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The map label for this gene is dacC [H]

Identifier: 86749795

GI number: 86749795

Start: 3059834

End: 3061093

Strand: Direct

Name: dacC [H]

Synonym: RPB_2678

Alternate gene names: 86749795

Gene position: 3059834-3061093 (Clockwise)

Preceding gene: 86749793

Following gene: 86749796

Centisome position: 57.39

GC content: 65.32

Gene sequence:

>1260_bases
ATGGTTCTGTTCACCGACTTGCCGACCATCCGATCGCGCCGCCGCCTGCCGCGCTGGCGCGCGCTGTTGGTCGGCCTGCT
GGTCATGACGATCGGATCGAACCAGGCGTTGGCTGCGAACCAGAGCGTGCAGGGCGCCAAGAAGGAAGACGTCGCCGGCG
GCTACGACACCGATGCGCCGAGCGCCATCCTGATCGACGGTGAAAGCGGCAGCGTGCTGTTCGAGAAGAACGCCGACGAA
TTGCGCGCGCCGTCGAGCATGCTGAAGCTGATGACCGTGGAGCTGGTGTTTCACCTGCTGGCCAAGGGTGAGATCAAGCC
GACCGACGAGTACAAGATCAGCGAATACGCATGGCGCCGCGGCGGCGCGCCGGCCGGCAACTCGACGATGTTCGCCGAAA
TTCACAGCAAGGTCGCGGTGGAGGACCTGCTCAAGGGCGCGATCATCCAGAGCGGCAACGATTCCTGCATCGCGCTGGCC
GAAGGCATCGCCGGCAGCGAGCCGGCATTCGTCGAGCGGATGACCAAGCGGGCGCGTGAGATCGGGCTGACGCAATCGAC
CTTCGCGAATTCCAACGGTCTGCCCGATCCCGGCAACAAGATGAGCGTGCGCGAACTCGGCCGGCTCGCGCGCCACATCA
TCCAGACCTATCCGAACGACTACAAGCTGTTCAGTGAGAAGGAATTCACCTGGAACAAGATCCGGCAGACCAACCGCAAC
CCGCTGCTGAATACGTTCAACGGCGCCGACGGGTTGAAGACCGGCTACACCAAGGACGGCGGCTACGGCATGGTCGGCTC
TGCGGTGCAGAACGGGATGCGGCTGATCGTGGTGGTCAACGGGATCGACGACATCGACGATCGAGCCAGCGAGGTCAAGA
AGCTGCTGGAATGGGGCTTCCGCAACTTCGAATCGCGCGCGCTGTTCGCTTCGGACGCGACGATCGGCTATGCGCGGGTG
TTCGGCGGTGAGAAGCGTTACGTCCCGTTGATCCCGGCCGAGCCGGTGCGGGTGATGGTGCGCAAGAACGGCAGCGACCG
GCTGATCGCGCGGATCGTGTATACCGGCCCGGTCGCAGCGCCGGTCGACGCCGGCCGCCGCATCGGCGTGGTGCGGGTGT
GGCGCGGCCCCAACCTTGCGGTCGAAGTGCCGCTGCAGGCGGCCGAGACCAATCCGGTCGGCTCGACCATGCGCCGCGCC
ATGGACGGCGCCAGCGAGTTGGTGATCGGGGTGTTTCGCGCCGGCATGGCAAAGCTCTGA

Upstream 100 bases:

>100_bases
CCGGCGTCGCCACAATGGAGAACAGTCCACTCCTGCCGTCCGTCCGGATGGGTGGAGACGATCCGCACCCTTGTTCGAAG
CCTGTCCCGGAACATTCTCG

Downstream 100 bases:

>100_bases
CAATGCTTGAACAGACAACCCAAACTGCCTCAGCTTGCGGCCATTTCATCACTTTCGAAGGGGGCGAGGGGGCCGGCAAA
TCAACCCAGATCAGGCTGCT

Product: Serine-type D-Ala-D-Ala carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MVLFTDLPTIRSRRRLPRWRALLVGLLVMTIGSNQALAANQSVQGAKKEDVAGGYDTDAPSAILIDGESGSVLFEKNADE
LRAPSSMLKLMTVELVFHLLAKGEIKPTDEYKISEYAWRRGGAPAGNSTMFAEIHSKVAVEDLLKGAIIQSGNDSCIALA
EGIAGSEPAFVERMTKRAREIGLTQSTFANSNGLPDPGNKMSVRELGRLARHIIQTYPNDYKLFSEKEFTWNKIRQTNRN
PLLNTFNGADGLKTGYTKDGGYGMVGSAVQNGMRLIVVVNGIDDIDDRASEVKKLLEWGFRNFESRALFASDATIGYARV
FGGEKRYVPLIPAEPVRVMVRKNGSDRLIARIVYTGPVAAPVDAGRRIGVVRVWRGPNLAVEVPLQAAETNPVGSTMRRA
MDGASELVIGVFRAGMAKL

Sequences:

>Translated_419_residues
MVLFTDLPTIRSRRRLPRWRALLVGLLVMTIGSNQALAANQSVQGAKKEDVAGGYDTDAPSAILIDGESGSVLFEKNADE
LRAPSSMLKLMTVELVFHLLAKGEIKPTDEYKISEYAWRRGGAPAGNSTMFAEIHSKVAVEDLLKGAIIQSGNDSCIALA
EGIAGSEPAFVERMTKRAREIGLTQSTFANSNGLPDPGNKMSVRELGRLARHIIQTYPNDYKLFSEKEFTWNKIRQTNRN
PLLNTFNGADGLKTGYTKDGGYGMVGSAVQNGMRLIVVVNGIDDIDDRASEVKKLLEWGFRNFESRALFASDATIGYARV
FGGEKRYVPLIPAEPVRVMVRKNGSDRLIARIVYTGPVAAPVDAGRRIGVVRVWRGPNLAVEVPLQAAETNPVGSTMRRA
MDGASELVIGVFRAGMAKL
>Mature_419_residues
MVLFTDLPTIRSRRRLPRWRALLVGLLVMTIGSNQALAANQSVQGAKKEDVAGGYDTDAPSAILIDGESGSVLFEKNADE
LRAPSSMLKLMTVELVFHLLAKGEIKPTDEYKISEYAWRRGGAPAGNSTMFAEIHSKVAVEDLLKGAIIQSGNDSCIALA
EGIAGSEPAFVERMTKRAREIGLTQSTFANSNGLPDPGNKMSVRELGRLARHIIQTYPNDYKLFSEKEFTWNKIRQTNRN
PLLNTFNGADGLKTGYTKDGGYGMVGSAVQNGMRLIVVVNGIDDIDDRASEVKKLLEWGFRNFESRALFASDATIGYARV
FGGEKRYVPLIPAEPVRVMVRKNGSDRLIARIVYTGPVAAPVDAGRRIGVVRVWRGPNLAVEVPLQAAETNPVGSTMRRA
MDGASELVIGVFRAGMAKL

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=355, Percent_Identity=40.5633802816901, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI87082022, Length=351, Percent_Identity=34.7578347578348, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1786851, Length=400, Percent_Identity=34, Blast_Score=193, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 45657; Mature: 45657

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLFTDLPTIRSRRRLPRWRALLVGLLVMTIGSNQALAANQSVQGAKKEDVAGGYDTDAP
CEEEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHCCCCCCCCCCC
SAILIDGESGSVLFEKNADELRAPSSMLKLMTVELVFHLLAKGEIKPTDEYKISEYAWRR
CEEEEECCCCCEEEECCHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHC
GGAPAGNSTMFAEIHSKVAVEDLLKGAIIQSGNDSCIALAEGIAGSEPAFVERMTKRARE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
IGLTQSTFANSNGLPDPGNKMSVRELGRLARHIIQTYPNDYKLFSEKEFTWNKIRQTNRN
CCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHCCCC
PLLNTFNGADGLKTGYTKDGGYGMVGSAVQNGMRLIVVVNGIDDIDDRASEVKKLLEWGF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
RNFESRALFASDATIGYARVFGGEKRYVPLIPAEPVRVMVRKNGSDRLIARIVYTGPVAA
CCCCCCEEEECCCCEEEHHHCCCCCCEEECCCCCCEEEEEECCCCCEEEEEEEECCCCCC
PVDAGRRIGVVRVWRGPNLAVEVPLQAAETNPVGSTMRRAMDGASELVIGVFRAGMAKL
CCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLFTDLPTIRSRRRLPRWRALLVGLLVMTIGSNQALAANQSVQGAKKEDVAGGYDTDAP
CEEEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHCCCCCCCCCCC
SAILIDGESGSVLFEKNADELRAPSSMLKLMTVELVFHLLAKGEIKPTDEYKISEYAWRR
CEEEEECCCCCEEEECCHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHC
GGAPAGNSTMFAEIHSKVAVEDLLKGAIIQSGNDSCIALAEGIAGSEPAFVERMTKRARE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
IGLTQSTFANSNGLPDPGNKMSVRELGRLARHIIQTYPNDYKLFSEKEFTWNKIRQTNRN
CCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHCCCC
PLLNTFNGADGLKTGYTKDGGYGMVGSAVQNGMRLIVVVNGIDDIDDRASEVKKLLEWGF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
RNFESRALFASDATIGYARVFGGEKRYVPLIPAEPVRVMVRKNGSDRLIARIVYTGPVAA
CCCCCCEEEECCCCEEEHHHCCCCCCEEECCCCCCEEEEEECCCCCEEEEEEEECCCCCC
PVDAGRRIGVVRVWRGPNLAVEVPLQAAETNPVGSTMRRAMDGASELVIGVFRAGMAKL
CCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]