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The map label for this gene is prpB [C]

Identifier: 86749488

GI number: 86749488

Start: 2724169

End: 2725038

Strand: Direct

Name: prpB [C]

Synonym: RPB_2368

Alternate gene names: 86749488

Gene position: 2724169-2725038 (Clockwise)

Preceding gene: 86749487

Following gene: 86749489

Centisome position: 51.09

GC content: 70.57

Gene sequence:

>870_bases
ATGGCCTGGCGCGACCGCCGCGGCGCGTTGCGGGCGATCCTCGAAGGATCGGCCTGCGTGCGCCCGGCGTCGGTGTATGA
TGCGATCTCGATCCGGATCGCCGACGATCTTCGCTTTCCGCTCGGGATGTTCGGCGGCTCAGTGGCGTCGCTGGCGATCC
TCGGCGATCCCGATAGCGCGCTGATCACGCTCACCGAACTCGCCGAGCAGATGCGGCGGATGGCGCGCGCTGCTGCATTG
CCGGTGCTGGTCGACGCCGATCACGGCTACGGCAACGCGCTCAACGTCCGCCGCACCGTGCAGGAGCTGGAGGCCGCAGG
CTGTGCCGGCCTCACCATCGAGGACACGCTGCTGCCGCAGGCCTATGGCGAAGCCAAGCCGCAACTGATCTCGTCGGAGG
AGGGGCTCGGCAAGATCAACGCCGCACTCGACGCGCGGCTCGATCCGTCGCTGGTGATCATCGGCCGCACCGGCGCGTGT
TCGATCAGTTCGCTCGACGATGCGATCGAGCGCGCGGTAGCTTACGAGGCGGCCGGCGTCGATGCGCTGTTCTTCACCGG
CGTGAAGGCGCGCGATCAGTTGCAAGCGATCAGCGCCGCGACGCGGCTGCCGATCGTGCTCGGCAGCCCGCCGGCGGAAC
TGGCCGATTGGGAGTACCTCGCCGCGCAGCGCGTGCGCATCGCCGTGCAGGGCCACGCGCCGATCGCTGCGGCGACCGAG
GCGGTGTTCAGGACGCTGTCGGCGCTCCGCGACGGCGCCGCGCCGCAGCAGCTCACCGGCCTCGCCACGCCCGAGCTGAT
GGACCGCGTCACCCGCGCATCGCTGGTCGACGAGCGCGGCGCCCGGTTTCTGGGGCTCGCACGCGAATGA

Upstream 100 bases:

>100_bases
TGCTGCGCGCCGAGCGCGACGGCACGGTGAAGAAGATCCACGCCGCGGCGGGCGCCACACTCGCCGTCGACGCGCTGATC
CTCGAGTTCGCGTAGCCGCG

Downstream 100 bases:

>100_bases
GCAGGGCGGTCCGGCAGGTGATCGTTCGCGGCCATGTGCAGGGGGTCGGCTATCGCGCCTGGGTCGCGACGACCGCGCAG
GCGCAGGGCCTCGAAGGCTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MAWRDRRGALRAILEGSACVRPASVYDAISIRIADDLRFPLGMFGGSVASLAILGDPDSALITLTELAEQMRRMARAAAL
PVLVDADHGYGNALNVRRTVQELEAAGCAGLTIEDTLLPQAYGEAKPQLISSEEGLGKINAALDARLDPSLVIIGRTGAC
SISSLDDAIERAVAYEAAGVDALFFTGVKARDQLQAISAATRLPIVLGSPPAELADWEYLAAQRVRIAVQGHAPIAAATE
AVFRTLSALRDGAAPQQLTGLATPELMDRVTRASLVDERGARFLGLARE

Sequences:

