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The map label for this gene is mutA [H]

Identifier: 86750646

GI number: 86750646

Start: 4046874

End: 4048745

Strand: Direct

Name: mutA [H]

Synonym: RPB_3536

Alternate gene names: 86750646

Gene position: 4046874-4048745 (Clockwise)

Preceding gene: 86750645

Following gene: 86750647

Centisome position: 75.9

GC content: 69.66

Gene sequence:

>1872_bases
ATGTCGTCTGCAATCAAAGACTTGCCGCTCGCCGCCGAATTCGCTCCGGCCGGCTATGACGACTGGCGCAAGCTCGCCCT
CGGCGTGCTGAAGGGCGCGCCGTTCGAAAAACTGCAAGGCAAGACCCCGGACGGCCTCCCGCTCGAACCGATTTATCCGC
GTGCGATCAATGCCTTACCGGTCGCCGGCCGGCCCCTCGGGGCGCCCTGGCAGATCGTCCAGCGGGTCGACCATCCCGAC
GCGGCCGAAGCCAACAAGCAGGCGCTGCACGATCTCGAAAACGGCGCCACCGGCCTCGCGCTGGTGTTCGCCGGCAGCGT
CGGCGGCCGCGGCTTCGGCCTGCCGCCGACCCGGGAGGCGATCGAGAAAGCGTTGCAGGACGTGCATTTGGACGCCGGTA
TCGGCATCGAGCTGCAATTCGCCCCGGAATCCTGCGACGTCGTTCGCCACCTCGTCGAGTTGATCAAGCGCCGCGGCACC
GACCCGGCCGCCTGCGACATCCGCTTCGGCATCGACCCGATCGGCGCCCGCGCCGTCCGCGGATCGAGCCCCACCGACTG
GAGCGAGATCGCGCGCGGCATTGCCGAAGTTGCGAGAAACCTCTGTGCCGCAGGCTTCAAAGGCCCGTTCCTCGCCGCCG
ACGGCCGCGTCGTGCACGACGCCGGCGGCTCCGAAGCGCAGGAACTCGCCTACGTCCTCGCCTCCGCCATCGCGTATCTG
CGCGCACTGGAAGCCGCCGCCGTGCCGCTCGATCAGGCCCGCGGCATGATTTTCGCGCGCCTCAGTGCCGACGCCGACCA
GTTCCTGACGCTGGCGAAATTCCGCGCGCTGCGCGTGCTGTGGGCGCGCATCGAACAGAGCTGCGGCCTCGCGCCGAAGC
CGCTGTTCGTCGCCGCCGAAACCGCGTGGCGGATGCTGACGCAACGCGATCCCTCGGTGAACATGCTGCGCGCCACGGTC
GCGACCTTCTCGGCCGCGCTCGGCGGCGCCAATGCGCTCGCGGTGCTGCCGCACACGCTGGCGCTCGGCCTGCCCGACGC
CTTGGCGCGCCGCATCGCCCGCAACACCCAACTGGTGCTGCTCGAAGAGTCGAACCTCGAAAAAGTCGCCGATCCCGCCG
CAGGATCGGGCGGCATCGAGGCGCTGACGCACGAACTCTGTGACGCCGCGTGGACGCAGTTTCAGGCCATCGAGCAGGCC
GGCGGCGTGTTCGCCGCGCTCGCCGCCAATCTGATCCAGCCCAAGATCGCAGCGACCCGCGCCGTGCGCGACAAGGCCAT
CGCCAAGCGCCGCGACGTGCTGACCGGCGCCAGCGAATTCCCCAACCTGCACGAGGCCCGCGCCACCGTGCTCGACGCCG
AGCCGATCGCGGTCCCCACTTTCGGCGAGGCCAAGATCAGCTTCGAACCGCTGACTCCGCTGCGGCTCGCAACGCCGTTC
GAAGTGCTGCGCGACAAGTCGGACGCCGTGCTGGCGCGCAAGGCAGCACGGCCGCAAATGTTCCTCGCCAATCTCGGCAC
GCCGGCGGATTTCACCGCACGCGCGACGTTTGCGAAGAGCTTCTTCGAGACCGGCGGCATCGAGGCGATCGACACCGAAG
GCTTCACCGATCCCGCGGCGCTGGCGGCGGCGTTCAAGGCCTCGGGCGCGGTGTTCGCCTGCCTGTGCTCTTCGGACAAA
GCCTATGCGGCTCATGCTGCGGCGGCCGCGCAGGCGCTGCGCGAAGCCGGCTGCGGGCGGATCTATCTCGCCGGCCGCCC
CGGCGAGCTGGAAGCGAGCCTGCGCGAGGCCGGCGTACACGACTTCATCTTCGCCGGCGGCGATGCGCTGGCGATGCTGA
ACGACGCCTGGCAGCGAATCGAGGCGGCATGA

