Click here to switch to the map view.

The map label for this gene is folK [H]

Identifier: 86750645

GI number: 86750645

Start: 4046236

End: 4046727

Strand: Direct

Name: folK [H]

Synonym: RPB_3535

Alternate gene names: 86750645

Gene position: 4046236-4046727 (Clockwise)

Preceding gene: 86750644

Following gene: 86750646

Centisome position: 75.89

GC content: 67.89

Gene sequence:

>492_bases
ATGGCTGAGGCGCTGATCGCGCTCGGCGGCAATGTCGGCGACGTCCGCGCGACGTTCGACAAGGCGATCGCCAATATCTG
CGGCATGACGCAGGGCGAACTGCTCGCCCGCTCGTCGGACTACGCGACCCCGCCCTGGGGCGACGAACAGCAGGAGCGCT
TCGTCAATGCCTGCGTGGCGATCGACACCGCGCTCGATCCGCACGCGTTGTTATTTACGCTGCACAAGATCGAGAAGCGC
TTCGGCCGCGACCGCGCGCAGGAGCGCCGCTGGGGTCCGCGCACGCTCGACCTCGATCTGCTGAGTTACGACGATGCGGT
GATCAATCAGCCCGGCCTGACGCTGCCGCATCCGCGTCTGTTCGAGCGCGCCTTCGTGCTGGTGCCGCTGGTCGAGATCC
GGCCGGACGGATTAGTCGGCGGCCGATCGCTGCAAGACGCCCTCGCTGGTCTGTCCACCGCCGGGATCGAGCGGCTGCCG
GACCGCGTCTGA

Upstream 100 bases:

>100_bases
ATCGGTTCGGTGAAGATCACCGTGCACAAGCCGCACGCGCCGATCGCGGCGATCTTCGACGACGTCGGCGTGATCATCAC
CCGCGCGCGGCAGCCCTCGC

Downstream 100 bases:

>100_bases
GCGGTTTTGCGCTGCCGCAGGTTTGCCACCGGTTTGCCGCAAGCGTTGTCTCGTTCCTTTGGCCCGAAACAACCGTTTGG
CAGGACGGTCCGCACGTGGC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MAEALIALGGNVGDVRATFDKAIANICGMTQGELLARSSDYATPPWGDEQQERFVNACVAIDTALDPHALLFTLHKIEKR
FGRDRAQERRWGPRTLDLDLLSYDDAVINQPGLTLPHPRLFERAFVLVPLVEIRPDGLVGGRSLQDALAGLSTAGIERLP
DRV

Sequences:

>Translated_163_residues
MAEALIALGGNVGDVRATFDKAIANICGMTQGELLARSSDYATPPWGDEQQERFVNACVAIDTALDPHALLFTLHKIEKR
FGRDRAQERRWGPRTLDLDLLSYDDAVINQPGLTLPHPRLFERAFVLVPLVEIRPDGLVGGRSLQDALAGLSTAGIERLP
DRV
>Mature_162_residues
AEALIALGGNVGDVRATFDKAIANICGMTQGELLARSSDYATPPWGDEQQERFVNACVAIDTALDPHALLFTLHKIEKRF
GRDRAQERRWGPRTLDLDLLSYDDAVINQPGLTLPHPRLFERAFVLVPLVEIRPDGLVGGRSLQDALAGLSTAGIERLPD
RV

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=136, Percent_Identity=41.1764705882353, Blast_Score=102, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324073, Length=135, Percent_Identity=35.5555555555556, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17886; Mature: 17754

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEALIALGGNVGDVRATFDKAIANICGMTQGELLARSSDYATPPWGDEQQERFVNACVA
CCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHH
IDTALDPHALLFTLHKIEKRFGRDRAQERRWGPRTLDLDLLSYDDAVINQPGLTLPHPRL
HHCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCCEEEEEHCCCCCHHHCCCCCCCCCHHH
FERAFVLVPLVEIRPDGLVGGRSLQDALAGLSTAGIERLPDRV
HHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEALIALGGNVGDVRATFDKAIANICGMTQGELLARSSDYATPPWGDEQQERFVNACVA
CCCEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHH
IDTALDPHALLFTLHKIEKRFGRDRAQERRWGPRTLDLDLLSYDDAVINQPGLTLPHPRL
HHCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCCEEEEEHCCCCCHHHCCCCCCCCCHHH
FERAFVLVPLVEIRPDGLVGGRSLQDALAGLSTAGIERLPDRV
HHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]