| Definition | Rhodopseudomonas palustris HaA2, complete genome. |
|---|---|
| Accession | NC_007778 |
| Length | 5,331,656 |
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The map label for this gene is pycA [H]
Identifier: 86749487
GI number: 86749487
Start: 2722148
End: 2724163
Strand: Direct
Name: pycA [H]
Synonym: RPB_2367
Alternate gene names: 86749487
Gene position: 2722148-2724163 (Clockwise)
Preceding gene: 86749486
Following gene: 86749488
Centisome position: 51.06
GC content: 66.47
Gene sequence:
>2016_bases ATGTTCAAACGTATTCTGATCGCCAATCGCGGCGAGATCGCCTGCCGGGTCATCAAGACCGCCCGCCTGATGGGAATCGA GACGGTCGCCGTCTATTCCGAGGCGGATCGCGACGCGTTGCACGTCGAGATGGCCGATGAAGCGGTCCTGATCGGACCGG CGGCGGCATCCGAGAGCTATCTGGTGATCGAGAAGATCGTCGAGGCCTGCCGCAAGACCGGCGCCGAGGCGGTGCATCCG GGCTACGGCTTCCTGTCCGAGCGCGAATCCTTCCCGCGTATCCTGGCCGACGCCGGCATCGTCTTCATCGGTCCCAACGC CGGCGCGATCGCCGCGATGGGCGACAAGATCGAATCCAAGAAGGCCGCCGCCAAGGCCAACGTCTCGACCGTGCCGGGCT ATCTCGGCGTGATCGAGGACGCCACCCACGCGGTGAAAATCGCCGACGAGATCGGCTATCCGGTGATGATCAAGGCCTCG GCCGGCGGCGGCGGCAAGGGCATGCGGATCGCGCATTCGACCAGTGAGGTCGCCGAAGGCTTCAACCTCGCCAAGGCGGA GGCGAAAGCCTCGTTCGGCGACGATCGCGTCTTCATCGAGAAATTCATCGTCGACCCGCGCCACATCGAAATCCAGGTGC TCGGCGACAAGCACGGCAACGTCATCTATCTCGGCGAGCGCGAATGCTCGATCCAGCGCCGCAACCAGAAGGTGATCGAG GAGGCGCCGTCGCCGCTGCTCGACGAGGTCACCCGCCGGAAGATGGGCGAGCAGGCGGTCGCGCTGGCGAAAGCGGTGCA GTACGATTCCGCCGGCACCGTGGAGTTCGTGGCCGGTCAGGACAAGAGCTTCTACTTCCTCGAAATGAACACCCGCCTGC AGGTCGAACACCCGGTCACCGAAATGATCACCGGCATCGACCTGGTCGAGCAGATGATCCGTGTCGCGGCCGGCGAGAAG CTCGAGCTTGCGCAGAAGGACGTCAGGCTGAAGGGCTGGGCGGTGGAAAGCCGGGTCTATGCGGAAGATCCGTTCCGCAA CTTCCTGCCGTCGATCGGCCGCCTGGTGAAGTATCGTCCGCCGAGCGAGAGCTCAGCCTCCGGCGTCACCGTGCGCAACG ACACCGGCGTGCAAGAAGGCGGCGAGATCTCGATCTTCTACGATCCGATGATCGCCAAGCTGGTGACGCATGCGCCGTCG CGCGCGGCGGCGATCGAGGCGCAGGCGCACGCGCTGGATGCGTTCTATGTCGATGGCATCCGCCACAACATCCCGTTCCT GTCGGCGCTGATGACGCATCCGCGCTGGCGCGAGGGCAATCTCTCGACCGGCTTCATCGCCGAGGAATTCCCGCAGGGCT TCGCCGCGCGGCTGCCGGAGGGCGACGTCGCCCGCCGCATCGCCGCGGTCGGCGCTGCGATCGACCGCGTCGTCGGCGAG CGCAAGCGCAAGATTTCCGGCCAGATGATCGGCCGCGCGGTGATCCGCGAACGCCGCCGCTGCGTCTGGCTCGAACGCAG CGAGATCGCGCTCGATGTGATCCGCGAGGGCGAGGGCTTCGTGGTGCGCTTCGTCGAGGCCGACGGATCGCTGGGGCAGT CGCATCAATTGCTGTCGTCGTGGATTCCCGGCGACCCGGTGTGGCAGGGGACCATCAACGGCAAGCCGGTCGCGGTGCAG GTCCGCTCGATCCCGAACGGCGTCCGGCTCGCGCATCACGGCTACGAAGTCGCGGTCAACGTCTTCACCGAGCGCGAAGC CTCGGCGGCGCGCTGGATGCTGGAGGGCAACAAGGCCGACACCGGCAAGAAGGTGCTGTGCCCGATGCCGGGTCTGGTGG TCTCGATCGCGGTGGTCGAAGGCCAGGAGGTCAAGGCCGGCGAGACGCTGGCGGTGGTCGAGGCGATGAAGATGCAGAAC GTGCTGCGCGCCGAGCGCGACGGCACGGTGAAGAAGATCCACGCCGCGGCGGGCGCCACACTCGCCGTCGACGCGCTGAT CCTCGAGTTCGCGTAG
Upstream 100 bases:
>100_bases AGTTTTCCTCGGCGTCAGAATTGTTACAAGCACACGCACGCCGATTGCCGTCCCTCGCCGGGAGGGCAGAACCACTCCCA AGGTCGCAAGCAACAAGAAC
Downstream 100 bases:
>100_bases CCGCGATGGCCTGGCGCGACCGCCGCGGCGCGTTGCGGGCGATCCTCGAAGGATCGGCCTGCGTGCGCCCGGCGTCGGTG TATGATGCGATCTCGATCCG
Product: carbamoyl-phosphate synthase L chain, ATP-binding
Products: NA
Alternate protein names: Pyruvic carboxylase A [H]
Number of amino acids: Translated: 671; Mature: 671
Protein sequence:
>671_residues MFKRILIANRGEIACRVIKTARLMGIETVAVYSEADRDALHVEMADEAVLIGPAAASESYLVIEKIVEACRKTGAEAVHP GYGFLSERESFPRILADAGIVFIGPNAGAIAAMGDKIESKKAAAKANVSTVPGYLGVIEDATHAVKIADEIGYPVMIKAS AGGGGKGMRIAHSTSEVAEGFNLAKAEAKASFGDDRVFIEKFIVDPRHIEIQVLGDKHGNVIYLGERECSIQRRNQKVIE EAPSPLLDEVTRRKMGEQAVALAKAVQYDSAGTVEFVAGQDKSFYFLEMNTRLQVEHPVTEMITGIDLVEQMIRVAAGEK LELAQKDVRLKGWAVESRVYAEDPFRNFLPSIGRLVKYRPPSESSASGVTVRNDTGVQEGGEISIFYDPMIAKLVTHAPS RAAAIEAQAHALDAFYVDGIRHNIPFLSALMTHPRWREGNLSTGFIAEEFPQGFAARLPEGDVARRIAAVGAAIDRVVGE RKRKISGQMIGRAVIRERRRCVWLERSEIALDVIREGEGFVVRFVEADGSLGQSHQLLSSWIPGDPVWQGTINGKPVAVQ VRSIPNGVRLAHHGYEVAVNVFTEREASAARWMLEGNKADTGKKVLCPMPGLVVSIAVVEGQEVKAGETLAVVEAMKMQN VLRAERDGTVKKIHAAAGATLAVDALILEFA
Sequences:
>Translated_671_residues MFKRILIANRGEIACRVIKTARLMGIETVAVYSEADRDALHVEMADEAVLIGPAAASESYLVIEKIVEACRKTGAEAVHP GYGFLSERESFPRILADAGIVFIGPNAGAIAAMGDKIESKKAAAKANVSTVPGYLGVIEDATHAVKIADEIGYPVMIKAS AGGGGKGMRIAHSTSEVAEGFNLAKAEAKASFGDDRVFIEKFIVDPRHIEIQVLGDKHGNVIYLGERECSIQRRNQKVIE EAPSPLLDEVTRRKMGEQAVALAKAVQYDSAGTVEFVAGQDKSFYFLEMNTRLQVEHPVTEMITGIDLVEQMIRVAAGEK LELAQKDVRLKGWAVESRVYAEDPFRNFLPSIGRLVKYRPPSESSASGVTVRNDTGVQEGGEISIFYDPMIAKLVTHAPS RAAAIEAQAHALDAFYVDGIRHNIPFLSALMTHPRWREGNLSTGFIAEEFPQGFAARLPEGDVARRIAAVGAAIDRVVGE RKRKISGQMIGRAVIRERRRCVWLERSEIALDVIREGEGFVVRFVEADGSLGQSHQLLSSWIPGDPVWQGTINGKPVAVQ VRSIPNGVRLAHHGYEVAVNVFTEREASAARWMLEGNKADTGKKVLCPMPGLVVSIAVVEGQEVKAGETLAVVEAMKMQN VLRAERDGTVKKIHAAAGATLAVDALILEFA >Mature_671_residues MFKRILIANRGEIACRVIKTARLMGIETVAVYSEADRDALHVEMADEAVLIGPAAASESYLVIEKIVEACRKTGAEAVHP GYGFLSERESFPRILADAGIVFIGPNAGAIAAMGDKIESKKAAAKANVSTVPGYLGVIEDATHAVKIADEIGYPVMIKAS AGGGGKGMRIAHSTSEVAEGFNLAKAEAKASFGDDRVFIEKFIVDPRHIEIQVLGDKHGNVIYLGERECSIQRRNQKVIE EAPSPLLDEVTRRKMGEQAVALAKAVQYDSAGTVEFVAGQDKSFYFLEMNTRLQVEHPVTEMITGIDLVEQMIRVAAGEK LELAQKDVRLKGWAVESRVYAEDPFRNFLPSIGRLVKYRPPSESSASGVTVRNDTGVQEGGEISIFYDPMIAKLVTHAPS RAAAIEAQAHALDAFYVDGIRHNIPFLSALMTHPRWREGNLSTGFIAEEFPQGFAARLPEGDVARRIAAVGAAIDRVVGE RKRKISGQMIGRAVIRERRRCVWLERSEIALDVIREGEGFVVRFVEADGSLGQSHQLLSSWIPGDPVWQGTINGKPVAVQ VRSIPNGVRLAHHGYEVAVNVFTEREASAARWMLEGNKADTGKKVLCPMPGLVVSIAVVEGQEVKAGETLAVVEAMKMQN VLRAERDGTVKKIHAAAGATLAVDALILEFA
Specific function: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second [H]
COG id: COG4770
COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 biotin carboxylation domain [H]
Homologues:
Organism=Homo sapiens, GI65506442, Length=675, Percent_Identity=50.5185185185185, Blast_Score=633, Evalue=0.0, Organism=Homo sapiens, GI189095269, Length=675, Percent_Identity=50.5185185185185, Blast_Score=632, Evalue=0.0, Organism=Homo sapiens, GI295821183, Length=673, Percent_Identity=49.1827637444279, Blast_Score=590, Evalue=1e-168, Organism=Homo sapiens, GI116805327, Length=679, Percent_Identity=42.120765832106, Blast_Score=506, Evalue=1e-143, Organism=Homo sapiens, GI106049528, Length=460, Percent_Identity=43.4782608695652, Blast_Score=365, Evalue=1e-101, Organism=Homo sapiens, GI106049295, Length=460, Percent_Identity=43.4782608695652, Blast_Score=365, Evalue=1e-101, Organism=Homo sapiens, GI106049292, Length=460, Percent_Identity=43.4782608695652, Blast_Score=365, Evalue=1e-101, Organism=Homo sapiens, GI38679960, Length=729, Percent_Identity=27.2976680384088, Blast_Score=238, Evalue=1e-62, Organism=Homo sapiens, GI38679974, Length=729, Percent_Identity=27.2976680384088, Blast_Score=238, Evalue=1e-62, Organism=Homo sapiens, GI38679977, Length=729, Percent_Identity=27.2976680384088, Blast_Score=238, Evalue=1e-62, Organism=Homo sapiens, GI38679967, Length=729, Percent_Identity=27.2976680384088, Blast_Score=238, Evalue=1e-62, Organism=Homo sapiens, GI38679971, Length=729, Percent_Identity=27.2976680384088, Blast_Score=238, Evalue=2e-62, Organism=Homo sapiens, GI134142062, Length=726, Percent_Identity=26.7217630853994, Blast_Score=228, Evalue=2e-59, Organism=Escherichia coli, GI1789654, Length=451, Percent_Identity=45.6762749445676, Blast_Score=387, Evalue=1e-108, Organism=Caenorhabditis elegans, GI17567343, Length=685, Percent_Identity=48.3211678832117, Blast_Score=595, Evalue=1e-170, Organism=Caenorhabditis elegans, GI71987519, Length=679, Percent_Identity=42.2680412371134, Blast_Score=465, Evalue=1e-131, Organism=Caenorhabditis elegans, GI17562816, Length=474, Percent_Identity=43.0379746835443, Blast_Score=367, Evalue=1e-102, Organism=Caenorhabditis elegans, GI71997168, Length=708, Percent_Identity=26.9774011299435, Blast_Score=210, Evalue=2e-54, Organism=Caenorhabditis elegans, GI71997163, Length=708, Percent_Identity=26.9774011299435, Blast_Score=210, Evalue=3e-54, Organism=Caenorhabditis elegans, GI133931226, Length=693, Percent_Identity=27.1284271284271, Blast_Score=201, Evalue=7e-52, Organism=Saccharomyces cerevisiae, GI6319685, Length=447, Percent_Identity=44.5190156599553, Blast_Score=378, Evalue=1e-105, Organism=Saccharomyces cerevisiae, GI6319695, Length=459, Percent_Identity=42.9193899782135, Blast_Score=350, Evalue=6e-97, Organism=Saccharomyces cerevisiae, GI6321376, Length=459, Percent_Identity=43.5729847494553, Blast_Score=341, Evalue=3e-94, Organism=Saccharomyces cerevisiae, GI6323863, Length=667, Percent_Identity=28.0359820089955, Blast_Score=235, Evalue=2e-62, Organism=Saccharomyces cerevisiae, GI6324343, Length=736, Percent_Identity=27.3097826086957, Blast_Score=234, Evalue=2e-62, Organism=Drosophila melanogaster, GI24651757, Length=452, Percent_Identity=49.7787610619469, Blast_Score=446, Evalue=1e-125, Organism=Drosophila melanogaster, GI24651759, Length=416, Percent_Identity=48.5576923076923, Blast_Score=397, Evalue=1e-110, Organism=Drosophila melanogaster, GI281363050, Length=457, Percent_Identity=45.0765864332604, Blast_Score=370, Evalue=1e-102, Organism=Drosophila melanogaster, GI24652224, Length=457, Percent_Identity=45.0765864332604, Blast_Score=370, Evalue=1e-102, Organism=Drosophila melanogaster, GI24652222, Length=457, Percent_Identity=45.0765864332604, Blast_Score=370, Evalue=1e-102, Organism=Drosophila melanogaster, GI24652212, Length=457, Percent_Identity=45.0765864332604, Blast_Score=370, Evalue=1e-102, Organism=Drosophila melanogaster, GI24652220, Length=457, Percent_Identity=45.0765864332604, Blast_Score=370, Evalue=1e-102, Organism=Drosophila melanogaster, GI24652210, Length=457, Percent_Identity=45.0765864332604, Blast_Score=370, Evalue=1e-102, Organism=Drosophila melanogaster, GI24652214, Length=457, Percent_Identity=45.0765864332604, Blast_Score=370, Evalue=1e-102, Organism=Drosophila melanogaster, GI19921944, Length=457, Percent_Identity=45.0765864332604, Blast_Score=370, Evalue=1e-102, Organism=Drosophila melanogaster, GI24652218, Length=457, Percent_Identity=45.0765864332604, Blast_Score=370, Evalue=1e-102, Organism=Drosophila melanogaster, GI24652216, Length=457, Percent_Identity=45.0765864332604, Blast_Score=370, Evalue=1e-102, Organism=Drosophila melanogaster, GI161076409, Length=748, Percent_Identity=26.8716577540107, Blast_Score=218, Evalue=9e-57, Organism=Drosophila melanogaster, GI161076407, Length=748, Percent_Identity=26.8716577540107, Blast_Score=218, Evalue=1e-56, Organism=Drosophila melanogaster, GI24586460, Length=748, Percent_Identity=26.8716577540107, Blast_Score=218, Evalue=1e-56, Organism=Drosophila melanogaster, GI24586458, Length=748, Percent_Identity=26.8716577540107, Blast_Score=218, Evalue=1e-56,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004549 - InterPro: IPR011761 - InterPro: IPR013815 - InterPro: IPR013816 - InterPro: IPR011764 - InterPro: IPR005482 - InterPro: IPR005479 - InterPro: IPR005481 - InterPro: IPR013817 - InterPro: IPR016185 - InterPro: IPR011054 [H]
Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]
EC number: =6.4.1.1 [H]
Molecular weight: Translated: 72786; Mature: 72786
Theoretical pI: Translated: 6.69; Mature: 6.69
Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MFKRILIANRGEIACRVIKTARLMGIETVAVYSEADRDALHVEMADEAVLIGPAAASESY CCCEEEEECCCCEEHHHHHHHHHHCEEEEEEECCCCCCEEEEEECCCEEEEECCCCCCCC LVIEKIVEACRKTGAEAVHPGYGFLSERESFPRILADAGIVFIGPNAGAIAAMGDKIESK HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCEEEECCCHHHHH KAAAKANVSTVPGYLGVIEDATHAVKIADEIGYPVMIKASAGGGGKGMRIAHSTSEVAEG HHHHHCCCCCCCCHHHHHHCCHHHEEEHHHCCCCEEEEECCCCCCCCEEEEECHHHHHCC FNLAKAEAKASFGDDRVFIEKFIVDPRHIEIQVLGDKHGNVIYLGERECSIQRRNQKVIE CCHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH EAPSPLLDEVTRRKMGEQAVALAKAVQYDSAGTVEFVAGQDKSFYFLEMNTRLQVEHPVT HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCEEEECCCHH EMITGIDLVEQMIRVAAGEKLELAQKDVRLKGWAVESRVYAEDPFRNFLPSIGRLVKYRP HHHHHHHHHHHHHHHHCCCCHHHHHHCCEEEEEEECCEEECCCHHHHHHHHHHHHEEECC PSESSASGVTVRNDTGVQEGGEISIFYDPMIAKLVTHAPSRAAAIEAQAHALDAFYVDGI CCCCCCCCEEEECCCCCCCCCEEEEEECHHHHHHHHCCCCCHHEEHHHHHHHHHHEECCH RHNIPFLSALMTHPRWREGNLSTGFIAEEFPQGFAARLPEGDVARRIAAVGAAIDRVVGE HHCCHHHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHH RKRKISGQMIGRAVIRERRRCVWLERSEIALDVIREGEGFVVRFVEADGSLGQSHQLLSS HHHHHHHHHHHHHHHHHHHHEEEEECCHHEEEEEECCCCEEEEEEECCCCCCHHHHHHHH WIPGDPVWQGTINGKPVAVQVRSIPNGVRLAHHGYEVAVNVFTEREASAARWMLEGNKAD CCCCCCEEECCCCCCEEEEEEECCCCCEEEEECCEEEEEEEEECCCCCHHEEEEECCCCC TGKKVLCPMPGLVVSIAVVEGQEVKAGETLAVVEAMKMQNVLRAERDGTVKKIHAAAGAT CCCEEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHCCCH LAVDALILEFA HHHHHHHHCCC >Mature Secondary Structure MFKRILIANRGEIACRVIKTARLMGIETVAVYSEADRDALHVEMADEAVLIGPAAASESY CCCEEEEECCCCEEHHHHHHHHHHCEEEEEEECCCCCCEEEEEECCCEEEEECCCCCCCC LVIEKIVEACRKTGAEAVHPGYGFLSERESFPRILADAGIVFIGPNAGAIAAMGDKIESK HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCEEEECCCHHHHH KAAAKANVSTVPGYLGVIEDATHAVKIADEIGYPVMIKASAGGGGKGMRIAHSTSEVAEG HHHHHCCCCCCCCHHHHHHCCHHHEEEHHHCCCCEEEEECCCCCCCCEEEEECHHHHHCC FNLAKAEAKASFGDDRVFIEKFIVDPRHIEIQVLGDKHGNVIYLGERECSIQRRNQKVIE CCHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH EAPSPLLDEVTRRKMGEQAVALAKAVQYDSAGTVEFVAGQDKSFYFLEMNTRLQVEHPVT HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCEEEECCCHH EMITGIDLVEQMIRVAAGEKLELAQKDVRLKGWAVESRVYAEDPFRNFLPSIGRLVKYRP HHHHHHHHHHHHHHHHCCCCHHHHHHCCEEEEEEECCEEECCCHHHHHHHHHHHHEEECC PSESSASGVTVRNDTGVQEGGEISIFYDPMIAKLVTHAPSRAAAIEAQAHALDAFYVDGI CCCCCCCCEEEECCCCCCCCCEEEEEECHHHHHHHHCCCCCHHEEHHHHHHHHHHEECCH RHNIPFLSALMTHPRWREGNLSTGFIAEEFPQGFAARLPEGDVARRIAAVGAAIDRVVGE HHCCHHHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHH RKRKISGQMIGRAVIRERRRCVWLERSEIALDVIREGEGFVVRFVEADGSLGQSHQLLSS HHHHHHHHHHHHHHHHHHHHEEEEECCHHEEEEEECCCCEEEEEEECCCCCCHHHHHHHH WIPGDPVWQGTINGKPVAVQVRSIPNGVRLAHHGYEVAVNVFTEREASAARWMLEGNKAD CCCCCCEEECCCCCCEEEEEEECCCCCEEEEECCEEEEEEEEECCCCCHHEEEEECCCCC TGKKVLCPMPGLVVSIAVVEGQEVKAGETLAVVEAMKMQNVLRAERDGTVKKIHAAAGAT CCCEEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHCCCH LAVDALILEFA HHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8688087; 11195096 [H]