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The map label for this gene is livH [H]

Identifier: 86750729

GI number: 86750729

Start: 4154086

End: 4155003

Strand: Reverse

Name: livH [H]

Synonym: RPB_3619

Alternate gene names: 86750729

Gene position: 4155003-4154086 (Counterclockwise)

Preceding gene: 86750730

Following gene: 86750728

Centisome position: 77.93

GC content: 63.07

Gene sequence:

>918_bases
ATGACGGAGACGTGTTCTTTCTGTTCGGGAGCGTTGCCTTTGACCACCGCCACGATCATCCAGTCCCTGGCCAGCGGTCT
GCTGATGGGACTTCTCTACGGCCTGGTCGCGGTCGGTCTCGCGCTGATCTTCGGCCTGATGGACGTCACCAATTTCGCCC
ACGGCGAATTCCTGATGCTGGCGATGTACATCACCTTCTTCCTGTTCACCTTCTTCGCGATCGACCCGTTGCTCTCCGCG
CCGTTGGTCGGCGGCGCGATGTTCCTGTTCGGAGCCGTGGCCTATCTGTTCGTCATCCGCTTCGCGATGCGGGCGAAAGC
CAATATTGGCATGGTGCAGATCTTCACCACCTTCGGCCTCGCGATCCTGATGCGGGGCCTCGCGCAATATTTCTTCACGC
CGGATTATCGCAGTATCAACGTCTCCTGGCTCGGCGGCAAGACGATCTCGTTCGGCGGGATCTTCCTGCCGGTGCCGCAA
CTGGTCGGCGCGCTGGTGTCGCTTGCGGCGTTCGGCGCGCTGTACTTCTTCATGAAGAAGACCGATTTCGGCCGCGCGCT
GGAGGCGACGCGCGAGGACGCCGGCGCCGTGGCGCTGGTCGGCATCGACAAGAACAAGGTGTTCGCGCTCGGTTGGGGGC
TCGGTTCGGCCCTGATCGGATTGGCCGGCGCGGTGATGGCGATGTTCTTCTACATCTATCCGGACGTCGGCGCCTCGTTC
GCGCTGATCGCCTATGTCACCGTGGCGCTCGGCGGCTTCGGCAGCGTGTTTGGTGCCTTCGCCGGCGGCATCATCGTCGG
CCTCGTCGAGGCCACCACCGCGCTGCTGTTGCCGCCATCGCTGAAGGCGGTCGGCATCTACGCGGTGTACCTGCTCGTTG
TCTTCATTCGGCCCCGTGGCCTGTTCGGATCGATCTGA

Upstream 100 bases:

>100_bases
GACGGCTCGCAGCCATTCGCCGTCATTGCGAGCGCAGCGAAGCAATCCAGAAGTTCCGAGTACGGCGCCCCTGGATTGCT
TCGTCGCTTCGCTCCTCGCA

Downstream 100 bases:

>100_bases
TGGACGAGGCTCATCTCAAGCGCCGCCGCCGCGATCTCATCGTCGCCACCGTGCTCGCCTGTATCGCGGCGCTGGTGCCG
CTGTTCGTCAAGGACGTCTA

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MTETCSFCSGALPLTTATIIQSLASGLLMGLLYGLVAVGLALIFGLMDVTNFAHGEFLMLAMYITFFLFTFFAIDPLLSA
PLVGGAMFLFGAVAYLFVIRFAMRAKANIGMVQIFTTFGLAILMRGLAQYFFTPDYRSINVSWLGGKTISFGGIFLPVPQ
LVGALVSLAAFGALYFFMKKTDFGRALEATREDAGAVALVGIDKNKVFALGWGLGSALIGLAGAVMAMFFYIYPDVGASF
ALIAYVTVALGGFGSVFGAFAGGIIVGLVEATTALLLPPSLKAVGIYAVYLLVVFIRPRGLFGSI

Sequences:

>Translated_305_residues
MTETCSFCSGALPLTTATIIQSLASGLLMGLLYGLVAVGLALIFGLMDVTNFAHGEFLMLAMYITFFLFTFFAIDPLLSA
PLVGGAMFLFGAVAYLFVIRFAMRAKANIGMVQIFTTFGLAILMRGLAQYFFTPDYRSINVSWLGGKTISFGGIFLPVPQ
LVGALVSLAAFGALYFFMKKTDFGRALEATREDAGAVALVGIDKNKVFALGWGLGSALIGLAGAVMAMFFYIYPDVGASF
ALIAYVTVALGGFGSVFGAFAGGIIVGLVEATTALLLPPSLKAVGIYAVYLLVVFIRPRGLFGSI
>Mature_304_residues
TETCSFCSGALPLTTATIIQSLASGLLMGLLYGLVAVGLALIFGLMDVTNFAHGEFLMLAMYITFFLFTFFAIDPLLSAP
LVGGAMFLFGAVAYLFVIRFAMRAKANIGMVQIFTTFGLAILMRGLAQYFFTPDYRSINVSWLGGKTISFGGIFLPVPQL
VGALVSLAAFGALYFFMKKTDFGRALEATREDAGAVALVGIDKNKVFALGWGLGSALIGLAGAVMAMFFYIYPDVGASFA
LIAYVTVALGGFGSVFGAFAGGIIVGLVEATTALLLPPSLKAVGIYAVYLLVVFIRPRGLFGSI

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=299, Percent_Identity=29.7658862876254, Blast_Score=101, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 32205; Mature: 32074

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETCSFCSGALPLTTATIIQSLASGLLMGLLYGLVAVGLALIFGLMDVTNFAHGEFLML
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AMYITFFLFTFFAIDPLLSAPLVGGAMFLFGAVAYLFVIRFAMRAKANIGMVQIFTTFGL
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AILMRGLAQYFFTPDYRSINVSWLGGKTISFGGIFLPVPQLVGALVSLAAFGALYFFMKK
HHHHHHHHHHHCCCCCCEEEEEEECCCEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHH
TDFGRALEATREDAGAVALVGIDKNKVFALGWGLGSALIGLAGAVMAMFFYIYPDVGASF
CCHHHHHHHHHHCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHH
ALIAYVTVALGGFGSVFGAFAGGIIVGLVEATTALLLPPSLKAVGIYAVYLLVVFIRPRG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
LFGSI
CCCCC
>Mature Secondary Structure 
TETCSFCSGALPLTTATIIQSLASGLLMGLLYGLVAVGLALIFGLMDVTNFAHGEFLML
CCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AMYITFFLFTFFAIDPLLSAPLVGGAMFLFGAVAYLFVIRFAMRAKANIGMVQIFTTFGL
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AILMRGLAQYFFTPDYRSINVSWLGGKTISFGGIFLPVPQLVGALVSLAAFGALYFFMKK
HHHHHHHHHHHCCCCCCEEEEEEECCCEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHH
TDFGRALEATREDAGAVALVGIDKNKVFALGWGLGSALIGLAGAVMAMFFYIYPDVGASF
CCHHHHHHHHHHCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHH
ALIAYVTVALGGFGSVFGAFAGGIIVGLVEATTALLLPPSLKAVGIYAVYLLVVFIRPRG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
LFGSI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]