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The map label for this gene is accA1 [H]

Identifier: 86750370

GI number: 86750370

Start: 3726675

End: 3728654

Strand: Reverse

Name: accA1 [H]

Synonym: RPB_3259

Alternate gene names: 86750370

Gene position: 3728654-3726675 (Counterclockwise)

Preceding gene: 86750371

Following gene: 86750369

Centisome position: 69.93

GC content: 68.84

Gene sequence:

>1980_bases
ATGAGTGCAACGCGCATGTTGAAATCCACACCTTTCACCAAAATCCTGATCGCCAATCGCGGCGAGATCGCGCTGCGCGT
GATGCGCACCGCACGCCGGATGGGCTACGGCGTGGTCGCGGTCTATTCCGAGGCCGACGTCGATGCCGCGCATGTCCGCG
CCGCCGACGAGGCGGTGGCGATCGGCGGCGCGCAGCCGTCGCAATCCTATCTCAACATTCCGGTGCTGATCGAAGCCGCC
CAGATCGCCGGCGCCGATGCCGTCCATCCGGGCTATGGCTTCCTCGCCGAGAACGAGGATTTCGCGGCCGCGTGCCGCGA
TGCCGGGCTGGTGTTCATCGGCCCGTCGGCGGAATCGATCGCGTCGATGGGCAACAAGGCTGGCGCCAAGGAGATCATGC
TGAAGGCTGGCGTGCCGTGCGTGCCCGGCTATCAGGGCGCCGATCAGAGCGACGCGGCGATGATCGCGGAGGCCGGCAAG
ATCGGCTTCCCAGTGATGATCAAGGCGGTCGCCGGCGGCGGCGGTCGCGGCATGCGGCTGGTGAAGGACGCAGCGGCGCT
GCCGGACGCGCTGCGCAGCGCGCGCTCGGAAGCGCAGGGCGCGTTCGGCGATCCGACCGTGATTCTCGAGCGCGCCATCG
TCGATCCGCGCCACATCGAGATCCAGGTGTTCGGCGATCGCTACGGCGCTGCGATCCATCTCGGCGAGCGCGATTGCTCG
GTGCAGCGCCGCCACCAGAAGCTGATCGAGGAAGCGCCGTCGCCGGCGGTTTCCGAAGCGCTGCGCGAACAGATGGGCAC
GGTCGCCGTCAACGCCGTGAAGGCGATCGGCTACGAGGGCGCCGGCACGCTGGAATTTCTGCTCGACGCGCAGGGCCAGT
TCTACTTCATGGAGATGAATACGCGGCTGCAGGTCGAGCATCCGGTGACCGAGGCGATCACCGGGCTCGATCTGGTCGAG
CTGCAGCTGCGCATCGCCGCCGGCGAGCCGTTGCCGCTGCGCCAGGACGATGTCACGTTCAAGGGCCACGCGATCGAGGT
GCGGCTGTGCTCGGAAGACGCCGATCACGACTTCATGCCACAGTCCGGCCGGATGGCGTTGTGGCGGATGCCGGAGGAAC
TGCGCGTCGAGCACGCGCTGCAATCCGGCGAGGCGATCCCGCCTTACTACGACTCGATGATCGCCAAGATCATCGCGACG
GGCCGCAGTCGCGACGAGGCGCGGCGCAAGCTGATCCACGGCCTCGACACCACCTTCGCGTTCGGCGTCACCACCAATCG
CGGCTTCCTCGCCGCGTGCCTGCGGCACGAGGCGTTCGCGCGCGGCGAGGCGACCACGGCGTTCATTGCGCAGCATCGCG
ACGCGCTGACACGCGCGTTGCCGGACGATGCGGTGCCGGCGACCGCTTTGGCTGGGCTGCTGCTCTACGTCACCGATCGG
CACGCGTCGCCGCATCGGCCGGGGCGCTCGCTGGCCGCGCTGTTTCCGACGCCGCTGCGGTTCGAGATCGACGGCCGGAC
GCAGACCTGCGAGGTCGTTCGCACGCGGGACGGCAGTTATCGCGTGAGCCATGACGGTCGCGCGACCTCGTTCACGGTCG
AGCACCTCACCGACGACGGCATCCGTTTCCAGGCCGGCGACTTCCGCGAATCCGCCGTCTATCACCGCGACGGCGAGCGG
TTGTTCGTGCAGCGGCTCGGCGTGAGCAACATCGTGGTCGATCGGACGCGCGCGGCGCCGCAGCGCGCGGCGGCGGCAGG
CGGCGACGGCAAGCTGCGCGCGGCGCTGAACGGCCGCGTCGTCGCGGTGCTGGTCAAGGCCGGCGACCGCGTCGAGGCCG
GGCAGCCGGTGCTGACGCTGGAAGCGATGAAGATGGAGCACGTGCATCTGGCGCCGGCATCGGGCATCATCGCGATCGAC
GTCGCCGAAGGCGAGCAGGTGACCACCGGCCGCATCGTGGCGGAAATCGAAGTTTCGTAG

Upstream 100 bases:

>100_bases
ACCCGCGTGACACCCGCGCCGTGCTGGCCGAGGTGCTGGCGATCTGTCGCGAAAGCGAGGCGCGCCAACCTCAGCGTATG
CAATTCGCGGTGTCCCGGGC

Downstream 100 bases:

>100_bases
CAGCACGGAAGAACATTTGCCCCGTCATTGCGAGCGAAGCGAAGCAATCCAGAAGCTCCGTGCGCTGAGCTGGATTGCTT
CGTCGCTTCGCTCCTCGCAA

Product: carbamoyl-phosphate synthase L chain, ATP-binding

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 659; Mature: 658

Protein sequence:

>659_residues
MSATRMLKSTPFTKILIANRGEIALRVMRTARRMGYGVVAVYSEADVDAAHVRAADEAVAIGGAQPSQSYLNIPVLIEAA
QIAGADAVHPGYGFLAENEDFAAACRDAGLVFIGPSAESIASMGNKAGAKEIMLKAGVPCVPGYQGADQSDAAMIAEAGK
IGFPVMIKAVAGGGGRGMRLVKDAAALPDALRSARSEAQGAFGDPTVILERAIVDPRHIEIQVFGDRYGAAIHLGERDCS
VQRRHQKLIEEAPSPAVSEALREQMGTVAVNAVKAIGYEGAGTLEFLLDAQGQFYFMEMNTRLQVEHPVTEAITGLDLVE
LQLRIAAGEPLPLRQDDVTFKGHAIEVRLCSEDADHDFMPQSGRMALWRMPEELRVEHALQSGEAIPPYYDSMIAKIIAT
GRSRDEARRKLIHGLDTTFAFGVTTNRGFLAACLRHEAFARGEATTAFIAQHRDALTRALPDDAVPATALAGLLLYVTDR
HASPHRPGRSLAALFPTPLRFEIDGRTQTCEVVRTRDGSYRVSHDGRATSFTVEHLTDDGIRFQAGDFRESAVYHRDGER
LFVQRLGVSNIVVDRTRAAPQRAAAAGGDGKLRAALNGRVVAVLVKAGDRVEAGQPVLTLEAMKMEHVHLAPASGIIAID
VAEGEQVTTGRIVAEIEVS

Sequences:

>Translated_659_residues
MSATRMLKSTPFTKILIANRGEIALRVMRTARRMGYGVVAVYSEADVDAAHVRAADEAVAIGGAQPSQSYLNIPVLIEAA
QIAGADAVHPGYGFLAENEDFAAACRDAGLVFIGPSAESIASMGNKAGAKEIMLKAGVPCVPGYQGADQSDAAMIAEAGK
IGFPVMIKAVAGGGGRGMRLVKDAAALPDALRSARSEAQGAFGDPTVILERAIVDPRHIEIQVFGDRYGAAIHLGERDCS
VQRRHQKLIEEAPSPAVSEALREQMGTVAVNAVKAIGYEGAGTLEFLLDAQGQFYFMEMNTRLQVEHPVTEAITGLDLVE
LQLRIAAGEPLPLRQDDVTFKGHAIEVRLCSEDADHDFMPQSGRMALWRMPEELRVEHALQSGEAIPPYYDSMIAKIIAT
GRSRDEARRKLIHGLDTTFAFGVTTNRGFLAACLRHEAFARGEATTAFIAQHRDALTRALPDDAVPATALAGLLLYVTDR
HASPHRPGRSLAALFPTPLRFEIDGRTQTCEVVRTRDGSYRVSHDGRATSFTVEHLTDDGIRFQAGDFRESAVYHRDGER
LFVQRLGVSNIVVDRTRAAPQRAAAAGGDGKLRAALNGRVVAVLVKAGDRVEAGQPVLTLEAMKMEHVHLAPASGIIAID
VAEGEQVTTGRIVAEIEVS
>Mature_658_residues
SATRMLKSTPFTKILIANRGEIALRVMRTARRMGYGVVAVYSEADVDAAHVRAADEAVAIGGAQPSQSYLNIPVLIEAAQ
IAGADAVHPGYGFLAENEDFAAACRDAGLVFIGPSAESIASMGNKAGAKEIMLKAGVPCVPGYQGADQSDAAMIAEAGKI
GFPVMIKAVAGGGGRGMRLVKDAAALPDALRSARSEAQGAFGDPTVILERAIVDPRHIEIQVFGDRYGAAIHLGERDCSV
QRRHQKLIEEAPSPAVSEALREQMGTVAVNAVKAIGYEGAGTLEFLLDAQGQFYFMEMNTRLQVEHPVTEAITGLDLVEL
QLRIAAGEPLPLRQDDVTFKGHAIEVRLCSEDADHDFMPQSGRMALWRMPEELRVEHALQSGEAIPPYYDSMIAKIIATG
RSRDEARRKLIHGLDTTFAFGVTTNRGFLAACLRHEAFARGEATTAFIAQHRDALTRALPDDAVPATALAGLLLYVTDRH
ASPHRPGRSLAALFPTPLRFEIDGRTQTCEVVRTRDGSYRVSHDGRATSFTVEHLTDDGIRFQAGDFRESAVYHRDGERL
FVQRLGVSNIVVDRTRAAPQRAAAAGGDGKLRAALNGRVVAVLVKAGDRVEAGQPVLTLEAMKMEHVHLAPASGIIAIDV
AEGEQVTTGRIVAEIEVS

