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The map label for this gene is mutL

Identifier: 86751283

GI number: 86751283

Start: 4747341

End: 4749134

Strand: Reverse

Name: mutL

Synonym: RPB_4176

Alternate gene names: 86751283

Gene position: 4749134-4747341 (Counterclockwise)

Preceding gene: 86751284

Following gene: 86751281

Centisome position: 89.07

GC content: 69.84

Gene sequence:

>1794_bases
ATGCCCGTCCGCCAGCTTCCCGAAACCATCGTCAACCGCATCGCCGCCGGCGAGGTGGTGGAGCGGCCGGCGAGCGTGGT
GAAGGAGCTGGTCGAAAACGCGATCGATGCCGGCGCCAGCCGCATCGACATCTTCTCGGATGGCGGCGGCCGGCGAAAGA
TCGTGATCGCCGACGACGGCAGCGGGATGACGCGGGCCGATCTCGCGCTCGCGGTCGATCGCCACGCCACCTCCAAGCTC
GACGACGAGGACCTCTTACAGATCCGCACGCTCGGCTTTCGCGGCGAGGCGCTGCCCTCGATCGGCGCGGTGGCGCGGCT
GACGATCACCACGCGCCATGCCGGCGAGCCGCATGCCTGGACGCTCGGCGTCGAGGGCGGTGACAAATCGCCGATTGCTC
CCGCGGCGCTGTCGCAAGGCACCCGGGTCGAGGTCGCTGATCTGTTCTTCGCCACCCCGGCGCGGCTGAAGTTTCTCAAG
ACCGATCGCACCGAGGCCGAGGCGATCCGCGACGTGGTGCGGCGGCTGGCGATGGCGCGGCCGGACATCGCCTTCACGCT
GGCCGGCGAAGAGCGCGCACCGGTGACCTGGGCGGCGGCGCTGCCCGGCGCGCCGGGGCAATTGATCCGGCTCGGCGACA
TTCTCGGCGCGGACTTTCGCGCCAATGCCATCGAGGTCCGCTCGGAACGCGAAGGCGTCGCGGTCGAGGGCTTCGCCGCG
TCGCCGGCGCTGACCCGCGCCAATGCGCTCGGGCAATATCTGTTCGTCAACGGCCGGCCGGTGCGCGACAAGCTGATCCT
CGGCGCTGTGCGCGCGGCCTATTCGGATTACTTGCCGCGCGATCGCCATCCGGTGGTGGCGCTGTTCGTCACGCTGGAGT
CGCGCGAGGTCGACGCCAATGTGCATCCGGCCAAGACCGAGGTGCGCTTCCGCAATGCCGGCCTGGTGCGTGCGCTGATC
GTCCACGCGCTGAAAGAAGGGCTGGCGCGCGAGGGCCGCCGCACCGCCGCCAACAGCGCCGGCAGCGTGATCTCGACCTT
CCGTCCCGCCTCGATGCCGGCTGCGAATTGGGACTGGCGTGCCTCGCCGTCTTATCCGGTCGGCGGCTCCGCGATCGATG
CGCCGTCTTTTGCCGAGCGCCCGCAGGCCGCGTTCGATGTCGGCGGGCCGAGCGCCGACATCCGCACGCACGAGGTCGCG
CCGGATCTGCTCGACCGCCCGCTCGGCGCGGCGCGGACGCAGATCCACGAGACCTACATCGTGTCGCAGACCCGCGACGG
GCTGATCGTTGTGGACCAGCACGCCGCCCACGAGCGCATCGTCTACGAGCGCTTGAAGGCGTCGCTCGCCGCCAACGGCG
TGCAGCGCCAGATCCTGCTGATCCCGGATATCGTTGAGATGGACGAGGCGACCGTCGAACGCCTGGTGGCGCGCGCCGAC
GAGCTGGCGCAATTCGGCCTCGTCGTCGAGAGCTTTGGCCCCGGCGCGGTCGCGGTGCGCGAGACGCCGTCGCTGCTCGG
CAAGACCGATGCGGCGTCGCTGCTGCGCGATCTCGCCGAGCATATGGCCGAATGGGACGAGGCGCTGCCGCTGGAGCGCC
GCCTGATGCACGTCGCCGCGACGATGGCCTGCCACGGCTCGGTGCGGGCCGGGCGCGTGCTCAAGCCCGAAGAGATGAAC
GCGCTGCTGCGCGAAATGGAAGCGACGCCGAATTCCGGCCAATGCAATCACGGCCGCCCGACCTATGTCGAACTGACGTT
GACCGATATCGAGAAGCTGTTCGGGCGAAGGTAG

Upstream 100 bases:

>100_bases
GCGGTTCCGTTGCGGAAGGCGGGGATGGAATGCTGGGCAACGCCTGCTTTTCCAGCCTTGGTCGCCTAGTATCGTTGCCT
CCGATCAACCGAGTCGCCTT

Downstream 100 bases:

>100_bases
TTGGTAGCGGAGCGCTGGGGCCTCCGTTCGCTCTCCACACATTCTGCGTCATCCTGAGGTGCGCGCCGTCTTCGGCGCGC
CTCGAAGGATGGACACGCGT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MPVRQLPETIVNRIAAGEVVERPASVVKELVENAIDAGASRIDIFSDGGGRRKIVIADDGSGMTRADLALAVDRHATSKL
DDEDLLQIRTLGFRGEALPSIGAVARLTITTRHAGEPHAWTLGVEGGDKSPIAPAALSQGTRVEVADLFFATPARLKFLK
TDRTEAEAIRDVVRRLAMARPDIAFTLAGEERAPVTWAAALPGAPGQLIRLGDILGADFRANAIEVRSEREGVAVEGFAA
SPALTRANALGQYLFVNGRPVRDKLILGAVRAAYSDYLPRDRHPVVALFVTLESREVDANVHPAKTEVRFRNAGLVRALI
VHALKEGLAREGRRTAANSAGSVISTFRPASMPAANWDWRASPSYPVGGSAIDAPSFAERPQAAFDVGGPSADIRTHEVA
PDLLDRPLGAARTQIHETYIVSQTRDGLIVVDQHAAHERIVYERLKASLAANGVQRQILLIPDIVEMDEATVERLVARAD
ELAQFGLVVESFGPGAVAVRETPSLLGKTDAASLLRDLAEHMAEWDEALPLERRLMHVAATMACHGSVRAGRVLKPEEMN
ALLREMEATPNSGQCNHGRPTYVELTLTDIEKLFGRR

Sequences:

>Translated_597_residues
MPVRQLPETIVNRIAAGEVVERPASVVKELVENAIDAGASRIDIFSDGGGRRKIVIADDGSGMTRADLALAVDRHATSKL
DDEDLLQIRTLGFRGEALPSIGAVARLTITTRHAGEPHAWTLGVEGGDKSPIAPAALSQGTRVEVADLFFATPARLKFLK
TDRTEAEAIRDVVRRLAMARPDIAFTLAGEERAPVTWAAALPGAPGQLIRLGDILGADFRANAIEVRSEREGVAVEGFAA
SPALTRANALGQYLFVNGRPVRDKLILGAVRAAYSDYLPRDRHPVVALFVTLESREVDANVHPAKTEVRFRNAGLVRALI
VHALKEGLAREGRRTAANSAGSVISTFRPASMPAANWDWRASPSYPVGGSAIDAPSFAERPQAAFDVGGPSADIRTHEVA
PDLLDRPLGAARTQIHETYIVSQTRDGLIVVDQHAAHERIVYERLKASLAANGVQRQILLIPDIVEMDEATVERLVARAD
ELAQFGLVVESFGPGAVAVRETPSLLGKTDAASLLRDLAEHMAEWDEALPLERRLMHVAATMACHGSVRAGRVLKPEEMN
ALLREMEATPNSGQCNHGRPTYVELTLTDIEKLFGRR
>Mature_596_residues
PVRQLPETIVNRIAAGEVVERPASVVKELVENAIDAGASRIDIFSDGGGRRKIVIADDGSGMTRADLALAVDRHATSKLD
DEDLLQIRTLGFRGEALPSIGAVARLTITTRHAGEPHAWTLGVEGGDKSPIAPAALSQGTRVEVADLFFATPARLKFLKT
DRTEAEAIRDVVRRLAMARPDIAFTLAGEERAPVTWAAALPGAPGQLIRLGDILGADFRANAIEVRSEREGVAVEGFAAS
PALTRANALGQYLFVNGRPVRDKLILGAVRAAYSDYLPRDRHPVVALFVTLESREVDANVHPAKTEVRFRNAGLVRALIV
HALKEGLAREGRRTAANSAGSVISTFRPASMPAANWDWRASPSYPVGGSAIDAPSFAERPQAAFDVGGPSADIRTHEVAP
DLLDRPLGAARTQIHETYIVSQTRDGLIVVDQHAAHERIVYERLKASLAANGVQRQILLIPDIVEMDEATVERLVARADE
LAQFGLVVESFGPGAVAVRETPSLLGKTDAASLLRDLAEHMAEWDEALPLERRLMHVAATMACHGSVRAGRVLKPEEMNA
LLREMEATPNSGQCNHGRPTYVELTLTDIEKLFGRR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=314, Percent_Identity=37.8980891719745, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI4505911, Length=325, Percent_Identity=29.5384615384615, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI189458898, Length=325, Percent_Identity=29.5384615384615, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI189458896, Length=318, Percent_Identity=28.3018867924528, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI4505913, Length=341, Percent_Identity=28.1524926686217, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI310128478, Length=341, Percent_Identity=28.1524926686217, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI263191589, Length=220, Percent_Identity=33.1818181818182, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI310128480, Length=298, Percent_Identity=25.8389261744966, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI91992162, Length=346, Percent_Identity=26.3005780346821, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI91992160, Length=346, Percent_Identity=26.3005780346821, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1790612, Length=418, Percent_Identity=41.6267942583732, Blast_Score=265, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI71991825, Length=333, Percent_Identity=33.6336336336336, Blast_Score=165, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17562796, Length=338, Percent_Identity=23.9644970414201, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323819, Length=361, Percent_Identity=34.9030470914127, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324247, Length=370, Percent_Identity=25.6756756756757, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325093, Length=716, Percent_Identity=21.2290502793296, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136968, Length=357, Percent_Identity=35.2941176470588, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI17136970, Length=355, Percent_Identity=25.9154929577465, Blast_Score=103, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_RHOP2 (Q2ISE2)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_487779.1
- ProteinModelPortal:   Q2ISE2
- SMR:   Q2ISE2
- STRING:   Q2ISE2
- GeneID:   3911984
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_4176
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- BioCyc:   RPAL316058:RPB_4176-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 64430; Mature: 64299

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVRQLPETIVNRIAAGEVVERPASVVKELVENAIDAGASRIDIFSDGGGRRKIVIADDG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECC
SGMTRADLALAVDRHATSKLDDEDLLQIRTLGFRGEALPSIGAVARLTITTRHAGEPHAW
CCCCHHHHHEEEHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCEE
TLGVEGGDKSPIAPAALSQGTRVEVADLFFATPARLKFLKTDRTEAEAIRDVVRRLAMAR
EEEECCCCCCCCCHHHHCCCCEEEEHHHHHCCCHHEEEEECCCHHHHHHHHHHHHHHHCC
PDIAFTLAGEERAPVTWAAALPGAPGQLIRLGDILGADFRANAIEVRSEREGVAVEGFAA
CCEEEEECCCCCCCEEEEECCCCCCCCCEEEHHHHCCCCCCCCEEECCCCCCCEEECCCC
SPALTRANALGQYLFVNGRPVRDKLILGAVRAAYSDYLPRDRHPVVALFVTLESREVDAN
CCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCC
VHPAKTEVRFRNAGLVRALIVHALKEGLAREGRRTAANSAGSVISTFRPASMPAANWDWR
CCCCHHEEEECCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHCCCCCCCCCCCCCC
ASPSYPVGGSAIDAPSFAERPQAAFDVGGPSADIRTHEVAPDLLDRPLGAARTQIHETYI
CCCCCCCCCCCCCCCCHHCCCCCEEECCCCCCCCCHHHCCHHHHHCCCCHHHHHHHHEEE
VSQTRDGLIVVDQHAAHERIVYERLKASLAANGVQRQILLIPDIVEMDEATVERLVARAD
EEECCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCHHHHHHHHHHHH
ELAQFGLVVESFGPGAVAVRETPSLLGKTDAASLLRDLAEHMAEWDEALPLERRLMHVAA
HHHHHHHHHCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TMACHGSVRAGRVLKPEEMNALLREMEATPNSGQCNHGRPTYVELTLTDIEKLFGRR
HHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHCCC
>Mature Secondary Structure 
PVRQLPETIVNRIAAGEVVERPASVVKELVENAIDAGASRIDIFSDGGGRRKIVIADDG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECC
SGMTRADLALAVDRHATSKLDDEDLLQIRTLGFRGEALPSIGAVARLTITTRHAGEPHAW
CCCCHHHHHEEEHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCEE
TLGVEGGDKSPIAPAALSQGTRVEVADLFFATPARLKFLKTDRTEAEAIRDVVRRLAMAR
EEEECCCCCCCCCHHHHCCCCEEEEHHHHHCCCHHEEEEECCCHHHHHHHHHHHHHHHCC
PDIAFTLAGEERAPVTWAAALPGAPGQLIRLGDILGADFRANAIEVRSEREGVAVEGFAA
CCEEEEECCCCCCCEEEEECCCCCCCCCEEEHHHHCCCCCCCCEEECCCCCCCEEECCCC
SPALTRANALGQYLFVNGRPVRDKLILGAVRAAYSDYLPRDRHPVVALFVTLESREVDAN
CCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCC
VHPAKTEVRFRNAGLVRALIVHALKEGLAREGRRTAANSAGSVISTFRPASMPAANWDWR
CCCCHHEEEECCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHCCCCCCCCCCCCCC
ASPSYPVGGSAIDAPSFAERPQAAFDVGGPSADIRTHEVAPDLLDRPLGAARTQIHETYI
CCCCCCCCCCCCCCCCHHCCCCCEEECCCCCCCCCHHHCCHHHHHCCCCHHHHHHHHEEE
VSQTRDGLIVVDQHAAHERIVYERLKASLAANGVQRQILLIPDIVEMDEATVERLVARAD
EEECCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCHHHHHHHHHHHH
ELAQFGLVVESFGPGAVAVRETPSLLGKTDAASLLRDLAEHMAEWDEALPLERRLMHVAA
HHHHHHHHHCCCCCCEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TMACHGSVRAGRVLKPEEMNALLREMEATPNSGQCNHGRPTYVELTLTDIEKLFGRR
HHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA