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The map label for this gene is yeaE [H]

Identifier: 86750365

GI number: 86750365

Start: 3720924

End: 3721769

Strand: Reverse

Name: yeaE [H]

Synonym: RPB_3254

Alternate gene names: 86750365

Gene position: 3721769-3720924 (Counterclockwise)

Preceding gene: 86750366

Following gene: 86750364

Centisome position: 69.81

GC content: 69.03

Gene sequence:

>846_bases
TTGAGTGGGGACACGCGCAAATTCGGCCGGGGCGGGCCGGAGATTGCGCCGATCGGACAGGGCACCTGGTACATCGACCG
GGGTGACCGGACGGCGGCGATCGCCGCGCTGCGGCGCGGCCTCGACCTCGGCATGACGCATATCGACACCGCCGAGATGT
ACGGCGATGCCGAGCCGCTGGTGGCGGAGGCCATCGACGGCCGGCGGGACCAGGTGTTCCTGGTCTCGAAGGTGCTGCCG
AGCAATGCCTCGCGGCGCGGCACCGTCGCCGCTTGCGAGCGCTCGCTGAAGCGGCTGAAGACCGACCGGCTCGACTGCTA
TCTGCTGCATTGGCGCGGGCAATATCGGCTGGCGGAAACCGTGGCGGCGTTCGAGGAACTGGTCGCCGCCGGCAAGATCC
GGTCATGGGGCGTCAGCAATTTCGACGTCGGCGATCTGTGGGAACTGCTCAAGGTCGCGGGGCCGGACAGGATCGCCTGC
AATCAGGTGCTGTATCATCTGCGCGAGCGCGCGATCGAGCATGCGGTGATCCCGTGGTGCGAGGCGCACGGCGTTGCGGT
CACCGCCTATTCACCATTCGGTCATGACGAGTTTCCCCTGCCGCGCAGCACGGAGGGGCGGCTGCTGCAGTCGATCGCCG
AGGCCCATGGCGCCACGCCACGGCAGGTGGCGCTGGCGTTTCTGACCCGGCGGCCGTCATTGTTCGCGATCCCGAAGGCT
GCCGACCCGGCGCATGCGGCCGACAATGCCGCGGCCGGATCGCTGCGGCTCTCCGATGACGAGATCGCGGCGATCGACCA
GGCCTGTCCGCTCGGGCCCGAACCGGCCAGCCTGCCGATGCTGTGA

Upstream 100 bases:

>100_bases
GCCGTGGCATTTGATGACCTATGAGTTCCGGCTGAAGCCGGGCAGGGGCGCGGCGCCGAAGCCGATGATGGCGGCGGCGG
AGTGACAACAGGAGCTCGCA

Downstream 100 bases:

>100_bases
GCGAGGCCGGGGCCGGCGCAGCCCGCCGCCGAGTCGCCGCGTGCATAGCCGCGTCCTGATTTCCGCGCTTGCGCGGCGGC
TACGAACATCGTTTTGTCGG

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MSGDTRKFGRGGPEIAPIGQGTWYIDRGDRTAAIAALRRGLDLGMTHIDTAEMYGDAEPLVAEAIDGRRDQVFLVSKVLP
SNASRRGTVAACERSLKRLKTDRLDCYLLHWRGQYRLAETVAAFEELVAAGKIRSWGVSNFDVGDLWELLKVAGPDRIAC
NQVLYHLRERAIEHAVIPWCEAHGVAVTAYSPFGHDEFPLPRSTEGRLLQSIAEAHGATPRQVALAFLTRRPSLFAIPKA
ADPAHAADNAAAGSLRLSDDEIAAIDQACPLGPEPASLPML

Sequences:

>Translated_281_residues
MSGDTRKFGRGGPEIAPIGQGTWYIDRGDRTAAIAALRRGLDLGMTHIDTAEMYGDAEPLVAEAIDGRRDQVFLVSKVLP
SNASRRGTVAACERSLKRLKTDRLDCYLLHWRGQYRLAETVAAFEELVAAGKIRSWGVSNFDVGDLWELLKVAGPDRIAC
NQVLYHLRERAIEHAVIPWCEAHGVAVTAYSPFGHDEFPLPRSTEGRLLQSIAEAHGATPRQVALAFLTRRPSLFAIPKA
ADPAHAADNAAAGSLRLSDDEIAAIDQACPLGPEPASLPML
>Mature_280_residues
SGDTRKFGRGGPEIAPIGQGTWYIDRGDRTAAIAALRRGLDLGMTHIDTAEMYGDAEPLVAEAIDGRRDQVFLVSKVLPS
NASRRGTVAACERSLKRLKTDRLDCYLLHWRGQYRLAETVAAFEELVAAGKIRSWGVSNFDVGDLWELLKVAGPDRIACN
QVLYHLRERAIEHAVIPWCEAHGVAVTAYSPFGHDEFPLPRSTEGRLLQSIAEAHGATPRQVALAFLTRRPSLFAIPKAA
DPAHAADNAAAGSLRLSDDEIAAIDQACPLGPEPASLPML

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI223468663, Length=281, Percent_Identity=31.6725978647687, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI291291012, Length=263, Percent_Identity=31.9391634980989, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI24497577, Length=288, Percent_Identity=29.5138888888889, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI5174391, Length=288, Percent_Identity=29.5138888888889, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI4502049, Length=294, Percent_Identity=28.9115646258503, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI310109922, Length=265, Percent_Identity=30.188679245283, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI45446745, Length=285, Percent_Identity=28.4210526315789, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4503285, Length=285, Percent_Identity=28.4210526315789, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310109920, Length=285, Percent_Identity=28.4210526315789, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI5453543, Length=285, Percent_Identity=28.0701754385965, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI5174695, Length=290, Percent_Identity=26.2068965517241, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI24497585, Length=282, Percent_Identity=24.113475177305, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI300116273, Length=273, Percent_Identity=26.7399267399267, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI24497583, Length=283, Percent_Identity=24.7349823321555, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1788081, Length=275, Percent_Identity=46.5454545454545, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI87082198, Length=279, Percent_Identity=28.673835125448, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1786400, Length=261, Percent_Identity=27.9693486590038, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787674, Length=285, Percent_Identity=30.5263157894737, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788070, Length=309, Percent_Identity=27.1844660194175, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI87081735, Length=279, Percent_Identity=28.673835125448, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI48994888, Length=172, Percent_Identity=31.9767441860465, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17552492, Length=263, Percent_Identity=28.1368821292776, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17537077, Length=292, Percent_Identity=28.7671232876712, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17537075, Length=290, Percent_Identity=29.3103448275862, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17566692, Length=289, Percent_Identity=25.9515570934256, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17564128, Length=292, Percent_Identity=27.7397260273973, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17537079, Length=293, Percent_Identity=26.6211604095563, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17538386, Length=279, Percent_Identity=28.673835125448, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561300, Length=266, Percent_Identity=27.8195488721804, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17550248, Length=288, Percent_Identity=23.2638888888889, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320576, Length=277, Percent_Identity=27.7978339350181, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6324694, Length=282, Percent_Identity=28.0141843971631, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320079, Length=288, Percent_Identity=28.4722222222222, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45553081, Length=289, Percent_Identity=29.4117647058824, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24644950, Length=295, Percent_Identity=28.4745762711864, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=30.078125, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24657054, Length=301, Percent_Identity=26.9102990033223, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24662789, Length=295, Percent_Identity=28.135593220339, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24663317, Length=295, Percent_Identity=24.7457627118644, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20129731, Length=289, Percent_Identity=27.681660899654, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356425, Length=290, Percent_Identity=25.5172413793103, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24662781, Length=294, Percent_Identity=27.2108843537415, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24662785, Length=279, Percent_Identity=27.5985663082437, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30514; Mature: 30383

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGDTRKFGRGGPEIAPIGQGTWYIDRGDRTAAIAALRRGLDLGMTHIDTAEMYGDAEPL
CCCCCCCCCCCCCCEEECCCCCEEEECCCCHHHHHHHHHCHHCCCHHCCHHHHHCCCCHH
VAEAIDGRRDQVFLVSKVLPSNASRRGTVAACERSLKRLKTDRLDCYLLHWRGQYRLAET
HHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
VAAFEELVAAGKIRSWGVSNFDVGDLWELLKVAGPDRIACNQVLYHLRERAIEHAVIPWC
HHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
EAHGVAVTAYSPFGHDEFPLPRSTEGRLLQSIAEAHGATPRQVALAFLTRRPSLFAIPKA
CCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCC
ADPAHAADNAAAGSLRLSDDEIAAIDQACPLGPEPASLPML
CCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGDTRKFGRGGPEIAPIGQGTWYIDRGDRTAAIAALRRGLDLGMTHIDTAEMYGDAEPL
CCCCCCCCCCCCCEEECCCCCEEEECCCCHHHHHHHHHCHHCCCHHCCHHHHHCCCCHH
VAEAIDGRRDQVFLVSKVLPSNASRRGTVAACERSLKRLKTDRLDCYLLHWRGQYRLAET
HHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
VAAFEELVAAGKIRSWGVSNFDVGDLWELLKVAGPDRIACNQVLYHLRERAIEHAVIPWC
HHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
EAHGVAVTAYSPFGHDEFPLPRSTEGRLLQSIAEAHGATPRQVALAFLTRRPSLFAIPKA
CCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCC
ADPAHAADNAAAGSLRLSDDEIAAIDQACPLGPEPASLPML
CCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]