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The map label for this gene is tmk [H]

Identifier: 86749796

GI number: 86749796

Start: 3061096

End: 3061836

Strand: Direct

Name: tmk [H]

Synonym: RPB_2679

Alternate gene names: 86749796

Gene position: 3061096-3061836 (Clockwise)

Preceding gene: 86749795

Following gene: 86749797

Centisome position: 57.41

GC content: 65.86

Gene sequence:

>741_bases
ATGCTTGAACAGACAACCCAAACTGCCTCAGCTTGCGGCCATTTCATCACTTTCGAAGGGGGCGAGGGGGCCGGCAAATC
AACCCAGATCAGGCTGCTGGCGCAGCGGCTGGAAAAGGCCGGGCTGGAGACCCTGGTGACGCGCGAGCCGGGCGGCTCGC
CGGGTGCAGAGATCATCCGGCATCTGTTGCTGGCCGGCGTCGGCCGGGCGATCGGCGGTGCTGAGGCTGAGGCGCTGCTG
TTCGCCGCGGCCCGCGACGACCATGTCCGCACATTGATCCAGCCCGCATTGGATCGCGGCGTCTGGGTGCTGTGCGACCG
GTTCTATGATTCGACCAGGGTCTACCAGGGTCGGCTCGGCGACGTCAGCCCTGGGATGCTGAACGCTTTGCAGGACGTCA
CCATCGGCACCATGAAGCCCGACCTCACCGTGATCCTCGACGTGCCGGTCGAAATCGGGCTGGCGCGCGCCGCAGTGCGT
CGCGGCAGCGATGCGCCCGACCGATTCGAATCCGAGAACATCGATTTTCATCGCCGGTTGCGCGACGCCTATCGGCAGAT
CGCGCGCGCCGAGCCGGAGCGCTGTGTGCTGGTCGATGCGCATGCCGAACCGAAGGTCGTGGCCGATCGGATCTGGCTGA
CGGTGCAGGAGCGGCTGCTGCAGTGGCCGCAGGCCAAACCCGCGGTGACGCCGAAGGCGAAAGCTAAGACGAAAACGAAG
ACCAAGGCGCGATCGGCATGA

Upstream 100 bases:

>100_bases
CCGAGACCAATCCGGTCGGCTCGACCATGCGCCGCGCCATGGACGGCGCCAGCGAGTTGGTGATCGGGGTGTTTCGCGCC
GGCATGGCAAAGCTCTGACA

Downstream 100 bases:

>100_bases
GCGCGCGCAAGGCTTCCACCGAGATCGCCGCGAAATCGCCGCGCGAGACCACGGCGCTGTTCGGGCATGCCGCCGCCGAG
CAGGCGCTGCTCGATGCCTA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLEQTTQTASACGHFITFEGGEGAGKSTQIRLLAQRLEKAGLETLVTREPGGSPGAEIIRHLLLAGVGRAIGGAEAEALL
FAAARDDHVRTLIQPALDRGVWVLCDRFYDSTRVYQGRLGDVSPGMLNALQDVTIGTMKPDLTVILDVPVEIGLARAAVR
RGSDAPDRFESENIDFHRRLRDAYRQIARAEPERCVLVDAHAEPKVVADRIWLTVQERLLQWPQAKPAVTPKAKAKTKTK
TKARSA

Sequences:

>Translated_246_residues
MLEQTTQTASACGHFITFEGGEGAGKSTQIRLLAQRLEKAGLETLVTREPGGSPGAEIIRHLLLAGVGRAIGGAEAEALL
FAAARDDHVRTLIQPALDRGVWVLCDRFYDSTRVYQGRLGDVSPGMLNALQDVTIGTMKPDLTVILDVPVEIGLARAAVR
RGSDAPDRFESENIDFHRRLRDAYRQIARAEPERCVLVDAHAEPKVVADRIWLTVQERLLQWPQAKPAVTPKAKAKTKTK
TKARSA
>Mature_246_residues
MLEQTTQTASACGHFITFEGGEGAGKSTQIRLLAQRLEKAGLETLVTREPGGSPGAEIIRHLLLAGVGRAIGGAEAEALL
FAAARDDHVRTLIQPALDRGVWVLCDRFYDSTRVYQGRLGDVSPGMLNALQDVTIGTMKPDLTVILDVPVEIGLARAAVR
RGSDAPDRFESENIDFHRRLRDAYRQIARAEPERCVLVDAHAEPKVVADRIWLTVQERLLQWPQAKPAVTPKAKAKTKTK
TKARSA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=204, Percent_Identity=41.6666666666667, Blast_Score=128, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 26894; Mature: 26894

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQTTQTASACGHFITFEGGEGAGKSTQIRLLAQRLEKAGLETLVTREPGGSPGAEIIR
CCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHH
HLLLAGVGRAIGGAEAEALLFAAARDDHVRTLIQPALDRGVWVLCDRFYDSTRVYQGRLG
HHHHHHHHHHCCCCCHHHEEEECCCCHHHHHHHHHHHHCCCEEEHHHHHCCHHHHCCCCC
DVSPGMLNALQDVTIGTMKPDLTVILDVPVEIGLARAAVRRGSDAPDRFESENIDFHRRL
CCCHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
RDAYRQIARAEPERCVLVDAHAEPKVVADRIWLTVQERLLQWPQAKPAVTPKAKAKTKTK
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
TKARSA
HHHCCC
>Mature Secondary Structure
MLEQTTQTASACGHFITFEGGEGAGKSTQIRLLAQRLEKAGLETLVTREPGGSPGAEIIR
CCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHH
HLLLAGVGRAIGGAEAEALLFAAARDDHVRTLIQPALDRGVWVLCDRFYDSTRVYQGRLG
HHHHHHHHHHCCCCCHHHEEEECCCCHHHHHHHHHHHHCCCEEEHHHHHCCHHHHCCCCC
DVSPGMLNALQDVTIGTMKPDLTVILDVPVEIGLARAAVRRGSDAPDRFESENIDFHRRL
CCCHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
RDAYRQIARAEPERCVLVDAHAEPKVVADRIWLTVQERLLQWPQAKPAVTPKAKAKTKTK
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
TKARSA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA