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The map label for this gene is icd [H]

Identifier: 86750841

GI number: 86750841

Start: 4267144

End: 4268370

Strand: Direct

Name: icd [H]

Synonym: RPB_3732

Alternate gene names: 86750841

Gene position: 4267144-4268370 (Clockwise)

Preceding gene: 86750835

Following gene: 86750843

Centisome position: 80.03

GC content: 63.33

Gene sequence:

>1227_bases
ATGGCGAAAATCAAGGTGACCAACCCCGTCGTCGAACTCGACGGTGACGAGATGACCCGCATCATCTGGCAGATGATCAA
GGACAAGCTCATCACCCCGTTCCTTGATGTCGAGCTGATGTATTTCGATCTGGGCATGGAACACCGCGACAAGACCGACG
ATCAGGTCACCATCGATGCGGCCAACGCCATCAAGCAGGTCGGCGTCGGCGTCAAATGCGCCACCATCACGCCGGACGAA
GCGCGGGTGCAGGAGTTCGGCCTCAAGAGCATGTGGAAGTCGCCGAACGGCACCATCCGCAACATCCTCGGCGGCGTGAT
CTTCCGCGAGCCGATCATCTGCAAGAACGTGCCGCGGCTGGTGCCGGGCTGGACCAAGCCGATCGTGATCGGCCGCCACG
CCTATGGCGACCAGTATCGCGCGACCGACATCAAGTTCCCCGGCCCCGGCACGCTGACCATGAAGTTCGTCGGCGACGAC
GGCCAGGTGATCGAGCGCGAAGTGTTCAAGGCGCCCGGCGCCGGCGTCGCGATGTCGATGTACAACCTCGACGAGTCGAT
CAAGGACTTCGCCCGCGCCTCGCTGAACTACGGCCTGATCCGCAACTATCCGGTCTACCTGTCGACCAAGAACACCATCA
TGAAAGTCTATGACGGGCGCTTCAAGGACATCTTCCAGGAGATCTTCGACGCCGAGTTCAAGAAGGAATACGACGCCAAG
GGCCTGACCTACGAGCACCGGCTGATCGACGACATGGTCGCCTCGGCGCTGAAATGGTCGGGCGGCTACGTCTGGGCCTG
CAAGAACTACGACGGCGACGTGCAGTCCGACACCGTGGCGCAGGGCTACGGCTCGCTCGGCCTGATGACCTCGGTGCTGA
TGACCCCGGACGGCAAGACCGTCGAGGCCGAAGCCGCCCACGGCACCGTCACCCGGCACTATCGCGAGCACCAGAAGGGC
AAGGCGACCTCGACCAATTCGATCGCCTCGATCTTCGCCTGGACCCGCGGCCTCGCCCATCGCGCCAAGCTCGACAGCAA
CGAGGAACTGGCCAAGTTCGCCGACACGCTGGAGAAGGTCTGCGTCGAGACGGTGGAAGCCGGCGCCATGACCAAGGACC
TCGCCCTCCTGGTCGGCGCCGACCAGCGCTGGCTGTCGACCGAAGGCTTCCTCGACAAGGTCGCGCAGAACCTGCACAAG
GCGATGAGCGAACCCGCCGCCGCGTAA

Upstream 100 bases:

>100_bases
CCCGTCCATTCACCTTTCGGCGGACCGCCCCCGGTGCTATAGCGGGCGCGGCTCACGCCCAATCCCGCCCCACGCTGTCG
CAAAGAAGGCCCGATCCCGC

Downstream 100 bases:

>100_bases
GCCGCGCGCAGCATCCGGACTGACGAAAGGCGCGGGGCCCGGCCCCCGCGCCTTTTTCGTGGGCTTGTTCCAAGCGTCGT
CCGCGAGCGTCTGCGAGCCC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MAKIKVTNPVVELDGDEMTRIIWQMIKDKLITPFLDVELMYFDLGMEHRDKTDDQVTIDAANAIKQVGVGVKCATITPDE
ARVQEFGLKSMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTKPIVIGRHAYGDQYRATDIKFPGPGTLTMKFVGDD
GQVIEREVFKAPGAGVAMSMYNLDESIKDFARASLNYGLIRNYPVYLSTKNTIMKVYDGRFKDIFQEIFDAEFKKEYDAK
GLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYREHQKG
KATSTNSIASIFAWTRGLAHRAKLDSNEELAKFADTLEKVCVETVEAGAMTKDLALLVGADQRWLSTEGFLDKVAQNLHK
AMSEPAAA

Sequences:

>Translated_408_residues
MAKIKVTNPVVELDGDEMTRIIWQMIKDKLITPFLDVELMYFDLGMEHRDKTDDQVTIDAANAIKQVGVGVKCATITPDE
ARVQEFGLKSMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTKPIVIGRHAYGDQYRATDIKFPGPGTLTMKFVGDD
GQVIEREVFKAPGAGVAMSMYNLDESIKDFARASLNYGLIRNYPVYLSTKNTIMKVYDGRFKDIFQEIFDAEFKKEYDAK
GLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYREHQKG
KATSTNSIASIFAWTRGLAHRAKLDSNEELAKFADTLEKVCVETVEAGAMTKDLALLVGADQRWLSTEGFLDKVAQNLHK
AMSEPAAA
>Mature_407_residues
AKIKVTNPVVELDGDEMTRIIWQMIKDKLITPFLDVELMYFDLGMEHRDKTDDQVTIDAANAIKQVGVGVKCATITPDEA
RVQEFGLKSMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTKPIVIGRHAYGDQYRATDIKFPGPGTLTMKFVGDDG
QVIEREVFKAPGAGVAMSMYNLDESIKDFARASLNYGLIRNYPVYLSTKNTIMKVYDGRFKDIFQEIFDAEFKKEYDAKG
LTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYREHQKGK
ATSTNSIASIFAWTRGLAHRAKLDSNEELAKFADTLEKVCVETVEAGAMTKDLALLVGADQRWLSTEGFLDKVAQNLHKA
MSEPAAA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=407, Percent_Identity=67.3218673218673, Blast_Score=578, Evalue=1e-165,
Organism=Homo sapiens, GI28178825, Length=411, Percent_Identity=64.963503649635, Blast_Score=552, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17540874, Length=399, Percent_Identity=68.1704260651629, Blast_Score=566, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17550822, Length=410, Percent_Identity=63.6585365853659, Blast_Score=552, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=60.4422604422604, Blast_Score=528, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6320137, Length=408, Percent_Identity=61.7647058823529, Blast_Score=528, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6323203, Length=411, Percent_Identity=60.0973236009732, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI21356561, Length=414, Percent_Identity=65.4589371980676, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI221330987, Length=414, Percent_Identity=65.4589371980676, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI221330985, Length=414, Percent_Identity=65.4589371980676, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI28574947, Length=414, Percent_Identity=65.4589371980676, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24660849, Length=414, Percent_Identity=65.4589371980676, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24660856, Length=414, Percent_Identity=65.4589371980676, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI221330983, Length=414, Percent_Identity=65.4589371980676, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24660868, Length=414, Percent_Identity=65.4589371980676, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24660860, Length=414, Percent_Identity=65.4589371980676, Blast_Score=572, Evalue=1e-163,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45330; Mature: 45199

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVTNPVVELDGDEMTRIIWQMIKDKLITPFLDVELMYFDLGMEHRDKTDDQVTIDA
CCEEEECCCEEEECCHHHHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCCCCEEEEEH
ANAIKQVGVGVKCATITPDEARVQEFGLKSMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHCHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTKPIVIGRHAYGDQYRATDIKFPGPGTLTMKFVGDDGQVIEREVFKAPGAGVAMSM
CCCCCCCEEEEECCCCCCCCCCEEECCCCCEEEEEEECCCCHHHHHHHHCCCCCCEEEHH
YNLDESIKDFARASLNYGLIRNYPVYLSTKNTIMKVYDGRFKDIFQEIFDAEFKKEYDAK
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
GLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTPDGKT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYREHQKGKATSTNSIASIFAWTRGLAHRAKLDSNEELAKFADTLEKV
EECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CVETVEAGAMTKDLALLVGADQRWLSTEGFLDKVAQNLHKAMSEPAAA
HHHHHHHCCHHHCEEEEECCCCHHHCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AKIKVTNPVVELDGDEMTRIIWQMIKDKLITPFLDVELMYFDLGMEHRDKTDDQVTIDA
CEEEECCCEEEECCHHHHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCCCCEEEEEH
ANAIKQVGVGVKCATITPDEARVQEFGLKSMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHCHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTKPIVIGRHAYGDQYRATDIKFPGPGTLTMKFVGDDGQVIEREVFKAPGAGVAMSM
CCCCCCCEEEEECCCCCCCCCCEEECCCCCEEEEEEECCCCHHHHHHHHCCCCCCEEEHH
YNLDESIKDFARASLNYGLIRNYPVYLSTKNTIMKVYDGRFKDIFQEIFDAEFKKEYDAK
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
GLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTPDGKT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYREHQKGKATSTNSIASIFAWTRGLAHRAKLDSNEELAKFADTLEKV
EECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CVETVEAGAMTKDLALLVGADQRWLSTEGFLDKVAQNLHKAMSEPAAA
HHHHHHHCCHHHCEEEEECCCCHHHCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]