>Translated_289_residues
MAWRDRRGALRAILEGSACVRPASVYDAISIRIADDLRFPLGMFGGSVASLAILGDPDSALITLTELAEQMRRMARAAAL
PVLVDADHGYGNALNVRRTVQELEAAGCAGLTIEDTLLPQAYGEAKPQLISSEEGLGKINAALDARLDPSLVIIGRTGAC
SISSLDDAIERAVAYEAAGVDALFFTGVKARDQLQAISAATRLPIVLGSPPAELADWEYLAAQRVRIAVQGHAPIAAATE
AVFRTLSALRDGAAPQQLTGLATPELMDRVTRASLVDERGARFLGLARE
>Mature_288_residues
AWRDRRGALRAILEGSACVRPASVYDAISIRIADDLRFPLGMFGGSVASLAILGDPDSALITLTELAEQMRRMARAAALP
VLVDADHGYGNALNVRRTVQELEAAGCAGLTIEDTLLPQAYGEAKPQLISSEEGLGKINAALDARLDPSLVIIGRTGACS
ISSLDDAIERAVAYEAAGVDALFFTGVKARDQLQAISAATRLPIVLGSPPAELADWEYLAAQRVRIAVQGHAPIAAATEA
VFRTLSALRDGAAPQQLTGLATPELMDRVTRASLVDERGARFLGLARE

Specific function: Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate

COG id: COG2513

COG function: function code G; PEP phosphonomutase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Oxaloacetate decarboxylase family

Homologues:

Organism=Escherichia coli, GI1786525, Length=165, Percent_Identity=41.2121212121212, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OADC_RHOP2 (Q2IXI7)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_485984.1
- STRING:   Q2IXI7
- GeneID:   3909367
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_2368
- eggNOG:   COG2513
- HOGENOM:   HBG728656
- OMA:   VDADHGY
- ProtClustDB:   CLSK868955
- BioCyc:   RPAL316058:RPB_2368-MONOMER
- HAMAP:   MF_01299
- InterPro:   IPR013785
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =4.1.1.3

Molecular weight: Translated: 30512; Mature: 30381

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: BINDING 47-47 BINDING 156-156 BINDING 232-232

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWRDRRGALRAILEGSACVRPASVYDAISIRIADDLRFPLGMFGGSVASLAILGDPDSA
CCCCCHHHHHHHHHCCCCCCCCHHHHHEEEEEEECCCCCCHHHCCCCCEEEEEECCCCCC
LITLTELAEQMRRMARAAALPVLVDADHGYGNALNVRRTVQELEAAGCAGLTIEDTLLPQ
EEEHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHCCH
AYGEAKPQLISSEEGLGKINAALDARLDPSLVIIGRTGACSISSLDDAIERAVAYEAAGV
HHCCCCCCEECCCCCCCHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
DALFFTGVKARDQLQAISAATRLPIVLGSPPAELADWEYLAAQRVRIAVQGHAPIAAATE
CEEEECCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHEEEEEEECCCCHHHHHH
AVFRTLSALRDGAAPQQLTGLATPELMDRVTRASLVDERGARFLGLARE
HHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCHHCCCCCC
>Mature Secondary Structure 
AWRDRRGALRAILEGSACVRPASVYDAISIRIADDLRFPLGMFGGSVASLAILGDPDSA
CCCCHHHHHHHHHCCCCCCCCHHHHHEEEEEEECCCCCCHHHCCCCCEEEEEECCCCCC
LITLTELAEQMRRMARAAALPVLVDADHGYGNALNVRRTVQELEAAGCAGLTIEDTLLPQ
EEEHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHCCH
AYGEAKPQLISSEEGLGKINAALDARLDPSLVIIGRTGACSISSLDDAIERAVAYEAAGV
HHCCCCCCEECCCCCCCHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
DALFFTGVKARDQLQAISAATRLPIVLGSPPAELADWEYLAAQRVRIAVQGHAPIAAATE
CEEEECCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHEEEEEEECCCCHHHHHH
AVFRTLSALRDGAAPQQLTGLATPELMDRVTRASLVDERGARFLGLARE
HHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA