVQALKRMFPDLYKPAFTRN
CCCCCCHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]