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=678, Percent_Identity=41.4454277286136, Blast_Score=484, Evalue=1e-136,
Organism=Homo sapiens, GI189095269, Length=679, Percent_Identity=38.880706921944, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI65506442, Length=669, Percent_Identity=38.863976083707, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI295821183, Length=657, Percent_Identity=38.0517503805175, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI106049528, Length=455, Percent_Identity=45.0549450549451, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI106049295, Length=455, Percent_Identity=45.0549450549451, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI106049292, Length=455, Percent_Identity=45.0549450549451, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI38679960, Length=733, Percent_Identity=27.8308321964529, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI38679977, Length=733, Percent_Identity=27.8308321964529, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI38679967, Length=733, Percent_Identity=27.8308321964529, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI38679974, Length=733, Percent_Identity=27.8308321964529, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI38679971, Length=733, Percent_Identity=27.8308321964529, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI134142062, Length=499, Percent_Identity=30.4609218436874, Blast_Score=227, Evalue=2e-59,
Organism=Escherichia coli, GI1789654, Length=442, Percent_Identity=48.868778280543, Blast_Score=396, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71987519, Length=655, Percent_Identity=41.3740458015267, Blast_Score=472, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17567343, Length=683, Percent_Identity=36.3103953147877, Blast_Score=400, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=457, Percent_Identity=44.6389496717724, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI133931226, Length=729, Percent_Identity=26.0631001371742, Blast_Score=215, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=732, Percent_Identity=25.6830601092896, Blast_Score=202, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=509, Percent_Identity=29.4695481335953, Blast_Score=202, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.3092550790068, Blast_Score=357, Evalue=4e-99,
Organism=Saccharomyces cerevisiae, GI6319695, Length=481, Percent_Identity=40.956340956341, Blast_Score=330, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6321376, Length=481, Percent_Identity=42.2037422037422, Blast_Score=327, Evalue=5e-90,
Organism=Saccharomyces cerevisiae, GI6324343, Length=729, Percent_Identity=28.2578875171468, Blast_Score=254, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6323863, Length=709, Percent_Identity=27.9266572637518, Blast_Score=246, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24651757, Length=676, Percent_Identity=41.4201183431953, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24651759, Length=633, Percent_Identity=40.4423380726698, Blast_Score=434, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=45.43429844098, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=45.43429844098, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=45.43429844098, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=45.43429844098, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=45.43429844098, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=45.43429844098, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=45.43429844098, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=45.43429844098, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=45.43429844098, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=45.43429844098, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI161076409, Length=730, Percent_Identity=27.6712328767123, Blast_Score=243, Evalue=4e-64,
Organism=Drosophila melanogaster, GI161076407, Length=730, Percent_Identity=27.6712328767123, Blast_Score=242, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24586460, Length=730, Percent_Identity=27.6712328767123, Blast_Score=242, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24586458, Length=730, Percent_Identity=27.6712328767123, Blast_Score=242, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 70700; Mature: 70569