Upstream 100 bases:

>100_bases
TGTCTCGTTCCTTTGGCCCGAAACAACCGTTTGGCAGGACGGTCCGCACGTGGCATTTTCCGGCCAAATCAAATTTTGTA
CCGGGAGCCCGATTTCAAAA

Downstream 100 bases:

>100_bases
CCGCGACCGGCAAAGCGGTGCTCACCGGCGGCTGCCAGTGCGGCGCGATCCGCTACGCGCTGTCGGCGCCGCCGCTGCGG
ATCACCTTGTGCCATTGCCG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 623; Mature: 622

Protein sequence:

>623_residues
MSSAIKDLPLAAEFAPAGYDDWRKLALGVLKGAPFEKLQGKTPDGLPLEPIYPRAINALPVAGRPLGAPWQIVQRVDHPD
AAEANKQALHDLENGATGLALVFAGSVGGRGFGLPPTREAIEKALQDVHLDAGIGIELQFAPESCDVVRHLVELIKRRGT
DPAACDIRFGIDPIGARAVRGSSPTDWSEIARGIAEVARNLCAAGFKGPFLAADGRVVHDAGGSEAQELAYVLASAIAYL
RALEAAAVPLDQARGMIFARLSADADQFLTLAKFRALRVLWARIEQSCGLAPKPLFVAAETAWRMLTQRDPSVNMLRATV
ATFSAALGGANALAVLPHTLALGLPDALARRIARNTQLVLLEESNLEKVADPAAGSGGIEALTHELCDAAWTQFQAIEQA
GGVFAALAANLIQPKIAATRAVRDKAIAKRRDVLTGASEFPNLHEARATVLDAEPIAVPTFGEAKISFEPLTPLRLATPF
EVLRDKSDAVLARKAARPQMFLANLGTPADFTARATFAKSFFETGGIEAIDTEGFTDPAALAAAFKASGAVFACLCSSDK
AYAAHAAAAAQALREAGCGRIYLAGRPGELEASLREAGVHDFIFAGGDALAMLNDAWQRIEAA

Sequences:

>Translated_623_residues
MSSAIKDLPLAAEFAPAGYDDWRKLALGVLKGAPFEKLQGKTPDGLPLEPIYPRAINALPVAGRPLGAPWQIVQRVDHPD
AAEANKQALHDLENGATGLALVFAGSVGGRGFGLPPTREAIEKALQDVHLDAGIGIELQFAPESCDVVRHLVELIKRRGT
DPAACDIRFGIDPIGARAVRGSSPTDWSEIARGIAEVARNLCAAGFKGPFLAADGRVVHDAGGSEAQELAYVLASAIAYL
RALEAAAVPLDQARGMIFARLSADADQFLTLAKFRALRVLWARIEQSCGLAPKPLFVAAETAWRMLTQRDPSVNMLRATV
ATFSAALGGANALAVLPHTLALGLPDALARRIARNTQLVLLEESNLEKVADPAAGSGGIEALTHELCDAAWTQFQAIEQA
GGVFAALAANLIQPKIAATRAVRDKAIAKRRDVLTGASEFPNLHEARATVLDAEPIAVPTFGEAKISFEPLTPLRLATPF
EVLRDKSDAVLARKAARPQMFLANLGTPADFTARATFAKSFFETGGIEAIDTEGFTDPAALAAAFKASGAVFACLCSSDK
AYAAHAAAAAQALREAGCGRIYLAGRPGELEASLREAGVHDFIFAGGDALAMLNDAWQRIEAA
>Mature_622_residues
SSAIKDLPLAAEFAPAGYDDWRKLALGVLKGAPFEKLQGKTPDGLPLEPIYPRAINALPVAGRPLGAPWQIVQRVDHPDA
AEANKQALHDLENGATGLALVFAGSVGGRGFGLPPTREAIEKALQDVHLDAGIGIELQFAPESCDVVRHLVELIKRRGTD
PAACDIRFGIDPIGARAVRGSSPTDWSEIARGIAEVARNLCAAGFKGPFLAADGRVVHDAGGSEAQELAYVLASAIAYLR
ALEAAAVPLDQARGMIFARLSADADQFLTLAKFRALRVLWARIEQSCGLAPKPLFVAAETAWRMLTQRDPSVNMLRATVA
TFSAALGGANALAVLPHTLALGLPDALARRIARNTQLVLLEESNLEKVADPAAGSGGIEALTHELCDAAWTQFQAIEQAG
GVFAALAANLIQPKIAATRAVRDKAIAKRRDVLTGASEFPNLHEARATVLDAEPIAVPTFGEAKISFEPLTPLRLATPFE
VLRDKSDAVLARKAARPQMFLANLGTPADFTARATFAKSFFETGGIEAIDTEGFTDPAALAAAFKASGAVFACLCSSDKA
YAAHAAAAAQALREAGCGRIYLAGRPGELEASLREAGVHDFIFAGGDALAMLNDAWQRIEAA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=473, Percent_Identity=26.0042283298097, Blast_Score=122, Evalue=1e-27,
Organism=Escherichia coli, GI1789284, Length=475, Percent_Identity=26.3157894736842, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25144500, Length=469, Percent_Identity=24.9466950959488, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 65612; Mature: 65480

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAIKDLPLAAEFAPAGYDDWRKLALGVLKGAPFEKLQGKTPDGLPLEPIYPRAINALP
CCCCHHCCCCHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCHHHCCCCC
VAGRPLGAPWQIVQRVDHPDAAEANKQALHDLENGATGLALVFAGSVGGRGFGLPPTREA
CCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHH
IEKALQDVHLDAGIGIELQFAPESCDVVRHLVELIKRRGTDPAACDIRFGIDPIGARAVR
HHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEC
GSSPTDWSEIARGIAEVARNLCAAGFKGPFLAADGRVVHDAGGSEAQELAYVLASAIAYL
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCCHHHHHHHHHHHHHHHH
RALEAAAVPLDQARGMIFARLSADADQFLTLAKFRALRVLWARIEQSCGLAPKPLFVAAE
HHHHHHHCCHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHH
TAWRMLTQRDPSVNMLRATVATFSAALGGANALAVLPHTLALGLPDALARRIARNTQLVL
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCEEEE
LEESNLEKVADPAAGSGGIEALTHELCDAAWTQFQAIEQAGGVFAALAANLIQPKIAATR
EECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHH
AVRDKAIAKRRDVLTGASEFPNLHEARATVLDAEPIAVPTFGEAKISFEPLTPLRLATPF
HHHHHHHHHHHHHHCCHHHCCCHHHHHHHEECCCCCCCCCCCCCEEEECCCCCCHHCCCH
EVLRDKSDAVLARKAARPQMFLANLGTPADFTARATFAKSFFETGGIEAIDTEGFTDPAA
HHHHCCCHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCHHH
LAAAFKASGAVFACLCSSDKAYAAHAAAAAQALREAGCGRIYLAGRPGELEASLREAGVH
HHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCC
DFIFAGGDALAMLNDAWQRIEAA
CEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSAIKDLPLAAEFAPAGYDDWRKLALGVLKGAPFEKLQGKTPDGLPLEPIYPRAINALP
CCCHHCCCCHHHCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCHHHCCCCC
VAGRPLGAPWQIVQRVDHPDAAEANKQALHDLENGATGLALVFAGSVGGRGFGLPPTREA
CCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHH
IEKALQDVHLDAGIGIELQFAPESCDVVRHLVELIKRRGTDPAACDIRFGIDPIGARAVR
HHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEC
GSSPTDWSEIARGIAEVARNLCAAGFKGPFLAADGRVVHDAGGSEAQELAYVLASAIAYL
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCCHHHHHHHHHHHHHHHH
RALEAAAVPLDQARGMIFARLSADADQFLTLAKFRALRVLWARIEQSCGLAPKPLFVAAE
HHHHHHHCCHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHH
TAWRMLTQRDPSVNMLRATVATFSAALGGANALAVLPHTLALGLPDALARRIARNTQLVL
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCEEEE
LEESNLEKVADPAAGSGGIEALTHELCDAAWTQFQAIEQAGGVFAALAANLIQPKIAATR
EECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHH
AVRDKAIAKRRDVLTGASEFPNLHEARATVLDAEPIAVPTFGEAKISFEPLTPLRLATPF
HHHHHHHHHHHHHHCCHHHCCCHHHHHHHEECCCCCCCCCCCCCEEEECCCCCCHHCCCH
EVLRDKSDAVLARKAARPQMFLANLGTPADFTARATFAKSFFETGGIEAIDTEGFTDPAA
HHHHCCCHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCHHH
LAAAFKASGAVFACLCSSDKAYAAHAAAAAQALREAGCGRIYLAGRPGELEASLREAGVH
HHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCC
DFIFAGGDALAMLNDAWQRIEAA
CEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]