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATRMLKSTPFTKILIANRGEIALRVMRTARRMGYGVVAVYSEADVDAAHVRAADEAVA
CCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCCCCEEE
IGGAQPSQSYLNIPVLIEAAQIAGADAVHPGYGFLAENEDFAAACRDAGLVFIGPSAESI
ECCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCCEEECCCCHHHHHHCCCEEEECCCHHHH
ASMGNKAGAKEIMLKAGVPCVPGYQGADQSDAAMIAEAGKIGFPVMIKAVAGGGGRGMRL
HHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHH
VKDAAALPDALRSARSEAQGAFGDPTVILERAIVDPRHIEIQVFGDRYGAAIHLGERDCS
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCH
VQRRHQKLIEEAPSPAVSEALREQMGTVAVNAVKAIGYEGAGTLEFLLDAQGQFYFMEMN
HHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEC
TRLQVEHPVTEAITGLDLVELQLRIAAGEPLPLRQDDVTFKGHAIEVRLCSEDADHDFMP
CEEEECCCHHHHHCCCEEEEEEEEEECCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCC
QSGRMALWRMPEELRVEHALQSGEAIPPYYDSMIAKIIATGRSRDEARRKLIHGLDTTFA
CCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEE
FGVTTNRGFLAACLRHEAFARGEATTAFIAQHRDALTRALPDDAVPATALAGLLLYVTDR
EEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEECC
HASPHRPGRSLAALFPTPLRFEIDGRTQTCEVVRTRDGSYRVSHDGRATSFTVEHLTDDG
CCCCCCCCCCCCEECCCCEEEEECCCCCEEEEEEECCCCEEECCCCCEEEEEEEECCCCC
IRFQAGDFRESAVYHRDGERLFVQRLGVSNIVVDRTRAAPQRAAAAGGDGKLRAALNGRV
CEEECCCCHHCCEEECCCCEEEHHHCCCCCEEEECCCCCCHHHHCCCCCCEEEEEECCEE
VAVLVKAGDRVEAGQPVLTLEAMKMEHVHLAPASGIIAIDVAEGEQVTTGRIVAEIEVS
EEEEEECCCCCCCCCCEEEEEEEEECEEEECCCCCEEEEEECCCCEEECCEEEEEEEEC
>Mature Secondary Structure 
SATRMLKSTPFTKILIANRGEIALRVMRTARRMGYGVVAVYSEADVDAAHVRAADEAVA
CCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHCCCCCEEE
IGGAQPSQSYLNIPVLIEAAQIAGADAVHPGYGFLAENEDFAAACRDAGLVFIGPSAESI
ECCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCCEEECCCCHHHHHHCCCEEEECCCHHHH
ASMGNKAGAKEIMLKAGVPCVPGYQGADQSDAAMIAEAGKIGFPVMIKAVAGGGGRGMRL
HHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHH
VKDAAALPDALRSARSEAQGAFGDPTVILERAIVDPRHIEIQVFGDRYGAAIHLGERDCS
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCH
VQRRHQKLIEEAPSPAVSEALREQMGTVAVNAVKAIGYEGAGTLEFLLDAQGQFYFMEMN
HHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEC
TRLQVEHPVTEAITGLDLVELQLRIAAGEPLPLRQDDVTFKGHAIEVRLCSEDADHDFMP
CEEEECCCHHHHHCCCEEEEEEEEEECCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCC
QSGRMALWRMPEELRVEHALQSGEAIPPYYDSMIAKIIATGRSRDEARRKLIHGLDTTFA
CCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEE
FGVTTNRGFLAACLRHEAFARGEATTAFIAQHRDALTRALPDDAVPATALAGLLLYVTDR
EEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEECC
HASPHRPGRSLAALFPTPLRFEIDGRTQTCEVVRTRDGSYRVSHDGRATSFTVEHLTDDG
CCCCCCCCCCCCEECCCCEEEEECCCCCEEEEEEECCCCEEECCCCCEEEEEEEECCCCC
IRFQAGDFRESAVYHRDGERLFVQRLGVSNIVVDRTRAAPQRAAAAGGDGKLRAALNGRV
CEEECCCCHHCCEEECCCCEEEHHHCCCCCEEEECCCCCCHHHHCCCCCCEEEEEECCEE
VAVLVKAGDRVEAGQPVLTLEAMKMEHVHLAPASGIIAIDVAEGEQVTTGRIVAEIEVS
EEEEEECCCCCCCCCCEEEEEEEEECEEEECCCCCEEEEEECCCCEEECCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]